Research Topics
Species | Natasha RekhtmanSummaryAffiliation: Memorial Sloan-Kettering Cancer Center Country: USA Publications
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Detail Information
Publications
Neuroendocrine tumors of the lung: an updateNatasha Rekhtman
Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
Arch Pathol Lab Med 134:1628-38. 2010..Markedly different prognostic implications and treatment paradigms for these tumors underscore the importance of accurate pathologic diagnosis...
Clarifying the spectrum of driver oncogene mutations in biomarker-verified squamous carcinoma of lung: lack of EGFR/KRAS and presence of PIK3CA/AKT1 mutationsNatasha Rekhtman
Department of Pathology, Thoracic Oncology Service, Department of Medicine, and Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, NY 10065, USA
Clin Cancer Res 18:1167-76. 2012....- Suitability of thoracic cytology for new therapeutic paradigms in non-small cell lung carcinoma: high accuracy of tumor subtyping and feasibility of EGFR and KRAS molecular testingNatasha Rekhtman
Department of Pathology, Memorial Sloan Kettering Cancer Center, New York City, New York 10065, USA
J Thorac Oncol 6:451-8. 2011..The aim of this study was to comprehensively review the performance of cytologic specimens for the above two goals in a high-volume clinical practice... - Immunohistochemical algorithm for differentiation of lung adenocarcinoma and squamous cell carcinoma based on large series of whole-tissue sections with validation in small specimensNatasha Rekhtman
Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, USA
Mod Pathol 24:1348-59. 2011..This simple algorithm achieves excellent accuracy in small specimens while conserving the tissue for potential predictive marker testing, which is now an essential consideration in advanced lung cancer specimens... - Subtyping of non-small cell lung carcinoma: a comparison of small biopsy and cytology specimensCarlie S Sigel
Department of Pathology, Memorial Sloan Kettering Cancer Center, New York City, New York 10065, USA
J Thorac Oncol 6:1849-56. 2011..The relative feasibility and accuracy of NSCLC subtyping by small biopsy versus cytology is not well established, particularly in current practice where immunohistochemistry (IHC) is becoming routinely used to aid in this distinction... - Predicting pulmonary adenocarcinoma outcome based on a cytology grading systemCarlie S Sigel
1Memorial Sloan Kettering Cancer Center, Department of Pathology, New York, New York, USA
Cancer Cytopathol 120:35-43. 2012..Therefore, we evaluated cytomorphologic features of previously histologically graded AD to identify features of potential prognostic significance... - Distinct profile of driver mutations and clinical features in immunomarker-defined subsets of pulmonary large-cell carcinomaNatasha Rekhtman
Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, USA
Mod Pathol 26:511-22. 2013..These findings have practical implications for diagnosis, predictive molecular testing and therapy selection... - Response to erlotinib in patients with EGFR mutant advanced non-small cell lung cancers with a squamous or squamous-like componentPaul K Paik
Thoracic Oncology Service, Division of Solid Tumor Oncology, Department of Medicine, Memorial Sloan Kettering Cancer Center, 300 East 66 Street, New York, NY 10065, USA
Mol Cancer Ther 11:2535-40. 2012..These tumors can mimic SCC in small samples. We propose an approach to increase the capture of these rare histology patients for EGFR mutation testing... - Analysis of Tumor Specimens at the Time of Acquired Resistance to EGFR-TKI Therapy in 155 Patients with EGFR-Mutant Lung CancersHelena A Yu
Authors Affiliations Thoracic Oncology Service, Division of Solid Tumor Oncology, Department of Medicine Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, Weill Cornell Medical College Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York and Division of Hematology Oncology, Vanderbilt Ingram Cancer Center, Nashville, Tennessee
Clin Cancer Res 19:2240-7. 2013..Smaller series have identified various mechanisms of resistance, but systematic evaluation of a large number of patients to definitively establish the frequency of various mechanisms has not been conducted... - Progenitor stem cell marker expression by pulmonary carcinomasAndre L Moreira
Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
Mod Pathol 23:889-95. 2010..Therefore, stem cell markers are expressed in lung cancers with different patterns seen for different histological types and degrees of differentiation... - EGFR exon 20 insertion mutations in lung adenocarcinomas: prevalence, molecular heterogeneity, and clinicopathologic characteristicsMaria E Arcila
Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA
Mol Cancer Ther 12:220-9. 2013..Insertions are structurally heterogeneous with potential implications for response to EGFR inhibitors... - Squamous-cell carcinomas of the lung: emerging biology, controversies, and the promise of targeted therapyAlexander Drilon
Department of Medicine Thoracic Oncology Service, Memorial Sloan Kettering Cancer Center, New York, NY, USA
Lancet Oncol 13:e418-26. 2012.... - Pathological diagnosis and classification of lung cancer in small biopsies and cytology: strategic management of tissue for molecular testingWilliam D Travis
Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA
Semin Respir Crit Care Med 32:22-31. 2011..The need for every institution to develop a multidisciplinary strategy to obtain these small specimens and process them not only for diagnosis but also for molecular testing is emphasized... - Advances in fine needle aspiration cytology for the diagnosis of pulmonary carcinomaAdnan Hasanovic
Department of Pathology, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA
Patholog Res Int 2011:897292. 2011..In this paper we will review the current concepts in the suitability and accuracy of fine needle aspiration biopsy, including diagnosis, classification, prognostic markers, and use of ancillary techniques... - Malignant solitary fibrous tumor: cytopathologic findings and differential diagnosisJustin A Bishop
Department of Pathology, Johns Hopkins Hospital, 600 North Wolfe Street, Baltimore, MD 21287, USA
Cancer Cytopathol 118:83-9. 2010..Malignant solitary fibrous tumors (SFTs) are extremely uncommon and poorly understood mesenchymal neoplasms. There are only rare published accounts of the cytopathologic features of these tumors, prompting the current study... 
A 62-year-old woman with a suspected thyroid noduleNatasha Rekhtman
Department of Pathology, The Johns Hopkins Hospital, Baltimore, MD 21287, USA
Arch Pathol Lab Med 129:1497-8. 2005