Mark Ptashne

Summary

Affiliation: Memorial Sloan-Kettering Cancer Center
Country: USA

Publications

  1. pmc Activator control of nucleosome occupancy in activation and repression of transcription
    Gene O Bryant
    Molecular Biology Program, Sloan Kettering Institute, New York, New York, United States of America
    PLoS Biol 6:2928-39. 2008
  2. doi request reprint Binding reactions: epigenetic switches, signal transduction and cancer
    Mark Ptashne
    Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, Box 595, New York, NY 10021, USA
    Curr Biol 19:R234-41. 2009
  3. ncbi request reprint Lambda's switch: lessons from a module swap
    Mark Ptashne
    Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Curr Biol 16:R459-62. 2006
  4. ncbi request reprint On learning to write
    Mark Ptashne
    Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, Box 595, New York, New York 10021, USA
    Curr Biol 17:R394-5. 2007
  5. ncbi request reprint On speaking, writing and inspiration
    Mark Ptashne
    Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, Box 595, New York, New York 10021, USA
    Curr Biol 17:R348-9. 2007
  6. ncbi request reprint On the use of the word 'epigenetic'
    Mark Ptashne
    Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Curr Biol 17:R233-6. 2007
  7. ncbi request reprint Repressors
    Mark Ptashne
    Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Curr Biol 17:R740-1. 2007
  8. ncbi request reprint Words
    Mark Ptashne
    Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
    Curr Biol 17:R533-5. 2007
  9. pmc A RSC/nucleosome complex determines chromatin architecture and facilitates activator binding
    Monique Floer
    Molecular Biology Program, Sloan Kettering Institute, 1275 York Avenue, New York, NY 10021, USA
    Cell 141:407-18. 2010
  10. pmc Proteolytic instability and the action of nonclassical transcriptional activators
    Xin Wang
    Molecular Biology Program, Sloan Kettering Institute, 1275 York Avenue, New York, NY 10021, USA
    Curr Biol 20:868-71. 2010

Collaborators

Detail Information

Publications29

  1. pmc Activator control of nucleosome occupancy in activation and repression of transcription
    Gene O Bryant
    Molecular Biology Program, Sloan Kettering Institute, New York, New York, United States of America
    PLoS Biol 6:2928-39. 2008
    ..These findings were made possible by our nucleosome occupancy assay. The assay, we believe, will prove useful in studying other outstanding issues in the field...
  2. doi request reprint Binding reactions: epigenetic switches, signal transduction and cancer
    Mark Ptashne
    Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, Box 595, New York, NY 10021, USA
    Curr Biol 19:R234-41. 2009
    ..Multiple negative and positive 'add-ons', often with small individual effects, make elementary systems that work, work better. Cancer illustrates various of these fundamental processes gone awry...
  3. ncbi request reprint Lambda's switch: lessons from a module swap
    Mark Ptashne
    Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Curr Biol 16:R459-62. 2006
    ..The resulting hybrid phage is viable, but a subtle phenotypic defect explains a puzzle concerning the workings of the switch...
  4. ncbi request reprint On learning to write
    Mark Ptashne
    Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, Box 595, New York, New York 10021, USA
    Curr Biol 17:R394-5. 2007
  5. ncbi request reprint On speaking, writing and inspiration
    Mark Ptashne
    Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, Box 595, New York, New York 10021, USA
    Curr Biol 17:R348-9. 2007
  6. ncbi request reprint On the use of the word 'epigenetic'
    Mark Ptashne
    Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Curr Biol 17:R233-6. 2007
    ..Here I wish to probe our use of language in this way, and to show how such a discussion leads to some more general considerations concerning gene regulation...
  7. ncbi request reprint Repressors
    Mark Ptashne
    Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Curr Biol 17:R740-1. 2007
  8. ncbi request reprint Words
    Mark Ptashne
    Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
    Curr Biol 17:R533-5. 2007
  9. pmc A RSC/nucleosome complex determines chromatin architecture and facilitates activator binding
    Monique Floer
    Molecular Biology Program, Sloan Kettering Institute, 1275 York Avenue, New York, NY 10021, USA
    Cell 141:407-18. 2010
    ..Higher eukaryotic RSC lacks the specific DNA-binding determinants found on yeast RSC, and evidently Gal4 works in those organisms despite whatever obstacle broadly positioned nucleosomes present...
  10. pmc Proteolytic instability and the action of nonclassical transcriptional activators
    Xin Wang
    Molecular Biology Program, Sloan Kettering Institute, 1275 York Avenue, New York, NY 10021, USA
    Curr Biol 20:868-71. 2010
    ..All three are unstable, and for the case analyzed in detail, stabilization decreases activity. Thus, to the extent tested, both classical and nonclassical activators work most efficiently when proteolytically unstable...
  11. ncbi request reprint Activation of the Gal1 gene of yeast by pairs of 'non-classical' activators
    Jason X Cheng
    Molecular Biology Program, Sloan Kettering Institute, New York, NY 10021, USA
    Curr Biol 14:1675-9. 2004
    ..The results are consistent with the finding that the classical activator Gal4, working at the GAL1 promoter, activates transcription by (at least in part) independently recruiting SAGA and Mediator...
  12. pmc HSP90/70 chaperones are required for rapid nucleosome removal upon induction of the GAL genes of yeast
    Monique Floer
    Molecular Biology Program, Sloan Kettering Institute, 1275 York Avenue, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 105:2975-80. 2008
    ..Removal of promoter-bound nucleosomes is delayed in a chaperone mutant, and our findings suggest an involvement of HSP90 and HSP70 in this early step in gene induction...
  13. pmc An effect of DNA sequence on nucleosome occupancy and removal
    Xin Wang
    Molecular Biology Program, Sloan Kettering Institute, New York, New York, USA
    Nat Struct Mol Biol 18:507-9. 2011
    ..As this occupancy is increased (by sequence alteration), nucleosome removal upon induction is decreased, as is mRNA production. These results explain why promoter sequences have evolved to form nucleosomes relatively inefficiently...
  14. doi request reprint Nucleosomes and the accessibility problem
    Xin Wang
    Molecular Biology Program, Sloan Kettering Institute, 1275 York Avenue, New York, NY 10065, USA
    Trends Genet 27:487-92. 2011
    ..These nucleosomes, evidently, inhibit basal transcription but are poised to be removed quickly upon command...
  15. ncbi request reprint Independent recruitment in vivo by Gal4 of two complexes required for transcription
    Gene O Bryant
    Molecular Biology Program, Sloan Kettering Institute, New York, NY 10021, USA
    Mol Cell 11:1301-9. 2003
    ..Our results are consistent with the notion that a single species of activator, Gal4, separately contacts, and thereby directly recruits, SAGA and Mediator...
  16. doi request reprint Transcription: a mechanism for short-term memory
    Mark Ptashne
    Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, Box 595, New York, New York 10021, USA
    Curr Biol 18:R25-7. 2008
    ..This memory is conveyed by a cytoplasmically transmitted galactokinase working as a signal transducer...
  17. ncbi request reprint Regulated recruitment and cooperativity in the design of biological regulatory systems
    Mark Ptashne
    Memorial Sloan Kettering Cancer Center, 1275 York Avenue, Box 595, New York, NY 10021, USA
    Philos Trans A Math Phys Eng Sci 361:1223-34. 2003
    ..These are examples of 'regulatory' decisions. A rather simple mechanism - called regulated recruitment - lies at the heart of many of these regulatory decisions...
  18. ncbi request reprint Two "what if" experiments
    Mark Ptashne
    Sloane Kettering Institute, New York, New York 10021, USA
    Cell 116:S71-2, 2 p following S76. 2004
  19. pmc Transcriptional activating regions target a cyclin-dependent kinase
    Aseem Z Ansari
    Program in Molecular Biology, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 99:14706-9. 2002
    ..The interaction evidently positions each activator, as it activates transcription, so that it gets phosphorylated by SRB10, and thus a common mechanism targets disparate substrates to the kinase...
  20. doi request reprint Regulation of a Mammalian gene bearing a CpG island promoter and a distal enhancer
    Georgina Berrozpe
    Molecular Biology Program, Memorial Sloan Kettering Cancer Center, 430 East 67 th Street, New York, NY 10065, USA
    Cell Rep 4:445-53. 2013
    ..As at the yeast GAL genes, the inhibitory effects of nucleosomes facilitate high factors of induction by mammalian activators working in the absence of specific repressors. ..
  21. pmc A target essential for the activity of a nonacidic yeast transcriptional activator
    Zhen Lu
    Molecular Biology Program, Sloan Kettering Institute, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 99:8591-6. 2002
    ..P201, unlike the typical yeast acidic activating region, does not work in mammalian cells, which is consistent with the notion that the unique target of P201 (Gal11) is absent from mammalian cells...
  22. ncbi request reprint Signal transduction. Imposing specificity on kinases
    Mark Ptashne
    Department of Molecular Biology, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Science 299:1025-7. 2003
  23. ncbi request reprint Responses of four yeast genes to changes in the transcriptional machinery are determined by their promoters
    Jason X Cheng
    Molecular Biology Program, Sloan Kettering Institute, New York, NY 10021, USA
    Curr Biol 12:1828-32. 2002
    ..These and additional results, including those of others, clarify how disparate activators can work at many different promoters...
  24. ncbi request reprint Telomere looping permits repression "at a distance" in yeast
    Zafar Zaman
    Molecular Biology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
    Curr Biol 12:930-3. 2002
    ..These and other results indicate that DNA-tethered Tup1 represses by interacting with some component of the transcriptional machinery binding to the promoter, an interaction that is facilitated by the preformed loop at the telomere...
  25. pmc Transcriptional activating regions target attached substrates to a cyclin-dependent kinase
    Aseem Z Ansari
    Department of Biochemistry and Genome Center, University of Wisconsin, Madison, WI 53706, USA
    Proc Natl Acad Sci U S A 102:2346-9. 2005
    ..In some cases, residues within the activating regions are also phosphorylated. The results define a mechanism by which a kinase is recruited to alternate substrates with diverse physiological consequences...
  26. ncbi request reprint Regulation of transcription: from lambda to eukaryotes
    Mark Ptashne
    Trends Biochem Sci 30:275-9. 2005
  27. ncbi request reprint A unified nomenclature for protein subunits of mediator complexes linking transcriptional regulators to RNA polymerase II
    Henri Marc Bourbon
    Mol Cell 14:553-7. 2004
  28. pmc RNA sequences that work as transcriptional activating regions
    Shamol Saha
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA
    Nucleic Acids Res 31:1565-70. 2003
    ..The result shows that although all natural activating regions characterized thus far are peptidic, this function can be served by other kinds of moieties as well...
  29. ncbi request reprint Design of artificial transcriptional activators with rigid poly-L-proline linkers
    Paramjit S Arora
    Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, California 91125, USA
    J Am Chem Soc 124:13067-71. 2002
    ..We find that there is an optimal linker length which separates the DNA and the activation region for transcription activation...