Research Topics
Species | Simon PowellSummaryAffiliation: Memorial Sloan-Kettering Cancer Center Country: USA Publications
Research Grants
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Detail Information
Publications
Radiotherapy for breast cancer in the 21st CenturySimon Powell
Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA
Breast J 16:S34-8. 2010..Biological enhancement of the effect of radiotherapy could allow dose reduction, with presumed reductions in the toxicity of treatment. In conclusion, breast cancer radiotherapy has much to understand and optimize in the 21st Century...- Targeting the DNA damage response for cancer therapySimon N Powell
Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, United States
DNA Repair (Amst) 8:1153-65. 2009..As these defects are specific to tumor cells, the development of new anti-cancer agents targeting these pathways may have an enhanced therapeutic window, with limited normal tissue toxicity... - Radiation field design and regional control in sentinel lymph node-positive breast cancer patients with omission of axillary dissectionJeremy Setton
Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
Cancer 118:1994-2003. 2012..The additional value of axillary radiotherapy in these patients is unknown... - Long-term outcomes in breast cancer patients undergoing immediate 2-stage expander/implant reconstruction and postmastectomy radiationAlice Ho
Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA
Cancer 118:2552-9. 2012..The long-term rates of permanent implant removal or replacement (PIRR) and clinical outcomes in patients treated with a uniform reconstructive surgery and radiation regimen were evaluated... - Patterns of utilization of adjuvant radiotherapy and outcomes in black women after breast conservation at a large multidisciplinary cancer centerSophia M Edwards-Bennett
Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
Int J Radiat Oncol Biol Phys 80:1102-8. 2011.... - Characteristics and outcomes of sentinel node-positive breast cancer patients after total mastectomy without axillary-specific treatmentSarah Milgrom
Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, NY, USA
Ann Surg Oncol 19:3762-70. 2012..Our aims were to evaluate the characteristics and outcomes of SLNB-positive TM patients who did not receive axillary-specific treatment and to compare them to similar patients who underwent breast-conserving surgery (BCS)... - Chest wall radiotherapy: middle ground for treatment of patients with one to three positive lymph nodes after mastectomyShannon M Macdonald
Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
Int J Radiat Oncol Biol Phys 75:1297-303. 2009.... 
The role of the BRCA1 tumor suppressor in DNA double-strand break repairJunran Zhang
Department of Radiation Oncology, Washington University in St. Louis, 4511 Forest Park Boulevard, St. Louis, Missouri 63108, USA
Mol Cancer Res 3:531-9. 2005..Finally, we will explore the idea that tumor suppression by BRCA1 depends on its control of DNA DSB repair, resulting in the promotion of error-free and the inhibition of error-prone recombinational repair...
Mammalian Rad9 plays a role in telomere stability, S- and G2-phase-specific cell survival, and homologous recombinational repairRaj K Pandita
Department of Radiation Oncology, Washington University School of Medicine, 4511 Forest Park Ave, St Louis, MO 63108, USA
Mol Cell Biol 26:1850-64. 2006..Together, these findings provide evidence of roles for mammalian Rad9 in telomere stability and HR repair as a mechanism for promoting cell survival after IR exposure...- MDC1 interacts with Rad51 and facilitates homologous recombinationJunran Zhang
Department of Radiation Oncology, MGH Cancer Center, Massachusetts General Hospital and Harvard Medical School, 149 13th Street, Charlestown, Massachusetts 02129, USA
Nat Struct Mol Biol 12:902-9. 2005..Together, our findings suggest that MDC1 functions in Rad51-mediated homologous recombination by retaining Rad51 in chromatin... - Therapeutic exploitation of tumor cell defects in homologous recombinationSimon N Powell
Department of Radiation Oncology, Washington University School of Medicine, 4511 Forest Park, St Louis, MO 63108, USA
Anticancer Agents Med Chem 8:448-60. 2008..Thus, functional assays of homologous recombination could become a useful technique to determine phenotype of human breast cancer, which in turn will influence the choice of therapy... - ATR affecting cell radiosensitivity is dependent on homologous recombination repair but independent of nonhomologous end joiningHongyan Wang
Department of Radiation Oncology, Kimmel Cancer Center of Jefferson Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
Cancer Res 64:7139-43. 2004..These results indicate that the effects of ATR on cell radiosensitivity are independent of NHEJ but are linked to HRR that may be affected by the deficient S and G(2) checkpoints... - The effect of age in the outcome and treatment of older women with ductal carcinoma in situAlice Ho
Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY, USA
Breast 20:71-7. 2011..00001) but not age. It is possible to identify older women with DCIS in whom the risk of recurrence is acceptably low after WLE alone. WLE alone may be a viable treatment option for select older women with DCIS... - Disassembly of MDC1 foci is controlled by ubiquitin-proteasome-dependent degradationWei Shi
Department of Radiation Oncology, Washington University School of Medicine, St Louis, Missouri 63108, USA
J Biol Chem 283:31608-16. 2008..Collectively, the evidence presented here supports a novel mechanism for the disassembly of MDC1 foci via ubiquitin-proteasome dependent degradation, which appears to be a key step for the efficient assembly of BRCA1 foci... - Utility of DNA repair protein foci for the detection of putative BRCA1 pathway defects in breast cancer biopsiesHenning Willers
Laboratory of Cellular and Molecular Radiation Oncology, Department of Radiation Oncology, Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, Massachusetts, USA
Mol Cancer Res 7:1304-9. 2009.... - Chk2 phosphorylation of BRCA1 regulates DNA double-strand break repairJunran Zhang
Department of Radiation Oncology, Massachusetts General Hospital Harvard Medical School, 149 13th Street, Charlestown, MA 02129, USA
Mol Cell Biol 24:708-18. 2004..We propose a dual regulatory role for BRCA1 in maintaining genome integrity, whereby BRCA1 phosphorylation status controls the selectivity of repair events dictated by HR and error-prone NHR... - Homologous recombination is the principal pathway for the repair of DNA damage induced by tirapazamine in mammalian cellsJames W Evans
Department of Radiation Oncology, Division of Radiation and Cancer Biology, Stanford University, Stanford, California 94305 5152, USA
Cancer Res 68:257-65. 2008.... - DNA damage induces p53-dependent BRCA1 nuclear exportZhihui Feng
Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA
J Biol Chem 279:28574-84. 2004..These results imply that, in addition to ATM-, ATR-, and Chk2-dependent phosphorylations, cytoplasmic relocalization of BRCA1 protein is a mechanism whereby BRCA1 function is regulated in response to DNA damage... - Checkpoint kinase 2-mediated phosphorylation of BRCA1 regulates the fidelity of nonhomologous end-joiningJing Zhuang
Department of Radiation Oncology, Vanderbilt University Medical Centre, 1301 22nd Avenue South, Nashville, TN 37232, USA
Cancer Res 66:1401-8. 2006..We suggest that the differential control of NHEJ subprocesses by BRCA1, in concert with Chk2, reduces the mutagenic potential of NHEJ, thereby contributing to the prevention of familial breast cancers... - Negative Regulation of AKT Activation by BRCA1Tao Xiang
Department of Radiation Oncology, Washington University School of Medicine, St Louis, Missouri 63108, USA
Cancer Res 68:10040-4. 2008..Our results show that BRCA1 is a negative regulator of the AKT pathway and imply the significance of the BRCA1/AKT pathway in tumorigenesis... - BRCA1- and BRCA2-deficient cells are sensitive to etoposide-induced DNA double-strand breaks via topoisomerase IIAlejandro D Treszezamsky
Department of Radiation Oncology, Massachusetts General Hospital, Boston, MA, USA
Cancer Res 67:7078-81. 2007..Overall, these results suggest that etoposide is a potentially useful drug in the treatment of BRCA-deficient human cancers... - The role of RPA2 phosphorylation in homologous recombination in response to replication arrestWei Shi
Department of Radiation Oncology, Washington University School of Medicine, St Louis, MO 63108, USA
Carcinogenesis 31:994-1002. 2010..Thus, our data suggest that RPA2 hyperphosphorylation plays a critical role in maintenance of genomic stability and cell survival after a DNA replication block via promotion of HR... - Roles of BRCA1 and BRCA2 in homologous recombination, DNA replication fidelity and the cellular response to ionizing radiationSimon N Powell
Department of Radiation Oncology, Massachusetts General Hospital, Boston, MA 02114, USA
Oncogene 22:5784-91. 2003..The unsolved mystery is the other genetic changes that must occur to turn a BRCA-deficient cell from a nonviable cell into a tumor cell capable of endless growth...
Research Grants
- DNA REPAIR--ROLE OF THE P53 TUMOR SUPPRESSOR PROTEINSimon Powell; Fiscal Year: 2005....
- DNA Recombinational Repair: Role of the p53 Tumor Suppressor ProteinSimon Powell; Fiscal Year: 2006....
- Roles of BRCA1, BRCA2 in Homologous RecombinationSimon Powell; Fiscal Year: 2007..Ultimately, the defects in HR that promote carcinogenesis by causing genetic instability may also offer a novel therapeutic target against the cancers that arise in this setting. ..
- AT: ERRORS IN DOUBLE STRAND BREAK REPAIRSimon Powell; Fiscal Year: 2003..Functional analysis will address the relationship between the NBS- containing protein complex and ATM in a DNA damage response pathway. ..
- DNA RECOMBINATION AND RADIATION RESISTANCESimon Powell; Fiscal Year: 1999....
- DNA RECOMBINATION AND RADIATION RESISTANCESimon Powell; Fiscal Year: 1993..A spectrum of clinical radiosensitivity will also be assessed...
- DNA Recombinational Repair: Role of the p53 Tumor Suppressor ProteinSimon N Powell; Fiscal Year: 2010....