Katrina Podsypanina

Summary

Affiliation: Memorial Sloan-Kettering Cancer Center
Country: USA

Publications

  1. ncbi Seeding and propagation of untransformed mouse mammary cells in the lung
    Katrina Podsypanina
    Program in Cancer Biology and Genetics, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Science 321:1841-4. 2008
  2. ncbi Evolution of somatic mutations in mammary tumors in transgenic mice is influenced by the inherited genotype
    Katrina Podsypanina
    Program in Cell Biology, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    BMC Med 2:24. 2004
  3. ncbi Oncogene cooperation in tumor maintenance and tumor recurrence in mouse mammary tumors induced by Myc and mutant Kras
    Katrina Podsypanina
    Program in Cancer Biology and Genetics, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 105:5242-7. 2008
  4. ncbi Changes in gene expression during the development of mammary tumors in MMTV-Wnt-1 transgenic mice
    Shixia Huang
    Program in Cancer Biology and Genetics, Sloan Kettering Institute, New York, NY 10021, USA
    Genome Biol 6:R84. 2005
  5. ncbi Regulation of transgenes in three-dimensional cultures of primary mouse mammary cells demonstrates oncogene dependence and identifies cells that survive deinduction
    Martin Jechlinger
    Program in Cancer Biology and Genetics, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA
    Genes Dev 23:1677-88. 2009
  6. ncbi Evidence that transgenes encoding components of the Wnt signaling pathway preferentially induce mammary cancers from progenitor cells
    Yi Li
    Department of Pathology, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 100:15853-8. 2003
  7. ncbi Analysis of PTEN mutation in non-familial pheochromocytoma
    Janusz Puc
    Institute for Cancer Genetics, Columbia University, New York, NY 10032, USA
    Ann N Y Acad Sci 1073:317-31. 2006
  8. ncbi Wnt-1 is dominant over neu in specifying mammary tumor expression profiles
    Shixia Huang
    Breast Center, Baylor College of Medicine, Houston, TX 77030, USA
    Technol Cancer Res Treat 5:565-71. 2006
  9. ncbi Comparison of expression profiles of metastatic versus primary mammary tumors in MMTV-Wnt-1 and MMTV-Neu transgenic mice
    Shixia Huang
    Dan L Duncan Cancer Center, Baylor College of Medicine, Houston, TX 77030 USA
    Neoplasia 10:118-24. 2008
  10. ncbi Introduction of oncogenes into mammary glands in vivo with an avian retroviral vector initiates and promotes carcinogenesis in mouse models
    Zhijun Du
    Breast Center, Baylor College of Medicine, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 103:17396-401. 2006

Research Grants

  1. Multiple mutations in tumor maintenance
    Katrina Podsypanina; Fiscal Year: 2007

Collaborators

Detail Information

Publications11

  1. ncbi Seeding and propagation of untransformed mouse mammary cells in the lung
    Katrina Podsypanina
    Program in Cancer Biology and Genetics, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Science 321:1841-4. 2008
    ..Mammary cells lacking oncogenic transgenes displayed a similar capacity for long-term residence in the lungs but did not form ectopic tumors...
  2. ncbi Evolution of somatic mutations in mammary tumors in transgenic mice is influenced by the inherited genotype
    Katrina Podsypanina
    Program in Cell Biology, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    BMC Med 2:24. 2004
    ..Secondary events also appear to be required for mammary tumorigenesis in MMTV-Neu transgenic mice because the transgene in the tumors usually contains an acquired mutation that activates the Neu protein-tyrosine kinase...
  3. ncbi Oncogene cooperation in tumor maintenance and tumor recurrence in mouse mammary tumors induced by Myc and mutant Kras
    Katrina Podsypanina
    Program in Cancer Biology and Genetics, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 105:5242-7. 2008
    ..These results demonstrate that tumor viability is maintained by each gene in a combination of oncogenes and that targeted approaches will also benefit from combination therapies...
  4. ncbi Changes in gene expression during the development of mammary tumors in MMTV-Wnt-1 transgenic mice
    Shixia Huang
    Program in Cancer Biology and Genetics, Sloan Kettering Institute, New York, NY 10021, USA
    Genome Biol 6:R84. 2005
    ..These mice might therefore be useful models for discovering changes in gene expression during cancer development...
  5. ncbi Regulation of transgenes in three-dimensional cultures of primary mouse mammary cells demonstrates oncogene dependence and identifies cells that survive deinduction
    Martin Jechlinger
    Program in Cancer Biology and Genetics, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA
    Genes Dev 23:1677-88. 2009
    ..Moreover, cells in the surviving spheres retain the ability to respond to reinduction and thus may represent the type of cells that give rise to recurrent tumors...
  6. ncbi Evidence that transgenes encoding components of the Wnt signaling pathway preferentially induce mammary cancers from progenitor cells
    Yi Li
    Department of Pathology, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 100:15853-8. 2003
    ..Thus, the developmental heterogeneity of different breast cancers is in part a consequence of differential effects of oncogenes on distinct cell types in the breast...
  7. ncbi Analysis of PTEN mutation in non-familial pheochromocytoma
    Janusz Puc
    Institute for Cancer Genetics, Columbia University, New York, NY 10032, USA
    Ann N Y Acad Sci 1073:317-31. 2006
    ....
  8. ncbi Wnt-1 is dominant over neu in specifying mammary tumor expression profiles
    Shixia Huang
    Breast Center, Baylor College of Medicine, Houston, TX 77030, USA
    Technol Cancer Res Treat 5:565-71. 2006
    ..These observations suggest that Wnt-1 is dominant over Neu in specifying mammary tumor expression profiles...
  9. ncbi Comparison of expression profiles of metastatic versus primary mammary tumors in MMTV-Wnt-1 and MMTV-Neu transgenic mice
    Shixia Huang
    Dan L Duncan Cancer Center, Baylor College of Medicine, Houston, TX 77030 USA
    Neoplasia 10:118-24. 2008
    ....
  10. ncbi Introduction of oncogenes into mammary glands in vivo with an avian retroviral vector initiates and promotes carcinogenesis in mouse models
    Zhijun Du
    Breast Center, Baylor College of Medicine, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 103:17396-401. 2006
    ..We conclude that infection of mammary glands with retrovirus vectors is an efficient means to screen candidate oncogenes for their capacity to initiate or promote mammary carcinogenesis in the mouse...
  11. ncbi Estrogen receptor positivity in mammary tumors of Wnt-1 transgenic mice is influenced by collaborating oncogenic mutations
    Xiaomei Zhang
    Breast Center, Baylor College of Medicine, One Baylor Plaza, N1210 03, Houston, TX 77030, USA
    Oncogene 24:4220-31. 2005
    ..This is a first report of a mouse model of antiestrogen-resistant ER-positive breast cancers, and could provide a powerful tool to study the molecular mechanisms that control antiestrogen resistance...

Research Grants2

  1. Multiple mutations in tumor maintenance
    Katrina Podsypanina; Fiscal Year: 2007
    ..to eradicate the tumor? 2) Of all the mutations contributing to tumorigenesis, which are the most critical to interfere with in order to eradicate cancer? 3) what are the oncogenic partners of the common human oncogenes MYC and RAS? ..