Anh Tuân Phan

Summary

Affiliation: Memorial Sloan-Kettering Cancer Center
Country: USA

Publications

  1. ncbi request reprint Small-molecule interaction with a five-guanine-tract G-quadruplex structure from the human MYC promoter
    Anh Tuân Phan
    Structural Biology Program, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Nat Chem Biol 1:167-73. 2005
  2. ncbi request reprint DNA architecture: from G to Z
    Anh Tuân Phan
    Structural Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Curr Opin Struct Biol 16:288-98. 2006
  3. ncbi request reprint Propeller-type parallel-stranded G-quadruplexes in the human c-myc promoter
    Anh Tuân Phan
    Structural Biology Program, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    J Am Chem Soc 126:8710-6. 2004
  4. ncbi request reprint Two-repeat Tetrahymena telomeric d(TGGGGTTGGGGT) Sequence interconverts between asymmetric dimeric G-quadruplexes in solution
    Anh Tuân Phan
    Cellular Biochemistry and Biophysics Program, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    J Mol Biol 338:93-102. 2004
  5. ncbi request reprint Structural basis for Diels-Alder ribozyme-catalyzed carbon-carbon bond formation
    Alexander Serganov
    Structural Biology Program, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Nat Struct Mol Biol 12:218-24. 2005
  6. ncbi request reprint Structure of the human telomere in K+ solution: an intramolecular (3 + 1) G-quadruplex scaffold
    Kim Ngoc Luu
    Structural Biology Program, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    J Am Chem Soc 128:9963-70. 2006
  7. ncbi request reprint Structural basis for discriminative regulation of gene expression by adenine- and guanine-sensing mRNAs
    Alexander Serganov
    Structural Biology Program, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Chem Biol 11:1729-41. 2004
  8. pmc Structure of two intramolecular G-quadruplexes formed by natural human telomere sequences in K+ solution
    Anh Tuân Phan
    Structural Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Nucleic Acids Res 35:6517-25. 2007
  9. pmc Different loop arrangements of intramolecular human telomeric (3+1) G-quadruplexes in K+ solution
    Anh Tuân Phan
    Structural Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Nucleic Acids Res 34:5715-9. 2006
  10. pmc Structure-function studies of FMRP RGG peptide recognition of an RNA duplex-quadruplex junction
    Anh Tuân Phan
    Structural Biology Program, Memorial Sloan Kettering Cancer Center, New York, New York, USA
    Nat Struct Mol Biol 18:796-804. 2011

Detail Information

Publications20

  1. ncbi request reprint Small-molecule interaction with a five-guanine-tract G-quadruplex structure from the human MYC promoter
    Anh Tuân Phan
    Structural Biology Program, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Nat Chem Biol 1:167-73. 2005
    ....
  2. ncbi request reprint DNA architecture: from G to Z
    Anh Tuân Phan
    Structural Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Curr Opin Struct Biol 16:288-98. 2006
    ..These results will enhance our understanding of the biology of these structures and provide a platform for drug design...
  3. ncbi request reprint Propeller-type parallel-stranded G-quadruplexes in the human c-myc promoter
    Anh Tuân Phan
    Structural Biology Program, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    J Am Chem Soc 126:8710-6. 2004
    ..The central loop contains two or six residues, while the two other loops contain only one residue...
  4. ncbi request reprint Two-repeat Tetrahymena telomeric d(TGGGGTTGGGGT) Sequence interconverts between asymmetric dimeric G-quadruplexes in solution
    Anh Tuân Phan
    Cellular Biochemistry and Biophysics Program, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    J Mol Biol 338:93-102. 2004
    ..In contrast to the human telomere counterpart, the proportions of the two forms here are similar for a wide range of temperatures; their unfolding rates are also similar, with an activation enthalpy of 153 kJ/mol...
  5. ncbi request reprint Structural basis for Diels-Alder ribozyme-catalyzed carbon-carbon bond formation
    Alexander Serganov
    Structural Biology Program, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Nat Struct Mol Biol 12:218-24. 2005
    ..We observe structural parallels in the independently evolved catalytic pocket architectures for ribozyme- and antibody-catalyzed Diels-Alder carbon-carbon bond-forming reactions...
  6. ncbi request reprint Structure of the human telomere in K+ solution: an intramolecular (3 + 1) G-quadruplex scaffold
    Kim Ngoc Luu
    Structural Biology Program, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    J Am Chem Soc 128:9963-70. 2006
    ..The topological characteristics of this (3 + 1) G-quadruplex scaffold should provide a unique platform for structure-based anticancer drug design targeted to human telomeric DNA...
  7. ncbi request reprint Structural basis for discriminative regulation of gene expression by adenine- and guanine-sensing mRNAs
    Alexander Serganov
    Structural Biology Program, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Chem Biol 11:1729-41. 2004
    ..Recognition specificity is associated with Watson-Crick pairing of the encapsulated adenine and guanine ligands with uridine and cytosine, respectively...
  8. pmc Structure of two intramolecular G-quadruplexes formed by natural human telomere sequences in K+ solution
    Anh Tuân Phan
    Structural Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Nucleic Acids Res 35:6517-25. 2007
    ..This structural information might be important for our understanding of telomere G-quadruplex structures and for anticancer drug design targeted to such scaffolds...
  9. pmc Different loop arrangements of intramolecular human telomeric (3+1) G-quadruplexes in K+ solution
    Anh Tuân Phan
    Structural Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Nucleic Acids Res 34:5715-9. 2006
    ..Furthermore, even small changes to flanking sequences can perturb the equilibrium between different coexisting G-quadruplex forms...
  10. pmc Structure-function studies of FMRP RGG peptide recognition of an RNA duplex-quadruplex junction
    Anh Tuân Phan
    Structural Biology Program, Memorial Sloan Kettering Cancer Center, New York, New York, USA
    Nat Struct Mol Biol 18:796-804. 2011
    ..These findings on FMRP RGG domain recognition by a combination of G-quadruplex and surrounding RNA sequences have implications for the recognition of other genomic G-rich RNAs...
  11. ncbi request reprint (3 + 1) Assembly of three human telomeric repeats into an asymmetric dimeric G-quadruplex
    Na Zhang
    Structural Biology Program, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    J Am Chem Soc 127:17277-85. 2005
    ..We discuss the possible implications of the new folding topology for understanding the structure of telomeric DNA, including t-loop formation, and for targeting G-quadruplexes in the telomeres...
  12. pmc An interlocked dimeric parallel-stranded DNA quadruplex: a potent inhibitor of HIV-1 integrase
    Anh Tuân Phan
    Structural Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 102:634-9. 2005
    ..Finally, we propose a model, based on molecular docking approaches, for positioning the 93del dimeric DNA quadruplex within a basic channel/canyon formed between subunits of a dimer of dimers of HIV-1 integrase...
  13. ncbi request reprint Two-repeat human telomeric d(TAGGGTTAGGGT) sequence forms interconverting parallel and antiparallel G-quadruplexes in solution: distinct topologies, thermodynamic properties, and folding/unfolding kinetics
    Anh Tuân Phan
    Cellular Biochemistry and Biophysics Program, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    J Am Chem Soc 125:15021-7. 2003
    ....
  14. ncbi request reprint Structure of an unprecedented G-quadruplex scaffold in the human c-kit promoter
    Anh Tuân Phan
    Structural Biology Program, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    J Am Chem Soc 129:4386-92. 2007
    ..This unique structural scaffold provides a highly specific platform for the future design of ligands specifically targeted to the promoter DNA of c-kit...
  15. ncbi request reprint Differentiation between unlabeled and very-low-level fully 15N,13C-labeled nucleotides for resonance assignments in nucleic acids
    Anh Tuân Phan
    Cellular Biochemistry and Biophysics Program, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    J Biomol NMR 23:257-62. 2002
    ..We expect this approach to be useful for selective monitoring of important functional domains and of their interactions in large nucleic acids...
  16. pmc Human telomere, oncogenic promoter and 5'-UTR G-quadruplexes: diverse higher order DNA and RNA targets for cancer therapeutics
    Dinshaw J Patel
    Structural Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Nucleic Acids Res 35:7429-55. 2007
    ....
  17. pmc Solution structures of all parallel-stranded monomeric and dimeric G-quadruplex scaffolds of the human c-kit2 promoter
    Vitaly Kuryavyi
    Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    Nucleic Acids Res 38:6757-73. 2010
    ..We propose that strand exchange during recombination events within guanine-rich segments, could potentially be mediated by a synapsis intermediate involving an intergenic parallel-stranded dimeric G-quadruplex...
  18. pmc Human telomeric DNA: G-quadruplex, i-motif and Watson-Crick double helix
    Anh Tuân Phan
    Groupe de Biophysique du Laboratoire de Physique de la Matière Condensée, CNRS UMR 7643, Ecole Polytechnique, 91128 Palaiseau, France
    Nucleic Acids Res 30:4618-25. 2002
    ..However, at lower pH values or higher temperatures, the G-quadruplex and/or the i-motif efficiently competed with the duplex. We also present kinetic and thermodynamic data for duplex association and for G-quadruplex/i-motif unfolding...
  19. ncbi request reprint Structural basis for recognition and sequestration of UUU(OH) 3' temini of nascent RNA polymerase III transcripts by La, a rheumatic disease autoantigen
    Marianna Teplova
    Structural Biology Program, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Mol Cell 21:75-85. 2006
    ....
  20. ncbi request reprint A site-specific low-enrichment (15)N,(13)C isotope-labeling approach to unambiguous NMR spectral assignments in nucleic acids
    Anh Tuân Phan
    Cellular Biochemistry and Biophysics Program, Memorial Sloan Kettering Cancer Center New York, New York 10021, USA
    J Am Chem Soc 124:1160-1. 2002
    ..This simple and cost-effective methodology is demonstrated on the d(GGGTTCAGG) DNA sequence, which forms a dimeric G-quadruplex containing G.G.G.G tetrads sandwiched between G.(C-A) triads...