Research Topics
Species | Anh Tuân PhanSummaryAffiliation: Memorial Sloan-Kettering Cancer Center Country: USA Publications
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Detail Information
Publications
Small-molecule interaction with a five-guanine-tract G-quadruplex structure from the human MYC promoterAnh Tuân Phan
Structural Biology Program, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
Nat Chem Biol 1:167-73. 2005....- DNA architecture: from G to ZAnh Tuân Phan
Structural Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
Curr Opin Struct Biol 16:288-98. 2006..These results will enhance our understanding of the biology of these structures and provide a platform for drug design... - Propeller-type parallel-stranded G-quadruplexes in the human c-myc promoterAnh Tuân Phan
Structural Biology Program, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
J Am Chem Soc 126:8710-6. 2004..The central loop contains two or six residues, while the two other loops contain only one residue... - Two-repeat Tetrahymena telomeric d(TGGGGTTGGGGT) Sequence interconverts between asymmetric dimeric G-quadruplexes in solutionAnh Tuân Phan
Cellular Biochemistry and Biophysics Program, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
J Mol Biol 338:93-102. 2004..In contrast to the human telomere counterpart, the proportions of the two forms here are similar for a wide range of temperatures; their unfolding rates are also similar, with an activation enthalpy of 153 kJ/mol... 
Structure of two intramolecular G-quadruplexes formed by natural human telomere sequences in K+ solutionAnh Tuân Phan
Structural Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
Nucleic Acids Res 35:6517-25. 2007..This structural information might be important for our understanding of telomere G-quadruplex structures and for anticancer drug design targeted to such scaffolds...- Different loop arrangements of intramolecular human telomeric (3+1) G-quadruplexes in K+ solutionAnh Tuân Phan
Structural Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
Nucleic Acids Res 34:5715-9. 2006..Furthermore, even small changes to flanking sequences can perturb the equilibrium between different coexisting G-quadruplex forms... - Structure-function studies of FMRP RGG peptide recognition of an RNA duplex-quadruplex junctionAnh Tuân Phan
Structural Biology Program, Memorial Sloan Kettering Cancer Center, New York, New York, USA
Nat Struct Mol Biol 18:796-804. 2011..These findings on FMRP RGG domain recognition by a combination of G-quadruplex and surrounding RNA sequences have implications for the recognition of other genomic G-rich RNAs... - An interlocked dimeric parallel-stranded DNA quadruplex: a potent inhibitor of HIV-1 integraseAnh Tuân Phan
Structural Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
Proc Natl Acad Sci U S A 102:634-9. 2005..Finally, we propose a model, based on molecular docking approaches, for positioning the 93del dimeric DNA quadruplex within a basic channel/canyon formed between subunits of a dimer of dimers of HIV-1 integrase... - Two-repeat human telomeric d(TAGGGTTAGGGT) sequence forms interconverting parallel and antiparallel G-quadruplexes in solution: distinct topologies, thermodynamic properties, and folding/unfolding kineticsAnh Tuân Phan
Cellular Biochemistry and Biophysics Program, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
J Am Chem Soc 125:15021-7. 2003.... - Structure of an unprecedented G-quadruplex scaffold in the human c-kit promoterAnh Tuân Phan
Structural Biology Program, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
J Am Chem Soc 129:4386-92. 2007..This unique structural scaffold provides a highly specific platform for the future design of ligands specifically targeted to the promoter DNA of c-kit... - Differentiation between unlabeled and very-low-level fully 15N,13C-labeled nucleotides for resonance assignments in nucleic acidsAnh Tuân Phan
Cellular Biochemistry and Biophysics Program, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
J Biomol NMR 23:257-62. 2002..We expect this approach to be useful for selective monitoring of important functional domains and of their interactions in large nucleic acids... - Human telomere, oncogenic promoter and 5'-UTR G-quadruplexes: diverse higher order DNA and RNA targets for cancer therapeuticsDinshaw J Patel
Structural Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
Nucleic Acids Res 35:7429-55. 2007.... - Solution structures of all parallel-stranded monomeric and dimeric G-quadruplex scaffolds of the human c-kit2 promoterVitaly Kuryavyi
Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
Nucleic Acids Res 38:6757-73. 2010..We propose that strand exchange during recombination events within guanine-rich segments, could potentially be mediated by a synapsis intermediate involving an intergenic parallel-stranded dimeric G-quadruplex... - Human telomeric DNA: G-quadruplex, i-motif and Watson-Crick double helixAnh Tuân Phan
Groupe de Biophysique du Laboratoire de Physique de la Matière Condensée, CNRS UMR 7643, Ecole Polytechnique, 91128 Palaiseau, France
Nucleic Acids Res 30:4618-25. 2002..However, at lower pH values or higher temperatures, the G-quadruplex and/or the i-motif efficiently competed with the duplex. We also present kinetic and thermodynamic data for duplex association and for G-quadruplex/i-motif unfolding... - Structural basis for recognition and sequestration of UUU(OH) 3' temini of nascent RNA polymerase III transcripts by La, a rheumatic disease autoantigenMarianna Teplova
Structural Biology Program, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
Mol Cell 21:75-85. 2006.... - A site-specific low-enrichment (15)N,(13)C isotope-labeling approach to unambiguous NMR spectral assignments in nucleic acidsAnh Tuân Phan
Cellular Biochemistry and Biophysics Program, Memorial Sloan Kettering Cancer Center New York, New York 10021, USA
J Am Chem Soc 124:1160-1. 2002..This simple and cost-effective methodology is demonstrated on the d(GGGTTCAGG) DNA sequence, which forms a dimeric G-quadruplex containing G.G.G.G tetrads sandwiched between G.(C-A) triads...