Ying Xian Pan
Affiliation: Memorial Sloan-Kettering Cancer Center
Pan Y. Identification and characterization of a novel promoter of the mouse mu opioid receptor gene (Oprm) that generates eight splice variants. Gene. 2002;295:97-108 pubmed
..Mutation analysis suggested that the TATA box in the basal core region played a fundamental role in the exon 11 promoter, whereas the NF-1 site acted as a positive element. ..
Xu J, Faskowitz A, Rossi G, Xu M, Lu Z, Pan Y, et al
. Stabilization of morphine tolerance with long-term dosing: association with selective upregulation of mu-opioid receptor splice variant mRNAs. Proc Natl Acad Sci U S A. 2015;112:279-84 pubmed publisher
..These findings reconcile preclinical and clinical observations regarding the development of morphine tolerance. ..
Xu J, Lu Z, Xu M, Pan L, Deng Y, Xie X, et al
. A heroin addiction severity-associated intronic single nucleotide polymorphism modulates alternative pre-mRNA splicing of the Î¼ opioid receptor gene OPRM1 via hnRNPH interactions. J Neurosci. 2014;34:11048-66 pubmed publisher
..Our studies delineate the role of this SNP as a modifier of OPRM1 alternative splicing via hnRNPH interactions, and suggest a functional link between an SNP-containing splicing modifier and the severity of heroin addiction. ..
Pan Y, Xu J, Mahurter L, Xu M, Gilbert A, Pasternak G. Identification and characterization of two new human mu opioid receptor splice variants, hMOR-1O and hMOR-1X. Biochem Biophys Res Commun. 2003;301:1057-61 pubmed
..These two new human mu opioid receptors are the first human MOR-1 variants containing new exons and suggest that the complex splicing present in mice may extend to humans. ..
Pan Y, Xu J, Bolan E, Moskowitz H, Xu M, Pasternak G. Identification of four novel exon 5 splice variants of the mouse mu-opioid receptor gene: functional consequences of C-terminal splicing. Mol Pharmacol. 2005;68:866-75 pubmed
..In conclusion, alterations in the amino acid sequence of the C terminus do not alter the mu-specificity of the receptor but they can influence the binding characteristics, efficacy, and potency of mu-opioids. ..
Pan Y, Xu J, Xu M, Rossi G, Matulonis J, Pasternak G. Involvement of exon 11-associated variants of the mu opioid receptor MOR-1 in heroin, but not morphine, actions. Proc Natl Acad Sci U S A. 2009;106:4917-22 pubmed publisher