Ying Xian Pan

Summary

Affiliation: Memorial Sloan-Kettering Cancer Center
Country: USA

Publications

  1. ncbi Identification and characterization of a novel promoter of the mouse mu opioid receptor gene (Oprm) that generates eight splice variants
    Ying Xian Pan
    Laboratory of Molecular Neuro Pharmacology, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
    Gene 295:97-108. 2002
  2. ncbi Identification of four novel exon 5 splice variants of the mouse mu-opioid receptor gene: functional consequences of C-terminal splicing
    Ying Xian Pan
    Laboratory of Molecular Neuropharmacology, Memorial Sloan Kettering Cancer Center, 1275 York Ave, New York, NY 10021, USA
    Mol Pharmacol 68:866-75. 2005
  3. ncbi Diversity and complexity of the mu opioid receptor gene: alternative pre-mRNA splicing and promoters
    Ying Xian Pan
    Department of Neurology, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    DNA Cell Biol 24:736-50. 2005
  4. ncbi Involvement of exon 11-associated variants of the mu opioid receptor MOR-1 in heroin, but not morphine, actions
    Ying Xian Pan
    Department of Neurology, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 106:4917-22. 2009
  5. ncbi Identification and characterization of two new human mu opioid receptor splice variants, hMOR-1O and hMOR-1X
    Ying Xian Pan
    Department of Neurology, Laboratory of Molecular Neuropharmacology, Memorial Sloan Kettering Cancer Center, 1275 York Ave, New York, NY 10021, USA
    Biochem Biophys Res Commun 301:1057-61. 2003
  6. ncbi Isolation and characterization of new exon 11-associated N-terminal splice variants of the human mu opioid receptor gene
    Jin Xu
    Department of Neurology and The Molecular Pharmacology and Chemistry Program, Memorial Sloan Kettering Cancer Center, New York, New York, USA
    J Neurochem 108:962-72. 2009
  7. ncbi Identification and characterization of seven new exon 11-associated splice variants of the rat μ opioid receptor gene, OPRM1
    Jin Xu
    Department of Neurology and Program in Molecular Pharmacology and Chemistry, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    Mol Pain 7:9. 2011
  8. ncbi Identification of three new alternatively spliced variants of the rat mu opioid receptor gene: dissociation of affinity and efficacy
    David A Pasternak
    Laboratory of Molecular Neuropharmacology, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    J Neurochem 91:881-90. 2004
  9. ncbi Truncated G protein-coupled mu opioid receptor MOR-1 splice variants are targets for highly potent opioid analgesics lacking side effects
    Susruta Majumdar
    Molecular Pharmacology and Chemistry Program and Department of Neurology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    Proc Natl Acad Sci U S A 108:19778-83. 2011
  10. ncbi Synthesis and evaluation of aryl-naloxamide opiate analgesics targeting truncated exon 11-associated μ opioid receptor (MOR-1) splice variants
    Susruta Majumdar
    Molecular Pharmacology and Chemistry Program, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA
    J Med Chem 55:6352-62. 2012

Research Grants

  1. Characterizing a novel promoter of mouse MOR-1 gene
    Ying Xian Pan; Fiscal Year: 2006
  2. Characterizing exon 11 promoter of the mu opioid receptor gene, OPRM
    Ying Xian Pan; Fiscal Year: 2009
  3. Characterizing exon 11 promoter of the mu opioid receptor gene, OPRM
    Ying Xian Pan; Fiscal Year: 2010
  4. Characterizing exon 11 promoter of the mu opioid receptor gene, OPRM
    Ying Xian Pan; Fiscal Year: 2010

Collaborators

Detail Information

Publications20

  1. ncbi Identification and characterization of a novel promoter of the mouse mu opioid receptor gene (Oprm) that generates eight splice variants
    Ying Xian Pan
    Laboratory of Molecular Neuro Pharmacology, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
    Gene 295:97-108. 2002
    ..Mutation analysis suggested that the TATA box in the basal core region played a fundamental role in the exon 11 promoter, whereas the NF-1 site acted as a positive element...
  2. ncbi Identification of four novel exon 5 splice variants of the mouse mu-opioid receptor gene: functional consequences of C-terminal splicing
    Ying Xian Pan
    Laboratory of Molecular Neuropharmacology, Memorial Sloan Kettering Cancer Center, 1275 York Ave, New York, NY 10021, USA
    Mol Pharmacol 68:866-75. 2005
    ..In conclusion, alterations in the amino acid sequence of the C terminus do not alter the mu-specificity of the receptor but they can influence the binding characteristics, efficacy, and potency of mu-opioids...
  3. ncbi Diversity and complexity of the mu opioid receptor gene: alternative pre-mRNA splicing and promoters
    Ying Xian Pan
    Department of Neurology, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    DNA Cell Biol 24:736-50. 2005
    ..This review summarizes these recent results and provides a new perspective on understanding and exploring complex opioid actions in animals and humans...
  4. ncbi Involvement of exon 11-associated variants of the mu opioid receptor MOR-1 in heroin, but not morphine, actions
    Ying Xian Pan
    Department of Neurology, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 106:4917-22. 2009
    ....
  5. ncbi Identification and characterization of two new human mu opioid receptor splice variants, hMOR-1O and hMOR-1X
    Ying Xian Pan
    Department of Neurology, Laboratory of Molecular Neuropharmacology, Memorial Sloan Kettering Cancer Center, 1275 York Ave, New York, NY 10021, USA
    Biochem Biophys Res Commun 301:1057-61. 2003
    ..These two new human mu opioid receptors are the first human MOR-1 variants containing new exons and suggest that the complex splicing present in mice may extend to humans...
  6. ncbi Isolation and characterization of new exon 11-associated N-terminal splice variants of the human mu opioid receptor gene
    Jin Xu
    Department of Neurology and The Molecular Pharmacology and Chemistry Program, Memorial Sloan Kettering Cancer Center, New York, New York, USA
    J Neurochem 108:962-72. 2009
    ..The presence of exon 11-associated variants in humans raises questions regarding their potential role in heroin and morphine-6beta-glucuronide actions in people as they do in mice...
  7. ncbi Identification and characterization of seven new exon 11-associated splice variants of the rat μ opioid receptor gene, OPRM1
    Jin Xu
    Department of Neurology and Program in Molecular Pharmacology and Chemistry, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    Mol Pain 7:9. 2011
    ..We now have examined 5' splicing in the rat...
  8. ncbi Identification of three new alternatively spliced variants of the rat mu opioid receptor gene: dissociation of affinity and efficacy
    David A Pasternak
    Laboratory of Molecular Neuropharmacology, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    J Neurochem 91:881-90. 2004
    ..Thus, selectivity of opioid action might be achieved by designing compounds with varying efficacies at different MOR-1 variants...
  9. ncbi Truncated G protein-coupled mu opioid receptor MOR-1 splice variants are targets for highly potent opioid analgesics lacking side effects
    Susruta Majumdar
    Molecular Pharmacology and Chemistry Program and Department of Neurology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    Proc Natl Acad Sci U S A 108:19778-83. 2011
    ....
  10. ncbi Synthesis and evaluation of aryl-naloxamide opiate analgesics targeting truncated exon 11-associated μ opioid receptor (MOR-1) splice variants
    Susruta Majumdar
    Molecular Pharmacology and Chemistry Program, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA
    J Med Chem 55:6352-62. 2012
    ..Thus, the aryl-naloxamide scaffold can generate a potent analgesic acting through the 6TM/E11 sites with advantageous side-effect profile and greater selectivity...
  11. ncbi Characterizing exons 11 and 1 promoters of the mu opioid receptor (Oprm) gene in transgenic mice
    Jin Xu
    Department of Neurology, Memorial Sloan Kettering Cancer Center, New York, NY 10021 USA
    BMC Mol Biol 7:41. 2006
    ..The aim of this study is to further characterize the E11 and E1 promoters in vivo using a transgenic mouse model...
  12. ncbi Expression of opioid receptors in mammalian cell lines
    Ying-Xian Pan
    Laboratory of Molecular Neuro-Pharmacology, Department of Neurology, Memorial Sloan-Kettering Cancer Center, New York, NY, USA
    Methods Mol Med 84:17-28. 2003
  13. ncbi Splicing factor hnRNPH drives an oncogenic splicing switch in gliomas
    Clare V LeFave
    Department of Molecular Pharmacology and Chemistry, Memorial Sloan Kettering Cancer Center, New York, NY, USA
    EMBO J 30:4084-97. 2011
    ....
  14. ncbi Identification of alternatively spliced variants from opioid receptor genes
    Ying-Xian Pan
    Laboratory of Molecular Neuro-Pharmacology, Department of Neurology, Memorial Sloan-Kettering Cancer Center, New York, NY, USA
    Methods Mol Med 84:65-75. 2003
  15. ncbi Mu opioid receptors in pain management
    Gavril Pasternak
    Department of Neurology, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, NY 10065, USA
    Acta Anaesthesiol Taiwan 49:21-5. 2011
    ..It now appears that this gene undergoes extensive splicing, in which a single gene can generate multiple proteins. Evidence now suggests that these splice variants may help explain the clinical variability in responses among patients...
  16. ncbi Molecular cloning of opioid receptors by cDNA library screening
    Ying-Xian Pan
    Laboratory of Molecular Neuro-Pharmacology, Department of Neurology, Memorial Sloan-Kettering Cancer Center, New York, NY, USA
    Methods Mol Med 84:3-16. 2003
  17. ncbi Functional analysis of MOR-1 splice variants of the mouse mu opioid receptor gene Oprm
    Elizabeth A Bolan
    Laboratory of Molecular Neuropharmacology, Memorial Sloan-Kettering Cancer Center, New York, New York 10021, USA
    Synapse 51:11-8. 2004
    ..Together, these findings reveal marked functional differences among the variants that only can be explained by their structural differences at the tip of their C-terminus...
  18. ncbi Opposing actions of neuronal nitric oxide synthase isoforms in formalin-induced pain in mice
    Yuri A Kolesnikov
    Department of Anesthesiology, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Brain Res 1289:14-21. 2009
    ..Together, these observations illustrate the complexity of nNOS in pain perception and the existence of opposing nNOS systems likely due to splice variants of nNOS...
  19. ncbi Dimerization of morphine and orphanin FQ/nociceptin receptors: generation of a novel opioid receptor subtype
    Ying-Xian Pan
    Laboratory of Molecular Neuropharmacology, Memorial Sloan-Kettering Cancer Center, Weill College of Medicine of Cornell University, 1275 York Avenue, New York, NY 10021, USA
    Biochem Biophys Res Commun 297:659-63. 2002
    ..Selective kappa(1) and delta opioids did not lower binding. Despite the dramatic increase in affinity for the opioid agonists in co-expressing cells, the opioid antagonists naloxone and diprenorphine failed to compete [3H]OFQ/N binding...

Research Grants9

  1. Characterizing a novel promoter of mouse MOR-1 gene
    Ying Xian Pan; Fiscal Year: 2006
    ..abstract_text> ..
  2. Characterizing exon 11 promoter of the mu opioid receptor gene, OPRM
    Ying Xian Pan; Fiscal Year: 2009
    ....
  3. Characterizing exon 11 promoter of the mu opioid receptor gene, OPRM
    Ying Xian Pan; Fiscal Year: 2010
    ....
  4. Characterizing exon 11 promoter of the mu opioid receptor gene, OPRM
    Ying Xian Pan; Fiscal Year: 2010
    ....