ERIC G contact PAMER

Summary

Affiliation: Memorial Sloan-Kettering Cancer Center
Country: USA

Publications

  1. ncbi request reprint Immune responses to Listeria monocytogenes
    Eric G Pamer
    Infectious Disease Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, Immunology Program, Sloan Kettering Institute, 1275 York Avenue, New York, New York 10021, USA
    Nat Rev Immunol 4:812-23. 2004
  2. ncbi request reprint Distinct in vivo dendritic cell activation by live versus killed Listeria monocytogenes
    Eric Muraille
    Groupe Avenir, Institut National de la Sante et de la Recherche Medicale, E 344, Universite de Nice Sophia Antipolis, Institut de Pharmacologie Moleculaire et Cellulaire, Valbonne, France
    Eur J Immunol 35:1463-71. 2005
  3. pmc Delayed protection by ESAT-6-specific effector CD4+ T cells after airborne M. tuberculosis infection
    Alena M Gallegos
    Infectious Diseases Service, Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10032, USA
    J Exp Med 205:2359-68. 2008
  4. pmc A gamma interferon independent mechanism of CD4 T cell mediated control of M. tuberculosis infection in vivo
    Alena M Gallegos
    NIH NIAID Laboratory of Parasitic Diseases, Bethesda, Maryland, United States of America
    PLoS Pathog 7:e1002052. 2011
  5. pmc Dectin-1 diversifies Aspergillus fumigatus-specific T cell responses by inhibiting T helper type 1 CD4 T cell differentiation
    Amariliz Rivera
    Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    J Exp Med 208:369-81. 2011
  6. pmc Profound alterations of intestinal microbiota following a single dose of clindamycin results in sustained susceptibility to Clostridium difficile-induced colitis
    Charlie G Buffie
    Infectious Diseases Service, Department of Medicine, Lucille Castori Center for Microbes, Inflammation and Cancer, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, New York, USA
    Infect Immun 80:62-73. 2012
  7. ncbi request reprint Immune responses to commensal and environmental microbes
    Eric G Pamer
    Infectious Diseases Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Nat Immunol 8:1173-8. 2007
  8. ncbi request reprint Priming of memory but not effector CD8 T cells by a killed bacterial vaccine
    G Lauvau
    Infectious Disease Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, Immunology Program, Sloan Kettering Institute, 1275 York Avenue, New York, NY 10021, USA
    Science 294:1735-9. 2001
  9. pmc Inflammatory monocytes facilitate adaptive CD4 T cell responses during respiratory fungal infection
    Tobias M Hohl
    Infectious Disease Service, Department of Medicine, and Immunology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    Cell Host Microbe 6:470-81. 2009
  10. pmc Additive roles for MCP-1 and MCP-3 in CCR2-mediated recruitment of inflammatory monocytes during Listeria monocytogenes infection
    Ting Jia
    Infectious Diseases Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    J Immunol 180:6846-53. 2008

Collaborators

Detail Information

Publications64

  1. ncbi request reprint Immune responses to Listeria monocytogenes
    Eric G Pamer
    Infectious Disease Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, Immunology Program, Sloan Kettering Institute, 1275 York Avenue, New York, New York 10021, USA
    Nat Rev Immunol 4:812-23. 2004
    ..These studies, which are yielding one of the most comprehensive pictures of the 'battle' between host and microorganism, are reviewed here...
  2. ncbi request reprint Distinct in vivo dendritic cell activation by live versus killed Listeria monocytogenes
    Eric Muraille
    Groupe Avenir, Institut National de la Sante et de la Recherche Medicale, E 344, Universite de Nice Sophia Antipolis, Institut de Pharmacologie Moleculaire et Cellulaire, Valbonne, France
    Eur J Immunol 35:1463-71. 2005
    ....
  3. pmc Delayed protection by ESAT-6-specific effector CD4+ T cells after airborne M. tuberculosis infection
    Alena M Gallegos
    Infectious Diseases Service, Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10032, USA
    J Exp Med 205:2359-68. 2008
    ..Our results demonstrate that pathogen-specific Th1 cells can provide protection against inhaled M. tuberculosis, but only after the first week of infection...
  4. pmc A gamma interferon independent mechanism of CD4 T cell mediated control of M. tuberculosis infection in vivo
    Alena M Gallegos
    NIH NIAID Laboratory of Parasitic Diseases, Bethesda, Maryland, United States of America
    PLoS Pathog 7:e1002052. 2011
    ....
  5. pmc Dectin-1 diversifies Aspergillus fumigatus-specific T cell responses by inhibiting T helper type 1 CD4 T cell differentiation
    Amariliz Rivera
    Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    J Exp Med 208:369-81. 2011
    ..fumigatus-specific CD4 T cells and enabling Th17 differentiation...
  6. pmc Profound alterations of intestinal microbiota following a single dose of clindamycin results in sustained susceptibility to Clostridium difficile-induced colitis
    Charlie G Buffie
    Infectious Diseases Service, Department of Medicine, Lucille Castori Center for Microbes, Inflammation and Cancer, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, New York, USA
    Infect Immun 80:62-73. 2012
    ..difficile infection at least 10 days following clindamycin, suggesting that resolution of diarrhea and weight gain may result from the activation of mucosal immune defenses...
  7. ncbi request reprint Immune responses to commensal and environmental microbes
    Eric G Pamer
    Infectious Diseases Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Nat Immunol 8:1173-8. 2007
    ..Recent studies have begun to reveal how the immune system tips the balance in favor of some microbes, allowing commensals to persist on mucosal surfaces while eliminating disease-causing pathogens...
  8. ncbi request reprint Priming of memory but not effector CD8 T cells by a killed bacterial vaccine
    G Lauvau
    Infectious Disease Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, Immunology Program, Sloan Kettering Institute, 1275 York Avenue, New York, NY 10021, USA
    Science 294:1735-9. 2001
    ..Our studies show that it is possible to dissociate T cell-dependent protective immunity from memory T cell expansion, and that generation of effector T cells may be necessary for long-term protective immunity...
  9. pmc Inflammatory monocytes facilitate adaptive CD4 T cell responses during respiratory fungal infection
    Tobias M Hohl
    Infectious Disease Service, Department of Medicine, and Immunology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    Cell Host Microbe 6:470-81. 2009
    ....
  10. pmc Additive roles for MCP-1 and MCP-3 in CCR2-mediated recruitment of inflammatory monocytes during Listeria monocytogenes infection
    Ting Jia
    Infectious Diseases Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    J Immunol 180:6846-53. 2008
    ..Our data demonstrate that MCP-3 and MCP-1 provide parallel contributions to CCR2-mediated inflammatory monocyte recruitment and that both chemokines are required for optimal innate immune defense against L. monocytogenes infection...
  11. ncbi request reprint Distinct regulation of H2-M3-restricted memory T cell responses in lymph node and spleen
    Alexander Ploss
    Infectious Diseases Service, Department of Medicine and Laboratory of Antimicrobial Immunity, Immunology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    J Immunol 175:5998-6005. 2005
    ..These results may have important implications for prime-boost vaccination strategies...
  12. pmc Selective expansion of the monocytic lineage directed by bacterial infection
    Natalya V Serbina
    Infectious Disease Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, Immunology Program, Sloan Kettering Institute, New York, NY 10021, USA
    J Immunol 183:1900-10. 2009
    ..Our studies demonstrate that TLR-mediated signals play an essential role in the maintenance of monocyte homeostasis during systemic bacterial infection...
  13. ncbi request reprint Pathogen-specific CD8 T cell responses are directly inhibited by IL-10
    Partha Sarathi Biswas
    Department of Medicine, Infectious Disease Service, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    J Immunol 179:4520-8. 2007
    ..Our studies demonstrate that IL-10 produced during bacterial infection directly limits expansion of pathogen-specific CD8 T cells and reveal an extrinsic regulatory mechanism that modulates the magnitude of memory T cell responses...
  14. pmc MyD88 and Type I interferon receptor-mediated chemokine induction and monocyte recruitment during Listeria monocytogenes infection
    Ting Jia
    Infectious Diseases Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    J Immunol 183:1271-8. 2009
    ..monocytogenes infection. Our studies demonstrate that distinct but partially overlapping signal transduction pathways provide redundancy that ensures optimal monocyte recruitment to sites of microbial infection...
  15. ncbi request reprint Feedback regulation of pathogen-specific T cell priming
    Phillip Wong
    Infectious Diseases Service, Department of Medicine, Immunology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Immunity 18:499-511. 2003
    ..Our studies demonstrate a feedback mechanism that limits the duration of effective in vivo antigen presentation, thereby modulating T cell responses by temporally restricting recruitment of naive T cells into the immune response...
  16. pmc Monocyte trafficking to hepatic sites of bacterial infection is chemokine independent and directed by focal intercellular adhesion molecule-1 expression
    Chao Shi
    Infectious Disease Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    J Immunol 184:6266-74. 2010
    ..monocytogenes-infected liver does not require chemokine receptor-mediated signals but instead is principally dependent on integrin- and extracellular matrix-mediated monocyte adhesion...
  17. ncbi request reprint Innate immune activation and CD4+ T cell priming during respiratory fungal infection
    Amariliz Rivera
    Infectious Diseases Service, Immunology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, Box 9, New York, New York 10021, USA
    Immunity 25:665-75. 2006
    ....
  18. pmc Distinct CD4+-T-cell responses to live and heat-inactivated Aspergillus fumigatus conidia
    Amariliz Rivera
    Memorial Sloan Kettering Cancer Center, Infectious Diseases Service, Immunology Program, Department of Medicine, New York, NY 10021, USA
    Infect Immun 73:7170-9. 2005
    ..How the adaptive immune system distinguishes between metabolically active and inactive fungal spores remains an important question...
  19. ncbi request reprint Rapid development of T cell memory
    Phillip Wong
    Infectious Diseases Service, Immunology Program, Department of Medicine, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
    J Immunol 172:7239-45. 2004
    ....
  20. ncbi request reprint Immune responses to Aspergillus fumigatus infections
    Amariliz Rivera
    Infectious Diseases Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Biol Blood Marrow Transplant 12:47-9. 2006
    ..Ongoing investigations of immune responses to A. fumigatus are likely to provide opportunities to enhance defenses against this pathogen in the immunocompromised host...
  21. pmc Aspergillus fumigatus triggers inflammatory responses by stage-specific beta-glucan display
    Tobias M Hohl
    Infectious Diseases Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York, USA
    PLoS Pathog 1:e30. 2005
    ..Selective responsiveness to germinating conidia provides the innate immune system with a mechanism to restrict inflammatory responses to metabolically active, potentially invasive fungal spores...
  22. pmc Chemokine receptor 5 is dispensable for innate and adaptive immune responses to Listeria monocytogenes infection
    Maggie X Zhong
    Infectious Disease Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, Immunology Program, Sloan Kettering Institute, New York, New York 10021, USA
    Infect Immun 72:1057-64. 2004
    ..Our data indicate that CCR5-mediated chemotaxis is not required for defense against infection with L. monocytogenes...
  23. pmc Voriconazole inhibits fungal growth without impairing antigen presentation or T-cell activation
    Heather L Van Epps
    Laboratory of Antimicrobial Immunity, Immunology Program, and Infectious Disease Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Antimicrob Agents Chemother 47:1818-23. 2003
    ..Thus, voriconazole appears to be a promising agent for use in in vitro studies of Aspergillus-specific T lymphocytes in animal models of IA...
  24. pmc Distinct responses of human monocyte subsets to Aspergillus fumigatus conidia
    Natalya V Serbina
    Infectious Disease Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    J Immunol 183:2678-87. 2009
    ..Our study demonstrates that functional CD14(+)CD16(-) and CD14(+)CD16(+) monocytes can be isolated from allogeneic hematopoietic stem cell transplantation donors and that these subsets differ in their response to A. fumigatus conidia...
  25. pmc Rescue of CD8 T cell-mediated antimicrobial immunity with a nonspecific inflammatory stimulus
    Roman A Tuma
    Infectious Disease Service, Department of Medicine and Immunology Program, Memorial Sloan Kettering Institute, New York, New York 10021, USA
    J Clin Invest 110:1493-501. 2002
    ..The ability to modulate long-term responsiveness of CD8 T cells with a transient, nonspecific inflammatory stimulus has importation implications for adoptive immunotherapy...
  26. ncbi request reprint Monocyte emigration from bone marrow during bacterial infection requires signals mediated by chemokine receptor CCR2
    Natalya V Serbina
    Infectious Disease Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, Immunology Program, Sloan Kettering Institute, New York, New York 10021, USA
    Nat Immunol 7:311-7. 2006
    ..Thus, CCR2-mediated signals in bone marrow determine the frequency of Ly6C(hi) monocytes in the circulation...
  27. pmc Aberrant tissue localization of fungus-specific CD4+ T cells in IL-10-deficient mice
    Amariliz Rivera
    Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    J Immunol 183:631-41. 2009
    ..Our studies demonstrate that disregulated immune responses in the gut can result in dramatic redistribution of pathogen-specific T cells within the host...
  28. pmc The changing epidemiology of vancomycin-resistant Enterococcus (VRE) bacteremia in allogeneic hematopoietic stem cell transplant (HSCT) recipients
    Mini Kamboj
    Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York, USA
    Biol Blood Marrow Transplant 16:1576-81. 2010
    ..The use of alternate agents with activity against Gram-positive bacteria for fever and neutropenia early after HSCT should be evaluated further in prospective studies...
  29. ncbi request reprint Clinical characterization of human metapneumovirus infection among patients with cancer
    Mini Kamboj
    Infectious Disease Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, Box 9, New York, NY 10065, USA
    J Infect 57:464-71. 2008
    ..hMPV infection in a large population of patients with underlying cancer and varying degrees of immunosuppression has not been reported. We sought to characterize hMPV infection in patients with cancer...
  30. pmc Vancomycin-resistant Enterococcus domination of intestinal microbiota is enabled by antibiotic treatment in mice and precedes bloodstream invasion in humans
    Carles Ubeda
    Infectious Diseases Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York, USA
    J Clin Invest 120:4332-41. 2010
    ..Thus, high-throughput DNA sequencing of the intestinal microbiota could identify patients at high risk of developing bacterial sepsis...
  31. pmc Monocyte-mediated defense against microbial pathogens
    Natalya V Serbina
    Infectious Diseases Service, Department of Medicine, Immunology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Annu Rev Immunol 26:421-52. 2008
    ..The in vivo mechanisms that promote chemokine secretion, monocyte differentiation and trafficking, and finally monocyte-mediated microbial killing remain active and important areas of investigation...
  32. ncbi request reprint Immunology. Giving credit where credit is due
    Natalya V Serbina
    Diseases Service and Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Science 301:1856-7. 2003
    ....
  33. ncbi request reprint TNF/iNOS-producing dendritic cells mediate innate immune defense against bacterial infection
    Natalya V Serbina
    Infectious Disease Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, Immunology Program, Sloan Kettering Institute, 1275 York Avenue, New York, NY 10021, USA
    Immunity 19:59-70. 2003
    ..Tip-DCs, as the predominant source of TNF and iNOS during L. monocytogenes infection, orchestrate and mediate innate immune defense against this intracellular bacterial pathogen...
  34. ncbi request reprint Sequential MyD88-independent and -dependent activation of innate immune responses to intracellular bacterial infection
    Natalya V Serbina
    Infectious Disease Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, Immunology Program, Sloan Kettering Institute, 1275 York Avenue, New York, NY 10021, USA
    Immunity 19:891-901. 2003
    ..Our results indicate that distinct microbial signals activate innate immune responses in an ordered, step-wise fashion, providing a mechanism to specify and modulate antimicrobial effector functions...
  35. ncbi request reprint Rapid expansion of cytomegalovirus-specific cytotoxic T lymphocytes by artificial antigen-presenting cells expressing a single HLA allele
    Genovefa A Papanicolaou
    Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA
    Blood 102:2498-505. 2003
    ..Furthermore, the CTL expansion obtained with AAPCs encoding full-length pp65 indicates that AAPCs may be used to present known as well as unknown CTL epitopes in the context of the AAPC's HLA...
  36. ncbi request reprint CD8 T cell responses to infectious pathogens
    Phillip Wong
    Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
    Annu Rev Immunol 21:29-70. 2003
    ..This review describes recent progress in some of the major murine models of CD8 T cell-mediated immunity to viral, bacterial, and protozoal infection...
  37. ncbi request reprint Disparate in vitro and in vivo requirements for IL-2 during antigen-independent CD8 T cell expansion
    Phillip Wong
    Department of Medicine, Immunology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    J Immunol 172:2171-6. 2004
    ..These results indicate that the requirements for autocrine IL-2 production by CD8 T cells differs between in vitro and in vivo conditions and suggests that factors in addition to IL-2 can support Ag-independent CD8 T cell proliferation...
  38. ncbi request reprint Quantitative studies of CD8+ T-cell responses during microbial infection
    Natalya Serbina
    Infectious Diseases Service, Memorial Sloan Kettering Cancer Center, Immunology Program, Sloan Kettering Institute, New York 10021, USA
    Curr Opin Immunol 15:436-42. 2003
    ..In the past year there have been many exciting new findings on CD8(+) T-cell priming, expansion and memory formation in response to microbial infection...
  39. ncbi request reprint Quantitation, selection, and functional characterization of Epstein-Barr virus-specific and alloreactive T cells detected by intracellular interferon-gamma production and growth of cytotoxic precursors
    Guenther Koehne
    Department of Pediatrics, Bone Marrow Transplantation Service, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Blood 99:1730-40. 2002
    ..Strikingly, the CD4(+)IFN-gamma(+) cell fractions were not cytotoxic against EBV-transformed or allogeneic targets...
  40. ncbi request reprint Homeostasis of naïve, effector and memory CD8 T cells
    Roman A Tuma
    Infectious Disease Service, Department of Medicine, Immunology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
    Curr Opin Immunol 14:348-53. 2002
    ..Also unexpected was the finding of programmed T cell proliferation following very brief exposure to antigen. These and other recent advances are summarized in the following review...
  41. pmc MyD88-mediated signals induce the bactericidal lectin RegIII gamma and protect mice against intestinal Listeria monocytogenes infection
    Katharina Brandl
    Infectious Diseases Service, Department of Medicine, Immunology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    J Exp Med 204:1891-900. 2007
    ..Our findings support a model of MyD88-mediated epithelial conditioning that protects the intestinal mucosa against bacterial invasion by inducing RegIII gamma...
  42. pmc Promiscuity of MHC class Ib-restricted T cell responses
    Alexander Ploss
    Infectious Diseases Service, Department of Medicine and Laboratory of Antimicrobial Immunity, Immunology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    J Immunol 171:5948-55. 2003
    ..monocytogenes. Although this degree of Ag receptor promiscuity is unusual for the adaptive immune system, it may be a more common feature of T cell responses restricted by nonpolymorphic MHC class Ib molecules...
  43. pmc Coordinating innate immune cells to optimize microbial killing
    Natalya V Serbina
    Infectious Disease Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, Immunology Program, Sloan Kettering Institute, 1275 York Avenue, New York, NY 10021, USA
    Immunity 29:672-4. 2008
    ..In this issue of Immunity, Kang et al. (2008) begin to reveal the cytokine and chemokine cascades that coordinate cellular responses induced by microbial pathogens...
  44. pmc Expression of cutaneous lymphocyte-associated antigen by CD8(+) T cells specific for a skin-tropic virus
    David M Koelle
    Department of Medicine, Department of Laboratory Medicine, and Department of Pathobiology, University of Washington, Seattle, Washington 98104, USA
    J Clin Invest 110:537-48. 2002
    ..The evaluation of vaccines for skin and mucosal pathogens should include study of the induction of appropriate tissue-specific homing molecules...
  45. ncbi request reprint Adoptive transfer of T-cell precursors enhances T-cell reconstitution after allogeneic hematopoietic stem cell transplantation
    Johannes L Zakrzewski
    Department of Medicine, Zuckerman Research Center 1404, Mailbox 111, New York, New York 10021, USA
    Nat Med 12:1039-47. 2006
    ..We conclude that the adoptive transfer of OP9-DL1-derived T-cell precursors markedly enhances T-cell reconstitution after transplantation, resulting in GVT activity without GVHD...
  46. ncbi request reprint Targeted deletion of T-cell clones using alpha-emitting suicide MHC tetramers
    Rui Rong Yuan
    Molecular Pharmacology and Chemistry Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Blood 104:2397-402. 2004
    ..Such an approach may allow a pathway to selective ablation of pathogenic T-cell clones ex vivo or in vivo without disturbing general immune function...
  47. ncbi request reprint T cell responses to Listeria monocytogenes
    Maria Lara-Tejero
    Infectious Diseases Service, Department of Medicine Immunology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York 10021, USA
    Curr Opin Microbiol 7:45-50. 2004
    ..During the past few years, progress has been made to understand the contribution of the innate immune system and CD4 T cells in the generation of robust, long lasting CD8 responses to L. monocytogenes...
  48. doi request reprint 2009 H1N1 influenza infection in cancer patients and hematopoietic stem cell transplant recipients
    Gil Redelman-Sidi
    Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    J Infect 60:257-63. 2010
    ..To determine outcome in patients with cancer and/or hematopoietic stem cell transplant (HSCT), we reviewed our recent experience at Memorial Sloan-Kettering Cancer Center (MSKCC)...
  49. pmc Bacterial flagellin stimulates Toll-like receptor 5-dependent defense against vancomycin-resistant Enterococcus infection
    Melissa A Kinnebrew
    Infectious Diseases Service, Department of Medicine, Immunology Program, Memorial Sloan Kettering Cancer Center, New York, New York, USA
    J Infect Dis 201:534-43. 2010
    ..By enhancing mucosal resistance to multidrug-resistant organisms, flagellin administration may provide a clinically useful approach to prevent infections in patients treated with broad-spectrum antibiotics...
  50. pmc Remodeling specific immunity by use of MHC tetramers: demonstration in a graft-versus-host disease model
    Barry J Kappel
    Department of Molecular Pharmacology, Memorial Sloan Kettering Cancer Center, Howard 719, Mailbox 531, 1275 York Ave, New York, NY 10021, USA
    Blood 107:2045-51. 2006
    ....
  51. pmc Cross-recognition of N-formylmethionine peptides is a general characteristic of H2-M3-restricted CD8+ T cells
    Alexander Ploss
    Infectious Diseases Service, Department of Medicine and Laboratory of Antimicrobial Immunity, Immunology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, New York 10021, USA
    Infect Immun 73:4423-6. 2005
    ..We deleted the nonredundant fMIVTLF epitope and found that Listeria monocytogenes still primed fMIVTLF-specific T cells. Thus, cross-reactivity appears to be a more general characteristic of H2-M3-restricted T cells...
  52. pmc Toll-like receptor 5 stimulation protects mice from acute Clostridium difficile colitis
    Irene Jarchum
    MImmunology Program, Department of Medicine Division of Infectious Disease, Memorial Sloan Kettering Cancer Center, New York, New York, USA
    Infect Immun 79:1498-503. 2011
    ..difficile colitis, potentially providing an approach to prevent C. difficile-induced pathology...
  53. ncbi request reprint Immunity to fungi
    Tobias M Hohl
    Infectious Diseases Service, Department of Medicine, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Curr Opin Immunol 18:465-72. 2006
    ..Greater understanding of the molecular mechanisms that underlie antifungal defense has provided a framework for the investigation of protective vaccines and strategies for therapeutic adoptive cell transfer...
  54. doi request reprint Risk factors for late Staphylococcus aureus bacteremia after allogeneic hematopoietic stem cell transplantation: a single-institution, nested case-controlled study
    Coralia N Mihu
    Department of Medicine, Infectious Disease, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Biol Blood Marrow Transplant 14:1429-33. 2008
    ..We recommend a high index of suspicion and empiric antistaphylococcal treatment pending culture results in high-risk patients undergoing HSCT...
  55. doi request reprint Toll-like receptor 4 polymorphisms and risk of gram-negative bacteremia after allogeneic stem cell transplantation. A prospective pilot study
    Nana Yaa Mensah
    Department of Medicine, Service of Infectious Disease, Memorial Sloan Kettering Cancer Center, New York, New York, USA
    Biol Blood Marrow Transplant 15:1130-3. 2009
    ..06) in univariate analysis, but not in multivariate analysis. A larger study is required to validate our findings and define genetic susceptibility to this serious infection in HSTC patients...
  56. pmc Essential role for neutrophils but not alveolar macrophages at early time points following Aspergillus fumigatus infection
    Monica M Mircescu
    Infectious Disease Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, Sloan Kettering Institute, New York, New York, USA
    J Infect Dis 200:647-56. 2009
    ..Our studies suggest that neutrophils, but not alveolar macrophages, provide essential anticonidial defense and that a brief period of influx into the respiratory tree is sufficient to prevent conidial germination and invasive disease...
  57. pmc Vancomycin-resistant enterococci exploit antibiotic-induced innate immune deficits
    Katharina Brandl
    Infectious Diseases Service, Department of Medicine, Immunology Program, Sloan Kettering Institute, New York, New York, USA
    Nature 455:804-7. 2008
    ....
  58. ncbi request reprint Defective control of latent Epstein-Barr virus infection in systemic lupus erythematosus
    Insoo Kang
    Section of Rheumatology, Department of Internal Medicine, Yale University School of Medicine, 300 Cedar Street, New Haven, CT 06520, USA
    J Immunol 172:1287-94. 2004
    ..These results demonstrate that patients with SLE have defective control of latent EBV infection that probably stems from altered T cell responses against EBV...
  59. ncbi request reprint Overexpression of IL-15 in vivo increases antigen-driven memory CD8+ T cells following a microbe exposure
    Toshiki Yajima
    Laboratory of Host Defense, Research Institute for Disease Mechanism and Control, Nagoya University School of Medicine, Nagoya 466 8550, Japan
    J Immunol 168:1198-203. 2002
    ..These results suggest that IL-15 plays an important role in long-term maintenance of Ag-specific memory CD8+ T cells following microbial exposure via promotion of cell survival and homeostatic proliferation...
  60. ncbi request reprint H2-M3-restricted memory T cells: persistence and activation without expansion
    Kristen M Kerksiek
    Section of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA
    J Immunol 170:1862-9. 2003
    ..monocytogenes infection, under different inflammatory circumstances M3-restricted T cell populations can maintain the ability to expand upon re-exposure to Ag...
  61. pmc In vivo depletion of CD11c+ dendritic cells abrogates priming of CD8+ T cells by exogenous cell-associated antigens
    Steffen Jung
    Molecular Pathogenesis Program, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York 10016, USA
    Immunity 17:211-20. 2002
    ..e., the sensitization of the immune system for cell-associated antigens. DC-depleted mice fail to mount CTL responses to infection with the intracellular bacterium Listeria monocytogenes and the rodent malaria parasite Plasmodium yoelii...
  62. ncbi request reprint The fate of low affinity tumor-specific CD8+ T cells in tumor-bearing mice
    Michael A Lyman
    Department of Immunology, The Scripps Research Institute, La Jolla, CA 92037, USA
    J Immunol 174:2563-72. 2005
    ..This tumor model should prove of great value in identifying protocols that can optimize the function of low avidity tumor-specific T cells...
  63. ncbi request reprint Cracking the fungal armor
    Tobias M Hohl
    Nat Med 12:730-2. 2006

Research Grants31

  1. H2-M3 RESTRICTED T CELL RESPONSES
    Eric Pamer; Fiscal Year: 2000
    ..Additionally, these experiments may provide novel insights into the factors driving in vivo T cell expansion and memory generation. ..
  2. Inflammation and T cell immunity to Listeria
    Eric Pamer; Fiscal Year: 2006
    ..Our studies will shed light on the important interactions between innate immunity and adaptive T cell responses. ..
  3. Characterization of Aspergillus fumigatus specific CD4 T cell responses.
    Eric Pamer; Fiscal Year: 2007
    ....
  4. CC-chemokines in Listeria infection.
    Eric Pamer; Fiscal Year: 2007
    ....
  5. RESEARCH TRAINING IN INFECTIOUS DISEASES
    Eric Pamer; Fiscal Year: 2007
    ..A curriculum of seminars, journal clubs, lab meetings and formal courses has been developed for fellows performing laboratory-based research. ..
  6. Characterization of Aspergillus fumigatus specific CD4 T cell responses.
    Eric Pamer; Fiscal Year: 2009
    ..abstract_text> ..
  7. Innate immune responses to microbial flora
    Eric Pamer; Fiscal Year: 2009
    ..Our third aim is to discover whether administration of molecules derived from bacteria can reverse the increased susceptibility to infection induced by antibiotic administration. ..
  8. CD4 T Cell Responses to M. Tuberculosis Infection
    Eric Pamer; Fiscal Year: 2009
    ..Using a novel mouse strain that was developed in our laboratory, we will discover new approaches to optimize immune clearance of M. tuberculosis. ..
  9. Characterization of Aspergillus fumigatus specific CD4 T cell responses.
    Eric G Pamer; Fiscal Year: 2010
    ..abstract_text> ..
  10. Innate immune responses to microbial flora
    Eric G Pamer; Fiscal Year: 2010
    ..Our third aim is to discover whether administration of molecules derived from bacteria can reverse the increased susceptibility to infection induced by antibiotic administration. ..
  11. Characterization of Aspergillus fumigatus specific CD4 T cell responses.
    Eric Pamer; Fiscal Year: 2006
    ....
  12. TNF Mediated Immune Defence Agaist Listeria Infection
    Eric Pamer; Fiscal Year: 2006
    ....
  13. T LYMPHOCYTE RESPONSES TO LISTERIA INFECTION
    Eric Pamer; Fiscal Year: 2001
    ..These experiments will shed light on how the size of the T cell response to an epitope is determined in vivo and are likely to provide ideas for optimizing vaccines which elicit dominant, long term T lymphocyte responses. ..
  14. DETERMINANTS OF ANTIGEN PROCESSING EFFICIENCY
    Eric Pamer; Fiscal Year: 2000
    ..These studies will determine requirements for efficient antigen processing. Knowing what determines the efficiency of MHC class I antigen processing is essential for the development of vaccines that elicit CTL. ..
  15. Inflammation and T cell immunity to Listeria
    Eric Pamer; Fiscal Year: 2002
    ..Our studies will shed light on the important interactions between innate immunity and adaptive T cell responses. ..
  16. T LYMPHOCYTE RESPONSES TO LISTERIA INFECTION
    Eric Pamer; Fiscal Year: 2002
    ..These experiments will shed light on how the size of the T cell response to an epitope is determined in vivo and are likely to provide ideas for optimizing vaccines which elicit dominant, long term T lymphocyte responses. ..
  17. H2-M3 RESTRICTED T CELL RESPONSES
    Eric Pamer; Fiscal Year: 2002
    ..Additionally, these experiments may provide novel insights into the factors driving in vivo T cell expansion and memory generation. ..
  18. CD4 T Cell Responses to M. Tuberculosis Infection
    ERIC G contact PAMER; Fiscal Year: 2010
    ..Using a novel mouse strain that was developed in our laboratory, we will discover new approaches to optimize immune clearance of M. tuberculosis. ..
  19. Inflammation and T cell immunity to Listeria
    Eric Pamer; Fiscal Year: 2003
    ..Our studies will shed light on the important interactions between innate immunity and adaptive T cell responses. ..
  20. Inflammation and T cell immunity to Listeria
    Eric Pamer; Fiscal Year: 2004
    ..Our studies will shed light on the important interactions between innate immunity and adaptive T cell responses. ..
  21. TNF Mediated Immune Defense Against Listeria Infection
    Eric Pamer; Fiscal Year: 2004
    ....
  22. H2-M3 RESTRICTED T CELL RESPONSES
    Eric Pamer; Fiscal Year: 2004
    ..Additionally, these experiments may provide novel insights into the factors driving in vivo T cell expansion and memory generation. ..
  23. TNF Mediated Immune Defence Agaist Listeria Infection
    Eric Pamer; Fiscal Year: 2005
    ....
  24. Inflammation and T cell immunity to Listeria
    Eric Pamer; Fiscal Year: 2005
    ..Our studies will shed light on the important interactions between innate immunity and adaptive T cell responses. ..
  25. TNF Mediated Immune Defense Against Listeria Infection
    Eric Pamer; Fiscal Year: 2007
    ....
  26. H2-M3 RESTRICTED T CELL RESPONSES
    Eric Pamer; Fiscal Year: 2001
    ..Additionally, these experiments may provide novel insights into the factors driving in vivo T cell expansion and memory generation. ..
  27. H2-M3 RESTRICTED T CELL RESPONSES
    Eric Pamer; Fiscal Year: 2003
    ..Additionally, these experiments may provide novel insights into the factors driving in vivo T cell expansion and memory generation. ..