Irene Orlow

Summary

Affiliation: Memorial Sloan-Kettering Cancer Center
Country: USA

Publications

  1. doi DNA damage and repair capacity in patients with lung cancer: prediction of multiple primary tumors
    Irene Orlow
    Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    J Clin Oncol 26:3560-6. 2008
  2. pmc Vitamin D receptor polymorphisms in patients with cutaneous melanoma
    Irene Orlow
    Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    Int J Cancer 130:405-18. 2012
  3. ncbi CDKN2A germline mutations in individuals with cutaneous malignant melanoma
    Irene Orlow
    Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    J Invest Dermatol 127:1234-43. 2007
  4. pmc Variants in hormone biosynthesis genes and risk of endometrial cancer
    Sara H Olson
    Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY, 10065, USA
    Cancer Causes Control 19:955-63. 2008
  5. ncbi Lifetime risk of melanoma in CDKN2A mutation carriers in a population-based sample
    Colin B Begg
    Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    J Natl Cancer Inst 97:1507-15. 2005
  6. pmc Tumor-infiltrating lymphocyte grade in primary melanomas is independently associated with melanoma-specific survival in the population-based genes, environment and melanoma study
    Nancy E Thomas
    Nancy E Thomas, Pamela A Groben, Honglin Hao, and David W Ollila, University of North Carolina, Chapel Hill, NC Klaus J Busam, Irene Orlow, Anne S Reiner, and Colin B Begg, Memorial Sloan Kettering Cancer Center, New York, NY Lynn From, Women s College Hospital, Toronto, Ontario Richard P Gallagher, British Columbia Cancer Research Centre, Vancouver, British Columbia, Canada Anne Kricker and Bruce K Armstrong, The University of Sydney, Sydney, New South Wales Alison Venn, Menzies Research Institute, Tasmania, Australia Hoda Anton Culver, University of California, Irvine Stephen B Gruber, University of Southern California, Los Angeles, CA Roberto Zanetti and Stefano Rosso, Center for Cancer Prevention, Torino, Italy Terence Dwyer, International Agency for Research on Cancer, Lyon, France Peter A Kanetsky, University of Pennsylvania, Philadelphia, PA Li Luo, Susan Paine
    J Clin Oncol 31:4252-9. 2013
  7. pmc Including additional controls from public databases improves the power of a genome-wide association study
    Semanti Mukherjee
    Gerstner Sloan Kettering Graduate School of Biomedical Sciences, Memorial Sloan Kettering Cancer Center, New York, USA
    Hum Hered 72:21-34. 2011
  8. doi Investigation of the effect of MDM2 SNP309 and TP53 Arg72Pro polymorphisms on the age of onset of cutaneous melanoma
    Javier Cotignola
    Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    J Invest Dermatol 132:1471-8. 2012
  9. pmc Functional polymorphisms in the promoter regions of MMP2 and MMP3 are not associated with melanoma progression
    Javier Cotignola
    Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY, USA
    J Negat Results Biomed 6:9. 2007
  10. pmc Patterns of persistent DNA damage associated with sun exposure and the glutathione S-transferase M1 genotype in melanoma patients
    MARK L STEINBERG
    Department of Chemistry, The City College of the City University of New York, New York, NY, USA
    Photochem Photobiol 85:379-86. 2009

Research Grants

Detail Information

Publications27

  1. doi DNA damage and repair capacity in patients with lung cancer: prediction of multiple primary tumors
    Irene Orlow
    Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    J Clin Oncol 26:3560-6. 2008
    ..Therefore, we evaluated constitutive and induced DNA damage, and repair capacity, in patients with multiple NSCLCs (cases) and compared the results to those obtained in patients with a single NSCLC (controls)...
  2. pmc Vitamin D receptor polymorphisms in patients with cutaneous melanoma
    Irene Orlow
    Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    Int J Cancer 130:405-18. 2012
    ..The VDR may play a role in melanomagenesis...
  3. ncbi CDKN2A germline mutations in individuals with cutaneous malignant melanoma
    Irene Orlow
    Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    J Invest Dermatol 127:1234-43. 2007
    ..With the exception of the variant in position -34 of CDKN2A of known functional consequence, the remaining rare variants in the non-coding region have no apparent impact on risk...
  4. pmc Variants in hormone biosynthesis genes and risk of endometrial cancer
    Sara H Olson
    Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY, 10065, USA
    Cancer Causes Control 19:955-63. 2008
    ..01). The insertion/deletion variant in CYP19A1 appears to be related to risk of endometrial cancer; risk associated with variants in this gene may vary according to BMI...
  5. ncbi Lifetime risk of melanoma in CDKN2A mutation carriers in a population-based sample
    Colin B Begg
    Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    J Natl Cancer Inst 97:1507-15. 2005
    ..In this study, we examined lifetime melanoma risk among CDKN2A mutation carriers using carriers who were identified in a population-based study of melanoma...
  6. pmc Tumor-infiltrating lymphocyte grade in primary melanomas is independently associated with melanoma-specific survival in the population-based genes, environment and melanoma study
    Nancy E Thomas
    Nancy E Thomas, Pamela A Groben, Honglin Hao, and David W Ollila, University of North Carolina, Chapel Hill, NC Klaus J Busam, Irene Orlow, Anne S Reiner, and Colin B Begg, Memorial Sloan Kettering Cancer Center, New York, NY Lynn From, Women s College Hospital, Toronto, Ontario Richard P Gallagher, British Columbia Cancer Research Centre, Vancouver, British Columbia, Canada Anne Kricker and Bruce K Armstrong, The University of Sydney, Sydney, New South Wales Alison Venn, Menzies Research Institute, Tasmania, Australia Hoda Anton Culver, University of California, Irvine Stephen B Gruber, University of Southern California, Los Angeles, CA Roberto Zanetti and Stefano Rosso, Center for Cancer Prevention, Torino, Italy Terence Dwyer, International Agency for Research on Cancer, Lyon, France Peter A Kanetsky, University of Pennsylvania, Philadelphia, PA Li Luo, Susan Paine
    J Clin Oncol 31:4252-9. 2013
    ..We addressed the issue in an international population-based study of patients with single and multiple primary melanomas...
  7. pmc Including additional controls from public databases improves the power of a genome-wide association study
    Semanti Mukherjee
    Gerstner Sloan Kettering Graduate School of Biomedical Sciences, Memorial Sloan Kettering Cancer Center, New York, USA
    Hum Hered 72:21-34. 2011
    ..Thus, through an empirical approach, this report provides practical guidance for using additional controls from publicly available datasets...
  8. doi Investigation of the effect of MDM2 SNP309 and TP53 Arg72Pro polymorphisms on the age of onset of cutaneous melanoma
    Javier Cotignola
    Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    J Invest Dermatol 132:1471-8. 2012
    ..Further studies are needed to determine whether a nearby functional polymorphism is responsible for this effect in premenopausal women...
  9. pmc Functional polymorphisms in the promoter regions of MMP2 and MMP3 are not associated with melanoma progression
    Javier Cotignola
    Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY, USA
    J Negat Results Biomed 6:9. 2007
    ..Functional polymorphisms in MMP genes' promoter regions may modulate the risk for melanoma progression...
  10. pmc Patterns of persistent DNA damage associated with sun exposure and the glutathione S-transferase M1 genotype in melanoma patients
    MARK L STEINBERG
    Department of Chemistry, The City College of the City University of New York, New York, NY, USA
    Photochem Photobiol 85:379-86. 2009
    ..These findings support the idea that exposure to solar radiation early in life may induce long-term cellular changes that lead to persistent DNA damage and altered patterns of gene expression...
  11. pmc Analysis of genetic variants in never-smokers with lung cancer facilitated by an Internet-based blood collection protocol: a preliminary report
    Nicolas Girard
    Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York, USA
    Clin Cancer Res 16:755-63. 2010
    ..We hypothesized that we could use the Internet to bolster the accrual of appropriate patients...
  12. pmc Evaluation of the clonal origin of multiple primary melanomas using molecular profiling
    Irene Orlow
    Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA
    J Invest Dermatol 129:1972-82. 2009
    ....
  13. pmc The use of hierarchical models for estimating relative risks of individual genetic variants: an application to a study of melanoma
    Marinela Capanu
    Memorial Sloan Kettering Cancer Center, 307 E 63rd Street, New York, NY 10021, U S A
    Stat Med 27:1973-92. 2008
    ..However, further research is needed to validate the application of asymptotic methods to such sparse data...
  14. pmc A replication study and genome-wide scan of single-nucleotide polymorphisms associated with pancreatic cancer risk and overall survival
    Jason A Willis
    Program in Cancer Biology and Genetics, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    Clin Cancer Res 18:3942-51. 2012
    ..To explore the effects of single-nucleotide polymorphisms (SNP) on pancreatic cancer risk and overall survival (OS)...
  15. pmc A metastasis or a second independent cancer? Evaluating the clonal origin of tumors using array copy number data
    Irina Ostrovnaya
    Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Stat Med 29:1608-21. 2010
    ..Our data analyses show that in many cases a strong clonal signal emerges. Sensitivity analyses show that most of the diagnoses are robust when the data are of high quality...
  16. pmc Radiation exposure, the ATM Gene, and contralateral breast cancer in the women's environmental cancer and radiation epidemiology study
    Jonine L Bernstein
    Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, 307 E 63rd St Fl 3, New York, NY 10065, USA
    J Natl Cancer Inst 102:475-83. 2010
    ..We investigated whether genetic variants in ATM play a clinically significant role in radiation-induced contralateral breast cancer in women...
  17. pmc Matrix Metalloproteinase-9 (MMP-9) polymorphisms in patients with cutaneous malignant melanoma
    Javier Cotignola
    Memorial Sloan Kettering Cancer Center, New York, NY, USA
    BMC Med Genet 8:10. 2007
    ..Some polymorphisms are known to influence gene expression, protein activity, stability, and interactions, and they were shown to be associated with certain tumor phenotypes and cancer risk...
  18. ncbi Allergies, variants in IL-4 and IL-4R alpha genes, and risk of pancreatic cancer
    Sara H Olson
    Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Cancer Detect Prev 31:345-51. 2007
    ..Although genes have been identified that are critical in allergic response, polymorphisms in these genes have not been studied in relation to risk of pancreatic cancer. We hypothesized that variants in these genes are related to risk...
  19. pmc Genomic and mutational profiling to assess clonal relationships between multiple non-small cell lung cancers
    Nicolas Girard
    Pao Lab, Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Clin Cancer Res 15:5184-90. 2009
    ..Decisions are currently made using the Martini and Melamed criteria, which are mostly based on tumor location and histologic type. New genomic tools could improve the ability to assess tumor clonality...
  20. pmc Analysis of over 10,000 Cases finds no association between previously reported candidate polymorphisms and ovarian cancer outcome
    Kristin L White
    Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USA
    Cancer Epidemiol Biomarkers Prev 22:987-92. 2013
    ....
  21. ncbi Mitochondrial DNA deletions in skin from melanoma patients
    Karen Hubbard
    Department of Biology, The City College of New York, Convent Ave and 160th St, New York, NY 10031, USA
    Ethn Dis 18:S2-38-43. 2008
    ..This may reflect a proliferative response to DNA damage induced by solar radiation in the high-risk group...
  22. doi Phase II study of extended-dose temozolomide in patients with melanoma
    Petra Rietschel
    Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    J Clin Oncol 26:2299-304. 2008
    ..We hypothesized that expression of methylguanine methyltransferase (MGMT) in the tumor would correlate with drug resistance to TMZ...
  23. ncbi Association between aryl hydrocarbon receptor genotype and survival in soft tissue sarcoma
    Marianne Berwick
    Memorial Sloan Kettering Cancer Center, New York, NY, USA
    J Clin Oncol 22:3997-4001. 2004
    ..Accumulating evidence shows that germline polymorphisms may affect survival in cancer. The purpose of this study was to investigate the association between polymorphisms in a group of candidate genes and survival with soft tissue sarcoma...
  24. pmc Interpretation of melanoma risk feedback in first-degree relatives of melanoma patients
    Jennifer L Hay
    Department of Psychiatry and Behavioral Sciences, Memorial Sloan Kettering Cancer Center, 641 Lexington Avenue, New York, NY 10022, USA
    J Cancer Epidemiol 2012:374842. 2012
    ....
  25. ncbi Variants in estrogen biosynthesis genes, sex steroid hormone levels, and endometrial cancer: a HuGE review
    Sara H Olson
    Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY, USA
    Am J Epidemiol 165:235-45. 2007
    ..Larger studies or combined studies that allow for investigation of gene-gene and gene-environment interactions are warranted...
  26. ncbi The prevalence of CDKN2A germ-line mutations and relative risk for cutaneous malignant melanoma: an international population-based study
    Marianne Berwick
    University of New Mexico, Department of Internal Medicine, New Mexico Cancer Research Facility, MSC08 4630, Room 103A, 1 University of New Mexico, Albuquerque, NM 87131, USA
    Cancer Epidemiol Biomarkers Prev 15:1520-5. 2006
    ..The results suggest that the relative risk of mutation carriers in the population may be lower than currently believed and that different mutations on the CDKN2A gene may confer substantially different risks of melanoma...
  27. pmc Variants in the ATM gene associated with a reduced risk of contralateral breast cancer
    Patrick Concannon
    Department of Biochemistry and Molecular Genetics and Center for Public Health Genomics, University of Virginia, Charlottesville, Virginia 22908 0733, USA
    Cancer Res 68:6486-91. 2008
    ..1-0.6; c.6348-54T>C RR, 0.2; 95% CI, 0.1-0.8]. These data suggest that some alleles of ATM may exert an antineoplastic effect, perhaps by altering the activity of ATM as an initiator of DNA damage responses or a regulator of p53...

Research Grants1