Research Topics
Genomes and GenesSpecies | Irene OrlowSummaryAffiliation: Memorial Sloan-Kettering Cancer Center Country: USA Publications
Research Grants
| Collaborators
|
Detail Information
Publications
DNA damage and repair capacity in patients with lung cancer: prediction of multiple primary tumorsIrene Orlow
Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
J Clin Oncol 26:3560-6. 2008..Therefore, we evaluated constitutive and induced DNA damage, and repair capacity, in patients with multiple NSCLCs (cases) and compared the results to those obtained in patients with a single NSCLC (controls)...
Vitamin D receptor polymorphisms in patients with cutaneous melanomaIrene Orlow
Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
Int J Cancer 130:405-18. 2012..The VDR may play a role in melanomagenesis...
CDKN2A germline mutations in individuals with cutaneous malignant melanomaIrene Orlow
Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
J Invest Dermatol 127:1234-43. 2007..With the exception of the variant in position -34 of CDKN2A of known functional consequence, the remaining rare variants in the non-coding region have no apparent impact on risk...- Variants in hormone biosynthesis genes and risk of endometrial cancerSara H Olson
Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY, 10065, USA
Cancer Causes Control 19:955-63. 2008..01). The insertion/deletion variant in CYP19A1 appears to be related to risk of endometrial cancer; risk associated with variants in this gene may vary according to BMI... - Lifetime risk of melanoma in CDKN2A mutation carriers in a population-based sampleColin B Begg
Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
J Natl Cancer Inst 97:1507-15. 2005..In this study, we examined lifetime melanoma risk among CDKN2A mutation carriers using carriers who were identified in a population-based study of melanoma... - Including additional controls from public databases improves the power of a genome-wide association studySemanti Mukherjee
Gerstner Sloan Kettering Graduate School of Biomedical Sciences, Memorial Sloan Kettering Cancer Center, New York, USA
Hum Hered 72:21-34. 2011..Thus, through an empirical approach, this report provides practical guidance for using additional controls from publicly available datasets... - Investigation of the effect of MDM2 SNP309 and TP53 Arg72Pro polymorphisms on the age of onset of cutaneous melanomaJavier Cotignola
Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
J Invest Dermatol 132:1471-8. 2012..Further studies are needed to determine whether a nearby functional polymorphism is responsible for this effect in premenopausal women... - Functional polymorphisms in the promoter regions of MMP2 and MMP3 are not associated with melanoma progressionJavier Cotignola
Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY, USA
J Negat Results Biomed 6:9. 2007..Functional polymorphisms in MMP genes' promoter regions may modulate the risk for melanoma progression... - Evaluation of the clonal origin of multiple primary melanomas using molecular profilingIrene Orlow
Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA
J Invest Dermatol 129:1972-82. 2009.... - Patterns of persistent DNA damage associated with sun exposure and the glutathione S-transferase M1 genotype in melanoma patientsMARK L STEINBERG
Department of Chemistry, The City College of the City University of New York, New York, NY, USA
Photochem Photobiol 85:379-86. 2009..These findings support the idea that exposure to solar radiation early in life may induce long-term cellular changes that lead to persistent DNA damage and altered patterns of gene expression... - Analysis of genetic variants in never-smokers with lung cancer facilitated by an Internet-based blood collection protocol: a preliminary reportNicolas Girard
Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York, USA
Clin Cancer Res 16:755-63. 2010..We hypothesized that we could use the Internet to bolster the accrual of appropriate patients... - The use of hierarchical models for estimating relative risks of individual genetic variants: an application to a study of melanomaMarinela Capanu
Memorial Sloan Kettering Cancer Center, 307 E 63rd Street, New York, NY 10021, U S A
Stat Med 27:1973-92. 2008..However, further research is needed to validate the application of asymptotic methods to such sparse data... - A replication study and genome-wide scan of single-nucleotide polymorphisms associated with pancreatic cancer risk and overall survivalJason A Willis
Program in Cancer Biology and Genetics, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
Clin Cancer Res 18:3942-51. 2012..To explore the effects of single-nucleotide polymorphisms (SNP) on pancreatic cancer risk and overall survival (OS)... - A metastasis or a second independent cancer? Evaluating the clonal origin of tumors using array copy number dataIrina Ostrovnaya
Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
Stat Med 29:1608-21. 2010..Our data analyses show that in many cases a strong clonal signal emerges. Sensitivity analyses show that most of the diagnoses are robust when the data are of high quality... - Radiation exposure, the ATM Gene, and contralateral breast cancer in the women's environmental cancer and radiation epidemiology studyJonine L Bernstein
Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, 307 E 63rd St Fl 3, New York, NY 10065, USA
J Natl Cancer Inst 102:475-83. 2010..We investigated whether genetic variants in ATM play a clinically significant role in radiation-induced contralateral breast cancer in women... - Matrix Metalloproteinase-9 (MMP-9) polymorphisms in patients with cutaneous malignant melanomaJavier Cotignola
Memorial Sloan Kettering Cancer Center, New York, NY, USA
BMC Med Genet 8:10. 2007..Some polymorphisms are known to influence gene expression, protein activity, stability, and interactions, and they were shown to be associated with certain tumor phenotypes and cancer risk... - Allergies, variants in IL-4 and IL-4R alpha genes, and risk of pancreatic cancerSara H Olson
Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
Cancer Detect Prev 31:345-51. 2007..Although genes have been identified that are critical in allergic response, polymorphisms in these genes have not been studied in relation to risk of pancreatic cancer. We hypothesized that variants in these genes are related to risk... - Genomic and mutational profiling to assess clonal relationships between multiple non-small cell lung cancersNicolas Girard
Pao Lab, Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
Clin Cancer Res 15:5184-90. 2009..Decisions are currently made using the Martini and Melamed criteria, which are mostly based on tumor location and histologic type. New genomic tools could improve the ability to assess tumor clonality... - Phase II study of extended-dose temozolomide in patients with melanomaPetra Rietschel
Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
J Clin Oncol 26:2299-304. 2008..We hypothesized that expression of methylguanine methyltransferase (MGMT) in the tumor would correlate with drug resistance to TMZ... - Mitochondrial DNA deletions in skin from melanoma patientsKaren Hubbard
Department of Biology, The City College of New York, Convent Ave and 160th St, New York, NY 10031, USA
Ethn Dis 18:S2-38-43. 2008..This may reflect a proliferative response to DNA damage induced by solar radiation in the high-risk group... - Association between aryl hydrocarbon receptor genotype and survival in soft tissue sarcomaMarianne Berwick
Memorial Sloan Kettering Cancer Center, New York, NY, USA
J Clin Oncol 22:3997-4001. 2004..Accumulating evidence shows that germline polymorphisms may affect survival in cancer. The purpose of this study was to investigate the association between polymorphisms in a group of candidate genes and survival with soft tissue sarcoma... - Interpretation of melanoma risk feedback in first-degree relatives of melanoma patientsJennifer L Hay
Department of Psychiatry and Behavioral Sciences, Memorial Sloan Kettering Cancer Center, 641 Lexington Avenue, New York, NY 10022, USA
J Cancer Epidemiol 2012:374842. 2012.... - Variants in estrogen biosynthesis genes, sex steroid hormone levels, and endometrial cancer: a HuGE reviewSara H Olson
Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY, USA
Am J Epidemiol 165:235-45. 2007..Larger studies or combined studies that allow for investigation of gene-gene and gene-environment interactions are warranted... - The prevalence of CDKN2A germ-line mutations and relative risk for cutaneous malignant melanoma: an international population-based studyMarianne Berwick
University of New Mexico, Department of Internal Medicine, New Mexico Cancer Research Facility, MSC08 4630, Room 103A, 1 University of New Mexico, Albuquerque, NM 87131, USA
Cancer Epidemiol Biomarkers Prev 15:1520-5. 2006..The results suggest that the relative risk of mutation carriers in the population may be lower than currently believed and that different mutations on the CDKN2A gene may confer substantially different risks of melanoma... - Variants in the ATM gene associated with a reduced risk of contralateral breast cancerPatrick Concannon
Department of Biochemistry and Molecular Genetics and Center for Public Health Genomics, University of Virginia, Charlottesville, Virginia 22908 0733, USA
Cancer Res 68:6486-91. 2008..1-0.6; c.6348-54T>C RR, 0.2; 95% CI, 0.1-0.8]. These data suggest that some alleles of ATM may exert an antineoplastic effect, perhaps by altering the activity of ATM as an initiator of DNA damage responses or a regulator of p53...
Research Grants
- Mutational Analysis of Clonality in Multiple Primary MelanomaIrene Orlow; Fiscal Year: 2007....