Tomoyo Okada

Summary

Affiliation: Memorial Sloan-Kettering Cancer Center
Country: USA

Publications

  1. pmc Merlin/NF-2 mediates contact inhibition of growth by suppressing recruitment of Rac to the plasma membrane
    Tomoyo Okada
    Cell Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    J Cell Biol 171:361-71. 2005
  2. ncbi request reprint Shedding light on Merlin's wizardry
    Tomoyo Okada
    Cell Biology Program, Sloan Kettering Institute for Cancer Research, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Trends Cell Biol 17:222-9. 2007
  3. pmc Loss of the tumor suppressor gene NF2, encoding merlin, constitutively activates integrin-dependent mTORC1 signaling
    Miguel A López-Lago
    Cell Biology Program, Sloan Kettering Institute for Cancer Research, Memorial Sloan Kettering Cancer Center, 1275 York Ave, New York, NY 10065, USA
    Mol Cell Biol 29:4235-49. 2009
  4. pmc The Rho GTPase Rnd1 suppresses mammary tumorigenesis and EMT by restraining Ras-MAPK signalling
    Tomoyo Okada
    Cell Biology Program, Sloan Kettering Institute for Cancer Research, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA
    Nat Cell Biol 17:81-94. 2015
  5. pmc Restoration of C/EBPα in dedifferentiated liposarcoma induces G2/M cell cycle arrest and apoptosis
    Yuhsin V Wu
    Sarcoma Biology Laboratory, Sarcoma Disease Management Program, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Genes Chromosomes Cancer 51:313-27. 2012
  6. ncbi request reprint Single- and multiple-molecule dynamics of the signaling from H-Ras to cRaf-1 visualized on the plasma membrane of living cells
    Kayo Hibino
    Department of Systems and Human Science, Graduate School of Engineering Science, Osaka University, 1 3 Machikaneyama cho, Toyonaka 560 8531, Japan
    Chemphyschem 4:748-53. 2003

Collaborators

  • Samuel Singer
  • Filippo Giancotti
  • Anna Sapino
  • Giorgio Inghirami
  • Yuhsin V Wu
  • Miguel A López-Lago
  • Kayo Hibino
  • Penelope Decarolis
  • C Joy Somberg
  • Cristina Antonescu
  • Rachael O'Connor
  • Rula C Geha
  • Nicholas Socci
  • Nick Socci
  • Miguel M Murillo
  • Yasushi Sako
  • Tohru Kataoka
  • Tomonobu M Watanabe
  • Toshio Yanagida
  • Atsuko Hikikoshi Iwane
  • Jun Kozuka

Detail Information

Publications6

  1. pmc Merlin/NF-2 mediates contact inhibition of growth by suppressing recruitment of Rac to the plasma membrane
    Tomoyo Okada
    Cell Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    J Cell Biol 171:361-71. 2005
    ..These results provide a framework for understanding the tumor suppressor function of Merlin and indicate that Merlin mediates contact inhibition of growth by suppressing recruitment of Rac to matrix adhesions...
  2. ncbi request reprint Shedding light on Merlin's wizardry
    Tomoyo Okada
    Cell Biology Program, Sloan Kettering Institute for Cancer Research, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Trends Cell Biol 17:222-9. 2007
    ..Here, we review these recent findings and their relevance to the tumor suppressor function of Merlin...
  3. pmc Loss of the tumor suppressor gene NF2, encoding merlin, constitutively activates integrin-dependent mTORC1 signaling
    Miguel A López-Lago
    Cell Biology Program, Sloan Kettering Institute for Cancer Research, Memorial Sloan Kettering Cancer Center, 1275 York Ave, New York, NY 10065, USA
    Mol Cell Biol 29:4235-49. 2009
    ....
  4. pmc The Rho GTPase Rnd1 suppresses mammary tumorigenesis and EMT by restraining Ras-MAPK signalling
    Tomoyo Okada
    Cell Biology Program, Sloan Kettering Institute for Cancer Research, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA
    Nat Cell Biol 17:81-94. 2015
    ..These results reveal a previously unappreciated mechanism through which Rnd1 restrains activation of Ras-MAPK signalling and breast tumour initiation and progression...
  5. pmc Restoration of C/EBPα in dedifferentiated liposarcoma induces G2/M cell cycle arrest and apoptosis
    Yuhsin V Wu
    Sarcoma Biology Laboratory, Sarcoma Disease Management Program, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Genes Chromosomes Cancer 51:313-27. 2012
    ..These results demonstrate that loss of C/EBPα is an important factor in suppressing apoptosis and maintaining the dedifferentiated state in DDLS. Restoring C/EBPα may be a useful therapeutic approach for DDLS...
  6. ncbi request reprint Single- and multiple-molecule dynamics of the signaling from H-Ras to cRaf-1 visualized on the plasma membrane of living cells
    Kayo Hibino
    Department of Systems and Human Science, Graduate School of Engineering Science, Osaka University, 1 3 Machikaneyama cho, Toyonaka 560 8531, Japan
    Chemphyschem 4:748-53. 2003