Garrett M Nash

Summary

Affiliation: Memorial Sloan-Kettering Cancer Center
Country: USA

Publications

  1. doi request reprint Close distal margin and rectal cancer recurrence after sphincter-preserving rectal resection
    Garrett M Nash
    Department of Surgery, Colorectal Service, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA
    Dis Colon Rectum 53:1365-73. 2010
  2. doi request reprint A predictive model for lymph node yield in colon cancer resection specimens
    Garrett M Nash
    Department of Surgery, Colorectal Service, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA
    Ann Surg 253:318-22. 2011
  3. doi request reprint KRAS mutation and microsatellite instability: two genetic markers of early tumor development that influence the prognosis of colorectal cancer
    Garrett M Nash
    Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, USA
    Ann Surg Oncol 17:416-24. 2010
  4. doi request reprint Response to neoadjuvant therapy in patients with early age-of-onset rectal cancer
    Emily Steinhagen
    Department of Surgery, Colorectal Service, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA
    Dis Colon Rectum 56:58-63. 2013
  5. doi request reprint Anastomotic leak following low anterior resection in stage IV rectal cancer is associated with poor survival
    James D Smith
    Colorectal Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA
    Ann Surg Oncol 20:2641-6. 2013
  6. doi request reprint Effects of obesity in rectal cancer surgery
    Hueylan Chern
    Colorectal Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    J Am Coll Surg 211:55-60. 2010
  7. doi request reprint Recurrence rates and prognostic factors in ypN0 rectal cancer after neoadjuvant chemoradiation and total mesorectal excision
    Anand Govindarajan
    Department of Colorectal Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA
    Ann Surg Oncol 18:3666-72. 2011
  8. pmc What is the significance of the circumferential margin in locally advanced rectal cancer after neoadjuvant chemoradiotherapy?
    Atthaphorn Trakarnsanga
    Colorectal Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA
    Ann Surg Oncol 20:1179-84. 2013
  9. pmc Challenging the feasibility and clinical significance of current guidelines on lymph node examination in rectal cancer in the era of neoadjuvant therapy
    Anand Govindarajan
    Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    J Clin Oncol 29:4568-73. 2011
  10. ncbi request reprint Management and outcome of perianal Paget's disease: a 6-decade institutional experience
    Daniel R Perez
    1Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York 2Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York
    Dis Colon Rectum 57:747-51. 2014

Collaborators

Detail Information

Publications37

  1. doi request reprint Close distal margin and rectal cancer recurrence after sphincter-preserving rectal resection
    Garrett M Nash
    Department of Surgery, Colorectal Service, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA
    Dis Colon Rectum 53:1365-73. 2010
    ..Negative surgical margins are important for local control of rectal cancer treated with sphincter-preserving surgery. However, the association of rectal cancer recurrence with close distal margin is not well established...
  2. doi request reprint A predictive model for lymph node yield in colon cancer resection specimens
    Garrett M Nash
    Department of Surgery, Colorectal Service, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA
    Ann Surg 253:318-22. 2011
    ..To develop a predictive model of lymph node yield in a series of colon cancer resection specimens with detailed anatomic and surgical technique data...
  3. doi request reprint KRAS mutation and microsatellite instability: two genetic markers of early tumor development that influence the prognosis of colorectal cancer
    Garrett M Nash
    Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, USA
    Ann Surg Oncol 17:416-24. 2010
    ....
  4. doi request reprint Response to neoadjuvant therapy in patients with early age-of-onset rectal cancer
    Emily Steinhagen
    Department of Surgery, Colorectal Service, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA
    Dis Colon Rectum 56:58-63. 2013
    ..The response to neoadjuvant treatment in patients ≤ 50 years of age is not known. Factors affecting the response to neoadjuvant therapy in this age group have not been evaluated...
  5. doi request reprint Anastomotic leak following low anterior resection in stage IV rectal cancer is associated with poor survival
    James D Smith
    Colorectal Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA
    Ann Surg Oncol 20:2641-6. 2013
    ..We measured the incidence of anastomotic leak and its association with clinical outcome...
  6. doi request reprint Effects of obesity in rectal cancer surgery
    Hueylan Chern
    Colorectal Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    J Am Coll Surg 211:55-60. 2010
    ..In this study, we evaluate whether higher body mass index (BMI) compromises surgical resection in patients with locally advanced, mid-to-low rectal cancer after neoadjuvant therapy, adversely affecting long-term oncologic outcomes...
  7. doi request reprint Recurrence rates and prognostic factors in ypN0 rectal cancer after neoadjuvant chemoradiation and total mesorectal excision
    Anand Govindarajan
    Department of Colorectal Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA
    Ann Surg Oncol 18:3666-72. 2011
    ..Patients with pathologically node-negative tumors have an improved prognosis, but recurrence patterns and independent prognostic factors in these patients have been incompletely characterized...
  8. pmc What is the significance of the circumferential margin in locally advanced rectal cancer after neoadjuvant chemoradiotherapy?
    Atthaphorn Trakarnsanga
    Colorectal Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA
    Ann Surg Oncol 20:1179-84. 2013
    ..However, its significance in the setting of long-course neoadjuvant chemoradiotherapy (nCRT) is not well defined...
  9. pmc Challenging the feasibility and clinical significance of current guidelines on lymph node examination in rectal cancer in the era of neoadjuvant therapy
    Anand Govindarajan
    Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    J Clin Oncol 29:4568-73. 2011
    ..We sought to examine the feasibility and clinical significance of current guidelines on nodal assessment in patients with rectal cancer (RC) treated with neoadjuvant radiation...
  10. ncbi request reprint Management and outcome of perianal Paget's disease: a 6-decade institutional experience
    Daniel R Perez
    1Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York 2Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York
    Dis Colon Rectum 57:747-51. 2014
    ..It is often noninvasive but frequently recurs locally. Invasive disease can metastasize to distant sites...
  11. doi request reprint Locoregional lymphadenectomy in the surgical management of anorectal melanoma
    Daniel R Perez
    Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA
    Ann Surg Oncol 20:2339-44. 2013
    ..Understanding the significance of lymphatic dissemination might assist in stratifying patients for either organ preservation or radical surgery...
  12. doi request reprint Immunohistochemistry as first-line screening for detecting colorectal cancer patients at risk for hereditary nonpolyposis colorectal cancer syndrome: a 2-antibody panel may be as predictive as a 4-antibody panel
    Jinru Shia
    Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, USA
    Am J Surg Pathol 33:1639-45. 2009
    ..Such a cost-effective approach carries significant implication, as immunohistochemistry is being widely used as first-line screening for HNPCC...
  13. doi request reprint Long-term survival after transanal excision of T1 rectal cancer
    Garrett M Nash
    Department of Surgery, Colorectal Service, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA
    Dis Colon Rectum 52:577-82. 2009
    ..However, the impact of transanal excision on cancer mortality has not been adequately studied. The purpose of this study was to compare oncologic outcomes of transanal excision with those of radical resection...
  14. doi request reprint Patterns of failure in patients with early onset (synchronous) resectable liver metastases from rectal cancer
    Jean M Butte
    Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    Cancer 118:5414-23. 2012
    ..In this study, the authors examined recurrence patterns and survival after resection of SLMRC...
  15. doi request reprint Nonoperative management of rectal cancer with complete clinical response after neoadjuvant therapy
    James D Smith
    Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    Ann Surg 256:965-72. 2012
    ....
  16. doi request reprint Whole-mount pathologic analysis of rectal cancer following neoadjuvant therapy: implications of margin status on long-term oncologic outcome
    James J Mezhir
    Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    Ann Surg 256:274-9. 2012
    ..We set out to determine the long-term oncologic impact of resection margins in patients with locally advanced rectal cancer using a comprehensive pathologic whole-mount section analysis...
  17. doi request reprint Pulmonary recurrence predominates after combined modality therapy for rectal cancer: an original retrospective study
    Peirong Ding
    Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    Ann Surg 256:111-6. 2012
    ..To characterize patterns of recurrence in locally advanced rectal cancer treated with combined modality therapy (CMT): neoadjuvant chemoradiation + total mesorectal excision + adjuvant chemotherapy...
  18. pmc Improved testing for microsatellite instability in colorectal cancer using a simplified 3-marker assay
    Iyare Esemuede
    Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA
    Ann Surg Oncol 17:3370-8. 2010
    ..However, the optimal assay for MSI status is unknown. We have evaluated a simplified 3-marker assay for MSI and compared it with the 5-marker (NCI) assay to see if technical variations in MSI testing are important...
  19. doi request reprint Rate of residual disease after complete endoscopic resection of malignant colonic polyp
    Jean M Butte
    Department of Surgery, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA
    Dis Colon Rectum 55:122-7. 2012
    ..Following polypectomy, colectomy is performed selectively to ensure complete clearance of neoplasia...
  20. doi request reprint KRAS mutation correlates with accelerated metastatic progression in patients with colorectal liver metastases
    Garrett M Nash
    Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA
    Ann Surg Oncol 17:572-8. 2010
    ..To examine more directly whether KRAS mutations are associated with accelerated metastatic progression, we evaluated KRAS mutation as well as Ki-67 expression in patients with colorectal liver metastases not treated with cetuximab...
  21. doi request reprint c-Met gene amplification is associated with advanced stage colorectal cancer and liver metastases
    Zhao Shi Zeng
    Department of Surgery, Colorectal Service, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
    Cancer Lett 265:258-69. 2008
    ..c-Met gene amplification is linked to metastatic progression, and is a viable target for a significant subset of advanced CRC...
  22. doi request reprint Systematic immunohistochemistry screening for Lynch syndrome in early age-of-onset colorectal cancer patients undergoing surgical resection
    Emily Steinhagen
    Department of Surgery, Colorectal Service, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    J Am Coll Surg 214:61-7. 2012
    ..Our study describes the impact of routine immunohistochemistry (IHC) analysis of tumor tissue for loss of MMR protein expression in early age-of-onset CRC patients undergoing resection...
  23. doi request reprint Neither FDG-PET Nor CT can distinguish between a pathological complete response and an incomplete response after neoadjuvant chemoradiation in locally advanced rectal cancer: a prospective study
    Jose G Guillem
    Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    Ann Surg 258:289-95. 2013
    ..To prospectively compare the ability of flourodeoxyglucose-positron emission tomography (FDG-PET) and computed tomography (CT) to identify a pathological complete response (pCR) in patients with rectal cancer treated by chemoradiation...
  24. doi request reprint Anastomotic leak is not associated with oncologic outcome in patients undergoing low anterior resection for rectal cancer
    James D Smith
    Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    Ann Surg 256:1034-8. 2012
    ..To examine the association between anastomotic leak and oncologic outcome after anterior resection, stratifying for defunctioning stoma...
  25. doi request reprint Early postoperative intraperitoneal chemotherapy following cytoreductive surgery for appendiceal mucinous neoplasms with isolated peritoneal metastasis
    Patrick L Wagner
    Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA
    Dis Colon Rectum 55:407-15. 2012
    ..At our institution, patients undergoing complete cytoreduction in this setting typically receive multiple cycles of early postoperative intraperitoneal chemotherapy...
  26. ncbi request reprint Detection of HER-2/neu gene amplification in breast cancer using a novel polymerase chain reaction/ligase detection reaction technique
    Daniel R Nathanson
    Department of Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    J Am Coll Surg 197:419-25. 2003
    ..We have evaluated a new PCR (polymerase chain reaction)-based assay for the detection of HER-2/neu gene amplification in human breast cancer...
  27. ncbi request reprint Neoadjuvant Radiation Therapy Prior to Total Mesorectal Excision for Rectal Cancer is Not Associated with Postoperative Complications Using Current Techniques
    Sarah A Milgrom
    Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA
    Ann Surg Oncol 21:2295-302. 2014
    ..This study aims to quantify 30-day complication rates after total mesorectal excision (TME) using current techniques and to assess for an association of these complications with neoadjuvant RT...
  28. ncbi request reprint Radical resection of rectal cancer primary tumor provides effective local therapy in patients with stage IV disease
    Garrett M Nash
    Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Ann Surg Oncol 9:954-60. 2002
    ..We have reviewed stage IV rectal cancer patients to evaluate the effectiveness of radical surgery without radiation as local therapy...
  29. doi request reprint Peritoneal debulking/intraperitoneal chemotherapy-non-sarcoma
    Kaitlyn J Kelly
    Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York
    J Surg Oncol 109:14-22. 2014
    ..The aim of this report is to explain the rationale and available techniques for CRS and IPC, and to highlight disease-specific considerations that should be taken into account when evaluating potential candidates for CRS and IPC...
  30. ncbi request reprint HER 2/neu expression and gene amplification in colon cancer
    Daniel R Nathanson
    Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Int J Cancer 105:796-802. 2003
    ..These data indicate that the primary mechanism of dysregulated HER 2/neu expression in colon cancer, as in breast cancer, is gene amplification...
  31. ncbi request reprint Evaluation of preoperative and postoperative radiotherapy on long-term functional results of straight coloanal anastomosis
    Daniel R Nathanson
    Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Dis Colon Rectum 46:888-94. 2003
    ....
  32. doi request reprint Single-incision versus multiport laparoscopic right and hand-assisted left colectomy: a case-matched comparison
    Sang W Lee
    New York Presbyterian Hospital, Weill Cornell Medical College, New York, New York, USA
    Dis Colon Rectum 54:1355-61. 2011
    ..New technology for single-incision laparoscopic colectomy is now commercially available, yet advantages of this approach over multiport laparoscopic colectomy have not been demonstrated...
  33. doi request reprint Accuracy of endorectal ultrasound for measurement of the closest predicted radial mesorectal margin for rectal cancer
    P Terry Phang
    St Paul s Hospital, University of British Columbia, Vancouver, British Columbia, Canada
    Dis Colon Rectum 55:59-64. 2012
    ..Endorectal ultrasound is also used to assess the clinical stage of the cancer that will determine the recommendation for neoadjuvant chemoradiation, but it has not been used to assess the closest predicted radial margin...
  34. ncbi request reprint Value of histopathology in predicting microsatellite instability in hereditary nonpolyposis colorectal cancer and sporadic colorectal cancer
    Jinru Shia
    Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY 10002, USA
    Am J Surg Pathol 27:1407-17. 2003
    ..Using a stepwise logistic regression model, a formula was generated that could be used to calculate the probability of a colorectal carcinoma being MSI-H based on morphologic features...
  35. ncbi request reprint Neoadjuvant chemotherapy first, followed by chemoradiation and then surgery, in the management of locally advanced rectal cancer
    Andrea Cercek
    From the aGastrointestinal Oncology Service, Department of Medicine, bDepartment of Radiation Therapy, and cColorectal Surgery Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York
    J Natl Compr Canc Netw 12:513-9. 2014
    ..FOLFOX and chemoradiation before planned TME results in tumor regression, a high rate of delivery of planned therapy, and a substantial rate of pathCRs, and offers a good platform for nonoperative management in select patients. ..
  36. pmc Long-term results of local excision for rectal cancer
    Philip B Paty
    Department of Surgery, Pathology, and Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Ann Surg 236:522-29; discussion 529-30. 2002
    ..To review the authors' experience with local excision of early rectal cancers to assess the effectiveness of initial treatment and of salvage surgery...
  37. doi request reprint Insurance but not race is associated with diverticulitis mortality in a statewide database
    Vanessa P Ho
    Department of Surgery, Weill Cornell Medical College, New York, New York, USA
    Dis Colon Rectum 54:559-65. 2011
    ..We examined the association of racial identity and insurance with admission, treatment, and mortality for patients admitted to inpatient care for acute diverticulitis...