K Nafa

Summary

Affiliation: Memorial Sloan-Kettering Cancer Center
Country: USA

Publications

  1. ncbi request reprint Factor V Leiden mutation investigated by amplification created restriction enzyme site (ACRES) in PNH patients with and without thrombosis
    K Nafa
    Department of Human Genetics, Memorial Sloan Kettering Cancer Center, New York, NY 0021, USA
    Haematologica 81:540-2. 1996
  2. ncbi request reprint The spectrum of somatic mutations in the PIG-A gene in paroxysmal nocturnal hemoglobinuria includes large deletions and small duplications
    K Nafa
    Department of Human Genetics, Memorial Sloan Kettering Cancer Center, NY, New York 10021, USA
    Blood Cells Mol Dis 24:370-84. 1998
  3. ncbi request reprint New somatic mutation in the PIG-A gene emerges at relapse of paroxysmal nocturnal hemoglobinuria
    K Nafa
    Department of Human Genetics, Memorial Sloan Kettering Cancer Center, New York, NY, USA
    Blood 92:3422-7. 1998
  4. ncbi request reprint Cytogenetic and morphological abnormalities in paroxysmal nocturnal haemoglobinuria
    D J Araten
    Department of Human Genetics, Memorial Sloan-Kettering Cancer Center, New York, USA
    Br J Haematol 115:360-8. 2001
  5. ncbi request reprint Association of clonal T-cell large granular lymphocyte disease and paroxysmal nocturnal haemoglobinuria (PNH): further evidence for a pathogenetic link between T cells, aplastic anaemia and PNH
    A Karadimitris
    Department of Human Genetics, Memorial Sloan-Kettering Cancer Center, New York, NY, USA
    Br J Haematol 115:1010-4. 2001

Collaborators

  • K Li
  • P Hillmen
  • M Ladanyi
  • F Boulad
  • D G Savage
  • A Karadimitris
  • D J Araten
  • R Notaro
  • L Luzzatto
  • A Kutlar
  • D Swirsky
  • M Weiss
  • I A Roberts
  • N Anagnostopoulos
  • R T Maziarz
  • H T Thaler
  • H Castro-Malaspina
  • R Thertulien
  • M Bessler
  • S Jhanwar
  • C S Rosenfeld
  • B H Childs
  • A E Stevens

Detail Information

Publications5

  1. ncbi request reprint Factor V Leiden mutation investigated by amplification created restriction enzyme site (ACRES) in PNH patients with and without thrombosis
    K Nafa
    Department of Human Genetics, Memorial Sloan Kettering Cancer Center, New York, NY 0021, USA
    Haematologica 81:540-2. 1996
    ..Fifty-six PNH patients were tested for Factor V Leiden mutation using Amplification Created Restriction Enzyme Site methods. PNH patients do not show an increased frequency of Factor V Leiden mutations...
  2. ncbi request reprint The spectrum of somatic mutations in the PIG-A gene in paroxysmal nocturnal hemoglobinuria includes large deletions and small duplications
    K Nafa
    Department of Human Genetics, Memorial Sloan Kettering Cancer Center, NY, New York 10021, USA
    Blood Cells Mol Dis 24:370-84. 1998
    ..The increasing number of identified missense PIG-A mutations should help elucidate structure-function relationships in the PIG-A protein...
  3. ncbi request reprint New somatic mutation in the PIG-A gene emerges at relapse of paroxysmal nocturnal hemoglobinuria
    K Nafa
    Department of Human Genetics, Memorial Sloan Kettering Cancer Center, New York, NY, USA
    Blood 92:3422-7. 1998
    ..These findings support the notion that the BM environment may create selective conditions favoring the expansion of PNH clones...
  4. ncbi request reprint Cytogenetic and morphological abnormalities in paroxysmal nocturnal haemoglobinuria
    D J Araten
    Department of Human Genetics, Memorial Sloan-Kettering Cancer Center, New York, USA
    Br J Haematol 115:360-8. 2001
    ..However, none of our patients developed excess blasts or leukaemia. We conclude that in patients with PNH cytogenetically abnormal clones are not necessarily malignant and may not be predictive of evolution to leukaemia...
  5. ncbi request reprint Association of clonal T-cell large granular lymphocyte disease and paroxysmal nocturnal haemoglobinuria (PNH): further evidence for a pathogenetic link between T cells, aplastic anaemia and PNH
    A Karadimitris
    Department of Human Genetics, Memorial Sloan-Kettering Cancer Center, New York, NY, USA
    Br J Haematol 115:1010-4. 2001
    ..Thus, T-LGL clones in AA, MDS and PNH probably expand as a result of antigenic stimulation. It is postulated that the antigen driving clonal T-cell proliferations in these disorders exists on haemopoietic stem cells...