Rajmohan Murali

Summary

Affiliation: Memorial Sloan-Kettering Cancer Center
Country: USA

Publications

  1. ncbi Tumours associated with BAP1 mutations
    Rajmohan Murali
    Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    Pathology 45:116-26. 2013
  2. ncbi Number of primary melanomas is an independent predictor of survival in patients with metastatic melanoma
    Rajmohan Murali
    Melanoma Institute Australia, Sydney, New South Wales, Australia
    Cancer 118:4519-29. 2012
  3. ncbi Clinical and pathologic factors associated with distant metastasis and survival in patients with thin primary cutaneous melanoma
    Rajmohan Murali
    Tissue Pathology and Diagnostic Oncology, Royal Prince Alfred Hospital, Sydney, NSW, Australia
    Ann Surg Oncol 19:1782-9. 2012
  4. ncbi Clinicopathologic features of incident and subsequent tumors in patients with multiple primary cutaneous melanomas
    Rajmohan Murali
    Tissue Pathology and Diagnostic Oncology, Royal Prince Alfred Hospital, Sydney, Australia
    Ann Surg Oncol 19:1024-33. 2012
  5. ncbi Sentinel lymph nodes containing very small (<0.1 mm) deposits of metastatic melanoma cannot be safely regarded as tumor-negative
    Rajmohan Murali
    Tissue Pathology and Diagnostic Oncology, Royal Prince Alfred Hospital, and Discipline of Pathology, Sydney Medical School, The University of Sydney, Sydney, NSW, Australia
    Ann Surg Oncol 19:1089-99. 2012
  6. ncbi Sentinel lymph node biopsy in patients with thin primary cutaneous melanoma
    Rajmohan Murali
    Tissue Pathology and Diagnostic Oncology, Royal Prince Alfred Hospital, Sydney, New South Wales, Australia
    Ann Surg 255:128-33. 2012
  7. ncbi Factors predicting recurrence and survival in sentinel lymph node-positive melanoma patients
    Rajmohan Murali
    Tissue Pathology and Diagnostic Oncology, Royal Prince Alfred Hospital, Sydney, NSW, Australia
    Ann Surg 253:1155-64. 2011
  8. ncbi Clinical and pathological features of metastases of primary cutaneous desmoplastic melanoma
    Rajmohan Murali
    Tissue Pathology and Diagnostic Oncology, Royal Prince Alfred Hospital, Sydney, NSW, Australia
    Histopathology 58:886-95. 2011
  9. ncbi Sentinel lymph node biopsy in pediatric and adolescent cutaneous melanoma patients
    Robert Howman-Giles
    Sydney Melanoma Unit and Melanoma Institute Australia, Royal Prince Alfred and Mater Hospitals, Sydney, NSW, Australia
    Ann Surg Oncol 17:138-43. 2010
  10. ncbi Tumor-infiltrating lymphocyte grade is an independent predictor of sentinel lymph node status and survival in patients with cutaneous melanoma
    Farhad Azimi
    Melanoma Institute Australia, 40 Rocklands Rd, North Sydney NSW 2060, Australia
    J Clin Oncol 30:2678-83. 2012

Detail Information

Publications47

  1. ncbi Tumours associated with BAP1 mutations
    Rajmohan Murali
    Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    Pathology 45:116-26. 2013
    ....
  2. ncbi Number of primary melanomas is an independent predictor of survival in patients with metastatic melanoma
    Rajmohan Murali
    Melanoma Institute Australia, Sydney, New South Wales, Australia
    Cancer 118:4519-29. 2012
    ..The authors sought to address the latter question in the current study...
  3. ncbi Clinical and pathologic factors associated with distant metastasis and survival in patients with thin primary cutaneous melanoma
    Rajmohan Murali
    Tissue Pathology and Diagnostic Oncology, Royal Prince Alfred Hospital, Sydney, NSW, Australia
    Ann Surg Oncol 19:1782-9. 2012
    ..We sought to identify clinical and pathologic factors associated with distant metastasis and survival in a large number of patients with thin melanoma treated at a single institution...
  4. ncbi Clinicopathologic features of incident and subsequent tumors in patients with multiple primary cutaneous melanomas
    Rajmohan Murali
    Tissue Pathology and Diagnostic Oncology, Royal Prince Alfred Hospital, Sydney, Australia
    Ann Surg Oncol 19:1024-33. 2012
    ....
  5. ncbi Sentinel lymph nodes containing very small (<0.1 mm) deposits of metastatic melanoma cannot be safely regarded as tumor-negative
    Rajmohan Murali
    Tissue Pathology and Diagnostic Oncology, Royal Prince Alfred Hospital, and Discipline of Pathology, Sydney Medical School, The University of Sydney, Sydney, NSW, Australia
    Ann Surg Oncol 19:1089-99. 2012
    ....
  6. ncbi Sentinel lymph node biopsy in patients with thin primary cutaneous melanoma
    Rajmohan Murali
    Tissue Pathology and Diagnostic Oncology, Royal Prince Alfred Hospital, Sydney, New South Wales, Australia
    Ann Surg 255:128-33. 2012
    ....
  7. ncbi Factors predicting recurrence and survival in sentinel lymph node-positive melanoma patients
    Rajmohan Murali
    Tissue Pathology and Diagnostic Oncology, Royal Prince Alfred Hospital, Sydney, NSW, Australia
    Ann Surg 253:1155-64. 2011
    ..We investigated in detail the influence of SN tumor characteristics and clinical and primary tumor parameters on clinical outcomes in a large cohort of patients treated in a single center...
  8. ncbi Clinical and pathological features of metastases of primary cutaneous desmoplastic melanoma
    Rajmohan Murali
    Tissue Pathology and Diagnostic Oncology, Royal Prince Alfred Hospital, Sydney, NSW, Australia
    Histopathology 58:886-95. 2011
    ..Our aim was to describe the histological features of metastases of primary DM and to determine whether they were predictive of outcome...
  9. ncbi Sentinel lymph node biopsy in pediatric and adolescent cutaneous melanoma patients
    Robert Howman-Giles
    Sydney Melanoma Unit and Melanoma Institute Australia, Royal Prince Alfred and Mater Hospitals, Sydney, NSW, Australia
    Ann Surg Oncol 17:138-43. 2010
    ..The present study takes advantage of the large Sydney Melanoma Unit (SMU) database to clarify this issue...
  10. ncbi Tumor-infiltrating lymphocyte grade is an independent predictor of sentinel lymph node status and survival in patients with cutaneous melanoma
    Farhad Azimi
    Melanoma Institute Australia, 40 Rocklands Rd, North Sydney NSW 2060, Australia
    J Clin Oncol 30:2678-83. 2012
    ..To determine whether density and distribution of tumor-infiltrating lymphocytes (TILs; TIL grade) is an independent predictor of sentinel lymph node (SLN) status and survival in patients with clinically localized primary cutaneous melanoma...
  11. ncbi Synchronous and metachronous malignancies in patients with melanoma: a clinicopathologic study highlighting the role of fine-needle biopsy cytology and potential diagnostic pitfalls
    Caroline L Cooper
    Tissue Pathology and Diagnostic Oncology, Royal Prince Alfred Hospital, Sydney Medical School, The University of Sydney, Sydney, New South Wales, Australia
    Melanoma Res 20:203-11. 2010
    ..Careful assessment of the FNB cytologic features and directed use of ancillary studies should enable accurate diagnosis in most cases and facilitate appropriate patient management...
  12. ncbi Prognostic factors in cutaneous desmoplastic melanoma: a study of 252 patients
    Rajmohan Murali
    Diagnostic Oncology and Tissue Pathology, Royal Prince Alfred Hospital, Camperdown, Sydney, New South Wales, Australia
    Cancer 116:4130-8. 2010
    ..Primary melanomas either may be entirely desmoplastic or almost entirely desmoplastic (pure DM [pDM]) or may exhibit a desmoplastic component admixed with a nondesmoplastic component (combined DM [cDM])...
  13. ncbi Sentinel lymph node biopsy in histologically ambiguous melanocytic tumors with spitzoid features (so-called atypical spitzoid tumors)
    Rajmohan Murali
    Sydney Melanoma Unit, Royal Prince Alfred Hospital, Camperdown, Sydney, NSW, 2050, Australia
    Ann Surg Oncol 15:302-9. 2008
    ..The current study evaluated the role of sentinel lymph node (SLN) biopsy in patients with such atypical spitzoid tumors...
  14. ncbi Increasing tumor thickness is associated with recurrence and poorer survival in patients with Merkel cell carcinoma
    Cathy S Lim
    Tissue Pathology and Diagnostic Oncology, Royal Prince Alfred Hospital, Camperdown, NSW, Australia
    Ann Surg Oncol 19:3325-34. 2012
    ..Clinical and pathologic factors associated with disease progression and mortality in patients with MCC are poorly defined. Recently, it has been reported that p63 expression in primary MCC is strongly associated with clinical outcome...
  15. ncbi Pigmented epithelioid melanocytoma: favorable outcome after 5-year follow-up
    Rajni V Mandal
    Department of Pathology, Massachusetts General Hospital, Boston, MA, USA
    Am J Surg Pathol 33:1778-82. 2009
    ..These findings provide further evidence that PEM is a unique low-grade melanocytic tumor with limited metastatic potential (to lymph nodes), but a favorable long-term clinical course...
  16. ncbi Interobserver variation in the histopathologic reporting of key prognostic parameters, particularly clark level, affects pathologic staging of primary cutaneous melanoma
    Rajmohan Murali
    Department of Anatomical Pathology, Royal Prince Alfred Hospital, Camperdown, NSW 2050, Australia
    Ann Surg 249:641-7. 2009
    ..However, detailed quantification of the magnitude of variation between observers and its effect on melanoma staging has not been reported...
  17. ncbi Pathologic examination of sentinel lymph nodes from melanoma patients
    Richard A Scolyer
    Department of Anatomical Pathology, Royal Prince Alfred Hospital, Camperdown, NSW, Australia
    Semin Diagn Pathol 25:100-11. 2008
    ..At present, the role of nonhistopathologic methods of SN evaluation, such as reverse transcription polymerase chain reaction (RT-PCR) and magnetic resonance spectroscopy, remains unclear, and these techniques require further evaluation...
  18. ncbi Non-Sentinel Node Risk Score (N-SNORE): a scoring system for accurately stratifying risk of non-sentinel node positivity in patients with cutaneous melanoma with positive sentinel lymph nodes
    Rajmohan Murali
    Tissue Pathology and Diagnostic Oncology, Royal Prince Alfred Hospital, Camperdown, NSW, Australia
    J Clin Oncol 28:4441-9. 2010
    ..We investigated clinicopathologic factors that predict NSN positivity in an attempt to identify patients who may be safely spared completion lymph node dissection (CLND)...
  19. ncbi Cutaneous head and neck squamous cell carcinoma with regional metastases: the prognostic importance of soft tissue metastases and extranodal spread
    Wendy Kelder
    Sydney Head and Neck Cancer Institute, Sydney Cancer Center, Royal Prince Alfred and Liverpool Hospitals, Sydney, Australia
    Ann Surg Oncol 19:274-9. 2012
    ..The aim of this study was to evaluate the prognosis of patients with STM from head and neck cSCC, and to compare this with that of node metastases with and without ENS...
  20. ncbi Lactate dehydrogenase 5 expression in melanoma increases with disease progression and is associated with expression of Bcl-XL and Mcl-1, but not Bcl-2 proteins
    Liqing Zhuang
    Tissue Pathology and Diagnostic Oncology, Royal Prince Alfred Hospital, Sydney, NSW, Australia
    Mod Pathol 23:45-53. 2010
    ..The strong correlation of LDH-5 expression with Mcl-1 expression suggests that treatment strategies inhibiting the activity of Mcl-1 in melanoma patients should be investigated...
  21. ncbi Cytologic features of metastatic and recurrent melanoma in patients with primary cutaneous desmoplastic melanoma
    Rajmohan Murali
    Department of Anatomical Pathology, Royal Prince Alfred Hospital, Camperdown, Sydney, Australia
    Am J Clin Pathol 130:715-23. 2008
    ..010) than did "pure" DMs. Recurrent and metastatic DM has a range of cytologic appearances. Awareness of the cytologic features and careful clinicopathologic correlation will assist in accurate FNB diagnosis...
  22. ncbi Desmoplastic neurotropic melanoma: a clinicopathologic analysis of 128 cases
    James Y Chen
    Department of Radiation Oncology, Sydney Cancer Centre, Royal Prince Alfred Hospital, Camperdown, New South Wales, Australia
    Cancer 113:2770-8. 2008
    ..The authors investigated the local recurrence rates for patients with DNM after surgery alone or surgery followed by radiotherapy (RT)...
  23. ncbi Atypical spitzoid melanocytic tumors with positive sentinel lymph nodes in children and teenagers, and comparison with histologically unambiguous and lethal melanomas
    Klaus J Busam
    Department of Pathology, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA
    Am J Surg Pathol 33:1386-95. 2009
    ..Our findings confirm that children and teenagers with ASMTs and positive SLNs have a less aggressive clinical course than those with histologically unambiguous melanoma...
  24. ncbi Sentinel lymph node biopsy for melanoma: aspects of pathologic assessment
    Rajmohan Murali
    Royal Prince Alfred Hospital, Department of Anatomical Pathology, Camperdown, Sydney, NSW 2050, Australia
    Future Oncol 4:535-51. 2008
    ..Several non-histopathologic methods of SLN evaluation have been investigated, and while some of them show promise for the future, excision and histopathologic examination currently remains the gold standard for the evaluation of SLNs...
  25. ncbi Histologically ambiguous ("borderline") primary cutaneous melanocytic tumors: approaches to patient management including the roles of molecular testing and sentinel lymph node biopsy
    Richard A Scolyer
    Melanoma Institute Australia, Sydney, NSW, Australia
    Arch Pathol Lab Med 134:1770-7. 2010
    ....
  26. ncbi Confirmation of sentinel lymph node identity by analysis of fine-needle biopsy samples using inductively coupled plasma-mass spectrometry
    Alison Beavis
    Department of Chemistry, Materials and Forensic Science, University of Technology, Sydney, New South Wales, Australia
    Ann Surg Oncol 15:934-40. 2008
    ..This involved the use of inductively coupled plasma-mass spectrometry (ICP-MS) to analyze antimony concentrations in fine-needle biopsy (FNB) samples from surgically procured lymph nodes...
  27. ncbi Interobserver reproducibility of histologic parameters of melanoma deposits in sentinel lymph nodes: implications for management of patients with melanoma
    Rajmohan Murali
    Department of Anatomical Pathology, Royal Prince Alfred Hospital, Sydney, Australia
    Cancer 115:5026-37. 2009
    ....
  28. ncbi The prognostic value of tumor mitotic rate and other clinicopathologic factors in patients with locoregional recurrences of melanoma
    Rajmohan Murali
    Royal Prince Alfred Hospital, Sydney, Camperdown, NSW, Australia
    Ann Surg Oncol 17:2992-9. 2010
    ..In this study, we sought to determine the prognostic value of MRR and other clinicopathologic factors in recurrent melanoma...
  29. ncbi The detection and significance of melanoma micrometastases in sentinel nodes
    Richard A Scolyer
    Sydney Melanoma Unit, Royal Prince Alfred Hospital, Camperdown, NSW 2050, Australia
    Surg Oncol 17:165-74. 2008
    ....
  30. ncbi Fine-needle biopsy of metastatic melanoma: clinical use and new applications
    Rajmohan Murali
    Tissue Pathology and Diagnostic Oncology, Royal Prince Alfred Hospital, Sydney, NSW, Australia
    Lancet Oncol 11:391-400. 2010
    ..In this review, the role of FNB as an important diagnostic modality in the management of suspected metastatic melanoma is described and other diagnostic and research applications of FNB are discussed...
  31. ncbi Blue nevi and related lesions: a review highlighting atypical and newly described variants, distinguishing features and diagnostic pitfalls
    Rajmohan Murali
    Royal Prince Alfred Hospital Discipline of Pathology, The University of Sydney, Camperdown Melanoma Institute Australia, New South Wales, Australia
    Adv Anat Pathol 16:365-82. 2009
    ....
  32. ncbi Digital papillary adenocarcinoma: a tumour that should be considered in the differential diagnosis of neoplasms involving the digits
    Richard A Scolyer
    Department of Tissue Pathology and Diagnostic Oncology, Royal Prince Alfred Hospital, Camperdown, NSW, Australia
    Pathology 45:55-61. 2013
    ..Digital papillary adenocarcinoma (DPA) is a rare malignant adnexal tumour that occurs almost exclusively in a digital location. Only two case series have been reported previously...
  33. ncbi The prognostic and staging implications of bone invasion in oral squamous cell carcinoma
    Ardalan Ebrahimi
    Sydney Head and Neck Cancer Institute, Royal Prince Alfred Hospital, Camperdown, Australia
    Cancer 117:4460-7. 2011
    ..A study was undertaken to determine whether bone invasion is an independent prognostic factor in oral squamous cell carcinoma (SCC) after taking into account the extent of bone invasion...
  34. ncbi Diagnostic accuracy of fine needle biopsy for metastatic melanoma and its implications for patient management
    Anna Doubrovsky
    Sydney Melanoma Unit, Sydney Cancer Centre, Royal Prince Alfred Hospital, Camperdown, NSW, 2050, Australia
    Ann Surg Oncol 15:323-32. 2008
    ..In this study, the accuracy of FNB for the diagnosis of metastatic melanoma was investigated...
  35. ncbi MAL2 and tumor protein D52 (TPD52) are frequently overexpressed in ovarian carcinoma, but differentially associated with histological subtype and patient outcome
    Jennifer A Byrne
    Molecular Oncology Laboratory, Children s Cancer Research Unit, The Children s Hospital at Westmead, Westmead, New South Wales, Australia
    BMC Cancer 10:497. 2010
    ..MAL2 binds tumor protein D52 (TPD52), which is frequently overexpressed in ovarian carcinoma, but the clinical significance of MAL2 and TPD52 overexpression was unknown...
  36. ncbi Diagnosis of cutaneous melanocytic tumours by four-colour fluorescence in situ hybridisation
    Adrienne L Morey
    Department of Anatomical Pathology, St Vincent s Hospital, Darlinghurst, NSW, Australia
    Pathology 41:383-7. 2009
    ..We performed four-colour fluorescence in situ hybridisation (FISH) analysis of melanocytic tumours to determine the accuracy of the technique in classifying melanocytic tumours as benign or malignant...
  37. ncbi So-called "malignant blue nevus": a clinicopathologic study of 23 patients
    Richard C W Martin
    Melanoma Institute Australia incorporating the Sydney Melanoma Unit, Royal Prince Alfred and Mater Hospitals, Sydney, New South Wales, Australia
    Cancer 115:2949-55. 2009
    ..quot; The authors report on a single-institutional clinicopathologic study of "blue nevus-like melanomas" (BNLMs)...
  38. ncbi Cytological features of transitional cell metaplasia of the lower female genital tract
    Rajmohan Murali
    Tissue Pathology and Diagnostic Oncology, Royal Prince Alfred Hospital, Camperdown, Australia
    Pathology 42:113-8. 2010
    ..Transitional cell metaplasia (TCM) of the cervix and vaginal vault is rarely reported. We sought to describe the clinical and cytological features and cytological differential diagnosis of TCM...
  39. ncbi A distinct subset of atypical Spitz tumors is characterized by BRAF mutation and loss of BAP1 expression
    Thomas Wiesner
    Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA
    Am J Surg Pathol 36:818-30. 2012
    ..Future studies are necessary to determine whether this subset has a predictable clinical behavior...
  40. ncbi Outcome of cervical intraepithelial neoplasia 2 diagnosed by punch biopsy in 131 women
    Zongqun Ding
    Sydney Gynaecologic Oncology Group, Sydney Cancer Centre, Sydney, New South Wales, Australia
    J Obstet Gynaecol Res 37:754-61. 2011
    ..To study the outcome of biopsy-diagnosed cervical intraepithelial neoplasia (CIN) 2 in patients treated by loop electrosurgical excision procedure (LEEP) or cold knife cone biopsy (CKC)...
  41. ncbi Fine-needle biopsy as a diagnostic technique for metastatic melanoma
    Rajmohan Murali
    Royal Prince Alfred Hospital, Department of Anatomical Pathology, Camperdown, NSW, 2050, Australia 61 2 9515 7011 61 2 9515 8405
    Expert Opin Med Diagn 2:1-10. 2008
    ....
  42. ncbi Diagnosis and management of sebaceous carcinoma: an Australian experience
    Michael B Dowd
    Department of Plastic Surgery, Nepean Hospital, Sydney, New South Wales, Australia
    ANZ J Surg 78:158-63. 2008
    ..Periorbital SC is approximately three times more common than extraorbital SC. To date, there are few data from an Australian source to document the prevalence or clinical outcome of this tumour...
  43. ncbi Outcomes following parotidectomy for metastatic squamous cell carcinoma with microscopic residual disease: implications for facial nerve preservation
    N Gopalakrishna Iyer
    Sydney Head and Neck Cancer Institute, Sydney Cancer Centre, Royal Prince Alfred Hospital, Sydney, Australia
    Head Neck 31:21-7. 2009
    ..This study aims to determine whether facial nerve preservation followed by radiotherapy is a reasonable option in patients with microscopic residual disease involving the facial nerve...
  44. ncbi Dabrafenib and its potential for the treatment of metastatic melanoma
    Alexander M Menzies
    Melanoma Institute Australia, Sydney, New South Wales, Australia
    Drug Des Devel Ther 6:391-405. 2012
    ..It is expected that new combinations of targeted drugs, such as the combination of dabrafenib and trametinib (GSK1120212, a MEK inhibitor), will provide higher response rates and more durable clinical benefit than dabrafenib monotherapy...
  45. ncbi Cytologic features of epithelioid hemangioendothelioma
    Rajmohan Murali
    Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, 1275 York Ave, New York, NY 10065, USA
    Am J Clin Pathol 136:739-46. 2011
    ..The presence of these features should prompt correlation with clinical, radiologic, and histologic features and immunohistochemical evaluation using vascular markers...
  46. ncbi Usefulness of smears in intra-operative diagnosis of newly described entities of CNS
    Winny Varikatt
    Institute of Clinical Pathology and Medical Research, Institute of Clinical Pathology and Medical Research, University of Western Sydney, Westmead Hospital, New South Wales, Australia
    Neuropathology 29:641-8. 2009
    ..These two tumours can further be differentiated based on their cell morphology and background...
  47. ncbi Clear cell atypical fibroxanthoma - report of a case with review of the literature
    Rajmohan Murali
    Department of Histopathology, Douglass Hanly Moir Laboratories, North Ryde, NSW, Australia
    J Cutan Pathol 33:343-8. 2006
    ..Murali R, Palfreeman S. Clear cell atypical fibroxanthoma - report of a case with review of the literature...