M A S Moore

Summary

Affiliation: Memorial Sloan-Kettering Cancer Center
Country: USA

Publications

  1. ncbi Targeting autocrine and paracrine VEGF receptor pathways inhibits human lymphoma xenografts in vivo
    Eunice S Wang
    Laboratory of Developmental Hematopoiesis, Cell Biology Program, Department of Medicine, Memorial Sloan-Kettering Cancer Center, 1275 York Ave, New York, NY 10021, USA
    Blood 104:2893-902. 2004
  2. ncbi Waking up HSCs: a new role for E-selectin
    Malcolm A S Moore
    Cell Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA
    Nat Med 18:1613-4. 2012
  3. ncbi Mobilization of endothelial and hematopoietic stem and progenitor cells by adenovector-mediated elevation of serum levels of SDF-1, VEGF, and angiopoietin-1
    M A Moore
    Laboratory of Developmental Hematopoiesis, Cell Biology Program, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Ann N Y Acad Sci 938:36-45; discussion 45-7. 2001
  4. ncbi Constitutive activation of Flt3 and STAT5A enhances self-renewal and alters differentiation of hematopoietic stem cells
    Malcolm A S Moore
    Moore Laboratory, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Exp Hematol 35:105-16. 2007
  5. ncbi NUP98 dysregulation in myeloid leukemogenesis
    M A S Moore
    Moore Laboratory, Cell Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Ann N Y Acad Sci 1106:114-42. 2007
  6. ncbi Commentary: the role of cell migration in the ontogeny of the lymphoid system
    Malcolm A S Moore
    Cell Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Stem Cells Dev 13:1-21. 2004
  7. ncbi Ex vivo expansion of stem and progenitor cells in co-culture of mobilized peripheral blood CD34+ cells on human endothelium transfected with adenovectors expressing thrombopoietin, c-kit ligand, and Flt-3 ligand
    Pierre Feugier
    James Ewing Laboratory of Developmental Hematopoiesis, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, Box 101, New York, NY 10021, USA
    J Hematother Stem Cell Res 11:127-38. 2002
  8. ncbi Putting the neo into neoangiogenesis
    Malcolm A S Moore
    Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, New York 10021, USA
    J Clin Invest 109:313-5. 2002
  9. ncbi Converging pathways in leukemogenesis and stem cell self-renewal
    Malcolm A S Moore
    James Ewing Laboratory of Developmental Hematopoiesis, Cell Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA
    Exp Hematol 33:719-37. 2005
  10. ncbi The role of chemoattraction in cancer metastases
    M A Moore
    James Ewing Laboratory of Developmental Hematopoiesis, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Bioessays 23:674-6. 2001

Research Grants

  1. FACTORS INFLUENCING STEM CELL AND PLATELET PRODUCTION
    Malcolm Moore; Fiscal Year: 2002
  2. Development of SL-101, An Immunotoxin that Targets Cancer Stem Cells
    Malcolm Moore; Fiscal Year: 2006

Detail Information

Publications56

  1. ncbi Targeting autocrine and paracrine VEGF receptor pathways inhibits human lymphoma xenografts in vivo
    Eunice S Wang
    Laboratory of Developmental Hematopoiesis, Cell Biology Program, Department of Medicine, Memorial Sloan-Kettering Cancer Center, 1275 York Ave, New York, NY 10021, USA
    Blood 104:2893-902. 2004
    ..12, methotrexate) consistently improved tumor responses over those of single-agent therapy. These data support the further clinical development of VEGFR-targeted approaches for the therapy of aggressive DLBCL...
  2. ncbi Waking up HSCs: a new role for E-selectin
    Malcolm A S Moore
    Cell Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA
    Nat Med 18:1613-4. 2012
    ..A new role in stem cell proliferation has now been identified for the adhesion molecule E-selectin expressed by bone marrow endothelial cells at the vascular niche (pages 1651-1657)...
  3. ncbi Mobilization of endothelial and hematopoietic stem and progenitor cells by adenovector-mediated elevation of serum levels of SDF-1, VEGF, and angiopoietin-1
    M A Moore
    Laboratory of Developmental Hematopoiesis, Cell Biology Program, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Ann N Y Acad Sci 938:36-45; discussion 45-7. 2001
    ..The combination of VEGF and angiopoietin produced a more prolonged elevation of these progenitors in the circulation with increased proliferation of capillaries and expansion of sinusoidal spaces in the marrow...
  4. ncbi Constitutive activation of Flt3 and STAT5A enhances self-renewal and alters differentiation of hematopoietic stem cells
    Malcolm A S Moore
    Moore Laboratory, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Exp Hematol 35:105-16. 2007
    ..To model human leukemogenesis by transduction of human hematopoietic stem cells (HSC) with genes associated with leukemia and expressed in leukemic stem cells...
  5. ncbi NUP98 dysregulation in myeloid leukemogenesis
    M A S Moore
    Moore Laboratory, Cell Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Ann N Y Acad Sci 1106:114-42. 2007
    ..Analysis of NUP98 allelic expression in AML and myelodysplastic syndrome showed loss of heterozygosity observed in 29% of the former and 8% of the latter. This was associated with poor prognosis...
  6. ncbi Commentary: the role of cell migration in the ontogeny of the lymphoid system
    Malcolm A S Moore
    Cell Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Stem Cells Dev 13:1-21. 2004
    ....
  7. ncbi Ex vivo expansion of stem and progenitor cells in co-culture of mobilized peripheral blood CD34+ cells on human endothelium transfected with adenovectors expressing thrombopoietin, c-kit ligand, and Flt-3 ligand
    Pierre Feugier
    James Ewing Laboratory of Developmental Hematopoiesis, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, Box 101, New York, NY 10021, USA
    J Hematother Stem Cell Res 11:127-38. 2002
    ....
  8. ncbi Putting the neo into neoangiogenesis
    Malcolm A S Moore
    Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, New York 10021, USA
    J Clin Invest 109:313-5. 2002
  9. ncbi Converging pathways in leukemogenesis and stem cell self-renewal
    Malcolm A S Moore
    James Ewing Laboratory of Developmental Hematopoiesis, Cell Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA
    Exp Hematol 33:719-37. 2005
    ....
  10. ncbi The role of chemoattraction in cancer metastases
    M A Moore
    James Ewing Laboratory of Developmental Hematopoiesis, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Bioessays 23:674-6. 2001
    ..This results in chemotaxis, or directed migration of tumor cells from their primary site via the circulation to the preferential sites of metastases. The evidence for this model and its significance are reviewed here...
  11. ncbi Constitutive activation of STAT5A promotes human hematopoietic stem cell self-renewal and erythroid differentiation
    Jan Jacob Schuringa
    Laboratory of Developmental Hematopoiesis, Cell Biology Program, Memorial Sloan Kettering Cancer Center, 1275 York Ave, New York, NY 10021, USA
    J Exp Med 200:623-35. 2004
    ..Our data indicate that a persistent activation of STAT5A in human hematopoietic stem and progenitor cells results in their enhanced self-renewal and diverts differentiation to the erythroid lineage...
  12. ncbi Osteopetrotic mouse stroma with thrombopoietin, c-kit ligand, and flk-2 ligand supports long-term mobilized CD34+ hematopoiesis in vitro
    Pierre Feugier
    James Ewing Laboratory of Developmental Hematopoiesis, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Stem Cells Dev 14:505-16. 2005
    ....
  13. ncbi Enforced activation of STAT5A facilitates the generation of embryonic stem-derived hematopoietic stem cells that contribute to hematopoiesis in vivo
    Jan Jacob Schuringa
    Laboratory of Developmental Hematopoiesis, Cell Biology Program, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Stem Cells 22:1191-204. 2004
    ..These data indicate that a persistent activation of STAT5A allows the generation of ES-derived HSCs that can, at least for an intermediate period, contribute to hematopoiesis in vivo...
  14. ncbi Methotrexate selection of long-term culture initiating cells following transduction of CD34(+) cells with a retrovirus containing a mutated human dihydrofolate reductase gene
    Naoko Takebe
    Program of Molecular Pharmacology and Experimental Therapeutics, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Cancer Gene Ther 9:308-20. 2002
    ..These are the first investigations to demonstrate selection for transduced long-term culture initiating cells using MTX. The DHFR/MTX system holds promise for improving selection of gene-transduced hematopoietic progenitor cells in vivo...
  15. ncbi Increased plasma levels of stromal-derived factor-1 (SDF-1/CXCL12) enhance human thrombopoiesis and mobilize human colony-forming cells (CFC) in NOD/SCID mice
    Lia E Perez
    Laboratory of Developmental Hematopoiesis, Cell Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA
    Exp Hematol 32:300-7. 2004
    ..Herein, we studied the in vivo effects of ad-SDF-1 and of an analogue peptide of SDF-1 (CTCE-0214) on human hematopoiesis in a xenotransplant model...
  16. ncbi Recruitment of stem and progenitor cells from the bone marrow niche requires MMP-9 mediated release of kit-ligand
    Beate Heissig
    Division of Hematology Oncology, Cornell University Medical College, New York, NY 10021, USA
    Cell 109:625-37. 2002
    ..Release of sKitL by MMP-9 enables BM repopulating cells to translocate to a permissive vascular niche favoring differentiation and reconstitution of the stem/progenitor cell pool...
  17. ncbi Multiple stages of malignant transformation of human endothelial cells modelled by co-expression of telomerase reverse transcriptase, SV40 T antigen and oncogenic N-ras
    Karen L MacKenzie
    James Ewing Laboratory of Developmental Haematopoiesis and Department of Human Genetics, Sloan Kettering Cancer Institute, New York, NY, USA
    Oncogene 21:4200-11. 2002
    ..This model will be useful for understanding mechanisms underlying vascular and angiogenic neoplasias, as well as for testing drugs designed to curtail aberrant EC growth...
  18. ncbi Expression of constitutively active Notch4 (Int-3) modulates myeloid proliferation and differentiation and promotes expansion of hematopoietic progenitors
    Q Ye
    James Ewing Laboratory of Developmental Hematopoiesis, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Leukemia 18:777-87. 2004
    ..These results strongly support the notion that Notch signaling inhibits differentiation and promotes expansion of hematopoietic stem/progenitor cells...
  19. ncbi Enforced expression of NUP98-HOXA9 in human CD34(+) cells enhances stem cell proliferation
    Ki Y Chung
    Department of Medicine and Moore Laboratory, Cell Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Cancer Res 66:11781-91. 2006
    ..The resulting protein stabilization may contribute to the leukemogenic activity of the fusion protein...
  20. ncbi Stromal cell lines from the aorta-gonado-mesonephros region are potent supporters of murine and human hematopoiesis
    Katja C Weisel
    Laboratory of Developmental Hematopoiesis, Cell Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA
    Exp Hematol 34:1505-16. 2006
    ..In addition, extensive phenotypic analysis should elucidate possible mechanisms involved in maintenance of hematopoietic stem cell function...
  21. ncbi Cytokine and chemokine networks influencing stem cell proliferation, differentiation, and marrow homing
    Malcolm A S Moore
    Memorial Sloan Kettering Cancer Center, Sloan Kettering Institute for Cancer Research, New York, New York 10021, USA
    J Cell Biochem Suppl 38:29-38. 2002
    ....
  22. ncbi Hematopoiesis controlled by distinct TIF1gamma and Smad4 branches of the TGFbeta pathway
    Wei He
    Cancer Biology and Genetics Program and Howard Hughes Medical Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Cell 125:929-41. 2006
    ..Thus, Smad2/3-TIF1gamma and Smad2/3-Smad4 function as complementary effector arms in the control of hematopoietic cell fate by the TGFbeta/Smad pathway...
  23. ncbi Angiogenic factors reconstitute hematopoiesis by recruiting stem cells from bone marrow microenvironment
    Shahin Rafii
    Cornell University Medical College, New York, New York 10021, USA
    Ann N Y Acad Sci 996:49-60. 2003
    ..PlGF promotes recruitment of VEGFR1(+) HSCs from a quiescent to a proliferative microenvironment within the BM, favoring differentiation, mobilization, and reconstitution of hematopoiesis...
  24. ncbi Enforced expression of an Flt3 internal tandem duplication in human CD34+ cells confers properties of self-renewal and enhanced erythropoiesis
    Ki Young Chung
    Laboratory of Developmental Hematopoiesis, Cell Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Blood 105:77-84. 2005
    ..Flt3-ITD+ acute myeloid leukemia (AML) blasts from patients invariably generated early AG1295-sensitive CAs in MS-5 cocultures, further validating the phenotype observed in transduced CD34+ cells...
  25. ncbi Limited proliferation and telomere dysfunction following telomerase inhibition in immortal murine fibroblasts
    Jessica Boklan
    James Ewing Laboratory of Developmental Hematopoiesis, Memorial Sloan-Kettering Cancer Center, New York, New York 10021, USA
    Cancer Res 62:2104-14. 2002
    ..Moreover, the murine model used here should prove useful in further evaluating telomerase inhibition as an anticancer therapy...
  26. ncbi Hematopoietic cells
    Malcolm A S Moore
    Moore Laboratory, Cell Biology Program, Memorial Sloan-Kettering Cancer Center, New York, New York, USA
    Methods Enzymol 418:208-42. 2006
    ....
  27. ncbi Antibody targeting of the insulin-like growth factor I receptor enhances the anti-tumor response of multiple myeloma to chemotherapy through inhibition of tumor proliferation and angiogenesis
    Kai Da Wu
    James Ewing Laboratory of Developmental Hematopoiesis, Cell Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Cancer Immunol Immunother 56:343-57. 2007
    ..Inhibition of IGF-IR by the A12 in vitro suppressed both constitutive and IGF-I-induced secretion of VEGF, indicating that a putative anti-angiogenic mechanism associated with the A12 treatment may contribute to its anti-tumor effect...
  28. ncbi Telomerase inhibition with an oligonucleotide telomerase template antagonist: in vitro and in vivo studies in multiple myeloma and lymphoma
    Eunice S Wang
    Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA
    Blood 103:258-66. 2004
    ..These data demonstrate that telomerase is important for the replication of mature B-cell neoplasia by stabilizing short telomeres, and they suggest that telomerase inhibition represents a novel therapeutic approach to MM and NHL...
  29. ncbi The effect of cantharidins on leukemic stem cells
    David C Dorn
    Moore Laboratory, Cell Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Int J Cancer 124:2186-99. 2009
    ..However, its potent in vitro LSC activity and pathway targeting may still be exploited clinically with a new generation of cantharidin derivatives or formulations and with appropriate drug combinations...
  30. ncbi The AML1-ETO fusion protein promotes the expansion of human hematopoietic stem cells
    James C Mulloy
    Laboratory of Molecular Hematopoiesis, Sloan Kettering Institute, New York, NY, USA
    Blood 99:15-23. 2002
    ..Thus, AML1-ETO enhances the self-renewal of pluripotent stem cells, the physiological target of many acute myeloid leukemias...
  31. ncbi Effects of the leukemia-associated AML1-ETO protein on hematopoietic stem and progenitor cells
    Stephen D Nimer
    Laboratory of Molecular Aspects of Hematopoiesis, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Oncogene 23:4249-54. 2004
    ..The direct effects of AML1-ETO on human and murine HSCs, and the potentially cooperating events that may contribute to its leukemogenic properties, are discussed...
  32. ncbi Placental growth factor reconstitutes hematopoiesis by recruiting VEGFR1(+) stem cells from bone-marrow microenvironment
    Koichi Hattori
    Department of Medicine, Cornell University Medical College, New York, New York, USA
    Nat Med 8:841-9. 2002
    ..Thus, PlGF promotes recruitment of VEGFR1(+) HSCs from a quiescent to a proliferative BM microenvironment, favoring differentiation, mobilization and reconstitution of hematopoiesis...
  33. ncbi Activity of a novel anti-folate (PDX, 10-propargyl 10-deazaaminopterin) against human lymphoma is superior to methotrexate and correlates with tumor RFC-1 gene expression
    Eunice S Wang
    Department of Medicine, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10021-6306, USA
    Leuk Lymphoma 44:1027-35. 2003
    ..These results demonstrate that the PDX has markedly greater potential activity against human NHL than MTX and warrants further preclinical and clinical evaluation...
  34. ncbi Investigation of antitumor effects of synthetic epothilone analogs in human myeloma models in vitro and in vivo
    Kai-Da Wu
    James Ewing Laboratory of Developmental Hematopoiesis, Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 102:10640-5. 2005
    ..mice treated with dEpoB or vehicle control, indicating that Flu may be a promising agent for MM therapy...
  35. ncbi Telomerase and telomere length in multiple myeloma: correlations with disease heterogeneity, cytogenetic status, and overall survival
    Kai-Da Wu
    Laboratory of Developmental Hematopoiesis, Cell Biology Program, Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA
    Blood 101:4982-9. 2003
    ..004). The 2-year survival rate for patients with TA levels lower than 25% was 81%, and it was 52% in those with higher TA levels (P <.0001)...
  36. ncbi Critical role for Kit-mediated Src kinase but not PI 3-kinase signaling in pro T and pro B cell development
    Valter Agosti
    Developmental Biology Program, Sloan Kettering Institute, New York, NY 10021, USA
    J Exp Med 199:867-78. 2004
    ..Therefore, Kit-mediated PI 3-kinase signaling and Src kinase family signaling is highly specific for different cellular contexts in vivo...
  37. ncbi Neural subtype specification of fertilization and nuclear transfer embryonic stem cells and application in parkinsonian mice
    Tiziano Barberi
    Laboratory of Stem Cell and Tumor Biology, Division of Neurosurgery and Developmental Biology Program, Weill Medical College of Cornell University, New York, New York 10021, USA
    Nat Biotechnol 21:1200-7. 2003
    ..Furthermore, transplantation of ES and ntES cell-derived dopaminergic neurons corrected the phenotype of a mouse model of Parkinson disease, demonstrating an in vivo application of therapeutic cloning in neural disease...
  38. ncbi Determination of telomerase activity and telomere length
    Kai-Da Wu
    Cell Biology Program, Sloan-Kettering Cancer Institute, New York, NY, USA
    Methods Mol Med 113:207-23. 2005
    ..We also discuss comparison with related assay methods...
  39. ncbi A novel orally active small molecule potently induces G1 arrest in primary myeloma cells and prevents tumor growth by specific inhibition of cyclin-dependent kinase 4/6
    Linda B Baughn
    Department of Pathology, Weill Medical College of Cornell University, 1300 York Avenue, New York, NY 10021, USA
    Cancer Res 66:7661-7. 2006
    ..PD 0332991, therefore, represents the first promising and specific inhibitor for therapeutic targeting of Cdk4/6 in multiple myeloma and possibly other B-cell cancers...
  40. ncbi Total synthesis of peribysin E necessitates revision of the assignment of its absolute configuration
    Angie R Angeles
    The Laboratory for Bioorganic Chemistry, Sloan-Kettering Institute for Cancer Research, 1275 York Avenue, New York, NY 10021, USA
    Angew Chem Int Ed Engl 46:1451-4. 2007
  41. ncbi The migrastatin family: discovery of potent cell migration inhibitors by chemical synthesis
    Christoph Gaul
    Laboratory for Bioorganic Chemistry, Sloan-Kettering Institute for Cancer Research, 1275 York Avenue, New York, New York 10021, USA
    J Am Chem Soc 126:11326-37. 2004
    ....
  42. ncbi Diverted total synthesis leads to the generation of promising cell-migration inhibitors for treatment of tumor metastasis: in vivo and mechanistic studies on the migrastatin core ether analog
    Thordur Oskarsson
    Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, New York 10065, USA
    J Am Chem Soc 132:3224-8. 2010
    ..Both in vivo and in vitro studies indicate that ME exhibits a concentration-dependent inhibitory effect on migration of breast cancer cells...
  43. ncbi Maintaining the self-renewal and differentiation potential of human CD34+ hematopoietic cells using a single genetic element
    James C Mulloy
    Cincinnati Children s Hospital Medical Center, 3333 Burnet Ave, Mail Location 7013, Cincinnati, OH 45229, USA
    Blood 102:4369-76. 2003
    ....
  44. ncbi Generation of functional hemangioblasts from human embryonic stem cells
    Shi Jiang Lu
    Advanced Cell Technology, Worcester, Massachusetts 01605, USA
    Nat Methods 4:501-9. 2007
    ..Our data suggest that hES-derived blast cells (hES-BCs) could be important in vascular repair...
  45. ncbi Regeneration of the infarcted heart with stem cells derived by nuclear transplantation
    Robert Lanza
    Advanced Cell Technology, Worcester, Mass, USA
    Circ Res 94:820-7. 2004
    ..Importantly, the magnitude of myocardial regeneration obtained in this study is significantly superior to that achieved with adult bone marrow cells...
  46. ncbi Elevated telomerase activity and minimal telomere loss in cord blood long-term cultures with extensive stem cell replication
    Loretta Gammaitoni
    Department of Oncological Sciences, IRCC-Institute for Cancer Research and Treatment, Laboratory of Clinical Oncology, University of Turin Medical School, Prov 142, 10060 Candiolo, Turin, Italy
    Blood 103:4440-8. 2004
    ..There is clearly a clinical value for a system that provides extensive stem cell expansion without concomitant telomere erosion...
  47. ncbi Telomere-driven karyotypic complexity concurs with p16INK4a inactivation in TP53-competent immortal endothelial cells
    Victoria W Wen
    Children's Cancer Institute Australia for Medical Research, Randwick, New South Wales, Australia
    Cancer Res 66:10691-700. 2006
    ..These investigations provide new insight to the role of p16(INK4a) as a tumor suppressor...
  48. ncbi Tumor necrosis factor alpha-stimulated endothelium: an inducer of dendritic cell development from hematopoietic progenitors and myeloid leukemic cells
    Anja Moldenhauer
    Institute for Transfusion Medicine, Charite, Universitätsmedizen Berlin, Berlin, Germany
    Stem Cells 22:144-57. 2004
    ..We conclude that, via the action of TNF-alpha, inflamed human endothelium can induce CD34+ and leukemic cells to differentiate into dendritic cells...
  49. ncbi Long-term bovine hematopoietic engraftment with clone-derived stem cells
    Robert Lanza
    Advanced Cell Technology, Worcester, Massachusetts, USA
    Cloning Stem Cells 7:95-106. 2005
    ..The fetal HSC showed a 10-fold competition advantage over adult HSC. Cloning generated histocompatible HSC capable of long-term multilineage engraftment in a large animal model...
  50. ncbi Genetic and functional characterization of isolated stromal cell lines from the aorta-gonado-mesonephros region
    Katja C Weisel
    University of Tubingen, Department of Hematology, Oncology, and Immunology, Otfried Muller Strasse 10, 72076 Tubingen, Germany
    Ann N Y Acad Sci 1044:51-9. 2005
    ..Stromal gene array analysis has identified genes that could play a role in hematopoietic support...
  51. ncbi Early hematopoietic zinc finger protein (EHZF), the human homolog to mouse Evi3, is highly expressed in primitive human hematopoietic cells
    Heather M Bond
    Department of Experimental and Clinical Medicine Gaetano Salvatore, University of Catanzaro Magna, Graecia, Italy
    Blood 103:2062-70. 2004
    ..Taken together, our data suggest that EHZF is likely to play a relevant role in the control of human hematopoiesis and might be implicated in the development of hematopoietic malignancies...
  52. ncbi STAT5-induced self-renewal and impaired myelopoiesis of human hematopoietic stem/progenitor cells involves down-modulation of C/EBPalpha
    Albertus T J Wierenga
    Department of Hematology, University Medical Center Groningen, Hanzeplein 1, 9700 RB Groningen, The Netherlands
    Blood 107:4326-33. 2006
    ..Our data indicate that down-modulation of C/EBPalpha is a prerequisite for STAT5-induced effects on self-renewal and myelopoiesis...
  53. ncbi Differences in the transmigration of different dendritic cells
    Anja Moldenhauer
    Institute for Transfusion Medicine, Charite Universitatsmedizin Berlin, Berlin, Germany
    Exp Hematol 34:745-52. 2006
    ..Their ability to migrate to the adjacent lymphatic system is relevant since their efficacy does also rely on their potential to interact with lymphocytes...
  54. ncbi Histone deacetylase inhibition improves dendritic cell differentiation of leukemic blasts with AML1-containing fusion proteins
    Anja Moldenhauer
    Institute for Transfusion Medicine and Immunehaematology, Campus Virchow Klinikum, Charite Universitatsmedizin Berlin, Augustenburger Platz 1, 13353 Berlin, Germany
    J Leukoc Biol 76:623-33. 2004
    ..This model system suggests that the Hdi supports the in vitro differentiation of DC from leukemic blasts with AML1-containing fusion proteins...
  55. ncbi Early hematopoietic zinc finger protein-zinc finger protein 521: a candidate regulator of diverse immature cells
    Heather M Bond
    Laboratory of Molecular Haematopoiesis, Department of Experimental and Clinical Medicine, University of Catanzaro Magna Graecia, 88100 Catanzaro, Italy
    Int J Biochem Cell Biol 40:848-54. 2008
    ..EHZF/ZNF521 is also abundant in medulloblastomas and other brain tumours. Taken together, the data available suggest a possible role for this factor in development, stem cell regulation and oncogenesis...
  56. ncbi Methotrexate and cytarabine inhibit progression of human lymphoma in NOD/SCID mice carrying a mutant dihydrofolate reductase and cytidine deaminase fusion gene
    Tulin Budak-Alpdogan
    Department of Medicine, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, New Brunswick, NJ 08901, USA
    Mol Ther 10:574-84. 2004
    ..05), suggesting that early treatment allowed for enrichment of transduced marrow progenitors. These results encourage clinical studies using this retroviral fusion gene construct...

Research Grants5

  1. FACTORS INFLUENCING STEM CELL AND PLATELET PRODUCTION
    Malcolm Moore; Fiscal Year: 2002
    ..e., adult populations acquiring features of neonatal cells, or whether there is a tendency for "immortalized" cells to undergo neoplastic transformation. ..
  2. Development of SL-101, An Immunotoxin that Targets Cancer Stem Cells
    Malcolm Moore; Fiscal Year: 2006
    ..SL-101 is designed to address the urgent need for leukemia therapies that provide durable remissions. This Phase I STTR grant will cover the development of SL-101 through key phases of pre-clinical development. ..