Debora S Marks

Summary

Affiliation: Memorial Sloan-Kettering Cancer Center
Country: USA

Publications

  1. pmc Human MicroRNA targets
    Bino John
    Computational Biology Center, Memorial Sloan Kettering Cancer Center, New York, New York, USA
    PLoS Biol 2:e363. 2004
  2. ncbi request reprint Antisense-mediated depletion reveals essential and specific functions of microRNAs in Drosophila development
    Dan Leaman
    Laboratory of Developmental Neurogenetics, Rockefeller University, 1230 York Ave, New York, New York 10021, USA
    Cell 121:1097-108. 2005
  3. ncbi request reprint Prediction of human microRNA targets
    Bino John
    Computational Biology Center, Memorial Sloan Kettering Cancer Center, New York, NY, USA
    Methods Mol Biol 342:101-13. 2006
  4. doi request reprint Target mRNA abundance dilutes microRNA and siRNA activity
    Aaron Arvey
    Computational Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    Mol Syst Biol 6:363. 2010
  5. pmc Transfection of small RNAs globally perturbs gene regulation by endogenous microRNAs
    Aly A Khan
    Department of Computer Science, Columbia University, New York, New York, USA
    Nat Biotechnol 27:549-55. 2009
  6. pmc MicroRNA targets in Drosophila
    Anton J Enright
    Computational Biology Center, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
    Genome Biol 5:R1. 2003
  7. pmc The developmental miRNA profiles of zebrafish as determined by small RNA cloning
    Po Yu Chen
    Laboratory of RNA Molecular Biology, The Rockefeller University, New York, New York 10021, USA
    Genes Dev 19:1288-93. 2005
  8. pmc Computational analysis of mouse piRNA sequence and biogenesis
    Doron Betel
    Computational and Systems Biology Center, Memorial Sloan Kettering Cancer Center, New York, New York, United States of America
    PLoS Comput Biol 3:e222. 2007
  9. pmc Off-target effects dominate a large-scale RNAi screen for modulators of the TGF-β pathway and reveal microRNA regulation of TGFBR2
    Nikolaus Schultz
    Computational Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA
    Silence 2:3. 2011

Collaborators

Detail Information

Publications9

  1. pmc Human MicroRNA targets
    Bino John
    Computational Biology Center, Memorial Sloan Kettering Cancer Center, New York, New York, USA
    PLoS Biol 2:e363. 2004
    ..microrna.org. Our analysis suggests that miRNA genes, which are about 1% of all human genes, regulate protein production for 10% or more of all human genes...
  2. ncbi request reprint Antisense-mediated depletion reveals essential and specific functions of microRNAs in Drosophila development
    Dan Leaman
    Laboratory of Developmental Neurogenetics, Rockefeller University, 1230 York Ave, New York, New York 10021, USA
    Cell 121:1097-108. 2005
    ..Our findings demonstrate that microRNAs act as specific and essential regulators in a wide range of developmental processes...
  3. ncbi request reprint Prediction of human microRNA targets
    Bino John
    Computational Biology Center, Memorial Sloan Kettering Cancer Center, New York, NY, USA
    Methods Mol Biol 342:101-13. 2006
    ..Anticipating their impact on genome-wide discovery of miRNA targets, we describe the various computational tools and web-based resources available to predict miRNA targets...
  4. doi request reprint Target mRNA abundance dilutes microRNA and siRNA activity
    Aaron Arvey
    Computational Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    Mol Syst Biol 6:363. 2010
    ..Our results are important for understanding microRNA regulation and may also have implications for siRNA design and small RNA therapeutics...
  5. pmc Transfection of small RNAs globally perturbs gene regulation by endogenous microRNAs
    Aly A Khan
    Department of Computer Science, Columbia University, New York, New York, USA
    Nat Biotechnol 27:549-55. 2009
    ..The competition and saturation effects have practical implications for miRNA target prediction, the design of siRNA and short hairpin RNA (shRNA) genomic screens and siRNA therapeutics...
  6. pmc MicroRNA targets in Drosophila
    Anton J Enright
    Computational Biology Center, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
    Genome Biol 5:R1. 2003
    ..Application to the D. melanogaster, Drosophila pseudoobscura and Anopheles gambiae genomes identifies several hundred target genes potentially regulated by one or more known miRNAs...
  7. pmc The developmental miRNA profiles of zebrafish as determined by small RNA cloning
    Po Yu Chen
    Laboratory of RNA Molecular Biology, The Rockefeller University, New York, New York 10021, USA
    Genes Dev 19:1288-93. 2005
    ..Computational predictions of zebrafish miRNA targets are provided that take into account the depth of evolutionary conservation. Besides miRNAs, we identified a prominent class of repeat-associated small interfering RNAs (rasiRNAs)...
  8. pmc Computational analysis of mouse piRNA sequence and biogenesis
    Doron Betel
    Computational and Systems Biology Center, Memorial Sloan Kettering Cancer Center, New York, New York, United States of America
    PLoS Comput Biol 3:e222. 2007
    ....
  9. pmc Off-target effects dominate a large-scale RNAi screen for modulators of the TGF-β pathway and reveal microRNA regulation of TGFBR2
    Nikolaus Schultz
    Computational Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA
    Silence 2:3. 2011
    ..The TGF-β pathway is integral to mammalian cell proliferation and survival, and aberrant TGF-β responses have been strongly implicated in cancer...