Yue Ming Li

Summary

Affiliation: Memorial Sloan-Kettering Cancer Center
Country: USA

Publications

  1. ncbi Soluble oligomers of the intramembrane serine protease YqgP are catalytically active in the absence of detergents
    Xiaojun Lei
    Molecular Pharmacology and Chemistry Program, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Biochemistry 47:11920-9. 2008
  2. ncbi An exo-cell assay for examining real-time gamma-secretase activity and inhibition
    Christopher C Shelton
    Molecular Pharmacology and Chemistry Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    Mol Neurodegener 4:22. 2009
  3. ncbi Structure of gamma-secretase and its trimeric pre-activation intermediate by single-particle electron microscopy
    Fabiana Renzi
    Department of Structural and Chemical Biology, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Biol Chem 286:21440-9. 2011
  4. ncbi BMS-708,163 targets presenilin and lacks notch-sparing activity
    Christina J Crump
    Molecular Pharmacology and Chemistry Program, Memorial Sloan Kettering Cancer Center, New York, New York 10065, United States
    Biochemistry 51:7209-11. 2012
  5. ncbi Activation and intrinsic gamma-secretase activity of presenilin 1
    Kwangwook Ahn
    Molecular Pharmacology and Chemistry Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065
    Proc Natl Acad Sci U S A 107:21435-40. 2010
  6. ncbi Modulation of gamma-secretase specificity using small molecule allosteric inhibitors
    Christopher C Shelton
    Molecular Pharmacology and Chemistry Program and High Throughput Screening Core Facility, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    Proc Natl Acad Sci U S A 106:20228-33. 2009
  7. ncbi An APP inhibitory domain containing the Flemish mutation residue modulates gamma-secretase activity for Abeta production
    Yuan Tian
    Molecular Pharmacology and Chemistry Program, Memorial Sloan Kettering Cancer Center, New York, New York, USA
    Nat Struct Mol Biol 17:151-8. 2010
  8. ncbi Dual role of alpha-secretase cleavage in the regulation of gamma-secretase activity for amyloid production
    Yuan Tian
    Molecular Pharmacology and Chemistry Program, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA
    J Biol Chem 285:32549-56. 2010
  9. ncbi Processing of Notch and amyloid precursor protein by gamma-secretase is spatially distinct
    Leonid Tarassishin
    Molecular Pharmacology and Chemistry Program, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 101:17050-5. 2004
  10. ncbi Familial Alzheimer disease presenilin-1 mutations alter the active site conformation of γ-secretase
    De Ming Chau
    Molecular Pharmacology and Chemistry Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    J Biol Chem 287:17288-96. 2012

Research Grants

  1. Regulation and function of gamma-secretase
    Yueming Li; Fiscal Year: 2007
  2. Regulation and function of gamma-secretase
    Yueming Li; Fiscal Year: 2009

Collaborators

Detail Information

Publications21

  1. ncbi Soluble oligomers of the intramembrane serine protease YqgP are catalytically active in the absence of detergents
    Xiaojun Lei
    Molecular Pharmacology and Chemistry Program, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Biochemistry 47:11920-9. 2008
    ..Therefore, this work not only provides a unique system for elucidating the reaction mechanism of rhomboid but also will facilitate the characterization of other intramembrane proteases as well as non-protease membrane proteins...
  2. ncbi An exo-cell assay for examining real-time gamma-secretase activity and inhibition
    Christopher C Shelton
    Molecular Pharmacology and Chemistry Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    Mol Neurodegener 4:22. 2009
    ....
  3. ncbi Structure of gamma-secretase and its trimeric pre-activation intermediate by single-particle electron microscopy
    Fabiana Renzi
    Department of Structural and Chemical Biology, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Biol Chem 286:21440-9. 2011
    ..Comparison with the structure of a trimeric pre-activation intermediate suggested that the incorporation of PEN-2 might contribute to the maturation of the active site architecture...
  4. ncbi BMS-708,163 targets presenilin and lacks notch-sparing activity
    Christina J Crump
    Molecular Pharmacology and Chemistry Program, Memorial Sloan Kettering Cancer Center, New York, New York 10065, United States
    Biochemistry 51:7209-11. 2012
    ..Furthermore, BMS-708,163 blocks the binding of four different active site-directed GSI photoaffinity probes. We therefore report that this compound acts as a nonselective γ-secretase inhibitor...
  5. ncbi Activation and intrinsic gamma-secretase activity of presenilin 1
    Kwangwook Ahn
    Molecular Pharmacology and Chemistry Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065
    Proc Natl Acad Sci U S A 107:21435-40. 2010
    ..Thus, we conclusively establish that activated PS is catalytically competent and the bimolecular interaction of PS1 and PEN2 can convert the PS1 zymogen to an active protease...
  6. ncbi Modulation of gamma-secretase specificity using small molecule allosteric inhibitors
    Christopher C Shelton
    Molecular Pharmacology and Chemistry Program and High Throughput Screening Core Facility, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    Proc Natl Acad Sci U S A 106:20228-33. 2009
    ..Furthermore, this class of selective inhibitors provides the basis for development of Alzheimer disease therapeutic agents...
  7. ncbi An APP inhibitory domain containing the Flemish mutation residue modulates gamma-secretase activity for Abeta production
    Yuan Tian
    Molecular Pharmacology and Chemistry Program, Memorial Sloan Kettering Cancer Center, New York, New York, USA
    Nat Struct Mol Biol 17:151-8. 2010
    ....
  8. ncbi Dual role of alpha-secretase cleavage in the regulation of gamma-secretase activity for amyloid production
    Yuan Tian
    Molecular Pharmacology and Chemistry Program, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA
    J Biol Chem 285:32549-56. 2010
    ..This work reveals an unforeseen role for α-secretase in generating an endogenous γ-secretase inhibitor that down-regulates the production of Aβ. Deregulation of this feedback mechanism may contribute to the pathogenesis of AD...
  9. ncbi Processing of Notch and amyloid precursor protein by gamma-secretase is spatially distinct
    Leonid Tarassishin
    Molecular Pharmacology and Chemistry Program, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 101:17050-5. 2004
    ..Furthermore, the fact that inhibitors first target gamma-secretase in the plasma membrane for Notch processing, and not for APP, will have important implications for drug development to treat Alzheimer's disease and cancer...
  10. ncbi Familial Alzheimer disease presenilin-1 mutations alter the active site conformation of γ-secretase
    De Ming Chau
    Molecular Pharmacology and Chemistry Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    J Biol Chem 287:17288-96. 2012
    ....
  11. ncbi Stereo-controlled synthesis of novel photoreactive gamma-secretase inhibitors
    Guangli Yang
    Organic Synthesis Core Facility, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA
    Bioorg Med Chem Lett 19:922-5. 2009
    ..Compounds 2 and 3 are potent gamma-secretase inhibitors and directly interact with presenilin-1, a catalytic subunit of gamma-secretase...
  12. ncbi Development of clickable active site-directed photoaffinity probes for γ-secretase
    Christina J Crump
    Molecular Pharmacology and Chemistry Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    Bioorg Med Chem Lett 22:2997-3000. 2012
    ....
  13. ncbi A miniaturized 1536-well format gamma-secretase assay
    Christopher C Shelton
    Molecular Pharmacology and Chemistry Program, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA
    Assay Drug Dev Technol 7:461-70. 2009
    ..This validated assay can readily be used for primary screening against large chemical libraries searching for novel inhibitors of gamma-secretase activity that may represent potential therapeutics for AD and a variety of neoplasms...
  14. ncbi Characterization of an atypical gamma-secretase complex from hematopoietic origin
    Lisa Placanica
    Molecular Pharmacology and Chemistry Program, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA
    Biochemistry 49:2796-804. 2010
    ..These data underscore the need for studying endogenous gamma-secretase to fully understand of the biology of gamma-secretase and its complexity as a molecular target for the development of disease therapeutics...
  15. ncbi High-throughput identification of inhibitors of human mitochondrial peptide deformylase
    Christophe Antczak
    High Throughput Screening Core Facility, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    J Biomol Screen 12:521-35. 2007
    ....
  16. ncbi {gamma}-Secretase Substrate Concentration Modulates the Abeta42/Abeta40 Ratio: IMPLICATIONS FOR ALZHEIMER DISEASE
    Ye Ingrid Yin
    Molecular Pharmacology and Chemistry Program, Memorial Sloan Kettering Cancer Center, New York, New York 10021 and Department of Biology, Rensselaer Polytechnic Institute, Troy, New York 12180
    J Biol Chem 282:23639-44. 2007
    ..Therefore, strategies lowering the Abeta42/Abeta40 ratio through partial reduction of gamma-secretase substrate production may introduce a practical therapeutic modality for treatment of AD...
  17. ncbi A dimeric Smac/diablo peptide directly relieves caspase-3 inhibition by XIAP. Dynamic and cooperative regulation of XIAP by Smac/Diablo
    Zhonghua Gao
    Cell Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    J Biol Chem 282:30718-27. 2007
    ..We also show that XIAP homotrimerizes via its C-terminal Ring domain, making its inhibitory activity toward caspase-3 more susceptible to Smac...
  18. ncbi Pen2 and presenilin-1 modulate the dynamic equilibrium of presenilin-1 and presenilin-2 gamma-secretase complexes
    Lisa Placanica
    Molecular Pharmacology and Chemistry Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    J Biol Chem 284:2967-77. 2009
    ....
  19. ncbi The processing of human rhomboid intramembrane serine protease RHBDL2 is required for its proteolytic activity
    Xiaojun Lei
    Molecular Pharmacology and Chemistry Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    J Mol Biol 394:815-25. 2009
    ....
  20. ncbi gamma-Secretase inhibitors abrogate oxaliplatin-induced activation of the Notch-1 signaling pathway in colon cancer cells resulting in enhanced chemosensitivity
    Raymond D Meng
    Department of Medicine, Division of Solid Tumor Oncology, Laboratory of New Drug Development, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA
    Cancer Res 69:573-82. 2009
    ..Therefore, combining GSIs with chemotherapy may represent a novel approach for treating metastatic colon cancers by mitigating the development of chemoresistance...
  21. ncbi Gender- and age-dependent gamma-secretase activity in mouse brain and its implication in sporadic Alzheimer disease
    Lisa Placanica
    Molecular Pharmacology and Chemistry Program, Memorial Sloan Kettering Cancer Center, New York, New York, United States of America
    PLoS ONE 4:e5088. 2009
    ..In addition, deceased Notch gamma-secretase activity may also contribute to neurodegeneration. Therefore, this study implicates altered gamma-secretase activity and specificity as a possible mechanism of sporadic AD during aging...

Research Grants5

  1. Regulation and function of gamma-secretase
    Yueming Li; Fiscal Year: 2007
    ..Moreover, these investigations will facilitate the development of potent and specific inhibitors of gamma-secretase for potential AD therapies. ..
  2. Regulation and function of gamma-secretase
    Yueming Li; Fiscal Year: 2009
    ..Moreover, these investigations will facilitate the development of potent and specific inhibitors of gamma-secretase for potential AD therapies. ..