Research Topics
Genomes and Genes | Ming O LiSummaryAffiliation: Memorial Sloan-Kettering Cancer Center Country: USA Publications
Research Grants
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Publications
Transforming growth factor-beta regulation of immune responsesMing O Li
Section of Immunobiology, Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, Connecticut 06520, USA
Annu Rev Immunol 24:99-146. 2006..This review highlights the findings that have advanced our understanding of TGF-beta in the immune system and in disease...- Transforming growth factor-beta: recent advances on its role in immune toleranceMartin A Kriegel
Howard Hughes Medical Institute, Yale University School of Medicine, Section of Immunobiology, New Haven, CT 06520, USA
Curr Rheumatol Rep 8:138-44. 2006..We will also discuss recent advances on the role of TGF-beta in immune-mediated diabetes, inflammatory bowel disease, arthritis, and systemic lupus erythematosus... - Transforming growth factor-beta controls development, homeostasis, and tolerance of T cells by regulatory T cell-dependent and -independent mechanismsMing O Li
Section of Immunobiology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
Immunity 25:455-71. 2006..This study reveals pleiotropic functions of TGF-beta signaling in T cells that may ensure a diverse and self-tolerant T cell repertoire in vivo... 
Contextual regulation of inflammation: a duet by transforming growth factor-beta and interleukin-10Ming O Li
Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
Immunity 28:468-76. 2008..The collective activity of TGF-beta and IL-10 ensures a controlled inflammatory response specifically targeting pathogens without evoking excessive immunopathology to self-tissues...- Foxo proteins cooperatively control the differentiation of Foxp3+ regulatory T cellsWeiming Ouyang
Memorial Sloan Kettering Cancer Center, New York, New York, USA
Nat Immunol 11:618-27. 2010..Thus, Foxo proteins have crucial roles in specifying the T(reg) cell lineage... 
Transforming growth factor-beta signaling curbs thymic negative selection promoting regulatory T cell developmentWeiming Ouyang
Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
Immunity 32:642-53. 2010..These findings reveal a critical function for TGF-beta in control of autoreactive T cell fates with important implications for understanding T cell self-tolerance mechanisms...- Autocrine transforming growth factor-β1 promotes in vivo Th17 cell differentiationIlona Gutcher
Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
Immunity 34:396-408. 2011..These findings reveal an essential role for activated T cell-produced TGF-β1 in promoting the differentiation of Th17 cells and controlling inflammatory diseases... - T cell surveillance of oncogene-induced prostate cancer is impeded by T cell-derived TGF-β1 cytokineMoses K Donkor
Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
Immunity 35:123-34. 2011..These findings reveal that T cell production of TGF-β1 is an essential requirement for tumors to evade immunosurveillance independent of TGF-β produced by tumors... - Neuropilin 1 is expressed on thymus-derived natural regulatory T cells, but not mucosa-generated induced Foxp3+ T reg cellsJonathan M Weiss
Kimmel Center for Biology and Medicine at the Skirball Institute, New York University School of Medicine, New York, NY 10016, USA
J Exp Med 209:1723-42, S1. 2012..In the same animals, iT reg cells in secondary lymphoid organs remain Nrp1(low). We also determined that, in spontaneous EAE, iT reg cells help to establish a chronic phase of the disease... - Foxo: in command of T lymphocyte homeostasis and toleranceWeiming Ouyang
Immunology Program, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA
Trends Immunol 32:26-33. 2011..The Foxo pathway probably enables a diverse and self-tolerant population of T cells in the steady state, which is an important prerequisite for the establishment of a functional adaptive immune system... - T cell- but not tumor cell-produced TGF-β1 promotes the development of spontaneous mammary cancerAbira Sarkar
Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
Oncotarget 2:1339-51. 2011..These findings reveal T cells but not tumor cells as a critical source of TGF-β1 that promotes tumor development... - Foxp3 exploits a pre-existent enhancer landscape for regulatory T cell lineage specificationRobert M Samstein
Howard Hughes Medical Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
Cell 151:153-66. 2012..Thus, in a late cellular differentiation process, Foxp3 defines Treg cell functionality in an "opportunistic" manner by largely exploiting the preformed enhancer network instead of establishing a new enhancer landscape... - Novel Foxo1-dependent transcriptional programs control T(reg) cell functionWeiming Ouyang
Immunology Program, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA
Nature 491:554-9. 2012..These findings show that the evolutionarily ancient Akt-Foxo1 signalling module controls a novel genetic program indispensable for T(reg) cell function... - An essential role of the Forkhead-box transcription factor Foxo1 in control of T cell homeostasis and toleranceWeiming Ouyang
Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
Immunity 30:358-71. 2009..These findings reveal crucial functions of Foxo1-dependent transcription in control of T cell homeostasis and tolerance... - TGF-beta: a master of all T cell tradesMing O Li
Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
Cell 134:392-404. 2008..The unique mechanism of TGF-beta activation and the plasticity of TGF-beta signaling create a stage for TGF-beta to integrate signals from multiple cell types and environmental cues to regulate T cells... - TGF-beta signaling is required for the function of insulin-reactive T regulatory cellsWei Du
Section of Endocrinology, Yale University School of Medicine, New Haven, Connecticut 066520, USA
J Clin Invest 116:1360-70. 2006.... - The presumptive phosphatidylserine receptor is dispensable for innate anti-inflammatory recognition and clearance of apoptotic cellsJustin E Mitchell
Department of Microbiology and Immunology, University of Illinois College of Medicine, 835 South Wolcott, Chicago, IL 60612, USA
J Biol Chem 281:5718-25. 2006..We conclude that PSR is not involved generally in either specific innate recognition or engulfment of apoptotic cells... - TGF-beta regulates in vivo expansion of Foxp3-expressing CD4+CD25+ regulatory T cells responsible for protection against diabetesYuFeng Peng
Section of Immunobiology and Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT 06520, USA
Proc Natl Acad Sci U S A 101:4572-7. 2004..Thus, these findings demonstrate a previously uncharacterized mechanism by which TGF-beta inhibits autoimmune diseases via regulation of the size of the CD4+CD25+ regulatory T cell pool in vivo... - Phosphatidylserine receptor is required for clearance of apoptotic cellsMing O Li
Section of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA
Science 302:1560-3. 2003..These data demonstrate a critical role for PSR in early stages of mammalian organogenesis and suggest that this receptor may be involved in respiratory distress syndromes and congenital brain malformations...
Research Grants
- TGF-beta and Common gamma-Chain Cytokine Crosstalk in T Cell RegulationMing Li; Fiscal Year: 2010..It has been established that the secreted molecule TGF-beta is a critical regulator of T cell differentiation and function. Experiments proposed here will define how TGF-beta controls T cells. ..