Ming O Li

Summary

Affiliation: Memorial Sloan-Kettering Cancer Center
Country: USA

Publications

  1. ncbi request reprint Transforming growth factor-beta regulation of immune responses
    Ming O Li
    Section of Immunobiology, Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Annu Rev Immunol 24:99-146. 2006
  2. ncbi request reprint Transforming growth factor-beta: recent advances on its role in immune tolerance
    Martin A Kriegel
    Howard Hughes Medical Institute, Yale University School of Medicine, Section of Immunobiology, New Haven, CT 06520, USA
    Curr Rheumatol Rep 8:138-44. 2006
  3. ncbi request reprint Transforming growth factor-beta controls development, homeostasis, and tolerance of T cells by regulatory T cell-dependent and -independent mechanisms
    Ming O Li
    Section of Immunobiology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Immunity 25:455-71. 2006
  4. doi request reprint Contextual regulation of inflammation: a duet by transforming growth factor-beta and interleukin-10
    Ming O Li
    Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    Immunity 28:468-76. 2008
  5. ncbi request reprint Foxo proteins cooperatively control the differentiation of Foxp3+ regulatory T cells
    Weiming Ouyang
    Memorial Sloan Kettering Cancer Center, New York, New York, USA
    Nat Immunol 11:618-27. 2010
  6. pmc Transforming growth factor-beta signaling curbs thymic negative selection promoting regulatory T cell development
    Weiming Ouyang
    Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    Immunity 32:642-53. 2010
  7. pmc Novel Foxo1-dependent transcriptional programs control T(reg) cell function
    Weiming Ouyang
    Immunology Program, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA
    Nature 491:554-9. 2012
  8. pmc Neuropilin 1 is expressed on thymus-derived natural regulatory T cells, but not mucosa-generated induced Foxp3+ T reg cells
    Jonathan M Weiss
    Kimmel Center for Biology and Medicine at the Skirball Institute, New York University School of Medicine, New York, NY 10016, USA
    J Exp Med 209:1723-42, S1. 2012
  9. pmc Autocrine transforming growth factor-β1 promotes in vivo Th17 cell differentiation
    Ilona Gutcher
    Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    Immunity 34:396-408. 2011
  10. ncbi request reprint The cellular and molecular origin of tumor-associated macrophages
    Ruth A Franklin
    Immunology Program, Memorial Sloan Kettering Cancer Center MSKCC, New York, NY 10065, USA Graduate Program in Immunology and Microbial Pathogenesis, Weill Cornell Graduate School of Medical Sciences, Cornell University, New York, NY 10065, USA
    Science 344:921-5. 2014

Collaborators

Detail Information

Publications25

  1. ncbi request reprint Transforming growth factor-beta regulation of immune responses
    Ming O Li
    Section of Immunobiology, Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Annu Rev Immunol 24:99-146. 2006
    ..This review highlights the findings that have advanced our understanding of TGF-beta in the immune system and in disease...
  2. ncbi request reprint Transforming growth factor-beta: recent advances on its role in immune tolerance
    Martin A Kriegel
    Howard Hughes Medical Institute, Yale University School of Medicine, Section of Immunobiology, New Haven, CT 06520, USA
    Curr Rheumatol Rep 8:138-44. 2006
    ..We will also discuss recent advances on the role of TGF-beta in immune-mediated diabetes, inflammatory bowel disease, arthritis, and systemic lupus erythematosus...
  3. ncbi request reprint Transforming growth factor-beta controls development, homeostasis, and tolerance of T cells by regulatory T cell-dependent and -independent mechanisms
    Ming O Li
    Section of Immunobiology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Immunity 25:455-71. 2006
    ..This study reveals pleiotropic functions of TGF-beta signaling in T cells that may ensure a diverse and self-tolerant T cell repertoire in vivo...
  4. doi request reprint Contextual regulation of inflammation: a duet by transforming growth factor-beta and interleukin-10
    Ming O Li
    Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    Immunity 28:468-76. 2008
    ..The collective activity of TGF-beta and IL-10 ensures a controlled inflammatory response specifically targeting pathogens without evoking excessive immunopathology to self-tissues...
  5. ncbi request reprint Foxo proteins cooperatively control the differentiation of Foxp3+ regulatory T cells
    Weiming Ouyang
    Memorial Sloan Kettering Cancer Center, New York, New York, USA
    Nat Immunol 11:618-27. 2010
    ..Thus, Foxo proteins have crucial roles in specifying the T(reg) cell lineage...
  6. pmc Transforming growth factor-beta signaling curbs thymic negative selection promoting regulatory T cell development
    Weiming Ouyang
    Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    Immunity 32:642-53. 2010
    ..These findings reveal a critical function for TGF-beta in control of autoreactive T cell fates with important implications for understanding T cell self-tolerance mechanisms...
  7. pmc Novel Foxo1-dependent transcriptional programs control T(reg) cell function
    Weiming Ouyang
    Immunology Program, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA
    Nature 491:554-9. 2012
    ..These findings show that the evolutionarily ancient Akt-Foxo1 signalling module controls a novel genetic program indispensable for T(reg) cell function...
  8. pmc Neuropilin 1 is expressed on thymus-derived natural regulatory T cells, but not mucosa-generated induced Foxp3+ T reg cells
    Jonathan M Weiss
    Kimmel Center for Biology and Medicine at the Skirball Institute, New York University School of Medicine, New York, NY 10016, USA
    J Exp Med 209:1723-42, S1. 2012
    ..In the same animals, iT reg cells in secondary lymphoid organs remain Nrp1(low). We also determined that, in spontaneous EAE, iT reg cells help to establish a chronic phase of the disease...
  9. pmc Autocrine transforming growth factor-β1 promotes in vivo Th17 cell differentiation
    Ilona Gutcher
    Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    Immunity 34:396-408. 2011
    ..These findings reveal an essential role for activated T cell-produced TGF-β1 in promoting the differentiation of Th17 cells and controlling inflammatory diseases...
  10. ncbi request reprint The cellular and molecular origin of tumor-associated macrophages
    Ruth A Franklin
    Immunology Program, Memorial Sloan Kettering Cancer Center MSKCC, New York, NY 10065, USA Graduate Program in Immunology and Microbial Pathogenesis, Weill Cornell Graduate School of Medical Sciences, Cornell University, New York, NY 10065, USA
    Science 344:921-5. 2014
    ..These findings reveal the ontogeny of TAMs and a discrete tumor-elicited inflammatory response, which may provide new opportunities for cancer immunotherapy. ..
  11. pmc TGF-β cytokine signaling promotes CD8+ T cell development and low-affinity CD4+ T cell homeostasis by regulation of interleukin-7 receptor α expression
    Weiming Ouyang
    Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    Immunity 39:335-46. 2013
    ..These findings reveal functions for TGF-β signaling in controlling IL-7Rα expression and in promoting T cell repertoire diversification...
  12. pmc The transcription factor Foxo1 controls central-memory CD8+ T cell responses to infection
    Myoungjoo V Kim
    Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    Immunity 39:286-97. 2013
    ..These findings demonstrate that Foxo1 is selectively incorporated into the genetic program that regulates memory CD8+ T cell responses to infection...
  13. pmc T cell surveillance of oncogene-induced prostate cancer is impeded by T cell-derived TGF-β1 cytokine
    Moses K Donkor
    Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    Immunity 35:123-34. 2011
    ..These findings reveal that T cell production of TGF-β1 is an essential requirement for tumors to evade immunosurveillance independent of TGF-β produced by tumors...
  14. pmc TGF-β: guardian of T cell function
    Soyoung A Oh
    Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065
    J Immunol 191:3973-9. 2013
    ..In this review we discuss the current understanding of TGF-β regulation of T cells. ..
  15. pmc Foxo: in command of T lymphocyte homeostasis and tolerance
    Weiming Ouyang
    Immunology Program, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA
    Trends Immunol 32:26-33. 2011
    ..The Foxo pathway probably enables a diverse and self-tolerant population of T cells in the steady state, which is an important prerequisite for the establishment of a functional adaptive immune system...
  16. pmc T cell- but not tumor cell-produced TGF-β1 promotes the development of spontaneous mammary cancer
    Abira Sarkar
    Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    Oncotarget 2:1339-51. 2011
    ..These findings reveal T cells but not tumor cells as a critical source of TGF-β1 that promotes tumor development...
  17. ncbi request reprint Transcriptional control of regulatory T cell development and function
    Chong T Luo
    Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA Louis V Gerstner Jr Graduate School of Biomedical Sciences, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    Trends Immunol 34:531-9. 2013
    ..These findings reveal that Treg cell lineage commitment is not only controlled by genetic and epigenetic imprinting, but also modulated by transcriptional programs responding to extracellular signals. ..
  18. pmc Foxp3 exploits a pre-existent enhancer landscape for regulatory T cell lineage specification
    Robert M Samstein
    Howard Hughes Medical Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    Cell 151:153-66. 2012
    ..Thus, in a late cellular differentiation process, Foxp3 defines Treg cell functionality in an "opportunistic" manner by largely exploiting the preformed enhancer network instead of establishing a new enhancer landscape...
  19. pmc An essential role of the Forkhead-box transcription factor Foxo1 in control of T cell homeostasis and tolerance
    Weiming Ouyang
    Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    Immunity 30:358-71. 2009
    ..These findings reveal crucial functions of Foxo1-dependent transcription in control of T cell homeostasis and tolerance...
  20. pmc TGF-beta: a master of all T cell trades
    Ming O Li
    Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Cell 134:392-404. 2008
    ..The unique mechanism of TGF-beta activation and the plasticity of TGF-beta signaling create a stage for TGF-beta to integrate signals from multiple cell types and environmental cues to regulate T cells...
  21. pmc TGF-beta regulates in vivo expansion of Foxp3-expressing CD4+CD25+ regulatory T cells responsible for protection against diabetes
    YuFeng Peng
    Section of Immunobiology and Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT 06520, USA
    Proc Natl Acad Sci U S A 101:4572-7. 2004
    ..Thus, these findings demonstrate a previously uncharacterized mechanism by which TGF-beta inhibits autoimmune diseases via regulation of the size of the CD4+CD25+ regulatory T cell pool in vivo...
  22. ncbi request reprint The presumptive phosphatidylserine receptor is dispensable for innate anti-inflammatory recognition and clearance of apoptotic cells
    Justin E Mitchell
    Department of Microbiology and Immunology, University of Illinois College of Medicine, 835 South Wolcott, Chicago, IL 60612, USA
    J Biol Chem 281:5718-25. 2006
    ..We conclude that PSR is not involved generally in either specific innate recognition or engulfment of apoptotic cells...
  23. pmc TGF-beta signaling is required for the function of insulin-reactive T regulatory cells
    Wei Du
    Section of Endocrinology, Yale University School of Medicine, New Haven, Connecticut 066520, USA
    J Clin Invest 116:1360-70. 2006
    ....
  24. ncbi request reprint Phosphatidylserine receptor is required for clearance of apoptotic cells
    Ming O Li
    Section of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA
    Science 302:1560-3. 2003
    ..These data demonstrate a critical role for PSR in early stages of mammalian organogenesis and suggest that this receptor may be involved in respiratory distress syndromes and congenital brain malformations...

Research Grants2

  1. TGF-beta and Common gamma-Chain Cytokine Crosstalk in T Cell Regulation
    Ming Li; Fiscal Year: 2010
    ..It has been established that the secreted molecule TGF-beta is a critical regulator of T cell differentiation and function. Experiments proposed here will define how TGF-beta controls T cells. ..