Jason S Lewis

Summary

Affiliation: Memorial Sloan-Kettering Cancer Center
Country: USA

Publications

  1. pmc Annotating MYC status with 89Zr-transferrin imaging
    Jason P Holland
    Radiochemistry Service, Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York, USA
    Nat Med 18:1586-91. 2012
  2. pmc Modular strategy for the construction of radiometalated antibodies for positron emission tomography based on inverse electron demand Diels-Alder click chemistry
    Brian M Zeglis
    Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York, United States
    Bioconjug Chem 22:2048-59. 2011
  3. pmc Measuring the pharmacodynamic effects of a novel Hsp90 inhibitor on HER2/neu expression in mice using Zr-DFO-trastuzumab
    Jason P Holland
    Radiochemistry Service, Department of Radiology, Memorial Sloan Kettering Cancer Center, Sloan Kettering Cancer Center, New York, New York, United States of America
    PLoS ONE 5:e8859. 2010
  4. pmc Magnitude of enhanced permeability and retention effect in tumors with different phenotypes: 89Zr-albumin as a model system
    Carola Heneweer
    Program in Molecular Pharmacology and Chemistry, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA
    J Nucl Med 52:625-33. 2011
  5. doi request reprint An imaging comparison of 64Cu-ATSM and 60Cu-ATSM in cancer of the uterine cervix
    Jason S Lewis
    Division of Radiological Sciences, Mallinckrodt Institute of Radiology, St Louis, Missouri, USA
    J Nucl Med 49:1177-82. 2008
  6. pmc Autoradiographic and small-animal PET comparisons between (18)F-FMISO, (18)F-FDG, (18)F-FLT and the hypoxic selective (64)Cu-ATSM in a rodent model of cancer
    Carmen S Dence
    Mallinckrodt Institute of Radiology, The Alvin J Siteman Cancer Center, Washington University School of Medicine, St Louis, MO 63110, USA
    Nucl Med Biol 35:713-20. 2008
  7. pmc Cerenkov luminescence imaging of medical isotopes
    Alessandro Ruggiero
    Nuclear Medicine Service, Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA
    J Nucl Med 51:1123-30. 2010
  8. ncbi request reprint Minimally invasive method of determining blood input function from PET images in rodents
    Joonyoung Kim
    Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Nucl Med 47:330-6. 2006
  9. pmc Gallium-68-labeled DOTA-rhenium-cyclized alpha-melanocyte-stimulating hormone analog for imaging of malignant melanoma
    Lihui Wei
    Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, MO 63110, USA
    Nucl Med Biol 34:945-53. 2007
  10. ncbi request reprint Synthesis and biologic evaluation of 64Cu-labeled rhenium-cyclized alpha-MSH peptide analog using a cross-bridged cyclam chelator
    Lihui Wei
    Division of Radiological Sciences, Mallinckrodt Institute of Radiology and the Alvin J Siteman Cancer Center, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Nucl Med 48:64-72. 2007

Research Grants

Detail Information

Publications84

  1. pmc Annotating MYC status with 89Zr-transferrin imaging
    Jason P Holland
    Radiochemistry Service, Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York, USA
    Nat Med 18:1586-91. 2012
    ..These preclinical data establish (89)Zr-transferrin as a sensitive tool for noninvasive measurement of oncogene-driven TFRC expression in prostate and potentially other cancers, with prospective near-term clinical application...
  2. pmc Modular strategy for the construction of radiometalated antibodies for positron emission tomography based on inverse electron demand Diels-Alder click chemistry
    Brian M Zeglis
    Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York, United States
    Bioconjug Chem 22:2048-59. 2011
    ....
  3. pmc Measuring the pharmacodynamic effects of a novel Hsp90 inhibitor on HER2/neu expression in mice using Zr-DFO-trastuzumab
    Jason P Holland
    Radiochemistry Service, Department of Radiology, Memorial Sloan Kettering Cancer Center, Sloan Kettering Cancer Center, New York, New York, United States of America
    PLoS ONE 5:e8859. 2010
    ..In addition, pharmacodynamic studies on HER2/neu expression levels in response to therapeutic doses of PU-H71 (a specific inhibitor of heat-shock protein 90 [Hsp90]) were conducted...
  4. pmc Magnitude of enhanced permeability and retention effect in tumors with different phenotypes: 89Zr-albumin as a model system
    Carola Heneweer
    Program in Molecular Pharmacology and Chemistry, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA
    J Nucl Med 52:625-33. 2011
    ..This study investigated the influence of different tumor phenotypes on the EPR effect, hypothesizing that a baseline level of uptake must be exceeded to visualize high and specific uptake of a targeted macromolecular radiotracer...
  5. doi request reprint An imaging comparison of 64Cu-ATSM and 60Cu-ATSM in cancer of the uterine cervix
    Jason S Lewis
    Division of Radiological Sciences, Mallinckrodt Institute of Radiology, St Louis, Missouri, USA
    J Nucl Med 49:1177-82. 2008
    ....
  6. pmc Autoradiographic and small-animal PET comparisons between (18)F-FMISO, (18)F-FDG, (18)F-FLT and the hypoxic selective (64)Cu-ATSM in a rodent model of cancer
    Carmen S Dence
    Mallinckrodt Institute of Radiology, The Alvin J Siteman Cancer Center, Washington University School of Medicine, St Louis, MO 63110, USA
    Nucl Med Biol 35:713-20. 2008
    ....
  7. pmc Cerenkov luminescence imaging of medical isotopes
    Alessandro Ruggiero
    Nuclear Medicine Service, Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA
    J Nucl Med 51:1123-30. 2010
    ..Here, we report the use of the inherent optical emissions from the decay of radiopharmaceuticals for Cerenkov luminescence imaging (CLI) of tumors in vivo and correlate the results with those obtained from concordant immuno-PET studies...
  8. ncbi request reprint Minimally invasive method of determining blood input function from PET images in rodents
    Joonyoung Kim
    Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Nucl Med 47:330-6. 2006
    ..A factor analysis (FA) technique for extracting the blood input function and myocardial time-activity curve from dynamic small-animal PET images of the rodent heart has been implemented to overcome these limitations...
  9. pmc Gallium-68-labeled DOTA-rhenium-cyclized alpha-melanocyte-stimulating hormone analog for imaging of malignant melanoma
    Lihui Wei
    Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, MO 63110, USA
    Nucl Med Biol 34:945-53. 2007
    ..This encouraged us to investigate DOTA-ReCCMSH(Arg11) labeled with another beta+-emitting radionuclide, 68Ga...
  10. ncbi request reprint Synthesis and biologic evaluation of 64Cu-labeled rhenium-cyclized alpha-MSH peptide analog using a cross-bridged cyclam chelator
    Lihui Wei
    Division of Radiological Sciences, Mallinckrodt Institute of Radiology and the Alvin J Siteman Cancer Center, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Nucl Med 48:64-72. 2007
    ..The goal of this study was to conjugate CBTE2A to the alpha-MSH targeting ReCCMSH(Arg(11)) peptide for labeling to (64)Cu and to investigate whether the increased metal-chelate stability with CBTE2A would improve imaging quality...
  11. pmc Imaging tumor burden in the brain with 89Zr-transferrin
    Michael J Evans
    Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA
    J Nucl Med 54:90-5. 2013
    ..Therefore, we reasoned that applying a radiolabeled derivative of transferrin ((89)Zr-labeled transferrin) may be an effective strategy to more thoroughly identify tumor tissue in the brain, regardless of the tumor's genetic background...
  12. ncbi request reprint In vivo assessment of tumor hypoxia in lung cancer with 60Cu-ATSM
    Farrokh Dehdashti
    Division of Nuclear Medicine, Edward Mallinckrodt Institute of Radiology, St Louis, MO 63110, USA
    Eur J Nucl Med Mol Imaging 30:844-50. 2003
    ..04; P=0.9). (60)Cu-ATSM-PET can be readily performed in patients with NSCLC and the tumor uptake of (60)Cu-ATSM reveals clinically unique information about tumor oxygenation that is predictive of tumor response to therapy...
  13. doi request reprint Assessing tumor hypoxia in cervical cancer by PET with 60Cu-labeled diacetyl-bis(N4-methylthiosemicarbazone)
    Farrokh Dehdashti
    Division of Nuclear Medicine, Edward Mallinckrodt Institute of Radiology, St Louis, Missouri 63110, USA
    J Nucl Med 49:201-5. 2008
    ..9). Pretherapy (60)Cu-ATSM PET provides clinically relevant information about tumor oxygenation that is predictive of outcome in patients with cervical cancer...
  14. pmc Examining the relationship between Cu-ATSM hypoxia selectivity and fatty acid synthase expression in human prostate cancer cell lines
    Amy L Vavere
    Division of Radiological Sciences, Washington University School of Medicine, St Louis, MO 63110, USA
    Nucl Med Biol 35:273-9. 2008
    ..As a defense mechanism in prostate cancer cells, the fatty acid synthesis pathway harnesses its oxidizing power for improving the redox balance despite conditions of extreme hypoxia, potentially altering Cu-ATSM hypoxia selectivity...
  15. ncbi request reprint Imaging of melanoma using 64Cu- and 86Y-DOTA-ReCCMSH(Arg11), a cyclized peptide analogue of alpha-MSH
    Paul McQuade
    Division of Radiological Sciences, Mallinckrodt Institute of Radiology and the Alvin J Siteman Cancer Center, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Med Chem 48:2985-92. 2005
    ..The data obtained suggests that DOTA-ReCCMSH(Arg(11)), when labeled with beta(+)-emitting radionuclides, has the potential for early detection of malignant melanoma by exploiting the sensitivity and high resolution of PET...
  16. ncbi request reprint Investigation into 64Cu-labeled Bis(selenosemicarbazone) and Bis(thiosemicarbazone) complexes as hypoxia imaging agents
    Paul McQuade
    Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, MO 63110, USA
    Nucl Med Biol 32:147-56. 2005
    ..Two approaches are to increase alkylation or to replace the sulfur atoms with selenium, resulting in the formation of selenosemicarbazones...
  17. ncbi request reprint Measurement of input functions in rodents: challenges and solutions
    Richard Laforest
    Division of Radiological Sciences, Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, MO 63110, USA
    Nucl Med Biol 32:679-85. 2005
    ..To be able to implement these approaches in rodent models of disease using small-animal PET (microPET), it is imperative that the input function is measured accurately...
  18. ncbi request reprint Assessment of myocardial metabolism in diabetic rats using small-animal PET: a feasibility study
    Michael J Welch
    The Division of Radiological Sciences, Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Nucl Med 47:689-97. 2006
    ..This feasibility study was undertaken to determine whether kinetic modeling in conjunction with small-animal PET could noninvasively quantify alterations in myocardial perfusion and substrate metabolism in rats...
  19. ncbi request reprint Assessment of myocardial blood flow using 15O-water and 1-11C-acetate in rats with small-animal PET
    Pilar Herrero
    Division of Radiological Sciences, Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Nucl Med 47:477-85. 2006
    ..This feasibility study was undertaken to determine whether myocardial blood flow (MBF, mL/g/min) could be quantified noninvasively in small rodents using microPET and 15O-water or 1-11C-acetate...
  20. pmc Melanoma imaging using (111)In-, (86)Y- and (68)Ga-labeled CHX-A''-Re(Arg11)CCMSH
    Lihui Wei
    Department of Radiology, Washington University School of Medicine, St Louis, MO 63110, USA
    Nucl Med Biol 36:345-54. 2009
    ..A novel alpha-melanocyte-stimulating hormone peptide analog CHX-A''-Re(Arg(11))CCMSH, which targeted the melanocortin-1 receptor (MC1-R) overexpressed on melanoma cells, was investigated for its biodistribution and tumor imaging properties...
  21. ncbi request reprint Cell line-dependent differences in uptake and retention of the hypoxia-selective nuclear imaging agent Cu-ATSM
    Paul Burgman
    Department of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Nucl Med Biol 32:623-30. 2005
    ..In this study, we examined the mechanisms underlying the uptake of (64)Cu in cells incubated with (64)Cu-ATSM...
  22. pmc The synthesis and evaluation of N1-(4-(2-[18F]-fluoroethyl)phenyl)-N8-hydroxyoctanediamide ([18F]-FESAHA), a PET radiotracer designed for the delineation of histone deacetylase expression in cancer
    Brian M Zeglis
    Radiochemistry Service, Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Nucl Med Biol 38:683-96. 2011
    ..Here, we describe the synthesis, characterization and evaluation of N(1)-(4-(2-[(18)F]-fluoroethyl)phenyl)-N(8)-hydroxyoctanediamide ([(18)F]-FESAHA), a PET tracer designed for the delineation of HDAC expression in cancer...
  23. ncbi request reprint Radiometal-labeled somatostatin analogs for applications in cancer imaging and therapy
    Jason S Lewis
    Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, MO, USA
    Methods Mol Biol 386:227-40. 2007
    ..Methods will also be presented for the in vitro and in vivo evaluation of the compounds produced...
  24. pmc 89Zr-DFO-J591 for immunoPET of prostate-specific membrane antigen expression in vivo
    Jason P Holland
    Radiochemistry Service, Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA
    J Nucl Med 51:1293-300. 2010
    ....
  25. ncbi request reprint Assessing tumor hypoxia in cervical cancer by positron emission tomography with 60Cu-ATSM: relationship to therapeutic response-a preliminary report
    Farrokh Dehdashti
    Division of Nuclear Medicine, Edward Mallinckrodt Institute of Radiology, St Louis, MO 63110, USA
    Int J Radiat Oncol Biol Phys 55:1233-8. 2003
    ..We have investigated whether pretreatment tumor hypoxia assessed by positron emission tomography (PET) with Cu-60 diacetyl-bis(N(4)-methylthiosemicarbazone) ((60)Cu-ATSM) predicts responsiveness to subsequent therapy in cervical cancer...
  26. pmc (64)Cu-labeled CB-TE2A and diamsar-conjugated RGD peptide analogs for targeting angiogenesis: comparison of their biological activity
    Lihui Wei
    Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, MO 63110, USA
    Nucl Med Biol 36:277-85. 2009
    ..In this study, the chelators CB-TE2A and diamsar were conjugated to cyclic RGDyK and RGDfD and the biological properties of (64)Cu-labeled peptides were compared...
  27. pmc A pretargeted PET imaging strategy based on bioorthogonal Diels-Alder click chemistry
    Brian M Zeglis
    Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA
    J Nucl Med 54:1389-96. 2013
    ..To this end, we report the development of a methodology for pretargeted PET imaging based on the bioorthogonal Diels-Alder click reaction between tetrazine and transcyclooctene...
  28. pmc Evaluation of a bromine-76-labeled progestin 16alpha,17alpha-dioxolane for breast tumor imaging and radiotherapy: in vivo biodistribution and metabolic stability studies
    Dong Zhou
    Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, MO 63110, USA
    Nucl Med Biol 35:655-63. 2008
    ..Progesterone receptors (PRs) are present in many breast tumors, and their levels are increased by certain endocrine therapies. They can be used as targets for diagnostic imaging and radiotherapy...
  29. pmc Efficient (18)F-labeling of large 37-amino-acid pHLIP peptide analogues and their biological evaluation
    Pierre Daumar
    Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    Bioconjug Chem 23:1557-66. 2012
    ..This reliable and efficient protocol promises to be useful for the (18)F-labeling of large peptides such as pHLIP and will accelerate the evaluation of numerous [(18)F]-pHLIP analogues as potential PET tracers...
  30. doi request reprint 1-11C-acetate as a PET radiopharmaceutical for imaging fatty acid synthase expression in prostate cancer
    Amy L Vavere
    Division of Radiological Sciences, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Nucl Med 49:327-34. 2008
    ..Fatty acid synthase (FAS) has been found to be overexpressed in prostate carcinomas, as well as other cancers, and it is possible that imaging with 1-(11)C-acetate could be a marker for its expression...
  31. pmc Targeting the internal epitope of prostate-specific membrane antigen with 89Zr-7E11 immuno-PET
    Alessandro Ruggiero
    Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York, USA
    J Nucl Med 52:1608-15. 2011
    ..The ability of (89)Zr-DFO-7E11 to delineate tumor response to therapy was also investigated, because it binds to the intracellular epitope of PSMA, which becomes available only on membrane disruption in dead or dying cells...
  32. pmc Standardized methods for the production of high specific-activity zirconium-89
    Jason P Holland
    Memorial Sloan Kettering Cancer Center, Department of Radiology, New York, NY 10065, USA
    Nucl Med Biol 36:729-39. 2009
    ..The detailed methods described can be easily translated to other radiochemistry facilities and will facilitate the use of (89)Zr in both basic science and clinical investigations...
  33. ncbi request reprint Assessment of regional tumor hypoxia using 18F-fluoromisonidazole and 64Cu(II)-diacetyl-bis(N4-methylthiosemicarbazone) positron emission tomography: Comparative study featuring microPET imaging, Po2 probe measurement, autoradiography, and fluorescent mic
    Joseph A O'Donoghue
    Department of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, NY, USA
    Int J Radiat Oncol Biol Phys 61:1493-502. 2005
    ..To compare two potential positron emission tomography (PET) tracers of tumor hypoxia in an animal model...
  34. ncbi request reprint Preparation of high specific activity (86)Y using a small biomedical cyclotron
    Jeongsoo Yoo
    Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, MO 63110, USA
    Nucl Med Biol 32:891-7. 2005
    ..We have established techniques for the routine, economical production of high purity, high specific activity 86Y on a small biomedical cyclotron that are translatable to other institutions...
  35. ncbi request reprint Dosimetry of 60/61/62/64Cu-ATSM: a hypoxia imaging agent for PET
    Richard Laforest
    Mallinckrodt Institute of Radiology, Washington University School of Medicine, Campus Box 8225, 510 S Kingshighway, St Louis, MO 63110, USA
    Eur J Nucl Med Mol Imaging 32:764-70. 2005
    ..Dosimetry calculations by the established Medical Internal Radionuclide Dose (MIRD) approach were performed with both animal and patient data...
  36. ncbi request reprint Three-dimensional maximum a posteriori (MAP) imaging with radiopharmaceuticals labeled with three Cu radionuclides
    Ananya Ruangma
    Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, MO 63110, USA
    Nucl Med Biol 33:217-26. 2006
    ....
  37. pmc A novel technology for the imaging of acidic prostate tumors by positron emission tomography
    Amy L Vavere
    Division of Radiological Sciences, Department of Radiology, Washington University School of Medicine, St Louis, MO, USA
    Cancer Res 69:4510-6. 2009
    ..This article introduces a novel class of noninvasive pH-selective positron emission tomography imaging agents and opens new research directions in the diagnosis of acidic solid tumors...
  38. doi request reprint The next generation of positron emission tomography radiopharmaceuticals in oncology
    Samuel L Rice
    Radiochemistry Service, Department of Radiology and Program in Molecular Pharmacology and Chemistry, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, USA
    Semin Nucl Med 41:265-82. 2011
    ....
  39. pmc Enzyme-mediated methodology for the site-specific radiolabeling of antibodies based on catalyst-free click chemistry
    Brian M Zeglis
    Department of Radiology and the Program in Molecular Pharmacology and Chemistry, Memorial Sloan Kettering Cancer Center, New York, New York, United States
    Bioconjug Chem 24:1057-67. 2013
    ..Ultimately, this strategy could play a critical role in the development of novel well-defined and highly immunoreactive radioimmunoconjugates for both the laboratory and clinic...
  40. pmc A practical guide to the construction of radiometallated bioconjugates for positron emission tomography
    Brian M Zeglis
    Department of Radiology and Program in Molecular Pharmacology and Chemistry Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Dalton Trans 40:6168-95. 2011
    ....
  41. ncbi request reprint Enhancing targeted radiotherapy by copper(II)diacetyl- bis(N4-methylthiosemicarbazone) using 2-deoxy-D-glucose
    Rebecca L Aft
    Department of Surgery, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Cancer Res 63:5496-504. 2003
    ..Our data indicate that the strategy of combining tumor-specific cytotoxic agents that function by differing mechanisms can result in an effective, selective, tumor-specific cell death with minimal effect on the host...
  42. ncbi request reprint Delineation of hypoxia in canine myocardium using PET and copper(II)-diacetyl-bis(N(4)-methylthiosemicarbazone)
    Jason S Lewis
    Division of Radiological Sciences, Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Nucl Med 43:1557-69. 2002
    ..Using canine models of hypoxic myocardium, we report our findings on *Cu-ATSM PET (*Cu is defined as either (60)Cu, (61)Cu, or (64)Cu) for the delineation of ischemic and hypoxic myocardium...
  43. pmc Imaging and treating tumor vasculature with targeted radiolabeled carbon nanotubes
    Alessandro Ruggiero
    Department of Medicine and Radiology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    Int J Nanomedicine 5:783-802. 2010
    ..These data have implications that support further imaging and radiotherapy studies using a SWCNT-based platform and focusing on the tumor vessels as the target...
  44. pmc Role of metalation in the topoisomerase IIα inhibition and antiproliferation activity of a series of α-heterocyclic-N4-substituted thiosemicarbazones and their Cu(II) complexes
    Brian M Zeglis
    Department of Radiology and the Molecular Pharmacology and Chemistry Program, Memorial Sloan Kettering Cancer Center, New York, New York 10065, United States
    J Med Chem 54:2391-8. 2011
    ..The copper complexes were also shown to inhibit the proliferation of breast cancer cells expressing high levels of topoisomerase-IIα (SK-BR-3) at lower concentrations than cells expressing lower levels of the enzyme (MCF-7)...
  45. doi request reprint Applying PET to broaden the diagnostic utility of the clinically validated CA19.9 serum biomarker for oncology
    Nerissa Therese Viola-Villegas
    Program in Molecular Pharmacology and Chemistry, Memorial Sloan Kettering Cancer Center, New York, New York
    J Nucl Med 54:1876-82. 2013
    ....
  46. ncbi request reprint In vivo imaging in a murine model of glioblastoma
    Sarah C Jost
    Department of Neurosurgery, Washington University, School of Medicine, St Louis, Missouri 63110, USA
    Neurosurgery 60:360-70; discussion 370-1. 2007
    ....
  47. doi request reprint Monitoring afatinib treatment in HER2-positive gastric cancer with 18F-FDG and 89Zr-trastuzumab PET
    Yelena Y Janjigian
    Gastrointestinal Oncology Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    J Nucl Med 54:936-43. 2013
    ....
  48. pmc Intraoperative imaging of positron emission tomographic radiotracers using Cerenkov luminescence emissions
    Jason P Holland
    Radiochemistry Service, Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    Mol Imaging 10:177-86, 1-3. 2011
    ..Overall, these results strongly support the continued development of CLI as a preclinical and possible clinical tool for use in molecular imaging and surgical procedures for accurately defining tumor margins...
  49. ncbi request reprint 64Cu-azabicyclo[3.2.2]nonane thiosemicarbazone complexes: radiopharmaceuticals for PET of topoisomerase II expression in tumors
    Lihui Wei
    Division of Radiological Sciences, Mallinckrodt Institute of Radiology, and Alvin J Siteman Cancer Center, Washington University School of Medicine, St Louis, MO 63110, USA
    J Nucl Med 47:2034-41. 2006
    ..The aim of this study was to investigate the relationship between the in vitro and in vivo behavior of novel (64)Cu-TSC complexes and the expression of Topo-II activity...
  50. ncbi request reprint Molecular imaging of gastrin-releasing peptide receptor-positive tumors in mice using 64Cu- and 86Y-DOTA-(Pro1,Tyr4)-bombesin(1-14)
    Grainne B Biddlecombe
    Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Bioconjug Chem 18:724-30. 2007
    ..The (86)Y analogue demonstrated excellent PET image quality in models of prostate cancer for the delineation of the GRPR-rich tumors and warrants further investigation...
  51. ncbi request reprint A prospective pilot study of (89)Zr-J591/prostate specific membrane antigen positron emission tomography in men with localized prostate cancer undergoing radical prostatectomy
    Joseph R Osborne
    Molecular Imaging and Therapy Service, Memorial Sloan Kettering Cancer Center, New York, New York
    J Urol 191:1439-45. 2014
    ..In this pilot study we explored the feasibility of (89)Zr labeled J591 monoclonal antibody positron emission tomography of localized prostate cancer...
  52. pmc Pairwise comparison of 89Zr- and 124I-labeled cG250 based on positron emission tomography imaging and nonlinear immunokinetic modeling: in vivo carbonic anhydrase IX receptor binding and internalization in mouse xenografts of clear-cell renal cell carcino
    Sarah M Cheal
    Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY, USA
    Eur J Nucl Med Mol Imaging 41:985-94. 2014
    ..We believe that this unique model better relates quantitative imaging data to the salient biological features of tumor antibody-antigen binding and turnover...
  53. doi request reprint Feasibility and predictability of perioperative PET and estrogen receptor ligand in patients with invasive breast cancer
    Mary L Gemignani
    Breast Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York
    J Nucl Med 54:1697-702. 2013
    ..The purpose of this study was to correlate (18)F-FES PET and ER expression in patients with primary, operable breast cancer...
  54. pmc (18)F-labeled-bioorthogonal liposomes for in vivo targeting
    Fabien Emmetiere
    Department of Radiology, Department of Medical Physics, Molecular Imaging and Therapy Service, Department of Radiology, and Molecular Pharmacology and Chemistry Program, Memorial Sloan Kettering Cancer Center, New York, New York, 10065, United States
    Bioconjug Chem 24:1784-9. 2013
    ....
  55. pmc Bromination from the macroscopic level to the tracer radiochemical level: (76)Br radiolabeling of aromatic compounds via electrophilic substitution
    Dong Zhou
    Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Bioconjug Chem 20:808-16. 2009
    ....
  56. ncbi request reprint Positron-emitting isotopes produced on biomedical cyclotrons
    Paul McQuade
    The Division of Radiological Sciences, Mallinckrodt Institute of Radiology, Washington University School of Medicine, Saint Louis, Missouri 63110, USA
    Curr Med Chem 12:807-18. 2005
    ....
  57. ncbi request reprint Copper-64-pyruvaldehyde-bis(N(4)-methylthiosemicarbazone) for the prevention of tumor growth at wound sites following laparoscopic surgery: monitoring therapy response with microPET and magnetic resonance imaging
    Jason S Lewis
    Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Cancer Res 62:445-9. 2002
    ..001). This study demonstrates the therapeutic potential of (64)Cu-PTSM in inhibiting cancer cell implantation and growth at doses well below the maximum tolerated dose, with no signs of toxicity to the hamsters...
  58. doi request reprint Clickable bifunctional radiometal chelates for peptide labeling
    Artem Y Lebedev
    Radiochemistry Service, Department of Radiology, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA
    Chem Commun (Camb) 46:1706-8. 2010
    ..Novel synthetic methods for producing an array of chelates for use in "click"-radiolabeling of peptides are described, and their reactivity with regards to subsequent conjugation and radiolabeling is discussed...
  59. pmc The growing impact of bioorthogonal click chemistry on the development of radiopharmaceuticals
    Dexing Zeng
    Department of Radiology, Molecular Imaging Laboratory, University of Pittsburgh, Pittsburgh, Pennsylvania 15219, USA
    J Nucl Med 54:829-32. 2013
    ....
  60. pmc Imaging androgen receptor signaling with a radiotracer targeting free prostate-specific antigen
    David Ulmert
    Department of Surgery, Howard Hughes Medical Institute, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA
    Cancer Discov 2:320-7. 2012
    ..Finally, we demonstrate that (89)Zr-5A10 can detect osseous prostate cancer lesions, a context where bone scans fail to discriminate malignant and nonmalignant signals...
  61. pmc Sandmeyer reaction repurposed for the site-selective, non-oxidizing radioiodination of fully-deprotected peptides: studies on the endogenous opioid peptide α-neoendorphin
    Julie E Pickett
    Molecular Pharmacology and Chemistry Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    Bioorg Med Chem Lett 23:4347-50. 2013
    ....
  62. pmc PET imaging with ⁸⁹Zr: from radiochemistry to the clinic
    Melissa A Deri
    Department of Radiology and the Program in Molecular Pharmacology and Chemistry, Memorial Sloan Kettering Cancer Center, New York, NY, USA
    Nucl Med Biol 40:3-14. 2013
    ..At bottom, it is hoped that this review will provide both the experienced investigator and new scientist with a full and critical overview of this exciting and fast-developing field...
  63. pmc An improved strategy for the synthesis of [¹⁸F]-labeled arabinofuranosyl nucleosides
    Hanwen Zhang
    Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    Nucl Med Biol 39:1182-8. 2012
    ..Ultimately, we believe that these high yielding syntheses of [(18)F]-FIAU, [(18)F]-FMAU and [(18)F]-FEAU will facilitate routine production for clinical applications...
  64. ncbi request reprint DOTA-D-Tyr(1)-octreotate: a somatostatin analogue for labeling with metal and halogen radionuclides for cancer imaging and therapy
    Wen Ping Li
    Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Bioconjug Chem 13:721-8. 2002
    ....
  65. ncbi request reprint Unconventional nuclides for radiopharmaceuticals
    Jason P Holland
    Radiochemistry Service, Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    Mol Imaging 9:1-20. 2010
    ..In particular, the properties and safety considerations associated with the increasingly prevalent PET nuclides 64Cu, 68Ga, 86Y, 89Zr, and 124I are discussed...
  66. pmc Radiopharmaceuticals in preclinical and clinical development for monitoring of therapy with PET
    Mark P S Dunphy
    Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA
    J Nucl Med 50:106S-21S. 2009
    ....
  67. pmc Synthesis and evaluation of 18F-labeled benzylguanidine analogs for targeting the human norepinephrine transporter
    Hanwen Zhang
    Department of Radiology, Memorial Sloan Kettering Cancer Center MSKCC, New York, NY, 10065, USA
    Eur J Nucl Med Mol Imaging 41:322-32. 2014
    ..i. We developed improved methods for the synthesis of known MIBG analogs, [(18)F]MFBG and [(18)F]PFBG and evaluated them in hNET reporter gene-transduced C6 rat glioma cells and xenografts...
  68. pmc (89)Zr-labeled paramagnetic octreotide-liposomes for PET-MR imaging of cancer
    Diane S Abou
    Molecular Pharmacology and Chemistry Program, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, Box 16, New York, New York, 10065, USA
    Pharm Res 30:878-88. 2013
    ..Here, we report pegylated liposome (LP) formulations, housing a MR T(1) contrast agent (Gd) and the positron-emitting (89)Zr (half-life: 3.27 days), for simultaneous PET and MR tumor imaging capabilities...
  69. ncbi request reprint [Tc(CO)(3)](+) chemistry: a promising new concept for SPECT? Against
    Michael J Welch
    Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, MO 63110, USA
    Eur J Nucl Med Mol Imaging 30:1302-4. 2003
  70. pmc Affinity-based proteomics reveal cancer-specific networks coordinated by Hsp90
    Kamalika Moulick
    Molecular Pharmacology and Chemistry Program, Sloan Kettering Institute, New York, New York, USA
    Nat Chem Biol 7:818-26. 2011
    ..We further show that the abundance of the PU-H71-enriched Hsp90 species, which is not dictated by Hsp90 expression alone, is predictive of the cell's sensitivity to Hsp90 inhibition...
  71. ncbi request reprint In vivo skeletal imaging of 18F-fluoride with positron emission tomography reveals damage- and time-dependent responses to fatigue loading in the rat ulna
    Matthew J Silva
    Department of Orthopaedic Surgery, Washington University School of Medicine, 1 Barnes Jewish Hospital Plaza, Suite 11300 WP, St Louis, MO 63110, USA
    Bone 39:229-36. 2006
    ....
  72. ncbi request reprint Molecular imaging: the application of small animal positron emission tomography
    Douglas J Rowland
    Radiation Sciences, Mallinckrodt Institute of Radiology, Washington University School of Medicine, Saint Louis, Missouri, USA
    J Cell Biochem Suppl 39:110-5. 2002
    ..In this Prospect small animal PET imaging will be described, specifically focusing on the current technologies, its applications in molecular imaging and the logistics of performing small animal PET...
  73. doi request reprint In vitro and in vivo evaluation of bifunctional bisthiosemicarbazone 64Cu-complexes for the positron emission tomography imaging of hypoxia
    Paul D Bonnitcha
    Department of Chemistry, Oxford University, Oxford, OX1 3TA, United Kingdom
    J Med Chem 51:2985-91. 2008
    ..These complexes demonstrate that H 2ATSM/A represents a novel and versatile synthetic platform that can be utilized to provide hypoxic cell selectivity through functionalization of the bisthiosemicarbazonate group...
  74. ncbi request reprint Copper bis(thiosemicarbazone) complexes as hypoxia imaging agents: structure-activity relationships
    Jason L J Dearling
    Biosciences Department, University of Kent, Canterbury CT2 7NJ, UK
    J Biol Inorg Chem 7:249-59. 2002
    ..The radioactivity uptake/release behaviour in the cells provides insight into possible mechanisms, and a model for hypoxia-selective intracellular trapping is discussed...
  75. ncbi request reprint Tumor hypoxia detected by positron emission tomography with 60Cu-ATSM as a predictor of response and survival in patients undergoing Neoadjuvant chemoradiotherapy for rectal carcinoma: a pilot study
    David W Dietz
    Department of Colorectal Surgery, Cleveland Clinic, Cleveland, Ohio 44195, USA
    Dis Colon Rectum 51:1641-8. 2008
    ....
  76. ncbi request reprint Synthesis, in vitro and in vivo characterization of (64)Cu(I) complexes derived from hydrophilic tris(hydroxymethyl)phosphane and 1,3,5-triaza-7-phosphaadamantane ligands
    Simone Alidori
    Dipartimento di Scienze Chimiche, Universita di Camerino, Via S Agostino 1, 62032, Camerino, MC, Italy
    J Biol Inorg Chem 13:307-15. 2008
    ..We also report the use of 1 as a building block for new radiopharmaceuticals, perhaps the first time such a method has been used in the production of copper radiopharmaceuticals...
  77. ncbi request reprint Intra-tumoral distribution of (64)Cu-ATSM: a comparison study with FDG
    Atsushi Obata
    Graduate School of Pharmaceutical Sciences, Kyoto University, Sakyo, 606 8151 Kyoto, Japan
    Nucl Med Biol 30:529-34. 2003
    ..18)F]FDG was distributed more widely with highest levels in the inner regions where pre-necrotic cells were mainly observed. (64)Cu-ATSM appears to be useful for the detection of hypoxic but active tumor cell regions in vivo...
  78. ncbi request reprint Basic characterization of 64Cu-ATSM as a radiotherapy agent
    Atsushi Obata
    Biomedical Imaging Research Center, University of Fukui, Matsuoka, Fukui 910 1193, Japan
    Nucl Med Biol 32:21-8. 2005
    ..These data allow us to postulate that 64Cu-ATSM will be able to attack the hypoxic tumor cells directly, as well as potentially affecting the peripheral nonhypoxic regions indirectly by the beta- particle decay of 64Cu...
  79. ncbi request reprint Preparation of 66Ga- and 68Ga-labeled Ga(III)-deferoxamine-folate as potential folate-receptor-targeted PET radiopharmaceuticals
    Carla J Mathias
    Department of Industrial and Physical Pharmacy, Purdue University, West, Lafayette, IN, USA
    Nucl Med Biol 30:725-31. 2003
    ..The autoradiographic images of 1 mm tumor sections demonstrate the gross heterogeneity of the KB cell tumor xenograft, as well as subtle disparity in the regional accumulation of the two radiotracers...
  80. ncbi request reprint Validation of a novel CHX-A'' derivative suitable for peptide conjugation: small animal PET/CT imaging using yttrium-86-CHX-A''-octreotide
    Thomas Clifford
    Radioimmune and Inorganic Chemistry Section, Radiation Oncology Branch, National Cancer Institute, Building 10 Center Drive, Bethesda, Maryland 20892 1088, USA
    J Med Chem 49:4297-304. 2006
    ..8 d) and (86)Y (T(1/2) = 14.7 h) demonstrated. Small animal PET/CT imaging results of (86)Y-CHX-A''-octreotide in a somatostatin receptor-positive tumor-bearing rat model are presented for the validation of the novel agent...
  81. pmc Imaging oxygenation of human tumours
    Anwar R Padhani
    Paul Strickland Scanner Centre, Mount Vernon Hospital, Rickmansworth Road, Northwood, Middlesex, HA6 2RN, UK
    Eur Radiol 17:861-72. 2007
    ..We discuss where developments are required for hypoxia imaging to become clinically useful and explore potential new uses for hypoxia imaging techniques including biological conformal radiotherapy...
  82. ncbi request reprint Small animal imaging. current technology and perspectives for oncological imaging
    Jason S Lewis
    Radiation Sciences, Washington University School of Medicine, Saint Louis, MO, USA
    Eur J Cancer 38:2173-88. 2002
    ..This review is focused on three modalities, PET, MR and optical imaging which are available to the scientist for oncological investigations in animals...
  83. ncbi request reprint Identification of a novel prostate tumor target, mindin/RG-1, for antibody-based radiotherapy of prostate cancer
    Renate Parry
    Berlex Biosciences, Richmond, California 94806, USA
    Cancer Res 65:8397-405. 2005
    ..We conclude that [90Y]-CHX-A''-DTPA-19G9 is a novel antibody conjugate that has considerable promise for therapy of metastatic prostate cancer in androgen-unresponsive patients...
  84. ncbi request reprint Hypoxia: importance in tumor biology, noninvasive measurement by imaging, and value of its measurement in the management of cancer therapy
    James L Tatum
    National Cancer Institute, Executive Plaza North, Room 6000, 6130 Executive Boulevard, Rockville, MD 20852 7440, USA
    Int J Radiat Biol 82:699-757. 2006
    ....

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