Eric Lai


Affiliation: Memorial Sloan-Kettering Cancer Center
Country: USA


  1. Lin C, Hu F, Dubruille R, Vedanayagam J, Wen J, Smibert P, et al. The hpRNA/RNAi Pathway Is Essential to Resolve Intragenomic Conflict in the Drosophila Male Germline. Dev Cell. 2018;46:316-326.e5 pubmed publisher
    ..Altogether, our data reveal how the adaptive capacity of hpRNAs is critically deployed to restrict selfish gonadal genetic systems that can exterminate a species. ..
  2. Shenker S, Miura P, Sanfilippo P, Lai E. IsoSCM: improved and alternative 3' UTR annotation using multiple change-point inference. RNA. 2015;21:14-27 pubmed publisher
    ..The IsoSCM software and source code are available from our website ..
  3. Joseph B, Kondo S, Lai E. Short cryptic exons mediate recursive splicing in Drosophila. Nat Struct Mol Biol. 2018;25:365-371 pubmed publisher
    ..Overall, these studies unify the mechanism of Drosophila recursive splicing with that in mammals. ..
  4. Duan H, de Navas L, Hu F, Sun K, Mavromatakis Y, Viets K, et al. The mir-279/996 cluster represses receptor tyrosine kinase signaling to determine cell fates in the Drosophila eye. Development. 2018;145: pubmed publisher
    ..Altogether, we reveal a rare setting of developmental cell specification that involves substantial miRNA control. ..
  5. Garaulet D, Lai E. Hox miRNA regulation within the Drosophila Bithorax complex: Patterning behavior. Mech Dev. 2015;138 Pt 2:151-159 pubmed publisher
  6. Mohammed J, Siepel A, Lai E. Diverse modes of evolutionary emergence and flux of conserved microRNA clusters. RNA. 2014;20:1850-63 pubmed publisher
  7. Westholm J, Miura P, Olson S, Shenker S, Joseph B, Sanfilippo P, et al. Genome-wide analysis of drosophila circular RNAs reveals their structural and sequence properties and age-dependent neural accumulation. Cell Rep. 2014;9:1966-80 pubmed publisher
    ..Interestingly, circular isoforms increase substantially relative to linear isoforms during CNS aging and constitute an aging biomarker. ..
  8. Lin C, Wen J, Bejarano F, Hu F, Bortolamiol Becet D, Kan L, et al. Characterization of a TUTase/RNase complex required for Drosophila gametogenesis. RNA. 2017;23:284-296 pubmed publisher
    ..Overall, our studies of a new tailing/trimming complex reveal unexpectedly specific requirements during gametogenesis. ..
  9. Sanfilippo P, Miura P, Lai E. Genome-wide profiling of the 3' ends of polyadenylated RNAs. Methods. 2017;126:86-94 pubmed publisher
    ..The data are single-nucleotide resolution and quantitative, and can be used for downstream analyses of APA. ..

More Information


  1. KAVALER J, Duan H, Aradhya R, de Navas L, Joseph B, Shklyar B, et al. miRNA suppression of a Notch repressor directs non-neuronal fate in Drosophila mechanosensory organs. J Cell Biol. 2018;217:571-583 pubmed publisher
    ..Thus, proper assembly of multicellular mechanosensory organs requires a double-negative circuit involving miRNA-mediated suppression of a Notch repressor to assign non-neuronal cell fate. ..
  2. Wen J, Duan H, Bejarano F, Okamura K, Fabian L, Brill J, et al. Adaptive regulation of testis gene expression and control of male fertility by the Drosophila hairpin RNA pathway. [Corrected]. Mol Cell. 2015;57:165-78 pubmed publisher
    ..Finally, the collected hpRNA loci chronicle an evolutionary timeline that reflects their origins from prospective target genes, mirroring a strategy described for plant miRNAs. ..
  3. Dai Q, Ren A, Westholm J, Duan H, Patel D, Lai E. Common and distinct DNA-binding and regulatory activities of the BEN-solo transcription factor family. Genes Dev. 2015;29:48-62 pubmed publisher
    ..Altogether, our data define an array of common and distinct biochemical and functional properties of this new family of transcription factors. ..
  4. Bortolamiol Becet D, Hu F, Jee D, Wen J, Okamura K, Lin C, et al. Selective Suppression of the Splicing-Mediated MicroRNA Pathway by the Terminal Uridyltransferase Tailor. Mol Cell. 2015;59:217-28 pubmed publisher
    ..Thus, Tailor activity may have had collateral impact on shaping populations of canonical miRNAs. ..
  5. Garaulet D, Sun K, Li W, Wen J, Panzarino A, O Neil J, et al. miR-124 Regulates Diverse Aspects of Rhythmic Behavior in Drosophila. J Neurosci. 2016;36:3414-21 pubmed publisher
    ..In summary,Drosophila mir-124 mutants reveal post-transcriptional control of circadian activities, and impact of BMP signaling in behavioral output. ..
  6. Sanfilippo P, Smibert P, Duan H, Lai E. Neural specificity of the RNA-binding protein Elav is achieved by post-transcriptional repression in non-neural tissues. Development. 2016;143:4474-4485 pubmed
    ..Altogether, we define unexpected post-transcriptional mechanisms that direct appropriate cell type-specific expression of a conserved neural RBP. ..
  7. Sanfilippo P, Wen J, Lai E. Landscape and evolution of tissue-specific alternative polyadenylation across Drosophila species. Genome Biol. 2017;18:229 pubmed publisher
    ..These data provide a critical resource for the Drosophila community and offer many insights into the complex control of alternative tissue-specific 3' UTR formation and its consequences for post-transcriptional regulatory networks. ..
  8. Jee D, Yang J, Park S, Farmer D, Wen J, Chou T, et al. Dual Strategies for Argonaute2-Mediated Biogenesis of Erythroid miRNAs Underlie Conserved Requirements for Slicing in Mammals. Mol Cell. 2018;69:265-278.e6 pubmed publisher
    ..Overall, the mammalian hematopoietic system has evolved multiple conserved requirements for Slicer-dependent miRNA biogenesis. ..