Jason Koutcher

Summary

Affiliation: Memorial Sloan-Kettering Cancer Center
Country: USA

Publications

  1. ncbi request reprint Multimodality registration without a dedicated multimodality scanner
    Bradley J Beattie
    Momorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Mol Imaging 6:108-20. 2007
  2. ncbi request reprint Detection of prostate cancer with MR spectroscopic imaging: an expanded paradigm incorporating polyamines
    Amita Shukla-Dave
    Department of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, NY 10021 USA
    Radiology 245:499-506. 2007
  3. pmc Average arterial input function for quantitative dynamic contrast enhanced magnetic resonance imaging of neck nodal metastases
    Amita Shukla Dave
    Department of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, NY, USA
    BMC Med Phys 9:4. 2009
  4. pmc MRI of mouse models for gliomas shows similarities to humans and can be used to identify mice for preclinical trials
    Jason A Koutcher
    Department of Medical Physics, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
    Neoplasia 4:480-5. 2002
  5. ncbi request reprint An 19F magnetic resonance-based in vivo assay of solid tumor methotrexate resistance: proof of principle
    William M Spees
    Department of Medical Physics, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
    Clin Cancer Res 11:1454-61. 2005
  6. pmc Dual targeting of EGFR can overcome a major drug resistance mutation in mouse models of EGFR mutant lung cancer
    Lucia Regales
    Pao Laboratory, Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA
    J Clin Invest 119:3000-10. 2009
  7. pmc mTOR promotes survival and astrocytic characteristics induced by Pten/AKT signaling in glioblastoma
    Xiaoyi Hu
    Department of Cancer Biology and Genetics, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Neoplasia 7:356-68. 2005
  8. doi request reprint Non-invasive molecular and functional imaging of cytosine deaminase and uracil phosphoribosyltransferase fused with red fluorescence protein
    Ligang Xing
    Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York 10065, USA
    Acta Oncol 47:1211-20. 2008
  9. pmc Development of new mouse lung tumor models expressing EGFR T790M mutants associated with clinical resistance to kinase inhibitors
    Lucia Regales
    Pao Lab, Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York, United States of America
    PLoS ONE 2:e810. 2007
  10. ncbi request reprint Imaging of dihydrofolate reductase fusion gene expression in xenografts of human liver metastases of colorectal cancer in living rats
    Philipp Mayer-Kuckuk
    Molecular Pharmacology and Therapeutics Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA
    Eur J Nucl Med Mol Imaging 30:1281-91. 2003

Research Grants

  1. 500 MHz Wide Bore NMR System
    Jason Koutcher; Fiscal Year: 2002
  2. 9.4T/20 cm MRI for Cancer Research
    Jason Koutcher; Fiscal Year: 2007
  3. Cytocidal Therapy In Vivo for Drug-Resistant Tumors
    Jason Koutcher; Fiscal Year: 2007
  4. Memorial Sloan Kettering Small Animal Imaging Research
    Jason Koutcher; Fiscal Year: 2007
  5. Dynamic Magnetic Resonance Imaging of Bone Tumors
    Jason Koutcher; Fiscal Year: 2007
  6. Optimizing Chemotherapy Dose Using 31P NMR Spectroscopy
    Jason Koutcher; Fiscal Year: 2006
  7. Memorial Sloan Kettering Small Animal Imaging Research
    Jason Koutcher; Fiscal Year: 2006
  8. Dynamic Magnetic Resonance Imaging of Bone Tumors
    Jason Koutcher; Fiscal Year: 2006
  9. Cytocidal Therapy In Vivo for Drug-Resistant Tumors
    Jason Koutcher; Fiscal Year: 2005
  10. Dynamic Magnetic Resonance Imaging of Bone Tumors
    Jason Koutcher; Fiscal Year: 2005

Detail Information

Publications59

  1. ncbi request reprint Multimodality registration without a dedicated multimodality scanner
    Bradley J Beattie
    Momorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Mol Imaging 6:108-20. 2007
    ....
  2. ncbi request reprint Detection of prostate cancer with MR spectroscopic imaging: an expanded paradigm incorporating polyamines
    Amita Shukla-Dave
    Department of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, NY 10021 USA
    Radiology 245:499-506. 2007
    ....
  3. pmc Average arterial input function for quantitative dynamic contrast enhanced magnetic resonance imaging of neck nodal metastases
    Amita Shukla Dave
    Department of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, NY, USA
    BMC Med Phys 9:4. 2009
    ..Further validation of the Avg-AIF approach with a larger population and in multiple regions is desirable...
  4. pmc MRI of mouse models for gliomas shows similarities to humans and can be used to identify mice for preclinical trials
    Jason A Koutcher
    Department of Medical Physics, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
    Neoplasia 4:480-5. 2002
    ..In contrast, low-grade murine oligodendrogliomas do not reveal contrast enhancement, similar to human tumors. MRI can be used to identify mice with brain neoplasms as inclusion criteria in preclinical trials...
  5. ncbi request reprint An 19F magnetic resonance-based in vivo assay of solid tumor methotrexate resistance: proof of principle
    William M Spees
    Department of Medical Physics, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
    Clin Cancer Res 11:1454-61. 2005
    ..Here we show the utility of an (19)F-labeled methotrexate (FMTX) with (19)F magnetic resonance to differentiate between sensitive and resistant tumors in vivo and thus predict therapeutic response...
  6. pmc Dual targeting of EGFR can overcome a major drug resistance mutation in mouse models of EGFR mutant lung cancer
    Lucia Regales
    Pao Laboratory, Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA
    J Clin Invest 119:3000-10. 2009
    ..Moreover, this approach could serve as an important model for targeting other receptor tyrosine kinases activated in human cancers...
  7. pmc mTOR promotes survival and astrocytic characteristics induced by Pten/AKT signaling in glioblastoma
    Xiaoyi Hu
    Department of Cancer Biology and Genetics, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Neoplasia 7:356-68. 2005
    ....
  8. doi request reprint Non-invasive molecular and functional imaging of cytosine deaminase and uracil phosphoribosyltransferase fused with red fluorescence protein
    Ligang Xing
    Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York 10065, USA
    Acta Oncol 47:1211-20. 2008
    ..Thus, we developed a preclinical tumor model to investigate the feasibility of using magnetic resonance spectroscopy and optical imaging to measure non-invasively CD and UPRT expression and function...
  9. pmc Development of new mouse lung tumor models expressing EGFR T790M mutants associated with clinical resistance to kinase inhibitors
    Lucia Regales
    Pao Lab, Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York, United States of America
    PLoS ONE 2:e810. 2007
    ..The EGFR T790M mutation confers acquired resistance to kinase inhibitors in human EGFR mutant lung adenocarcinoma, is occasionally detected before treatment, and may confer genetic susceptibility to lung cancer...
  10. ncbi request reprint Imaging of dihydrofolate reductase fusion gene expression in xenografts of human liver metastases of colorectal cancer in living rats
    Philipp Mayer-Kuckuk
    Molecular Pharmacology and Therapeutics Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA
    Eur J Nucl Med Mol Imaging 30:1281-91. 2003
    ..It is concluded that the two examined nucleotide imaging methods are feasible techniques for monitoring of DHFR-HSV TK fusion protein expression in hepatic colorectal tumor tissue in living animals...
  11. pmc Feasibility of using limited-population-based average R10 for pharmacokinetic modeling of osteosarcoma dynamic contrast-enhanced magnetic resonance imaging data
    Wei Huang
    Department of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Magn Reson Imaging 27:852-8. 2009
    ..61+/-0.19 and 0.55+/-0.14) obtained with the average R(10) approach. The results suggest that it is feasible, as well as practical, to use a limited-population-based average R(10) for pharmacokinetic modeling of osteosarcoma DCE-MRI data...
  12. ncbi request reprint Correlation of proton MR spectroscopic imaging with gleason score based on step-section pathologic analysis after radical prostatectomy
    Kristen L Zakian
    Department of Medical Physics, Memorial Sloan Kettering Cancer Center, 1275 York Ave, New York, NY 10021, USA
    Radiology 234:804-14. 2005
    ..To determine whether hydrogen 1 magnetic resonance (MR) spectroscopic imaging can be used to predict aggressiveness of prostate cancer...
  13. ncbi request reprint Preliminary assessment of magnetic resonance spectroscopic imaging in predicting treatment outcome in patients with prostate cancer at high risk for relapse
    Darko Pucar
    Department of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Clin Prostate Cancer 3:174-81. 2004
    ..Although MRSI did not provide added prognostic value to MRI in this small number of patients, MRSI might increase the confidence of the clinician in assessing risk on MRI by contributing supporting metabolic data...
  14. ncbi request reprint High-resolution imaging of bone precursor cells within the intact bone marrow cavity of living mice
    Philipp Mayer-Kuckuk
    In Vivo Cellular Molecular Imaging Center, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Mol Ther 12:33-41. 2005
    ..In summary, we describe a versatile platform suitable for studying the biology of many bone marrow cell types in living bone...
  15. ncbi request reprint Liver regeneration in humans is characterized by significant changes in cellular phosphorus metabolism: assessment using proton-decoupled 31P-magnetic resonance spectroscopic imaging
    Kristen L Zakian
    Department of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Magn Reson Med 54:264-71. 2005
    ..This study demonstrates that 31P MRSI can be used to assess metabolic changes in humans during liver regeneration, and may be useful for assessing derangement of the regenerative process or guiding adjuvant chemotherapies...
  16. pmc J-difference lactate editing at 3.0 Tesla in the presence of strong lipids
    Mari A Smith
    Department of Medical Physics, Mail Box 84, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
    J Magn Reson Imaging 28:1492-8. 2008
    ..To implement in vivo detection of lactate in the presence of lipids by proton magnetic resonance spectroscopy at a 3 Tesla (T) field strength for potential applications in human tumors outside of the brain...
  17. ncbi request reprint 1H magnetic resonance spectroscopy of prostate cancer: biomarkers for tumor characterization
    Kristen L Zakian
    Department of Medical Physics, Memorial Sloan Kettering Cancer Center, NY, USA
    Cancer Biomark 4:263-76. 2008
    ..This article reviews the assessment of choline-containing compounds, citrate, and polyamines as markers for prostate tumor detection and aggressiveness...
  18. ncbi request reprint The utility of magnetic resonance imaging and spectroscopy for predicting insignificant prostate cancer: an initial analysis
    Amita Shukla-Dave
    Department of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, NY, USA
    BJU Int 99:786-93. 2007
    ..To design new models that combine clinical variables and biopsy data with magnetic resonance imaging (MRI) and MR spectroscopic imaging (MRSI) data, and assess their value in predicting the probability of insignificant prostate cancer...
  19. ncbi request reprint Chronic prostatitis: MR imaging and 1H MR spectroscopic imaging findings--initial observations
    Amita Shukla-Dave
    Department of Radiology, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
    Radiology 231:717-24. 2004
    ..To determine whether chronic prostatitis affects three-dimensional proton magnetic resonance (MR) spectroscopic imaging in evaluation of disease in the peripheral zone...
  20. pmc Registration of planar bioluminescence to magnetic resonance and x-ray computed tomography images as a platform for the development of bioluminescence tomography reconstruction algorithms
    Bradley J Beattie
    Memorial Sloan Kettering Cancer Center, Department of Neurology, 1275 York Avenue, New York, New York 10065, USA
    J Biomed Opt 14:024045. 2009
    ..36+/-0.23 mm. Additional experiments highlight some of the confounds that are often overlooked in the BLT reconstruction process, and for two of these confounds, simple corrections are proposed...
  21. ncbi request reprint Murine S factors for liver, spleen, and kidney
    Katherine S Kolbert
    Imaging and Spectroscopic Physics Service, Department of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    J Nucl Med 44:784-91. 2003
    ..Absorbed fractions for 5 monoenergetic electrons, ranging in energy from 0.5 to 2 MeV, are also provided...
  22. pmc Semi-automatic deformable registration of prostate MR images to pathological slices
    Yousef Mazaheri
    Department of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA
    J Magn Reson Imaging 32:1149-57. 2010
    ..To present a semi-automatic deformable registration algorithm for co-registering T2-weighted (T2w) images of the prostate with whole-mount pathological sections of prostatectomy specimens...
  23. ncbi request reprint Pharmacokinetics and Biodistribution of (86)Y-Trastuzumab for (90)Y dosimetry in an ovarian carcinoma model: correlative MicroPET and MRI
    Stig Palm
    Department of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    J Nucl Med 44:1148-55. 2003
    ..MicroPET and MRI-based preclinical biodistribution and localization data were obtained and used to assess the therapeutic potential of (90)Y-trastuzumab monoclonal antibody (mAb) (anti-HER2/neu) against ovarian carcinoma...
  24. ncbi request reprint Transition zone prostate cancer: metabolic characteristics at 1H MR spectroscopic imaging--initial results
    Kristen L Zakian
    Departments of Medical Physics, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
    Radiology 229:241-7. 2003
    ..To determine whether cancers of the prostate transition zone (TZ) possess a unique metabolic pattern by which they may be identified at proton magnetic resonance (MR) spectroscopic imaging...
  25. pmc An exploratory study of endorectal magnetic resonance imaging and spectroscopy of the prostate as preoperative predictive biomarkers of biochemical relapse after radical prostatectomy
    Kristen L Zakian
    Department of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    J Urol 184:2320-7. 2010
    ..We determined whether pretreatment endorectal magnetic resonance imaging/magnetic resonance spectroscopic imaging predicts biochemical recurrence after radical prostatectomy...
  26. ncbi request reprint A fluorine-labeled methotrexate as a probe for monitoring tumor antifolate pharmacokinetics: synthesis, in vitro cytotoxicity, and pilot in vivo 19F magnetic resonance spectra
    William M Spees
    Department of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Mol Cancer Ther 2:933-9. 2003
    ....
  27. doi request reprint Prostate cancer: identification with combined diffusion-weighted MR imaging and 3D 1H MR spectroscopic imaging--correlation with pathologic findings
    Yousef Mazaheri
    Department of Medical Physics, Memorial Sloan Kettering Cancer Center, 1275 York Ave, Room C 278, New York, NY 10021, USA
    Radiology 246:480-8. 2008
    ....
  28. pmc Expression of the bifunctional suicide gene CDUPRT increases radiosensitization and bystander effect of 5-FC in prostate cancer cells
    Ligang Xing
    Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    Radiother Oncol 92:345-52. 2009
    ....
  29. pmc Prostate tumor volume measurement with combined T2-weighted imaging and diffusion-weighted MR: correlation with pathologic tumor volume
    Yousef Mazaheri
    Department of Medical Physics, Memorial Sloan Kettering Cancer Center, 1275 York Ave, Room C 278, New York, NY 10065, USA
    Radiology 252:449-57. 2009
    ....
  30. pmc Proton MRS detects metabolic changes in hormone sensitive and resistant human prostate cancer models CWR22 and CWR22r
    H Carl Le
    Department of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Magn Reson Med 62:1112-9. 2009
    ..01). Metabolic changes in total choline by proton MRSI can be used as an early biomarker of response for advanced-stage prostate cancer in targeted therapy such as 17-allylamino, 17-demethoxygeldanamycin...
  31. ncbi request reprint Identification of prognostic markers in bone sarcomas using proton-decoupled phosphorus magnetic resonance spectroscopy
    Kristen L Zakian
    Department of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Cancer Res 63:9042-7. 2003
    ..The results are promising, although a prospective study is necessary for confirmation. (31)P MRSI appears to be a useful tool for the prediction of survival before therapy in bone sarcomas...
  32. pmc Fat-free MRI based on magnetization exchange
    Jin Hong Chen
    Sarcoma Disease Management Program, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA
    Magn Reson Med 63:713-8. 2010
    ..Unlike most fat suppression techniques, this method is not compromised by the static or radiofrequency field heterogeneity and is equally efficient for all fat resonances independent of their chemical shift frequency...
  33. ncbi request reprint Metabolic response of the CWR22 prostate tumor xenograft after 20 Gy of radiation studied by 1H spectroscopic imaging
    Jonathan P Dyke
    Citigroup Biomedical Imaging Center, Department of Radiology, Weill Cornell Medical College, New York, New York 10021, USA
    Clin Cancer Res 9:4529-36. 2003
    ..Current markers of tumor progression such as prostate-specific antigen (PSA) do not provide spatial information about tumor extent or regions of high metabolic activity...
  34. pmc Feasibility of using limited-population-based arterial input function for pharmacokinetic modeling of osteosarcoma dynamic contrast-enhanced MRI data
    Ya Wang
    Department of Medical Physics, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
    Magn Reson Med 59:1183-9. 2008
    ..Further validation with a larger population and multiple regions is desirable...
  35. ncbi request reprint Image-fusion of MR spectroscopic images for treatment planning of gliomas
    Jenghwa Chang
    Department of Medical Physics, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, New York 10021, USA
    Med Phys 33:32-40. 2006
    ..In conclusion, an image-fusion protocol was developed that successfully incorporates MRSI information into the IMRT treatment plan for glioma...
  36. pmc Reciprocal feedback regulation of PI3K and androgen receptor signaling in PTEN-deficient prostate cancer
    Brett S Carver
    Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    Cancer Cell 19:575-86. 2011
    ....
  37. pmc Accuracy and reproducibility of tumor positioning during prolonged and multi-modality animal imaging studies
    Mutian Zhang
    Department of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    Phys Med Biol 53:5867-82. 2008
    ..The process of transporting the animal between instruments introduced additional errors of approximately 0.2 mm. In serial animal imaging studies, the positioning reproducibility within approximately 0.8 mm could be obtained...
  38. pmc Noninvasive multimodality imaging of the tumor microenvironment: registered dynamic magnetic resonance imaging and positron emission tomography studies of a preclinical tumor model of tumor hypoxia
    HyungJoon Cho
    Department of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    Neoplasia 11:247-59, 2p following 259. 2009
    ....
  39. pmc Imaging transgene activity in vivo
    Terence P F Gade
    Department of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Cancer Res 68:2878-84. 2008
    ..This study presents a translational imaging paradigm for precise, in vivo measurements of transgene activity with potential applications in both preclinical and clinical settings...
  40. ncbi request reprint Targeted elimination of prostate cancer by genetically directed human T lymphocytes
    Terence P F Gade
    Department of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Cancer Res 65:9080-8. 2005
    ..These results thus provide a strong rationale for undertaking phase I clinical studies to assess PSMA-targeted T cells in patients with metastatic prostate cancer...
  41. pmc Pten dose dictates cancer progression in the prostate
    Lloyd C Trotman
    Molecular Biology Program, Memorial Sloan Kettering Cancer Center, Sloan Kettering Institute, New York, New York, USA
    PLoS Biol 1:E59. 2003
    ..Our results provide conclusive genetic support for the notion that PTEN is haploinsufficient in tumor suppression and that its dose is a key determinant in cancer progression...
  42. ncbi request reprint Dose-dependent effects of platelet-derived growth factor-B on glial tumorigenesis
    Alan H Shih
    Department of Cancer Biology and Genetics, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
    Cancer Res 64:4783-9. 2004
    ..Our data show that PDGFR signaling quantitatively regulates tumor grade and is required to sustain high-grade oligodendrogliomas...
  43. pmc Atrasentan (ABT-627) enhances perfusion and reduces hypoxia in a human tumor xenograft model
    Kwang Mo Yang
    Department of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, NY, USA
    Cancer Biol Ther 8:1940-6. 2009
    ..Although Atrasentan had no independent effect on the growth of HT29 tumors, Atrasentan combined with 20 Gy radiation led to a modest but significant increase in tumor growth delay compared to radiation alone...
  44. ncbi request reprint Preclinical evaluation of tumor microvascular response to a novel antiangiogenic/antitumor agent RO0281501 by dynamic contrast-enhanced MRI at 1.5 T
    Manickam Muruganandham
    Department of Medical Physics, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
    Mol Cancer Ther 5:1950-7. 2006
    ..Its effects on tumor vasculature can be monitored and assessed by DCE-MRI on a 1.5 T human MR scanner with clinically available gadopentetate dimeglumine contrast, which will facilitate clinical trials with this or similar agents...
  45. ncbi request reprint Development of a new reporter gene system--dsRed/xanthine phosphoribosyltransferase-xanthine for molecular imaging of processes behind the intact blood-brain barrier
    Mikhail Doubrovin
    Memorial Sloan Kettering Cancer Center, 1275 York Avenue, Box 513, New York, NY 10021, USA
    Mol Imaging 2:93-112. 2003
    ..quot; Therefore, the novel dsRed/XPRT fusion gene can be used as a multimodality reporter system in the biological applications requiring two independent reporter genes, including the cells located behind the BBB...
  46. ncbi request reprint Osteogenic and Ewing sarcomas: estimation of necrotic fraction during induction chemotherapy with dynamic contrast-enhanced MR imaging
    Jonathan P Dyke
    Department of Radiology, Weill Medical College of Cornell University, 1300 York Ave, Box 234, New York, NY 10021 4885, USA
    Radiology 228:271-8. 2003
    ..The ability to determine response to induction chemotherapy by means of noninvasive monitoring of necrotic fraction with perfusion MR imaging methods may provide useful prognostic information and help surgical planning...
  47. pmc Noninvasive assessment of tumor microenvironment using dynamic contrast-enhanced magnetic resonance imaging and 18F-fluoromisonidazole positron emission tomography imaging in neck nodal metastases
    Jacobus F A Jansen
    Department of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    Int J Radiat Oncol Biol Phys 77:1403-10. 2010
    ....
  48. doi request reprint Imaging intratumoral convection: pressure-dependent enhancement in chemotherapeutic delivery to solid tumors
    Terence P F Gade
    Department of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Clin Cancer Res 15:247-55. 2009
    ..We investigated the hypothesis that improved intratumoral convection can alter tumor metabolism and enhance the delivery of a LMW chemotherapeutic agent to solid tumors...
  49. ncbi request reprint In vivo 5-fluorouracil and fluoronucleotide T1 relaxation time measurements using the variable nutation angle method
    Terence P F Gade
    Department of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Magn Reson Med 52:169-73. 2004
    ..The determined T1's for 5FU and FNuc (2.3 +/- 0.1 s and 1.3 +/- 0.1 s, respectively) represent the first reported in vivo measurements for these metabolites in tumor...
  50. ncbi request reprint In vivo tumor lactate relaxation measurements by selective multiple-quantum-coherence (Sel-MQC) transfer
    Manickam Muruganandham
    Department of Medical Physics and Radiology, Memorial Sloan Kettering Cancer Center, New York, New York, USA
    Magn Reson Med 52:902-6. 2004
    ..The present approach will allow investigators to correct for the relaxation-induced Lac signal loss in Sel-MQC experiments for the quantitative mapping of in vivo tumor Lac distribution...
  51. pmc Prostate cancer: correlation of MR imaging and MR spectroscopy with pathologic findings after radiation therapy-initial experience
    Darko Pucar
    Department of Radiology, Medical Physics, Epidemiology and Biostatistics, Urology, Pathology, and Medicine, Memorial Sloan Kettering Cancer Center, 1275 York Ave, New York, NY 10021, USA
    Radiology 236:545-53. 2005
    ..To prospectively evaluate magnetic resonance (MR) imaging and MR spectroscopy for depiction of local prostate cancer recurrence after external-beam radiation therapy, with step-section pathologic findings as the standard of reference...
  52. ncbi request reprint Metabolic signatures associated with a NAD synthesis inhibitor-induced tumor apoptosis identified by 1H-decoupled-31P magnetic resonance spectroscopy
    Manickam Muruganandham
    Department of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Clin Cancer Res 11:3503-13. 2005
    ..In the present study, we used 1H-decoupled phosphorus (31P) magnetic resonance spectroscopy (MRS) to examine the metabolic changes associated with FK866 induced tumor cell death in a mouse mammary carcinoma...
  53. ncbi request reprint In vivo 19F magnetic resonance spectroscopy and chemical shift imaging of tri-fluoro-nitroimidazole as a potential hypoxia reporter in solid tumors
    Daniel Procissi
    Department of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, New York, USA
    Clin Cancer Res 13:3738-47. 2007
    ....
  54. ncbi request reprint Detection and quantitative analysis of early stage orthotopic murine bladder tumor using in vivo magnetic resonance imaging
    Eiji Kikuchi
    Department of Urology, Memorial Sloan Kettering Cancer Center, New York, New York, USA
    J Urol 170:1375-8. 2003
    ..We evaluated in vivo magnetic resonance imaging (MRI) as a noninvasive method for early detection and quantitative measurements of superficial tumors in an orthotopic murine bladder tumor model...
  55. pmc Crucial role of p53-dependent cellular senescence in suppression of Pten-deficient tumorigenesis
    Zhenbang Chen
    Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, Sloan Kettering Institute, 1275 York Avenue, New York, New York 10021, USA
    Nature 436:725-30. 2005
    ..Our results demonstrate the relevance of cellular senescence in restricting tumorigenesis in vivo and support a model for cooperative tumour suppression in which p53 is an essential failsafe protein of Pten-deficient tumours...
  56. ncbi request reprint Magnetic resonance spectroscopy and clinical cancer prognosis
    Kristen L Zakian
    Acad Radiol 11:365-7. 2004
  57. ncbi request reprint Prediction of treatment response of head and neck cancers with P-31 MR spectroscopy from pretreatment relative phosphomonoester levels
    Amita Shukla-Dave
    Dept of Radiology, University of Pennsylvania Medical Center, Philadelphia, USA
    Acad Radiol 9:688-94. 2002
    ..Frequent regional node involvement facilitates surface coil investigation with phosphorus-31 magnetic resonance spectroscopy...
  58. pmc The absence of p53 promotes metastasis in a novel somatic mouse model for hepatocellular carcinoma
    Brian C Lewis
    University of Massachusetts Medical School, 364 Plantation St, LRB 521, Worcester, MA 01605, USA
    Mol Cell Biol 25:1228-37. 2005
    ..Tumors induced in p53 null, TVA transgenic mice by PyMT mutants with changes in specific tyrosine residues fail to form metastases, indicating that metastasis is dependent on both the oncogene and the absence of p53...
  59. ncbi request reprint Evidence for shutter-speed variation in CR bolus-tracking studies of human pathology
    Thomas E Yankeelov
    Chemistry Department, Brookhaven National Laboratory, Upton, NY 11973, USA
    NMR Biomed 18:173-85. 2005
    ..Normal muscle regions in the leg allow validation of the shutter-speed model K(trans), v(e), and tau(i) magnitudes, by comparison with results of previous careful rat leg studies not possible for human subjects...

Research Grants12

  1. 500 MHz Wide Bore NMR System
    Jason Koutcher; Fiscal Year: 2002
    ..Thus this proposal, if funded , will support a very broad base of scientist and medical researchers in this area. ..
  2. 9.4T/20 cm MRI for Cancer Research
    Jason Koutcher; Fiscal Year: 2007
    ..The approaches to addressing these problems are quite varied but have in common the feasibility to readily translate any of these findings from the preclinical to the clinical realm, based on existing technology. ..
  3. Cytocidal Therapy In Vivo for Drug-Resistant Tumors
    Jason Koutcher; Fiscal Year: 2007
    ..If validated clinically, the proposed therapy will open the way for cure of metastatic breast cancer, and the therapeutic strategy likely will apply to other drug-resistant types of cancer. ..
  4. Memorial Sloan Kettering Small Animal Imaging Research
    Jason Koutcher; Fiscal Year: 2007
    ..abstract_text> ..
  5. Dynamic Magnetic Resonance Imaging of Bone Tumors
    Jason Koutcher; Fiscal Year: 2007
    ..If successful, it will provide a tool to predict failure/response to chemotherapy, resulting in patient specific treatment which will likely enhance outcome. ..
  6. Optimizing Chemotherapy Dose Using 31P NMR Spectroscopy
    Jason Koutcher; Fiscal Year: 2006
    ..The doses determined in these studies, will allow further Phase II studies of this strategy. If measurements of 6PG in peripheral blood lymphocytes correlate with tumor 6PG, future studies would not require further NMR studies. ..
  7. Memorial Sloan Kettering Small Animal Imaging Research
    Jason Koutcher; Fiscal Year: 2006
    ..abstract_text> ..
  8. Dynamic Magnetic Resonance Imaging of Bone Tumors
    Jason Koutcher; Fiscal Year: 2006
    ..If successful, it will provide a tool to predict failure/response to chemotherapy, resulting in patient specific treatment which will likely enhance outcome. ..
  9. Cytocidal Therapy In Vivo for Drug-Resistant Tumors
    Jason Koutcher; Fiscal Year: 2005
    ..If validated clinically, the proposed therapy will open the way for cure of metastatic breast cancer, and the therapeutic strategy likely will apply to other drug-resistant types of cancer. ..
  10. Dynamic Magnetic Resonance Imaging of Bone Tumors
    Jason Koutcher; Fiscal Year: 2005
    ..If successful, it will provide a tool to predict failure/response to chemotherapy, resulting in patient specific treatment which will likely enhance outcome. ..
  11. Dynamic Magnetic Resonance Imaging of Bone Tumors
    Jason Koutcher; Fiscal Year: 2004
    ..If successful, it will provide a tool to predict failure/response to chemotherapy, resulting in patient specific treatment which will likely enhance outcome. ..