D S Klimstra

Summary

Affiliation: Memorial Sloan-Kettering Cancer Center
Country: USA

Publications

  1. doi request reprint Histopathologic and immunohistochemical features of tissue adherent to multitined electrodes after RF ablation of liver malignancies can help predict local tumor progression: initial results
    Constantinos T Sofocleous
    Section of Interventional Radiology, Memorial Sloan Kettering Cancer Center, 1275 York Ave, Room H 118, New York, NY 10065, USA
    Radiology 249:364-74. 2008
  2. ncbi request reprint Nonductal neoplasms of the pancreas
    David S Klimstra
    Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, USA
    Mod Pathol 20:S94-112. 2007
  3. doi request reprint Pathology reporting of neuroendocrine tumors: essential elements for accurate diagnosis, classification, and staging
    David S Klimstra
    Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    Semin Oncol 40:23-36. 2013
  4. pmc Genome wide analysis and clinical correlation of chromosomal and transcriptional mutations in cancers of the biliary tract
    George Miller
    Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    J Exp Clin Cancer Res 28:62. 2009
  5. ncbi request reprint The 2006 Fred Waldorf Stewart Award recipient Juan Rosai, MD
    David S Klimstra
    Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Am J Surg Pathol 31:649-51. 2007
  6. doi request reprint An algorithmic approach to the diagnosis of pancreatic neoplasms
    David S Klimstra
    Department of Pathology, Memorial Sloan Kettering Cancer Center, 1275 York Ave, New York, NY 10065, USA
    Arch Pathol Lab Med 133:454-64. 2009
  7. doi request reprint The pathologic classification of neuroendocrine tumors: a review of nomenclature, grading, and staging systems
    David S Klimstra
    Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    Pancreas 39:707-12. 2010
  8. ncbi request reprint Cystic, mucin-producing neoplasms of the pancreas: the distinguishing features of mucinous cystic neoplasms and intraductal papillary mucinous neoplasms
    David S Klimstra
    Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Semin Diagn Pathol 22:318-29. 2005
  9. doi request reprint Intraductal papillary mucinous neoplasms of the pancreas: clinical and pathological features and diagnostic approach
    N Katabi
    Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    J Clin Pathol 61:1303-13. 2008
  10. ncbi request reprint Solid-pseudopapillary tumor of the pancreas: a typically cystic carcinoma of low malignant potential
    D S Klimstra
    Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Semin Diagn Pathol 17:66-80. 2000

Detail Information

Publications93

  1. doi request reprint Histopathologic and immunohistochemical features of tissue adherent to multitined electrodes after RF ablation of liver malignancies can help predict local tumor progression: initial results
    Constantinos T Sofocleous
    Section of Interventional Radiology, Memorial Sloan Kettering Cancer Center, 1275 York Ave, Room H 118, New York, NY 10065, USA
    Radiology 249:364-74. 2008
    ..To determine whether histopathologic and immunohistochemical features of tissue adherent to electrodes after radiofrequency (RF) ablation of liver malignancies can help predict local tumor progression (LTP)...
  2. ncbi request reprint Nonductal neoplasms of the pancreas
    David S Klimstra
    Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, USA
    Mod Pathol 20:S94-112. 2007
    ..This review details the clinical and pathologic features of these nonductal neoplasms, highlighting diagnostic criteria including the use of specific immunohistochemical stains to define the cellular differentiation of the neoplasms...
  3. doi request reprint Pathology reporting of neuroendocrine tumors: essential elements for accurate diagnosis, classification, and staging
    David S Klimstra
    Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    Semin Oncol 40:23-36. 2013
    ..This review will present the most widely used systems for classifying, grading, and staging NETs and will summarize the recommendations for the data to be included in standard pathology reports of these uncommon tumors...
  4. pmc Genome wide analysis and clinical correlation of chromosomal and transcriptional mutations in cancers of the biliary tract
    George Miller
    Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    J Exp Clin Cancer Res 28:62. 2009
    ..The pathogenesis of biliary cancers is ill-defined. This study investigates changes in gene expression and copy number in biliary cancers and correlates these changes with anatomical site of origin, histopathology and outcome...
  5. ncbi request reprint The 2006 Fred Waldorf Stewart Award recipient Juan Rosai, MD
    David S Klimstra
    Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Am J Surg Pathol 31:649-51. 2007
  6. doi request reprint An algorithmic approach to the diagnosis of pancreatic neoplasms
    David S Klimstra
    Department of Pathology, Memorial Sloan Kettering Cancer Center, 1275 York Ave, New York, NY 10065, USA
    Arch Pathol Lab Med 133:454-64. 2009
    ..The pancreas gives rise to an array of distinct neoplasms that can be solid, cystic, or intraductal and can recapitulate the various lines of differentiation present in the normal gland...
  7. doi request reprint The pathologic classification of neuroendocrine tumors: a review of nomenclature, grading, and staging systems
    David S Klimstra
    Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    Pancreas 39:707-12. 2010
    ....
  8. ncbi request reprint Cystic, mucin-producing neoplasms of the pancreas: the distinguishing features of mucinous cystic neoplasms and intraductal papillary mucinous neoplasms
    David S Klimstra
    Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Semin Diagn Pathol 22:318-29. 2005
    ..The purpose of this review is to highlight the clinical and pathological characteristics of MCNs and IPMNs, with an emphasis of the features that distinguish them and allow proper pathological subclassification...
  9. doi request reprint Intraductal papillary mucinous neoplasms of the pancreas: clinical and pathological features and diagnostic approach
    N Katabi
    Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    J Clin Pathol 61:1303-13. 2008
    ..This review addresses the clinical and pathological features of IPMNs, emphasising their diagnostic criteria, differential diagnosis and biological behaviour. Problematic issues in the pathological evaluation of IPMNs are discussed...
  10. ncbi request reprint Solid-pseudopapillary tumor of the pancreas: a typically cystic carcinoma of low malignant potential
    D S Klimstra
    Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Semin Diagn Pathol 17:66-80. 2000
    ..Nonetheless, the biological behavior of solid-pseudopapillary tumor is well established. The tumor is indolent, with infrequent metastases to liver or peritoneum and usually long survival, even in the presence of disseminated disease...
  11. ncbi request reprint Lymphoplasmacytic sclerosing (autoimmune) pancreatitis
    David S Klimstra
    Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Semin Diagn Pathol 21:237-46. 2004
    ..This review presents the defining clinical and pathologic features of LPSP and discusses the ongoing efforts to understand the pathogenesis of this disease...
  12. doi request reprint Pathology reporting of neuroendocrine tumors: application of the Delphic consensus process to the development of a minimum pathology data set
    David S Klimstra
    Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    Am J Surg Pathol 34:300-13. 2010
    ..Examination of the areas of disagreement reveals significant opportunities for collaborative study to resolve unanswered questions...
  13. pmc The c-myc and PyMT oncogenes induce different tumor types in a somatic mouse model for pancreatic cancer
    Brian C Lewis
    Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Genes Dev 17:3127-38. 2003
    ..Our model appears to be useful for elucidating the genetic alterations, target cells, and signaling pathways that are important in the genesis of different types of pancreatic cancer...
  14. ncbi request reprint Colloid (mucinous noncystic) carcinoma of the pancreas
    N V Adsay
    Department of Pathology, Karmanos Cancer Institute, Harper Hospital, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    Am J Surg Pathol 25:26-42. 2001
    ..The luminalization of the basal aspects of the tumor cells may be the cause of stromal mucin accumulation that characterizes colloid carcinoma and may act as a containing factor...
  15. ncbi request reprint Immunohistochemical and genetic analysis of non-small cell and small cell gallbladder carcinoma and their precursor lesions
    Anil V Parwani
    Department of Pathology, The Johns Hopkins Hospital, Baltimore, Maryland 21231 2410, USA
    Mod Pathol 16:299-308. 2003
    ..It is noteworthy that all of these alterations occur at the level of carcinoma in situ...
  16. ncbi request reprint Cystic forms of typically solid pancreatic tumors
    N V Adsay
    Department of Pathology, The Karmanos Cancer Institute, Harper Hospital, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Semin Diagn Pathol 17:81-8. 2000
    ....
  17. ncbi request reprint A phase II trial of neoadjuvant cisplatin-fluorouracil followed by postoperative intraperitoneal floxuridine-leucovorin in patients with locally advanced gastric cancer
    B Brenner
    Gastrointestinal Oncology Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, Cornell University of New York, New York 10021, USA
    Ann Oncol 17:1404-11. 2006
    ..v.) cisplatin and fluorouracil (5-FU), surgery and postoperative intraperitoneal (i.p.) floxuridine (FUdR) and leucovorin (LV) in patients with locally advanced gastric cancer...
  18. ncbi request reprint Results of total pancreatectomy for adenocarcinoma of the pancreas
    H M Karpoff
    Department of Surgery, Memorial Sloan-Kettering Cancer Center, 1275 York Ave, New York, NY 10021, USA
    Arch Surg 136:44-7; discussion 48. 2001
    ..In patients who require total pancreatectomy for ductal adenocarcinoma, the survival is so poor as to bring into question the value of the operation...
  19. pmc Preferential expression of MUC6 in oncocytic and pancreatobiliary types of intraductal papillary neoplasms highlights a pyloropancreatic pathway, distinct from the intestinal pathway, in pancreatic carcinogenesis
    Olca Basturk
    Departments of Pathology, New York University, NY, USA
    Am J Surg Pathol 34:364-70. 2010
    ....
  20. doi request reprint Clinical significance of intraoperative bile duct margin assessment for hilar cholangiocarcinoma
    Itaru Endo
    Department of Surgery, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA
    Ann Surg Oncol 15:2104-12. 2008
    ..Frozen section analysis of bile duct margins is often used to guide the extent of surgical resection for hilar cholangiocarcinoma (HCCA), but the usefulness of this practice is unknown...
  21. ncbi request reprint Clinically aggressive solid pseudopapillary tumors of the pancreas: a report of two cases with components of undifferentiated carcinoma and a comparative clinicopathologic analysis of 34 conventional cases
    Laura H Tang
    Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Am J Surg Pathol 29:512-9. 2005
    ..The possibility that these tumors represent high-grade malignant transformation of a conventional low-grade SPT is proposed...
  22. ncbi request reprint Intraductal and papillary variants of acinar cell carcinomas: a new addition to the challenging differential diagnosis of intraductal neoplasms
    Olca Basturk
    Department of Pathology, Wayne State University and Karmanos Cancer Institute, Detroit, MI 48201, USA
    Am J Surg Pathol 31:363-70. 2007
    ..The clinical significance of this variant is difficult to determine; however, it appears that the tumors are relatively small and metastasis at presentation is less common than typically seen in ACCs (1/7 vs. 50%)...
  23. ncbi request reprint Expression of novel markers of pancreatic ductal adenocarcinoma in pancreatic nonductal neoplasms: additional evidence of different genetic pathways
    Dengfeng Cao
    Department of Pathology, The Johns Hopkins Medical Institutions, Baltimore, MD 21231 2410, USA
    Mod Pathol 18:752-61. 2005
    ....
  24. ncbi request reprint Does graded histologic response after neoadjuvant chemotherapy predict survival for completely resected gastric cancer?
    John C Mansour
    Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
    Ann Surg Oncol 14:3412-8. 2007
    ..After publication of the MAGIC trial results, preoperative chemotherapy is increasingly used to treat advanced gastric cancer before resection. Tools for measuring response must be assessed...
  25. doi request reprint Use of immunohistochemistry for IgG4 in the distinction of autoimmune pancreatitis from peritumoral pancreatitis
    Deepti Dhall
    Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    Hum Pathol 41:643-52. 2010
    ....
  26. ncbi request reprint Management of primary liver sarcomas
    Juürgen Weitz
    Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York, USA
    Cancer 109:1391-6. 2007
    ..Primary hepatic sarcoma is a rare entity. The objectives of the study were to define treatment and long-term outcome and to identify prognostic factors...
  27. ncbi request reprint Differential cell cycle-regulatory protein expression in biliary tract adenocarcinoma: correlation with anatomic site, pathologic variables, and clinical outcome
    William R Jarnagin
    Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    J Clin Oncol 24:1152-60. 2006
    ..This clinicopathologic study characterizes differences in cell cycle-regulatory protein expression across the spectrum of BTA...
  28. ncbi request reprint Cetuximab shows activity in colorectal cancer patients with tumors that do not express the epidermal growth factor receptor by immunohistochemistry
    Ki Young Chung
    Gastrointestinal Oncology Service, Memorial Sloan Kettering Cancer Center, H 816, New York, NY 10021, USA
    J Clin Oncol 23:1803-10. 2005
    ....
  29. ncbi request reprint Comparison of two antibodies for immunohistochemical evaluation of epidermal growth factor receptor expression in colorectal carcinomas, adenomas, and normal mucosa
    Rohit Bhargava
    Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Cancer 106:1857-62. 2006
    ..Two antibodies, the PharmDx kit and the 31G7 clone, are used commonly for immunohistochemistry by various laboratories. No comparative studies on the performance of these 2 antibodies are available...
  30. doi request reprint Immunohistochemical expression of folate receptor alpha in colorectal carcinoma: patterns and biological significance
    Jinru Shia
    Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Hum Pathol 39:498-505. 2008
    ..The significance of such an association as well as the prognostic value of FRalpha expression deserves further exploration...
  31. ncbi request reprint High-grade neuroendocrine carcinoma of the ampulla of vater: a clinicopathologic and immunohistochemical analysis of 14 cases
    Hind Nassar
    Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Am J Surg Pathol 29:588-94. 2005
    ..Thus, there are differences in the molecular phenotypes of these two types of ampullary carcinoma, supporting the distinction of poorly differentiated carcinomas with a neuroendocrine phenotype from those without...
  32. ncbi request reprint Limitations of ampullectomy in the treatment of nonfamilial ampullary neoplasms
    Kevin K Roggin
    Department of Surgery, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
    Ann Surg Oncol 12:971-80. 2005
    ....
  33. doi request reprint Immunohistochemical staining for DNA mismatch repair proteins in intestinal tract carcinoma: how reliable are biopsy samples?
    Jinru Shia
    Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Am J Surg Pathol 35:447-54. 2011
    ..However, whether biopsy samples can be reliably used for mismatch repair protein detection remains to be determined...
  34. pmc Papillary phenotype confers improved survival after resection of hilar cholangiocarcinoma
    William R Jarnagin
    Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Ann Surg 241:703-12; discussion 712-4. 2005
    ..The current study compares outcome after resection of papillary hilar cholangiocarcinoma to that of the more common nodular-sclerosing subtype...
  35. ncbi request reprint Epidermal growth factor receptor expression and gene amplification in colorectal carcinoma: an immunohistochemical and chromogenic in situ hybridization study
    Jinru Shia
    Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Mod Pathol 18:1350-6. 2005
    ..Additional studies are needed to determine whether epidermal growth factor receptor gene amplification bears any informative value in predicting response to cetuximab-based therapy...
  36. doi request reprint Pathologic classification and clinical behavior of the spectrum of goblet cell carcinoid tumors of the appendix
    Laura H Tang
    Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    Am J Surg Pathol 32:1429-43. 2008
    ..Surgical management with right hemicolectomy is recommended after appendectomy for most cases, particularly those with an adenocarcinoma component (groups B and C)...
  37. ncbi request reprint Clinical characteristics and outcomes from an institutional series of acinar cell carcinoma of the pancreas and related tumors
    Kyle D Holen
    Memorial Sloan Kettering Cancer Center, Gastrointestinal Oncology Service, Department of Medicine, New York, NY 10021, USA
    J Clin Oncol 20:4673-8. 2002
    ..Acinar cell carcinoma is a rare tumor of the exocrine pancreas. Clinical features such as prognostic information, survival, and treatment outcomes are unknown. We present the largest retrospective review to date...
  38. pmc Activation of PyMT in beta cells induces irreversible hyperplasia, but oncogene-dependent acinar cell carcinomas when activated in pancreatic progenitors
    Yi Chieh Nancy Du
    Program in Cancer Biology and Genetics, Memorial Sloan Kettering Cancer Center, New York, New York, USA
    PLoS ONE 4:e6932. 2009
    ....
  39. ncbi request reprint Differential expression of alpha-methylacyl-coenzyme A racemase in colorectal carcinoma bears clinical and pathologic significance
    Anne Lin
    Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Hum Pathol 38:850-6. 2007
    ..Further investigation on interaction between AMACR and other known colorectal cancer development pathways may provide new insights on colorectal carcinogenesis...
  40. doi request reprint A phase 1 dose-escalation study of irinotecan in combination with 17-allylamino-17-demethoxygeldanamycin in patients with solid tumors
    Archie N Tse
    Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Clin Cancer Res 14:6704-11. 2008
    ..We conducted a phase I study of irinotecan and the Hsp90 inhibitor 17AAG, which can also down-regulate Chk1, in patients with solid tumors...
  41. ncbi request reprint Intraductal papillary-mucinous neoplasms of the pancreas: an analysis of in situ and invasive carcinomas in 28 patients
    N Volkan Adsay
    Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York 1002, USA
    Cancer 94:62-77. 2002
    ..Associated invasive carcinomas, reported to occur in up to 30% of patients, often are mucinous and clinically indolent...
  42. doi request reprint A novel prognostic nomogram is more accurate than conventional staging systems for predicting survival after resection of hepatocellular carcinoma
    Clifford S Cho
    Hepatobiliary Service, Memorial Sloan Kettering Cancer Center, New York, NY, USA
    J Am Coll Surg 206:281-91. 2008
    ..Numerous staging systems have been devised for purposes of risk classification; we sought to identify the optimal staging system to predict postoperative survival...
  43. pmc Use of avian retroviral vectors to introduce transcriptional regulators into mammalian cells for analyses of tumor maintenance
    William Pao
    Departments of Medicine, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 100:8764-9. 2003
    ....
  44. ncbi request reprint Value of histopathology in predicting microsatellite instability in hereditary nonpolyposis colorectal cancer and sporadic colorectal cancer
    Jinru Shia
    Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY 10002, USA
    Am J Surg Pathol 27:1407-17. 2003
    ..Using a stepwise logistic regression model, a formula was generated that could be used to calculate the probability of a colorectal carcinoma being MSI-H based on morphologic features...
  45. ncbi request reprint Barrett's esophagus and adenocarcinoma of the gastroesophageal junction: a pathologic perspective
    Laura H Tang
    Department of Pathology, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, Room C507, New York, NY 10021, USA
    Surg Oncol Clin N Am 15:715-32. 2006
    ..The potential identification and isolation of markers for screening purposes and possibly prognostic information are areas of considerable clinical and scientific interest...
  46. doi request reprint Pancreatic adenocarcinoma in a young patient population--12-year experience at Memorial Sloan Kettering Cancer Center
    A Duffy
    Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA
    J Surg Oncol 100:8-12. 2009
    ..This report examines a large cohort of patients with PAC <or=45 years of age evaluated at MSKCC over a 12-year period...
  47. ncbi request reprint Pancreatic tumors with cystic dilatation of the ducts: intraductal papillary mucinous neoplasms and intraductal oncocytic papillary neoplasms
    N V Adsay
    Department of Pathology, The Karmanos Cancer Institute, Harper Hospital, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Semin Diagn Pathol 17:16-30. 2000
    ..Therefore, IPMNs and IOPNs should be examined carefully and sampled extensively, first, to confirm that the main pathology is an intraductal process and, more importantly, to rule out the presence of an invasive carcinoma...
  48. ncbi request reprint Lipid-rich variant of pancreatic endocrine neoplasms
    Rajendra Singh
    Department of Pathology, Harper Hospital and Karmanos Cancer Institute, Wayne State University, Detroit, MI 48201, USA
    Am J Surg Pathol 30:194-200. 2006
    ..EM supports the name lipid-rich for this variant. The findings suggest that the pathogenesis of lipid-rich tumors may be different from the VHL-associated clear-cell variants of PENs...
  49. ncbi request reprint Positive immunohistochemical staining of KIT in solid-pseudopapillary neoplasms of the pancreas is not associated with KIT/PDGFRA mutations
    Dengfeng Cao
    Department of Pathology, The Sol Goldman Pancreatic Cancer Research Center, The Johns Hopkins Medical Institutions, Baltimore, MD, USA
    Mod Pathol 19:1157-63. 2006
    ....
  50. doi request reprint Perihepatic lymph node micrometastases impact outcome after partial hepatectomy for colorectal metastases
    Joseph J Bennett
    Division of Hepatobiliary Surgery, Department of Surgery, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA
    Ann Surg Oncol 15:1130-6. 2008
    ..This study uses standard pathologic analysis and immunohistochemistry (IHC) to determine the impact of occult metastatic disease to perihepatic LN in patients with colorectal cancer undergoing hepatectomy...
  51. ncbi request reprint Clinical and pathologic features of proximal biliary strictures masquerading as hilar cholangiocarcinoma
    Carlos U Corvera
    Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    J Am Coll Surg 201:862-9. 2005
    ..Nontraumatic inflammatory hilar strictures are uncommon, but are known to mimic malignancy. This study examines the clinical and pathologic features of benign idiopathic strictures...
  52. doi request reprint Defining surgical indications for type I gastric carcinoid tumor
    Rebecca A Gladdy
    Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA
    Ann Surg Oncol 16:3154-60. 2009
    ..The management of this indolent disease is controversial. The aim of this study was to evaluate endoscopic surveillance (ES) compare with surgical resection (SR) for type I GC...
  53. doi request reprint Prognostic factors of recurrence in salivary carcinoma ex pleomorphic adenoma, with emphasis on the carcinoma histologic subtype: a clinicopathologic study of 43 cases
    Nora Katabi
    Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY 10075, USA
    Hum Pathol 41:927-34. 2010
    ..The presence of myoepithelial carcinoma subtype increases the risk of recurrence in carcinoma ex pleomorphic adenoma, especially within the group of intracapsular/minimally invasive tumors...
  54. ncbi request reprint Hepatic intraductal oncocytic papillary carcinoma
    Robert C G Martin
    Hepatobiliary Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Cancer 95:2180-7. 2002
    ..Intraductal oncocytic papillary carcinomas (IOPCs) of the liver present as large, mucin-filled, cystic lesions lined by noninvasive or focally microinvasive oncocytic tumors...
  55. ncbi request reprint Pathogenesis of colloid (pure mucinous) carcinoma of exocrine organs: Coupling of gel-forming mucin (MUC2) production with altered cell polarity and abnormal cell-stroma interaction may be the key factor in the morphogenesis and indolent behavior of collo
    N Volkan Adsay
    Department of Pathology, Karamanos Cancer Institute and Wayne State University, Detroit, Michigan 48201, USA
    Am J Surg Pathol 27:571-8. 2003
    ..This distinctive mucin, accumulated in the stroma surrounding the CC cells, may act as a containing factor, slackening the spread of the cells...
  56. pmc Biologic predictors of survival in node-negative gastric cancer
    David A Kooby
    Department of Surgery, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
    Ann Surg 237:828-35; discussion 835-7. 2003
    ..To evaluate factors predictive of survival following curative resection for node-negative gastric adenocarcinoma...
  57. ncbi request reprint Immunohistochemical staining of cytologic smears with MIB-1 helps distinguish low-grade from high-grade neuroendocrine neoplasms
    Oscar Lin
    Department of Pathology, Memorial Sloan Kettering Cancer Center, 1275 York Ave, New York, NY 10021, USA
    Am J Clin Pathol 120:209-16. 2003
    ..Our study demonstrates that MIB-1 dramatically stratifies NENs as low-grade or high-grade. Therefore, the proliferation index also correlates with grade of NEN in cytology specimens...
  58. ncbi request reprint Impact of steatosis on perioperative outcome following hepatic resection
    David A Kooby
    Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    J Gastrointest Surg 7:1034-44. 2003
    ..Steatosis alone should not preclude aggressive hepatic resection for neoplasms when indicated; however, patients with marked steatosis undergoing large resections should still be approached with due caution...
  59. ncbi request reprint Primary follicular lymphoma of the gastrointestinal tract: a clinical and pathologic study of 26 cases
    Jinru Shia
    Department of Pathology, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, U S A
    Am J Surg Pathol 26:216-24. 2002
    ..The estimated 5-year disease-free survival was 62%, and median disease-free survival was 69 months. The estimated 5-year relapse-free survival was 54%, and the median relapse-free survival was 63 months...
  60. ncbi request reprint Value of immunohistochemical detection of DNA mismatch repair proteins in predicting germline mutation in hereditary colorectal neoplasms
    Jinru Shia
    Department of Pathology, Memorial Sloan Kettering, Cancer Center, New York, NY 10021, USA
    Am J Surg Pathol 29:96-104. 2005
    ....
  61. ncbi request reprint The dichotomy in the preinvasive neoplasia to invasive carcinoma sequence in the pancreas: differential expression of MUC1 and MUC2 supports the existence of two separate pathways of carcinogenesis
    N Volkan Adsay
    Department of Pathology, Karmanos Cancer Institute, Detroit, Michigan, USA
    Mod Pathol 15:1087-95. 2002
    ....
  62. doi request reprint Is nonsmall cell type high-grade neuroendocrine carcinoma of the tubular gastrointestinal tract a distinct disease entity?
    Jinru Shia
    Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Am J Surg Pathol 32:719-31. 2008
    ..These tumors are clinically aggressive. Prospective studies using defined diagnostic criteria are needed to determine their biologic characteristics and optimal management...
  63. ncbi request reprint Malignant pancreatic tumors in childhood and adolescence: The Memorial Sloan-Kettering experience, 1967 to present
    Nicholas A Shorter
    Department of Surgery and Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, USA
    J Pediatr Surg 37:887-92. 2002
    ..As a result, the treatment approach to these patients has yet to be standardized, and much of the information available in the literature, particularly with regard to the role of chemotherapy and radiation, is anecdotal...
  64. ncbi request reprint Subclassification of gastrointestinal stromal tumors based on evaluation by electron microscopy and immunohistochemistry
    R A Erlandson
    Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Ultrastruct Pathol 20:373-93. 1996
    ..Despite their similar light microscopic appearance, GIST are phenotypically heterogeneous, requiring both ultrastructural and immunohistochemical studies for accurate characterization...
  65. ncbi request reprint Squamous-lined cysts of the pancreas: lymphoepithelial cysts, dermoid cysts (teratomas), and accessory-splenic epidermoid cysts
    N V Adsay
    Department of Pathology, The Karmanos Cancer Institute Detroit Medical Center, Wayne State University, MI 48076, USA
    Semin Diagn Pathol 17:56-65. 2000
    ..Subepithelial lymphoid tissue is not a feature. They are sometimes complicated by suppurative infections. The importance of these lesions is in their distinction from other cystic neoplasms, especially mucinous cystic tumors...
  66. ncbi request reprint Neuroendocrine carcinomas of the colon and rectum
    P E Bernick
    Colorectal Service, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Dis Colon Rectum 47:163-9. 2004
    ..This study was designed to review experience with neuroendocrine carcinomas of the colon and rectum at a single institution, with emphasis on the pathology and clinical characteristics of this uncommon malignancy...
  67. pmc Small-cell carcinoma of the gastrointestinal tract: a retrospective study of 64 cases
    B Brenner
    The Gastrointestinal Oncology Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Br J Cancer 90:1720-6. 2004
    ..Mixed tumour histology is common and may affect therapy. Surgery, combined with chemotherapy, should be considered for LD. The value of the VALSG system was implied and possible differences from small-cell lung cancer were noted...
  68. pmc Family history of cancer, body weight, and p53 nuclear overexpression in Duke's C colorectal cancer
    Z F Zhang
    Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Br J Cancer 71:888-93. 1995
    ..The results suggest that p53 overexpression may be related to genetic predisposition to colorectal cancer, and p53-positive and p53-negative colorectal cancers may be controlled by different aetiological pathways...
  69. ncbi request reprint Squamous-cell carcinoma of the rectum: a rare but curable tumor
    Caio S R Nahas
    Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Dis Colon Rectum 50:1393-400. 2007
    ..This study was designed to evaluate one institution's experience with treatment outcomes for rectal squamous-cell carcinoma...
  70. pmc Solid-pseudopapillary tumors of the pancreas are genetically distinct from pancreatic ductal adenocarcinomas and almost always harbor beta-catenin mutations
    Susan C Abraham
    Department of Pathology, Division of Gastrointestinal Liver Pathology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205 2196, USA
    Am J Pathol 160:1361-9. 2002
    ..Overexpression of p53 was limited to only 3 of 19 (15.8%) SPTs. These results emphasize the two distinct, divergent genetic pathways of neoplastic progression in pancreatic ductal and nonductal neoplasms...
  71. ncbi request reprint Increased endocrine cells in treated rectal adenocarcinomas: a possible reflection of endocrine differentiation in tumor cells induced by chemotherapy and radiotherapy
    Jinru Shia
    Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Am J Surg Pathol 26:863-72. 2002
    ..The possible mechanism for the increased endocrine cells in treated rectal adenocarcinomas may be related to induction of endocrine differentiation in tumor cells by cytotoxic insult...
  72. doi request reprint Immunohistochemistry as first-line screening for detecting colorectal cancer patients at risk for hereditary nonpolyposis colorectal cancer syndrome: a 2-antibody panel may be as predictive as a 4-antibody panel
    Jinru Shia
    Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, USA
    Am J Surg Pathol 33:1639-45. 2009
    ..Such a cost-effective approach carries significant implication, as immunohistochemistry is being widely used as first-line screening for HNPCC...
  73. ncbi request reprint Histopathological diagnosis of pancreatic intraepithelial neoplasia and intraductal papillary-mucinous neoplasms: interobserver agreement
    Daniel S Longnecker
    Department of Pathology, Dartmouth Hitchcock Medical Center, Lebanon, NH 03756, USA
    Pancreas 31:344-9. 2005
    ....
  74. ncbi request reprint Solid-pseudopapillary tumor of the pancreas: a surgical enigma?
    Robert C G Martin
    Gastric and Mixed Tumor Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Ann Surg Oncol 9:35-40. 2002
    ..This study was designed to define the clinicopathological characteristics and the effect of surgical intervention...
  75. ncbi request reprint Role of the DPC4 tumor suppressor gene in adenocarcinoma of the ampulla of Vater: analysis of 140 cases
    Denis M McCarthy
    Department of Pathology, The Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
    Mod Pathol 16:272-8. 2003
    ..Although ampullary and pancreatic adenocarcinomas share histologic and molecular features, ampullary carcinomas are less likely to show loss of Dpc4 expression or K-ras gene mutations...
  76. ncbi request reprint Determining prognosis in patients with pancreatic endocrine neoplasms: can the WHO classification system be simplified?
    Cristina R Ferrone
    Department of Surgery, Memorial Sloan Kettering Cancer Center, Howard 1223, 1275 York Ave, New York, NY 10021, USA
    J Clin Oncol 25:5609-15. 2007
    ..This study compares the prognostic value of a simplified staging and grading system with the WHO system in a large single-institution study...
  77. ncbi request reprint Pleomorphic pancreatic endocrine neoplasms: a variant commonly confused with adenocarcinoma
    Sui Y Zee
    Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Am J Surg Pathol 29:1194-200. 2005
    ..There does not appear to be prognostic significance to these nuclear changes, and the morphologic features of pleomorphic PENs otherwise resemble those of their conventional counterparts...
  78. ncbi request reprint Expression of thyroid transcription factor-1 and other markers in sclerosing hemangioma of the lung
    P B Illei
    Department of Pathology, Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA
    Arch Pathol Lab Med 125:1335-9. 2001
    ..2 likely represent entrapped metaplastic alveolar epithelium, whereas the papillary lining cells expressing only EMA more likely constitute true neoplastic cells similar to those in the solid areas...
  79. doi request reprint Acinar cell carcinoma of the pancreas metastatic to the ovary: a report of 4 cases
    Efsevia Vakiani
    Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    Am J Surg Pathol 32:1540-5. 2008
    ....
  80. pmc Sonic hedgehog acts at multiple stages during pancreatic tumorigenesis
    Jennifer P Morton
    Program in Gene Function and Expression, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Proc Natl Acad Sci U S A 104:5103-8. 2007
    ..Collectively, our findings demonstrate crucial roles for Shh signaling in multiple stages of pancreatic carcinogenesis...
  81. pmc Genetic and immunohistochemical analysis of pancreatic acinar cell carcinoma: frequent allelic loss on chromosome 11p and alterations in the APC/beta-catenin pathway
    Susan C Abraham
    Department of Pathology, Division of GI LiverPathology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205 2196, USA
    Am J Pathol 160:953-62. 2002
    ..These results indicate that ACCs are genetically distinct from pancreatic ductal adenocarcinomas, but some cases contain genetic alterations common to histologically similar pancreatoblastomas...
  82. doi request reprint The cellular composition of osteoclastlike giant cell-containing tumors of the pancreatobiliary tree
    Deepti Dhall
    Am J Surg Pathol 32:335-7; author response 337. 2008
  83. ncbi request reprint Acinar cell cystadenoma of the pancreas: a new entity?
    Giuseppe Zamboni
    Department of Pathology, University of Verona, Italy
    Am J Surg Pathol 26:698-704. 2002
    ..We therefore suggest the term acinar cell cystadenoma...
  84. ncbi request reprint Prognostic factors in pancreatic endocrine neoplasms: an analysis of 136 cases with a proposal for low-grade and intermediate-grade groups
    Steven N Hochwald
    Department of Surgery, University of Florida College of Medicine, Gainesville, FL, USA
    J Clin Oncol 20:2633-42. 2002
    ..The purpose of this study was to evaluate prognostic factors in pancreatic endocrine neoplasms recently treated at a single institution...
  85. ncbi request reprint Combined hepatocellular-cholangiocarcinoma: a histopathologic, immunohistochemical, and in situ hybridization study
    Satish K Tickoo
    Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Am J Surg Pathol 26:989-97. 2002
    ..The tumor followed an aggressive clinical course, with overall 3-and 5-year survival rates of 30% and 18%, and in the resected cases of 38% and 24%, respectively...
  86. doi request reprint Histologic grade is correlated with outcome after resection of hepatic neuroendocrine neoplasms
    Clifford S Cho
    Section of Surgical Oncology, University of Wisconsin School of Medicine and Public Health, H4 724 Clinical Sciences Center, 600 Highland Avenue, Madison, WI 53792 7375, USA
    Cancer 113:126-34. 2008
    ..Consequently, guidelines for treatment remain unclear. Current pathologic classification systems do not permit meaningful discrimination of hepatic neuroendocrine neoplasms...
  87. ncbi request reprint Aberrant p53 staining does not predict cisplatin resistance in locally advanced non-small cell lung cancer
    Elizabeth A Johnson
    Mayo Clinic Jacksonville, 4500 San Pablo Road, Jacksonville, FL 32224, USA
    Cancer Invest 20:686-92. 2002
    ..45%) (p = 0.042). A trend toward longer median survivals was seen in patients with positive p53 staining. This study does not support the ability of p53 staining to predict chemotherapy resistance...
  88. ncbi request reprint Classification of types of intraductal papillary-mucinous neoplasm of the pancreas: a consensus study
    Toru Furukawa
    Department of Molecular Pathology, Tohoku University School of Medicine, 2 1 Seiryomachi, Sendai, 980 8575, Japan
    Virchows Arch 447:794-9. 2005
    ..These definitions can be used for further analyses of the clinicopathological significance of the variations of IPMN...
  89. ncbi request reprint Ductuloinsular tumors of the pancreas: endocrine tumors with entrapped nonneoplastic ductules
    Susanne van Eeden
    Department of Pathology, Academic Medical Center, Amsterdam, The Netherlands
    Am J Surg Pathol 28:813-20. 2004
    ..quot;Pancreatic endocrine tumors with entrapped ductules" would be the preferred nomenclature since it better reflects the nonneoplastic nature of the ductules...
  90. ncbi request reprint Pathologically and biologically distinct types of epithelium in intraductal papillary mucinous neoplasms: delineation of an "intestinal" pathway of carcinogenesis in the pancreas
    N Volkan Adsay
    Departments of Pathology, Karmanos Cancer Institute and Wayne State University, Detroit, MI 48201, USA
    Am J Surg Pathol 28:839-48. 2004
    ....
  91. ncbi request reprint Intramucosal poorly differentiated colorectal carcinoma: can it be managed conservatively?
    Jinru Shia
    Am J Surg Pathol 32:1586-8; author reply 1588-9. 2008
  92. pmc Stabilization of beta-catenin induces pancreas tumor formation
    Patrick W Heiser
    Diabetes Center, University of California, San Francisco, CA, USA
    Gastroenterology 135:1288-300. 2008
    ..Here, we sought to address the role of beta-catenin signaling in pancreas tumorigenesis...
  93. ncbi request reprint Chronic pancreatitis or pancreatic ductal adenocarcinoma?
    N Volkan Adsay
    Department of Pathology, The Karmanos Cancer Institute and Wayne State University School of Medicine, Detroit, Michigan, USA
    Semin Diagn Pathol 21:268-76. 2004
    ..Combinations of these criteria should aid in the differential diagnosis of invasive ductal adenocarcinoma from benign/reactive ducts in the pancreas...