Research Topics
Genomes and Genes
Species | Robert J KleinSummaryAffiliation: Memorial Sloan-Kettering Cancer Center Country: USA Publications
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Detail Information
Publications
Complement factor H polymorphism in age-related macular degenerationRobert J Klein
Laboratory of Statistical Genetics, Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
Science 308:385-9. 2005..This polymorphism is in a region of CFH that binds heparin and C-reactive protein. The CFH gene is located on chromosome 1 in a region repeatedly linked to AMD in family-based studies...- Evaluation of multiple risk-associated single nucleotide polymorphisms versus prostate-specific antigen at baseline to predict prostate cancer in unscreened menRobert J Klein
Program in Cancer Biology and Genetics, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
Eur Urol 61:471-7. 2012..Although case-control studies have identified numerous single nucleotide polymorphisms (SNPs) associated with prostate cancer, the clinical role of these SNPs remains unclear... - Power analysis for genome-wide association studiesRobert J Klein
Program in Cancer Biology and Genetics, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY, USA
BMC Genet 8:58. 2007..To choose the proper sample size and genotyping platform for such studies, power calculations that take into account genetic model, tag SNP selection, and the population of interest are required... - Blood biomarker levels to aid discovery of cancer-related single-nucleotide polymorphisms: kallikreins and prostate cancerRobert J Klein
Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
Cancer Prev Res (Phila) 3:611-9. 2010..874 versus 0.866), providing proof in principle to clinical application for our findings... 
Germline BRCA mutations denote a clinicopathologic subset of prostate cancerDavid J Gallagher
Clinical Genetics Service, Department of Medicine, Urology Service, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
Clin Cancer Res 16:2115-21. 2010..Increased prostate cancer risk has been reported for BRCA mutation carriers, but BRCA-associated clinicopathologic features have not been clearly defined...- A replication study and genome-wide scan of single-nucleotide polymorphisms associated with pancreatic cancer risk and overall survivalJason A Willis
Program in Cancer Biology and Genetics, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
Clin Cancer Res 18:3942-51. 2012..To explore the effects of single-nucleotide polymorphisms (SNP) on pancreatic cancer risk and overall survival (OS)... - The 6q22.33 locus and breast cancer susceptibilityTomas Kirchhoff
Clinical Genetics Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA
Cancer Epidemiol Biomarkers Prev 18:2468-75. 2009..Further functional studies of candidate genes are in progress, and a large replication analysis is being completed as part of an international consortium... - Susceptibility loci associated with prostate cancer progression and mortalityDavid J Gallagher
Department of Medicine, Clinical Genetics Service, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, Albert Einstein College of Medicine, New York, New York 10065, USA
Clin Cancer Res 16:2819-32. 2010..Prostate cancer is a heterogeneous disease with a variable natural history that is not accurately predicted by currently used prognostic tools... - Polymorphisms at the Microseminoprotein-beta locus associated with physiologic variation in beta-microseminoprotein and prostate-specific antigen levelsXing Xu
Program in Cancer Biology and Genetics, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA
Cancer Epidemiol Biomarkers Prev 19:2035-42. 2010..Therefore, we wished to determine the association between SNPs at MSMB, the gene encoding beta-MSP, and the levels of prostate-produced biomarkers beta-MSP, PSA, and human kallikrein 2 (hK2) in blood and semen... - Analysis of genetic variation in Ashkenazi Jews by high density SNP genotypingAdam B Olshen
Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA
BMC Genet 9:14. 2008..435,632 SNPs overlapped and met annotation criteria in the two groups... - Including additional controls from public databases improves the power of a genome-wide association studySemanti Mukherjee
Gerstner Sloan Kettering Graduate School of Biomedical Sciences, Memorial Sloan Kettering Cancer Center, New York, USA
Hum Hered 72:21-34. 2011..Thus, through an empirical approach, this report provides practical guidance for using additional controls from publicly available datasets... - Common genetic variants and modification of penetrance of BRCA2-associated breast cancerMia M Gaudet
Department of Epidemiology and Population Health and Department of Obstetrics and Gynecology and Women s Health, Albert Einstein College of Medicine, New York, New York, United States of America
PLoS Genet 6:e1001183. 2010..28, 95% CI 1.18-1.39, ). These results indicate that SNPs that modify BRCA2 penetrance identified by an agnostic approach thus far are limited to variants that also modify risk of sporadic BRCA2 wild-type breast cancer... - Analysis of genetic variants in never-smokers with lung cancer facilitated by an Internet-based blood collection protocol: a preliminary reportNicolas Girard
Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York, USA
Clin Cancer Res 16:755-63. 2010..We hypothesized that we could use the Internet to bolster the accrual of appropriate patients... - Genome-wide association studies of cancerZsofia K Stadler
Clinical Genetics Service andthe Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, NY, NY 10021, USA
J Clin Oncol 28:4255-67. 2010..To date, however, the clinical utility of GWAS-derived risk markers remains limited... - A germline JAK2 SNP is associated with predisposition to the development of JAK2(V617F)-positive myeloproliferative neoplasmsOuti Kilpivaara
Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA
Nat Genet 41:455-9. 2009..We found that JAK2(V617F) is preferentially acquired in cis with the predisposition allele. These data suggest that germline variation is an important contributor to MPN phenotype and predisposition... - Rare de novo germline copy-number variation in testicular cancerZsofia K Stadler
Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
Am J Hum Genet 91:379-83. 2012.... - Susceptibility loci associated with specific and shared subtypes of lymphoid malignanciesJoseph Vijai
Clinical Genetics Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York, USA
PLoS Genet 9:e1003220. 2013..These results, showing novel susceptibility regions and allelic heterogeneity, point to the existence of pathways of susceptibility to both shared as well as specific subtypes of lymphoid malignancy... - Predicting functionally important SNP classes based on negative selectionMark A Levenstien
Program in Cancer Biology and Genetics, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
BMC Bioinformatics 12:26. 2011..We aim to identify and prioritize groups of SNPs that are more likely to affect phenotypes in order to facilitate efficient SNP selection for follow-up studies... - Genome-wide association study provides evidence for a breast cancer risk locus at 6q22.33Bert Gold
Laboratory of Genomic Diversity, Human Genetics Section, National Cancer Institute Frederick, Frederick, MD 21702, USA
Proc Natl Acad Sci U S A 105:4340-5. 2008..Candidate genes in the 6q22.33 region include ECHDC1, which encodes a protein involved in mitochondrial fatty acid oxidation, and also RNF146, which encodes a ubiquitin protein ligase, both known pathways in breast cancer pathogenesis... 
Linkage disequilibrium mapping for complex disease genesAndrew Dewan
Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, CT, USA
Methods Mol Biol 376:85-107. 2007..The chapter covers issues such as study design, high-throughput genotyping technologies, statistical analysis, and others. Many of the materials are based on and related to our recent experiences in case-control-association studies...- Strong association of the Y402H variant in complement factor H at 1q32 with susceptibility to age-related macular degenerationSepideh Zareparsi
Department of Ophthalmology and Visual Sciences, University of Michigan, Ann Arbor, MI, USA
Am J Hum Genet 77:149-53. 2005..39 (95% confidence interval 0.36-0.42) and the genotype relative risk to be 2.44 (95% confidence interval 2.08-2.83) for TC heterozygotes and 5.93 (95% confidence interval 4.33-8.02) for CC homozygotes... - RSEARCH: finding homologs of single structured RNA sequencesRobert J Klein
Howard Hughes Medical Institute and Department of Genetics, Washington University School of Medicine, Saint Louis, Missouri 63110, USA
BMC Bioinformatics 4:44. 2003..No programs have yet been published that allow searching a sequence database for homologs of a single RNA molecule on the basis of secondary structure...