Robert J Klein

Summary

Affiliation: Memorial Sloan-Kettering Cancer Center
Country: USA

Publications

  1. pmc Complement factor H polymorphism in age-related macular degeneration
    Robert J Klein
    Laboratory of Statistical Genetics, Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Science 308:385-9. 2005
  2. pmc Genetic architecture of prostate cancer in the Ashkenazi Jewish population
    J Vijai
    Clinical Genetics Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    Br J Cancer 105:864-9. 2011
  3. pmc Evaluation of multiple risk-associated single nucleotide polymorphisms versus prostate-specific antigen at baseline to predict prostate cancer in unscreened men
    Robert J Klein
    Program in Cancer Biology and Genetics, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    Eur Urol 61:471-7. 2012
  4. pmc Power analysis for genome-wide association studies
    Robert J Klein
    Program in Cancer Biology and Genetics, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY, USA
    BMC Genet 8:58. 2007
  5. pmc Blood biomarker levels to aid discovery of cancer-related single-nucleotide polymorphisms: kallikreins and prostate cancer
    Robert J Klein
    Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    Cancer Prev Res (Phila) 3:611-9. 2010
  6. pmc Germline BRCA mutations denote a clinicopathologic subset of prostate cancer
    David J Gallagher
    Clinical Genetics Service, Department of Medicine, Urology Service, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Clin Cancer Res 16:2115-21. 2010
  7. pmc A replication study and genome-wide scan of single-nucleotide polymorphisms associated with pancreatic cancer risk and overall survival
    Jason A Willis
    Program in Cancer Biology and Genetics, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    Clin Cancer Res 18:3942-51. 2012
  8. doi The 6q22.33 locus and breast cancer susceptibility
    Tomas Kirchhoff
    Clinical Genetics Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA
    Cancer Epidemiol Biomarkers Prev 18:2468-75. 2009
  9. pmc Susceptibility loci associated with prostate cancer progression and mortality
    David J Gallagher
    Department of Medicine, Clinical Genetics Service, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, Albert Einstein College of Medicine, New York, New York 10065, USA
    Clin Cancer Res 16:2819-32. 2010
  10. pmc Polymorphisms at the Microseminoprotein-beta locus associated with physiologic variation in beta-microseminoprotein and prostate-specific antigen levels
    Xing Xu
    Program in Cancer Biology and Genetics, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA
    Cancer Epidemiol Biomarkers Prev 19:2035-42. 2010

Detail Information

Publications27

  1. pmc Complement factor H polymorphism in age-related macular degeneration
    Robert J Klein
    Laboratory of Statistical Genetics, Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Science 308:385-9. 2005
    ..This polymorphism is in a region of CFH that binds heparin and C-reactive protein. The CFH gene is located on chromosome 1 in a region repeatedly linked to AMD in family-based studies...
  2. pmc Genetic architecture of prostate cancer in the Ashkenazi Jewish population
    J Vijai
    Clinical Genetics Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    Br J Cancer 105:864-9. 2011
    ..No study has yet investigated whether these single nucleotide polymorphisms (SNPs) are associated with prostate cancer in the Ashkenazi Jewish (AJ) population...
  3. pmc Evaluation of multiple risk-associated single nucleotide polymorphisms versus prostate-specific antigen at baseline to predict prostate cancer in unscreened men
    Robert J Klein
    Program in Cancer Biology and Genetics, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    Eur Urol 61:471-7. 2012
    ..Although case-control studies have identified numerous single nucleotide polymorphisms (SNPs) associated with prostate cancer, the clinical role of these SNPs remains unclear...
  4. pmc Power analysis for genome-wide association studies
    Robert J Klein
    Program in Cancer Biology and Genetics, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY, USA
    BMC Genet 8:58. 2007
    ..To choose the proper sample size and genotyping platform for such studies, power calculations that take into account genetic model, tag SNP selection, and the population of interest are required...
  5. pmc Blood biomarker levels to aid discovery of cancer-related single-nucleotide polymorphisms: kallikreins and prostate cancer
    Robert J Klein
    Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    Cancer Prev Res (Phila) 3:611-9. 2010
    ..874 versus 0.866), providing proof in principle to clinical application for our findings...
  6. pmc Germline BRCA mutations denote a clinicopathologic subset of prostate cancer
    David J Gallagher
    Clinical Genetics Service, Department of Medicine, Urology Service, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Clin Cancer Res 16:2115-21. 2010
    ..Increased prostate cancer risk has been reported for BRCA mutation carriers, but BRCA-associated clinicopathologic features have not been clearly defined...
  7. pmc A replication study and genome-wide scan of single-nucleotide polymorphisms associated with pancreatic cancer risk and overall survival
    Jason A Willis
    Program in Cancer Biology and Genetics, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    Clin Cancer Res 18:3942-51. 2012
    ..To explore the effects of single-nucleotide polymorphisms (SNP) on pancreatic cancer risk and overall survival (OS)...
  8. doi The 6q22.33 locus and breast cancer susceptibility
    Tomas Kirchhoff
    Clinical Genetics Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA
    Cancer Epidemiol Biomarkers Prev 18:2468-75. 2009
    ..Further functional studies of candidate genes are in progress, and a large replication analysis is being completed as part of an international consortium...
  9. pmc Susceptibility loci associated with prostate cancer progression and mortality
    David J Gallagher
    Department of Medicine, Clinical Genetics Service, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, Albert Einstein College of Medicine, New York, New York 10065, USA
    Clin Cancer Res 16:2819-32. 2010
    ..Prostate cancer is a heterogeneous disease with a variable natural history that is not accurately predicted by currently used prognostic tools...
  10. pmc Polymorphisms at the Microseminoprotein-beta locus associated with physiologic variation in beta-microseminoprotein and prostate-specific antigen levels
    Xing Xu
    Program in Cancer Biology and Genetics, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA
    Cancer Epidemiol Biomarkers Prev 19:2035-42. 2010
    ..Therefore, we wished to determine the association between SNPs at MSMB, the gene encoding beta-MSP, and the levels of prostate-produced biomarkers beta-MSP, PSA, and human kallikrein 2 (hK2) in blood and semen...
  11. pmc Analysis of genetic variation in Ashkenazi Jews by high density SNP genotyping
    Adam B Olshen
    Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA
    BMC Genet 9:14. 2008
    ..435,632 SNPs overlapped and met annotation criteria in the two groups...
  12. pmc Common genetic variants and modification of penetrance of BRCA2-associated breast cancer
    Mia M Gaudet
    Department of Epidemiology and Population Health and Department of Obstetrics and Gynecology and Women s Health, Albert Einstein College of Medicine, New York, New York, United States of America
    PLoS Genet 6:e1001183. 2010
    ..28, 95% CI 1.18-1.39, ). These results indicate that SNPs that modify BRCA2 penetrance identified by an agnostic approach thus far are limited to variants that also modify risk of sporadic BRCA2 wild-type breast cancer...
  13. pmc Including additional controls from public databases improves the power of a genome-wide association study
    Semanti Mukherjee
    Gerstner Sloan Kettering Graduate School of Biomedical Sciences, Memorial Sloan Kettering Cancer Center, New York, USA
    Hum Hered 72:21-34. 2011
    ..Thus, through an empirical approach, this report provides practical guidance for using additional controls from publicly available datasets...
  14. pmc A recurrent germline PAX5 mutation confers susceptibility to pre-B cell acute lymphoblastic leukemia
    Sohela Shah
    1 Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, New York, USA 2 Clinical Genetics Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York, USA 3
    Nat Genet 45:1226-31. 2013
    ..These data extend the role of PAX5 alterations in the pathogenesis of pre-B cell ALL and implicate PAX5 in a new syndrome of susceptibility to pre-B cell neoplasia. ..
  15. pmc A germline JAK2 SNP is associated with predisposition to the development of JAK2(V617F)-positive myeloproliferative neoplasms
    Outi Kilpivaara
    Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA
    Nat Genet 41:455-9. 2009
    ..We found that JAK2(V617F) is preferentially acquired in cis with the predisposition allele. These data suggest that germline variation is an important contributor to MPN phenotype and predisposition...
  16. pmc Analysis of genetic variants in never-smokers with lung cancer facilitated by an Internet-based blood collection protocol: a preliminary report
    Nicolas Girard
    Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York, USA
    Clin Cancer Res 16:755-63. 2010
    ..We hypothesized that we could use the Internet to bolster the accrual of appropriate patients...
  17. pmc Genome-wide association studies of cancer
    Zsofia K Stadler
    Clinical Genetics Service andthe Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, NY, NY 10021, USA
    J Clin Oncol 28:4255-67. 2010
    ..To date, however, the clinical utility of GWAS-derived risk markers remains limited...
  18. pmc Variants at IRX4 as prostate cancer expression quantitative trait loci
    Xing Xu
    1 Clinical Genetics Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA 2 Program in Cancer Biology and Genetics, Memorial Sloan Kettering Cancer Center, New York, NY, USA
    Eur J Hum Genet 22:558-63. 2014
    ..Cis-eQTL analysis in relevant tissues, even with a small sample size, can be a powerful method to expedite functional follow-up of GWAS. ..
  19. pmc Susceptibility loci associated with specific and shared subtypes of lymphoid malignancies
    Joseph Vijai
    Clinical Genetics Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York, USA
    PLoS Genet 9:e1003220. 2013
    ..These results, showing novel susceptibility regions and allelic heterogeneity, point to the existence of pathways of susceptibility to both shared as well as specific subtypes of lymphoid malignancy...
  20. pmc Rare de novo germline copy-number variation in testicular cancer
    Zsofia K Stadler
    Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    Am J Hum Genet 91:379-83. 2012
    ....
  21. ncbi Genetic Variation in DNA Repair Pathways and Risk of Non-Hodgkin's Lymphoma
    Justin Rendleman
    NYU School of Medicine, New York University, New York, New York, United States of America
    PLoS ONE 9:e101685. 2014
    ..While the findings generated here warrant independent validation, the results of our large study suggest that ATM may be a novel locus associated with the risk of multiple subtypes of NHL. ..
  22. pmc Predicting functionally important SNP classes based on negative selection
    Mark A Levenstien
    Program in Cancer Biology and Genetics, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    BMC Bioinformatics 12:26. 2011
    ..We aim to identify and prioritize groups of SNPs that are more likely to affect phenotypes in order to facilitate efficient SNP selection for follow-up studies...
  23. pmc Genome-wide association study provides evidence for a breast cancer risk locus at 6q22.33
    Bert Gold
    Laboratory of Genomic Diversity, Human Genetics Section, National Cancer Institute Frederick, Frederick, MD 21702, USA
    Proc Natl Acad Sci U S A 105:4340-5. 2008
    ..Candidate genes in the 6q22.33 region include ECHDC1, which encodes a protein involved in mitochondrial fatty acid oxidation, and also RNF146, which encodes a ubiquitin protein ligase, both known pathways in breast cancer pathogenesis...
  24. ncbi Linkage disequilibrium mapping for complex disease genes
    Andrew Dewan
    Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, CT, USA
    Methods Mol Biol 376:85-107. 2007
    ..The chapter covers issues such as study design, high-throughput genotyping technologies, statistical analysis, and others. Many of the materials are based on and related to our recent experiences in case-control-association studies...
  25. pmc Strong association of the Y402H variant in complement factor H at 1q32 with susceptibility to age-related macular degeneration
    Sepideh Zareparsi
    Department of Ophthalmology and Visual Sciences, University of Michigan, Ann Arbor, MI, USA
    Am J Hum Genet 77:149-53. 2005
    ..39 (95% confidence interval 0.36-0.42) and the genotype relative risk to be 2.44 (95% confidence interval 2.08-2.83) for TC heterozygotes and 5.93 (95% confidence interval 4.33-8.02) for CC homozygotes...
  26. pmc RSEARCH: finding homologs of single structured RNA sequences
    Robert J Klein
    Howard Hughes Medical Institute and Department of Genetics, Washington University School of Medicine, Saint Louis, Missouri 63110, USA
    BMC Bioinformatics 4:44. 2003
    ..No programs have yet been published that allow searching a sequence database for homologs of a single RNA molecule on the basis of secondary structure...