M W Kattan

..We discuss the goals of any staging system, what markers should be included, and models of markers...

..The goal of this study was to create and to externally validate a nomogram for predicting the probability that a patient will develop metastasis within 5 years after three-dimensional conformal radiation therapy (CRT)...

..A competing risks nomogram is produced to estimate the probability of death due to sarcoma for patients who have already developed a local recurrence of their initially treated soft-tissue sarcoma...

..Clinical decisions could be informed by individualized estimates of treatment benefit, rather than by average treatment effects...

..There is controversy as to whether artificial neural networks and other machine learning methods provide predictions that are more accurate than those provided by traditional statistical models when applied to censored data...

..The popular approaches are described, and one particular method, the standard gamble, is advocated. Utility is easily measured by the standard gamble, and it has good psychometric and theoretical properties...

..We believe these tools are useful and necessary for patient counseling, follow-up scheduling, and clinical trial design and analysis...

..Such an individualized approach should add value in medical decision making whenever an accurate prediction of the outcome may guide treatment selection...

..The purpose of this study was to develop a nomogram to improve the accuracy of predicting outcome after three-dimensional conformal radiotherapy...

..There is need for additional models that predict other clinical end points, especially survival adjusted for quality of life...

..There is a need for additional nomograms that predict outcomes after salvage therapy, as well other clinical end points, including QOL-adjusted survival...

..CONCLUSIONS: Using clinical information, we produced 2 calibrated and validated nomograms, which accurately predict pathologically negative lymph nodes in men with localized prostate cancer who are candidates for radical prostatectomy...

..These variables were of negligible prognostic value in men who received surgery. Studies with longer follow-up, that examine alternative end points, and that follow treatment(s) besides surgery are needed...

..We describe the patient populations to which they apply and the outcomes predicted, and record their individual characteristics...

..Thus, a new preoperative nomogram provides robust predictions of prostate cancer recurrence up to 10 years after radical prostatectomy...

..These nomograms have good discriminatory ability and calibration, and may benefit the patient and clinician when the various treatment options for prostate cancer are being considered...

..We evaluated the prognostic significance of PSMs using multiple methods of analysis accounting for patients who received adjuvant therapy...

..4). CONCLUSIONS: On multivariate analysis low preoperative total testosterone was associated with advanced pathological stage but not with BCR. Future studies are warranted with data on more patients who have progressed...

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..The nomogram may be useful for patient counseling, clinical trial design and patient followup planning...

..CONCLUSIONS: The pretreatment nomogram we developed may be useful to physicians and patients in estimating the probability of successful treatment 5 years after brachytherapy for clinically localized prostate cancer...

..We have compared various modifications to the original ASTRO definition on our series of 1213 patients treated with transperineal permanent prostate brachytherapy...

..To investigate the biochemical control rate in patients undergoing permanent prostate brachytherapy as a function of the biologically effective dose (BED) and risk group...

..78 and 0.74, respectively (p = 0.8). The postoperative index was 0.85 and 0.83, respectively (p = 0.9). CONCLUSIONS: Preoperative and postoperative nomograms can be applied accurately to an individual regardless of race...

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..0001). CONCLUSIONS: For prostate cancer localization erMRI contributes significant incremental value to DRE or TRUS biopsy findings (each p <0.0001)...

..Overall, the reported 10-year BFR rates in this study were favorable. Strategies for ensuring the best quality implant should be used and, when reporting brachytherapy outcomes, the implant quality should be noted...

..ml. Further research should address identifying patients who can safely avoid aggressive therapy...

..01). CONCLUSION: Incorporation of the Partin nomogram results and MRI findings regarding both extracapsular extension and seminal vesicle invasion improves the MR prediction of LNM in patients with prostate cancer...

..Similarly, patients with a low risk of progression could be placed into observation protocols, potentially sparing them from exhaustive and inappropriate investigations...

..If decision analysis is used to counsel individual patients, careful consideration must be given to the method of preference elicitation...

..Our results demonstrate that accurate predictions may be expected across different patient populations...

..We developed a user-friendly prediction model (nomogram) based on a large data set to assist in predicting the presence of SLN metastasis...

..This tool should be useful for patient counseling, follow-up scheduling, and clinical trial eligibility determination...

..0.715, p=0.039). In this setting, hK2 did not add diagnostic information. Measurements of individual forms of suPAR and PSA isoforms contributed significantly to discrimination of men with PCa from those with no evidence of malignancy...

..To design new models that combine clinical variables and biopsy data with magnetic resonance imaging (MRI) and MR spectroscopic imaging (MRSI) data, and assess their value in predicting the probability of insignificant prostate cancer...

..It may be reasonable to target RCC patients displaying altered bcl-2 levels for molecular therapies, such as anti-bcl2, should metastatic disease develop...

..It seems that most clinicians can improve their predictive ability by using the nomogram to predict the likelihood of additional non-SLN metastases in a woman with a positive SLN biopsy result...

..Selection among them and progress in this field are hampered by the lack of comparisons for predictive accuracy...

..Numerous staging systems have been devised for purposes of risk classification; we sought to identify the optimal staging system to predict postoperative survival...

..This tool takes several characteristics into account simultaneously. This model should enable improved patient counseling and treatment selection...

..Measurements of fPSA and hK2 improve on our ability to counsel patients prior to treatment as to their risk of BCR...

..Time to full recovery is primarily dictated by recovery of erectile function. This information is helpful for patients interested in their chances of returning to their preoperative functional state...

..Unique to predictive models, the nomogram predictions can be adjusted for the disease-free interval that a patient has achieved after RP...

..To investigate whether magnetic resonance imaging (MRI) findings, when converted into a scoring system, can predict the biochemical recurrence of prostate cancer after radical prostatectomy (RP)...

..Selected patients with high-grade disease and/or a rapid PSADT who were previously thought to be destined to develop progressive metastatic disease may achieve a durable response to salvage radiotherapy...

..DSS nomograms aid in more accurate counseling of patients, identification of patients appropriate for adjuvant therapy, and stratification of patients for clinical trials and molecular analysis...

..This nomogram may be useful for patient counseling, clinical trial design and effective patient followup strategies...

..Knowledge of renal cortical tumor histological subtype is critical for projecting prognosis, tailoring follow-up strategies, and designing clinical trials...

..Nevertheless, many more predictive tools, comparisons between them, and improvements to existing tools are needed...

..CONCLUSIONS: The information provided by systematic biopsies substantially improves the ability to predict outcome following RP. However, some incremental predictive accuracy was achieved by adding systematic biopsy features...

..The ability of the nomogram to evaluate the effects of preop CRT on survival is limited by the potential effects of preop CRT on factors within the nomogram...

..We believe these nomograms will become indispensable tools for patient counseling and clinical trial design in patients with HRPC...

..Caveolin therefore appears to be associated with human prostate cancer progression and is also present in primary and metastatic human breast cancer...

..The evaluation of potency preservation after treatment of localized prostate cancer with transperineal permanent prostate brachytherapy (PPB) and the efficacy of sildenafil were studied...

..Although easy to implement, there remains significant heterogeneity within each stage grouping. In the era of multimodality treatment, a more refined tool is needed to predict recurrence...

..To date, only one prediction model has been reported for patients with epithelial ovarian carcinoma (EOC). The objective of this study was to develop a more accurate survival nomogram for patients with bulky stage IIIC EOC...

..We evaluated our series of open radical prostatectomy cases to determine the likelihood of this outcome and develop a nomogram predicting the trifecta...

..We analyzed the surgical learning curve for prostate cancer recurrence after radical prostatectomy...

..This robust platform has broad applications in patient diagnosis, treatment management, and prognostication...

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..We developed a predictive model that could be used in the preoperative setting...

..On the basis of outcome data from that trial, the authors developed a nomogram for predicting the probability of 12-month progression-free survival for patients who received sunitinib therapy...

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..CONCLUSIONS: The PCI is reliable and, at best, only modestly affected by cultural differences when administered to culturally distinct English-speaking men or when translated into French...

..Due to this and previously reported data the definition of stage pT4 disease should be modified in the next version of the TNM staging system...

..We evaluated men undergoing repeat prostate biopsies for persistently increased serum prostate specific antigen (PSA) levels to determine if race was a predictor of cancer detection...

..The purpose of this study was to determine whether the extent of palpable cancer within the prostate predicts outcome after radical prostatectomy...

..By adjusting for patient risk, this method can provide a more precise assessment of phase 2 treatment efficacy, thereby improving the decision whether to proceed to a phase 3 clinical trial...

..Men with clinically detected localized prostate cancer treated without curative intent are at risk of complications from local tumor growth. We investigated rates of local progression and need for local therapy among such men...

..We hypothesized that the risk of prostate cancer on biopsy for a given PSA level is affected by identifiable characteristics of the cohort under study...

..To determine whether cancers of the prostate transition zone (TZ) possess a unique metabolic pattern by which they may be identified at proton magnetic resonance (MR) spectroscopic imaging...

..We examined variations in the rate of positive surgical margins among surgeons after controlling for the severity of disease and volume of cases per surgeon...

..To retrospectively determine whether endorectal magnetic resonance (MR) imaging findings contribute incremental value to the Kattan nomogram for predicting seminal vesicle invasion (SVI) in patients with prostate cancer...

..Accurate estimates of the likelihood of additional disease in the axilla could assist greatly in decision-making regarding further treatment...

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..We sought to determine whether the risk of lung cancer varies predictably among smokers...

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..We previously demonstrated that there is a learning curve for open radical prostatectomy. We sought to determine whether the effects of the learning curve are modified by pathologic stage...

..In the current study, the experimental designs and statistical methods used in contemporary molecular marker studies are reviewed, particularly with respect to whether these evaluated a marker's clinical value...

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..We prospectively evaluated RC cases with transitional cell carcinoma of the bladder to determine which factors may contribute to the variability in the number of reported LNs...

..Recent studies of surgery for cancer have demonstrated variations in outcomes among hospitals and among surgeons. We sought to examine variations in morbidity after radical prostatectomy for prostate cancer...

..The authors compare and contrast the diagnostic and risk prediction approaches and attempt to identify the types of medical problem to which each is best suited...

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..To assess the difference in biochemical freedom from relapse (BFR) between patients with clinically localized prostate cancer having Gleason Grade (GG) 3 + 4 vs. 4 + 3 disease treated with permanent prostate brachytherapy (PPB)...

..To define methodology to show clinical benefit for patients in the state of a rising prostate-specific antigen (PSA)...

..Ten definitions of BCR were evaluated to identify the one that best explains metastatic progression...

..To determine whether predictive value of endorectal magnetic resonance (MR) imaging findings in detection of prostate cancer extracapsular extension (ECE) is significantly affected by the reader's subspecialty experience...

..In the current study, the authors determined the incremental value of endorectal magnetic resonance imaging (eMRI) in making this decision...

..A single US institution database was used to test the validity of the pancreatic adenocarcinoma nomogram established at Memorial Sloan-Kettering Cancer Center...

..Cox regression failed to identify an improvement in PSA-FFR with RT-PPB or the addition of hormones. Although these conclusions question the role for RT-PPB, only a comparative trial will be able to answer this question definitively...

..Predictive nomograms are becoming increasingly used to define and predict outcome. They can be developed at presentation or following treatment and include variables not conventionally used in standard staging systems...

..To assess the incremental value of endorectal magnetic resonance (MR) imaging findings in addition to clinical variables for prediction of extracapsular extension (ECE) in patients with prostate cancer...

..To assess retrospectively the incremental value of endorectal coil magnetic resonance (MR) imaging and combined endorectal MR imaging-MR spectroscopic imaging to the staging nomograms for predicting organ-confined prostate cancer (OCPC)...

..Greater incorporation of decision-analytic techniques into urology research and clinical practice might improve decision making, and thereby improve patient outcomes...

..To assess the difference in prostate-specific antigen (PSA) response kinetics in patients undergoing either (125)I or (103)Pd permanent prostate brachytherapy (PPB)...

..To determine whether hydrogen 1 magnetic resonance (MR) spectroscopic imaging can be used to predict aggressiveness of prostate cancer...

..The goal of this study was the development of a prognostic outcomes nomogram to predict the 5-year disease recurrence risk after radical cystectomy...

..The model is intended for use in analyzing a population of subjects who are undergoing lung cancer screening or receiving lung cancer chemoprevention, to determine whether the intervention has altered lung cancer mortality...