JOHANNA JOYCE

Summary

Affiliation: Memorial Sloan-Kettering Cancer Center
Country: USA

Publications

  1. ncbi request reprint Therapeutic targeting of the tumor microenvironment
    Johanna A Joyce
    Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Cancer Cell 7:513-20. 2005
  2. ncbi request reprint Tumour-host interactions: implications for developing anti-cancer therapies
    Bedrick B Gadea
    Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Expert Rev Mol Med 8:1-32. 2006
  3. pmc CSF-1R inhibition alters macrophage polarization and blocks glioma progression
    Stephanie M Pyonteck
    1 Cancer Biology and Genetics, Memorial Sloan Kettering Cancer Center MSKCC, New York, New York, USA 2
    Nat Med 19:1264-72. 2013
  4. pmc Identification and characterization of poorly differentiated invasive carcinomas in a mouse model of pancreatic neuroendocrine tumorigenesis
    Karen E Hunter
    Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, New York, USA
    PLoS ONE 8:e64472. 2013
  5. ncbi request reprint Multiple roles for cysteine cathepsins in cancer
    Johanna A Joyce
    Department of Biochemistry and Biophysics, Diabetes and Comprehensive Cancer Centers, University of California at San Francisco, San Francisco, California, USA
    Cell Cycle 3:1516-619. 2004
  6. pmc Microenvironmental regulation of metastasis
    Johanna A Joyce
    Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, USA
    Nat Rev Cancer 9:239-52. 2009
  7. ncbi request reprint Cysteine cathepsin proteases as pharmacological targets in cancer
    Carmela Palermo
    Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, Box 372, New York, NY 10021, USA
    Trends Pharmacol Sci 29:22-8. 2008
  8. pmc Cathepsin L is responsible for processing and activation of proheparanase through multiple cleavages of a linker segment
    Ghada Abboud-Jarrous
    Department of Oncology, Hadassah Hebrew University Medical Center, Jerusalem, Israel
    J Biol Chem 283:18167-76. 2008
  9. ncbi request reprint Inhibition of cysteine cathepsin protease activity enhances chemotherapy regimens by decreasing tumor growth and invasiveness in a mouse model of multistage cancer
    Katherine M Bell-McGuinn
    Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Cancer Res 67:7378-85. 2007
  10. ncbi request reprint Cysteine cathepsins and the cutting edge of cancer invasion
    Vasilena Gocheva
    Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Cell Cycle 6:60-4. 2007

Collaborators

Detail Information

Publications14

  1. ncbi request reprint Therapeutic targeting of the tumor microenvironment
    Johanna A Joyce
    Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Cancer Cell 7:513-20. 2005
  2. ncbi request reprint Tumour-host interactions: implications for developing anti-cancer therapies
    Bedrick B Gadea
    Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Expert Rev Mol Med 8:1-32. 2006
    ..Here, we will discuss recent efforts to address these key challenges and offer perspectives on the translation of discoveries made in model systems to the clinic...
  3. pmc CSF-1R inhibition alters macrophage polarization and blocks glioma progression
    Stephanie M Pyonteck
    1 Cancer Biology and Genetics, Memorial Sloan Kettering Cancer Center MSKCC, New York, New York, USA 2
    Nat Med 19:1264-72. 2013
    ..Our results identify TAMs as a promising therapeutic target for proneural gliomas and establish the translational potential of CSF-1R inhibition for GBM. ..
  4. pmc Identification and characterization of poorly differentiated invasive carcinomas in a mouse model of pancreatic neuroendocrine tumorigenesis
    Karen E Hunter
    Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, New York, USA
    PLoS ONE 8:e64472. 2013
    ..The identification of PDICs in this mouse model provides a unique opportunity to study the pathology and molecular characteristics of PD-PanNETs...
  5. ncbi request reprint Multiple roles for cysteine cathepsins in cancer
    Johanna A Joyce
    Department of Biochemistry and Biophysics, Diabetes and Comprehensive Cancer Centers, University of California at San Francisco, San Francisco, California, USA
    Cell Cycle 3:1516-619. 2004
    ....
  6. pmc Microenvironmental regulation of metastasis
    Johanna A Joyce
    Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, USA
    Nat Rev Cancer 9:239-52. 2009
    ..This Review describes experimental data demonstrating the role of the microenvironment in metastasis, identifies areas for future research and suggests possible new therapeutic avenues...
  7. ncbi request reprint Cysteine cathepsin proteases as pharmacological targets in cancer
    Carmela Palermo
    Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, Box 372, New York, NY 10021, USA
    Trends Pharmacol Sci 29:22-8. 2008
    ..In this review, we highlight recent studies that now allow us to evaluate critically whether cysteine cathepsin inhibition represents a viable therapeutic strategy for the treatment of cancer...
  8. pmc Cathepsin L is responsible for processing and activation of proheparanase through multiple cleavages of a linker segment
    Ghada Abboud-Jarrous
    Department of Oncology, Hadassah Hebrew University Medical Center, Jerusalem, Israel
    J Biol Chem 283:18167-76. 2008
    ..The critical involvement of cathepsin L in proheparanase processing and activation offers new strategies for inhibiting the prometastatic, proangiogenic, and proinflammatory activities of heparanase...
  9. ncbi request reprint Inhibition of cysteine cathepsin protease activity enhances chemotherapy regimens by decreasing tumor growth and invasiveness in a mouse model of multistage cancer
    Katherine M Bell-McGuinn
    Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Cancer Res 67:7378-85. 2007
    ..These results encourage the development and continuing evaluation of cysteine cathepsin inhibitors as cancer therapeutics...
  10. ncbi request reprint Cysteine cathepsins and the cutting edge of cancer invasion
    Vasilena Gocheva
    Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Cell Cycle 6:60-4. 2007
    ..Therefore, cathepsins are now emerging as major players in tumor progression, making them potential drug targets for a wide range of human cancers...
  11. pmc Distinct roles for cysteine cathepsin genes in multistage tumorigenesis
    Vasilena Gocheva
    Cancer Biology and Genetics Program, Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Genes Dev 20:543-56. 2006
    ..Thus individual cysteine cathepsin genes make distinctive contributions to tumorigenesis...
  12. ncbi request reprint A functional heparan sulfate mimetic implicates both heparanase and heparan sulfate in tumor angiogenesis and invasion in a mouse model of multistage cancer
    Johanna A Joyce
    Department of Biochemistry and Biophysics, Diabetes and Comprehensive Cancer Centers, University of California at San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143 0534, USA
    Oncogene 24:4037-51. 2005
    ..These data encourage clinical applications of inhibitors such as PI-88 for the many human cancers where heparanase expression is elevated or mobilization of HS-binding regulatory factors is implicated...
  13. ncbi request reprint Cathepsin cysteine proteases are effectors of invasive growth and angiogenesis during multistage tumorigenesis
    Johanna A Joyce
    Department of Biochemistry and Biophysics, Diabetes and Comprehensive Cancer Centers, University of California at San Francisco, 94143, USA
    Cancer Cell 5:443-53. 2004
    ..Cysteine cathepsins are also upregulated during HPV16-induced cervical carcinogenesis, further encouraging consideration of this protease family as a therapeutic target in human cancers...
  14. ncbi request reprint Stage-specific vascular markers revealed by phage display in a mouse model of pancreatic islet tumorigenesis
    Johanna A Joyce
    Department of Biochemistry and Biophysics, Diabetes and Comprehensive Cancer Centers, University of California, San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143, USA
    Cancer Cell 4:393-403. 2003
    ..One peptide is homologous with pro-PDGF-B, which is expressed in endothelial cells, while its receptor is expressed in pericytes...