Research Topics | JOHANNA JOYCESummaryAffiliation: Memorial Sloan-Kettering Cancer Center Country: USA Publications
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Publications
Therapeutic targeting of the tumor microenvironmentJohanna A Joyce
Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
Cancer Cell 7:513-20. 2005- Tumour-host interactions: implications for developing anti-cancer therapiesBedrick B Gadea
Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
Expert Rev Mol Med 8:1-32. 2006..Here, we will discuss recent efforts to address these key challenges and offer perspectives on the translation of discoveries made in model systems to the clinic... 
Microenvironmental regulation of metastasisJohanna A Joyce
Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, USA
Nat Rev Cancer 9:239-52. 2009..This Review describes experimental data demonstrating the role of the microenvironment in metastasis, identifies areas for future research and suggests possible new therapeutic avenues...- Multiple roles for cysteine cathepsins in cancerJohanna A Joyce
Department of Biochemistry and Biophysics, Diabetes and Comprehensive Cancer Centers, University of California at San Francisco, San Francisco, California, USA
Cell Cycle 3:1516-619. 2004.... - Cysteine cathepsin proteases as pharmacological targets in cancerCarmela Palermo
Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, Box 372, New York, NY 10021, USA
Trends Pharmacol Sci 29:22-8. 2008..In this review, we highlight recent studies that now allow us to evaluate critically whether cysteine cathepsin inhibition represents a viable therapeutic strategy for the treatment of cancer... - Cathepsin L is responsible for processing and activation of proheparanase through multiple cleavages of a linker segmentGhada Abboud-Jarrous
Department of Oncology, Hadassah Hebrew University Medical Center, Jerusalem, Israel
J Biol Chem 283:18167-76. 2008..The critical involvement of cathepsin L in proheparanase processing and activation offers new strategies for inhibiting the prometastatic, proangiogenic, and proinflammatory activities of heparanase... - Inhibition of cysteine cathepsin protease activity enhances chemotherapy regimens by decreasing tumor growth and invasiveness in a mouse model of multistage cancerKatherine M Bell McGuinn
Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
Cancer Res 67:7378-85. 2007..These results encourage the development and continuing evaluation of cysteine cathepsin inhibitors as cancer therapeutics... - Cysteine cathepsins and the cutting edge of cancer invasionVasilena Gocheva
Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
Cell Cycle 6:60-4. 2007..Therefore, cathepsins are now emerging as major players in tumor progression, making them potential drug targets for a wide range of human cancers... - Distinct roles for cysteine cathepsin genes in multistage tumorigenesisVasilena Gocheva
Cancer Biology and Genetics Program, Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
Genes Dev 20:543-56. 2006..Thus individual cysteine cathepsin genes make distinctive contributions to tumorigenesis... - A functional heparan sulfate mimetic implicates both heparanase and heparan sulfate in tumor angiogenesis and invasion in a mouse model of multistage cancerJohanna A Joyce
Department of Biochemistry and Biophysics, Diabetes and Comprehensive Cancer Centers, University of California at San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143 0534, USA
Oncogene 24:4037-51. 2005..These data encourage clinical applications of inhibitors such as PI-88 for the many human cancers where heparanase expression is elevated or mobilization of HS-binding regulatory factors is implicated... - Cathepsin cysteine proteases are effectors of invasive growth and angiogenesis during multistage tumorigenesisJohanna A Joyce
Department of Biochemistry and Biophysics, Diabetes and Comprehensive Cancer Centers, University of California at San Francisco, 94143, USA
Cancer Cell 5:443-53. 2004..Cysteine cathepsins are also upregulated during HPV16-induced cervical carcinogenesis, further encouraging consideration of this protease family as a therapeutic target in human cancers... - Stage-specific vascular markers revealed by phage display in a mouse model of pancreatic islet tumorigenesisJohanna A Joyce
Department of Biochemistry and Biophysics, Diabetes and Comprehensive Cancer Centers, University of California, San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143, USA
Cancer Cell 4:393-403. 2003..One peptide is homologous with pro-PDGF-B, which is expressed in endothelial cells, while its receptor is expressed in pericytes...
Research Grants
- Dissecting the Function of Cysteine Cathepsins in the Tumor MicroenvironmentJOHANNA JOYCE; Fiscal Year: 2010....
- Dissecting the Function of Cysteine Cathepsins in the Tumor MicroenvironmentJOHANNA JOYCE; Fiscal Year: 2007....
- Dissecting the Function of Cysteine Cathepsins in the Tumor MicroenvironmentJOHANNA JOYCE; Fiscal Year: 2009....