XUEJUN contact JIANG

Summary

Affiliation: Memorial Sloan-Kettering Cancer Center
Country: USA

Publications

  1. pmc Interaction between FIP200 and ATG16L1 distinguishes ULK1 complex-dependent and -independent autophagy
    Noor Gammoh
    Cell Biology Department, Memorial Sloan Kettering Cancer Center, New York, New York, USA
    Nat Struct Mol Biol 20:144-9. 2013
  2. ncbi request reprint Cytochrome C-mediated apoptosis
    Xuejun Jiang
    Cell Biology Program, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Annu Rev Biochem 73:87-106. 2004
  3. pmc Apoptotic and autophagic cell death induced by histone deacetylase inhibitors
    Yufang Shao
    Cell Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 101:18030-5. 2004
  4. ncbi request reprint Histone deacetylase inhibitors in programmed cell death and cancer therapy
    Paul A Marks
    Cell Biology Program, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Cell Cycle 4:549-51. 2005
  5. ncbi request reprint Essential roles of the Bcl-2 family of proteins in caspase-2-induced apoptosis
    Zhonghua Gao
    Cell Biology Program, Memorial Sloan Kettering Cancer Center, Cornell University Weill Graduate School of Medical Sciences, New York, New York 10021, USA
    J Biol Chem 280:38271-5. 2005
  6. pmc PHAPI/pp32 suppresses tumorigenesis by stimulating apoptosis
    Wei Pan
    Cell Biology Program, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    J Biol Chem 284:6946-54. 2009
  7. pmc A dimeric Smac/diablo peptide directly relieves caspase-3 inhibition by XIAP. Dynamic and cooperative regulation of XIAP by Smac/Diablo
    Zhonghua Gao
    Cell Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    J Biol Chem 282:30718-27. 2007
  8. ncbi request reprint Selective compounds define Hsp90 as a major inhibitor of apoptosis in small-cell lung cancer
    Anna Rodina
    Program in Molecular Pharmacology and Chemistry, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, New York 10021, USA
    Nat Chem Biol 3:498-507. 2007
  9. pmc Caspase-9 holoenzyme is a specific and optimal procaspase-3 processing machine
    Qian Yin
    Department of Biochemistry, Weill Medical College of Cornell University, New York, New York 10021, USA
    Mol Cell 22:259-68. 2006
  10. pmc NEDD4-1 is a proto-oncogenic ubiquitin ligase for PTEN
    Xinjiang Wang
    Cell Biology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, Box 522, New York, NY 10021, USA
    Cell 128:129-39. 2007

Collaborators

  • Hao Wu
  • Paul A Marks
  • G Chiosis
  • Pier P Pandolfi
  • P Wipf
  • Richard N Kolesnick
  • Geoffrey W Krystal
  • Andrea Alimonti
  • W Zhang
  • C Cordon-Cardo
  • Zhonghua Gao
  • Xinjiang Wang
  • Qian Yin
  • Yufang Shao
  • Wei Pan
  • Noor Gammoh
  • Judith Mesicek
  • Cheryl Habrukowich
  • Hyun Eui Kim
  • Xiaojing Yue
  • Li S da Graca
  • Junru Wang
  • Anna Rodina
  • Xiaodong Wang
  • Devrim Acehan
  • Michael Overholtzer
  • Oliver Florey
  • David K Han
  • Taya Feldman
  • Kimberly Dodge-Kafka
  • Timothy Hla
  • Mallika Ghosh
  • Andrew Le
  • Adriana Haimovitz-Friedman
  • Hyunmi Lee
  • Anastasia Skobeleva
  • Robert Bittman
  • Karim Rezaul
  • Zvi Fuks
  • Evgeny V Berdyshev
  • Zaiguo Li
  • Fenghe Du
  • Zhongcheng Xin
  • Liang Chen
  • Weidong Song
  • Zhijun Xi
  • Hediye Erdjument-Bromage
  • Sara Felts
  • Cristina C Clement
  • Theresa Koppie
  • Yuhong She
  • Joan Massague
  • Lloyd C Trotman
  • Jeffrey L Brodsky
  • Paul Tempst
  • Yue Ming Li
  • Julie Litz
  • Zhenbang Chen
  • Maria Vilenchik
  • Joungnam Kim
  • Julia Aguirre
  • Yanlong Kang
  • Kamalika Moulick
  • Yuan Tian
  • Anne Chiang
  • Nian Wu
  • Jee Y Chung
  • Yu Chih Lo
  • Su Chang Lin
  • Hyun Ho Park
  • Christopher W Akey
  • David Gene Morgan
  • John E Heuser

Detail Information

Publications18

  1. pmc Interaction between FIP200 and ATG16L1 distinguishes ULK1 complex-dependent and -independent autophagy
    Noor Gammoh
    Cell Biology Department, Memorial Sloan Kettering Cancer Center, New York, New York, USA
    Nat Struct Mol Biol 20:144-9. 2013
    ..This study therefore identifies a previously uncharacterized interaction between the ULK1 and ATG5 complexes that can distinguish ULK1-dependent and -independent autophagy processes...
  2. ncbi request reprint Cytochrome C-mediated apoptosis
    Xuejun Jiang
    Cell Biology Program, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Annu Rev Biochem 73:87-106. 2004
    ..In this review, we focus on the recent progress in understanding the biochemical mechanisms and regulation of the pathway, the roles of the pathway in physiology and disease, and their potential therapeutic values...
  3. pmc Apoptotic and autophagic cell death induced by histone deacetylase inhibitors
    Yufang Shao
    Cell Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 101:18030-5. 2004
    ..Induction of autophagic cell death by HDAC inhibitors has clear clinical implications in treating cancers with apoptotic defects...
  4. ncbi request reprint Histone deacetylase inhibitors in programmed cell death and cancer therapy
    Paul A Marks
    Cell Biology Program, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Cell Cycle 4:549-51. 2005
    ..In this review, we discuss the study of HDAC inhibitors in cell death and cancer research, the implications of our recent findings, and some outstanding questions that need to be addressed...
  5. ncbi request reprint Essential roles of the Bcl-2 family of proteins in caspase-2-induced apoptosis
    Zhonghua Gao
    Cell Biology Program, Memorial Sloan Kettering Cancer Center, Cornell University Weill Graduate School of Medical Sciences, New York, New York 10021, USA
    J Biol Chem 280:38271-5. 2005
    ..Collectively, these results indicate that proteolytic activation of Bid and the subsequent induction of the mitochondrial apoptotic pathway through Bax/Bak is essential for apoptosis triggered by caspase-2...
  6. pmc PHAPI/pp32 suppresses tumorigenesis by stimulating apoptosis
    Wei Pan
    Cell Biology Program, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    J Biol Chem 284:6946-54. 2009
    ..Disruption of the nuclear localization signal of PHAPI caused a modest decrease of its tumor-suppressive function, indicating that nuclear localization of PHAPI contributes to, but is not essential for, tumor suppression...
  7. pmc A dimeric Smac/diablo peptide directly relieves caspase-3 inhibition by XIAP. Dynamic and cooperative regulation of XIAP by Smac/Diablo
    Zhonghua Gao
    Cell Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    J Biol Chem 282:30718-27. 2007
    ..We also show that XIAP homotrimerizes via its C-terminal Ring domain, making its inhibitory activity toward caspase-3 more susceptible to Smac...
  8. ncbi request reprint Selective compounds define Hsp90 as a major inhibitor of apoptosis in small-cell lung cancer
    Anna Rodina
    Program in Molecular Pharmacology and Chemistry, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, New York 10021, USA
    Nat Chem Biol 3:498-507. 2007
    ..These results provide important evidence for a transformation-specific interplay between chaperones in regulating apoptosis in malignant cells...
  9. pmc Caspase-9 holoenzyme is a specific and optimal procaspase-3 processing machine
    Qian Yin
    Department of Biochemistry, Weill Medical College of Cornell University, New York, New York 10021, USA
    Mol Cell 22:259-68. 2006
    ..Therefore, in addition to dimerization, the apoptosome activates caspase-9 by enhancing its affinity for procaspase-3, which is important for procaspase-3 activation at the physiological concentration...
  10. pmc NEDD4-1 is a proto-oncogenic ubiquitin ligase for PTEN
    Xinjiang Wang
    Cell Biology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, Box 522, New York, NY 10021, USA
    Cell 128:129-39. 2007
    ..Therefore, NEDD4-1 is a potential proto-oncogene that negatively regulates PTEN via ubiquitination, a paradigm analogous to that of Mdm2 and p53...
  11. pmc Sphingosine interaction with acidic leucine-rich nuclear phosphoprotein-32A (ANP32A) regulates PP2A activity and cyclooxygenase (COX)-2 expression in human endothelial cells
    Cheryl Habrukowich
    Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, Cornell University, Center for Vascular Biology, New York, New York 10065, USA
    J Biol Chem 285:26825-31. 2010
    ..Knockdown of ANP32A expression further induced p38 SAPK and COX-2. These data identify ANP32A as a novel molecular target of sphingoid bases that regulates cellular signaling events and inflammatory gene expression...
  12. doi request reprint Ceramide synthases 2, 5, and 6 confer distinct roles in radiation-induced apoptosis in HeLa cells
    Judith Mesicek
    Laboratory of Signal Transduction, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
    Cell Signal 22:1300-7. 2010
    ..These data add to the growing body of evidence demonstrating interplay among the CerS proteins in a stress stimulus-, cell type- and subcellular compartment-specific manner...
  13. ncbi request reprint PTEN: a default gate-keeping tumor suppressor with a versatile tail
    Xinjiang Wang
    Cell Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    Cell Res 18:807-16. 2008
    ..Further, a comparative analysis of PTEN and p53 suggests while p53 needs to be activated to suppress tumorigenesis (a dormant gatekeeper), PTEN is probably a constitutive surveillant against cancer development, thus a default gatekeeper...
  14. ncbi request reprint Distinctive roles of PHAP proteins and prothymosin-alpha in a death regulatory pathway
    Xuejun Jiang
    Howard Hughes Medical Institute, Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Science 299:223-6. 2003
    ..Thus, this chemical-biological combinatory approach has revealed the regulatory roles of oncoprotein ProT and tumor suppressor PHAP in apoptosis...
  15. ncbi request reprint PHAPI, CAS, and Hsp70 promote apoptosome formation by preventing Apaf-1 aggregation and enhancing nucleotide exchange on Apaf-1
    Hyun Eui Kim
    Howard Hughes Medical Institute, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA
    Mol Cell 30:239-47. 2008
    ..These studies indicated that PHAPI, CAS, and Hsp70 play an important regulatory role during apoptosis...
  16. ncbi request reprint Three-dimensional structure of the apoptosome: implications for assembly, procaspase-9 binding, and activation
    Devrim Acehan
    Department of Physiology and Biophysics, Boston University School of Medicine, 700 Albany Street, Boston, MA 02118, USA
    Mol Cell 9:423-32. 2002
    ..This complex promotes the efficient activation of procaspase-3. Therefore, the cleavage of procaspase-9 is not required to form an active cell death complex...
  17. ncbi request reprint Mitochondrially localized EGFR is subjected to autophagic regulation and implicated in cell survival
    Xiaojing Yue
    The Institute of Microbiology, Chinese Academy of Sciences, Beijing, China
    Autophagy 4:641-9. 2008
    ..Taken together, we conclude that EGFR mitochondrial localization is regulated by either autophagy or programmed cell death and is correlated with cell survival...
  18. ncbi request reprint Assays and characterization of mammalian phosphatidylinositol 4,5-bisphosphate-sensitive phospholipase D
    Xuejun Jiang
    Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    Methods Enzymol 345:328-34. 2002

Research Grants7

  1. Molecular Regulation of Apoptosome Activity
    Xuejun Jiang; Fiscal Year: 2006
    ..This work should also shed light on designing novel cancer therapies by targeting this pathway. ..
  2. Molecular Regulation of Apoptosome Activity
    Xuejun Jiang; Fiscal Year: 2007
    ..This work should also shed light on designing novel cancer therapies by targeting this pathway. ..
  3. Identification of Inhibitory Compounds for Apaf-1 by High Throughput Screening
    Xuejun Jiang; Fiscal Year: 2009
    ..They will also be important pharmacological tools for studying mechanisms and roles of cytochrome c-mediated apoptosis in various physiological and disease processes. ..
  4. Molecular Regulation of Apoptosome Activity
    Xuejun Jiang; Fiscal Year: 2009
    ..This work should also shed light on designing novel cancer therapies by targeting this pathway. ..
  5. Molecular Regulation of Apoptosome Activity
    Xuejun Jiang; Fiscal Year: 2010
    ..This work should also shed light on designing novel cancer therapies by targeting this pathway. ..
  6. Identification of Inhibitory Compounds for Apaf-1 by High Throughput Screening
    XUEJUN contact JIANG; Fiscal Year: 2010
    ..They will also be important pharmacological tools for studying mechanisms and roles of cytochrome c-mediated apoptosis in various physiological and disease processes. ..