Research Topics | XUEJUN contact JIANGSummaryAffiliation: Memorial Sloan-Kettering Cancer Center Country: USA Publications
Research Grants
| Collaborators
|
Detail Information
Publications
Cytochrome C-mediated apoptosisXuejun Jiang
Cell Biology Program, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
Annu Rev Biochem 73:87-106. 2004..In this review, we focus on the recent progress in understanding the biochemical mechanisms and regulation of the pathway, the roles of the pathway in physiology and disease, and their potential therapeutic values...
Apoptotic and autophagic cell death induced by histone deacetylase inhibitorsYufang Shao
Cell Biology Program, Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA
Proc Natl Acad Sci U S A 101:18030-5. 2004..Induction of autophagic cell death by HDAC inhibitors has clear clinical implications in treating cancers with apoptotic defects...- Histone deacetylase inhibitors in programmed cell death and cancer therapyPaul A Marks
Cell Biology Program, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
Cell Cycle 4:549-51. 2005..In this review, we discuss the study of HDAC inhibitors in cell death and cancer research, the implications of our recent findings, and some outstanding questions that need to be addressed... - Essential roles of the Bcl-2 family of proteins in caspase-2-induced apoptosisZhonghua Gao
Cell Biology Program, Memorial Sloan Kettering Cancer Center, Cornell University Weill Graduate School of Medical Sciences, New York, New York 10021, USA
J Biol Chem 280:38271-5. 2005..Collectively, these results indicate that proteolytic activation of Bid and the subsequent induction of the mitochondrial apoptotic pathway through Bax/Bak is essential for apoptosis triggered by caspase-2... - Selective compounds define Hsp90 as a major inhibitor of apoptosis in small-cell lung cancerAnna Rodina
Program in Molecular Pharmacology and Chemistry, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, New York 10021, USA
Nat Chem Biol 3:498-507. 2007..These results provide important evidence for a transformation-specific interplay between chaperones in regulating apoptosis in malignant cells... - Caspase-9 holoenzyme is a specific and optimal procaspase-3 processing machineQian Yin
Department of Biochemistry, Weill Medical College of Cornell University, New York, New York 10021, USA
Mol Cell 22:259-68. 2006..Therefore, in addition to dimerization, the apoptosome activates caspase-9 by enhancing its affinity for procaspase-3, which is important for procaspase-3 activation at the physiological concentration... - A dimeric Smac/diablo peptide directly relieves caspase-3 inhibition by XIAP. Dynamic and cooperative regulation of XIAP by Smac/DiabloZhonghua Gao
Cell Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
J Biol Chem 282:30718-27. 2007..We also show that XIAP homotrimerizes via its C-terminal Ring domain, making its inhibitory activity toward caspase-3 more susceptible to Smac... - PHAPI/pp32 suppresses tumorigenesis by stimulating apoptosisWei Pan
Cell Biology Program, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
J Biol Chem 284:6946-54. 2009..Disruption of the nuclear localization signal of PHAPI caused a modest decrease of its tumor-suppressive function, indicating that nuclear localization of PHAPI contributes to, but is not essential for, tumor suppression... 
PTEN: a default gate-keeping tumor suppressor with a versatile tailXinjiang Wang
Cell Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
Cell Res 18:807-16. 2008..Further, a comparative analysis of PTEN and p53 suggests while p53 needs to be activated to suppress tumorigenesis (a dormant gatekeeper), PTEN is probably a constitutive surveillant against cancer development, thus a default gatekeeper...- Ceramide synthases 2, 5, and 6 confer distinct roles in radiation-induced apoptosis in HeLa cellsJudith Mesicek
Laboratory of Signal Transduction, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
Cell Signal 22:1300-7. 2010..These data add to the growing body of evidence demonstrating interplay among the CerS proteins in a stress stimulus-, cell type- and subcellular compartment-specific manner... - Sphingosine interaction with acidic leucine-rich nuclear phosphoprotein-32A (ANP32A) regulates PP2A activity and cyclooxygenase (COX)-2 expression in human endothelial cellsCheryl Habrukowich
Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, Cornell University, Center for Vascular Biology, New York, New York 10065, USA
J Biol Chem 285:26825-31. 2010..Knockdown of ANP32A expression further induced p38 SAPK and COX-2. These data identify ANP32A as a novel molecular target of sphingoid bases that regulates cellular signaling events and inflammatory gene expression... - NEDD4-1 is a proto-oncogenic ubiquitin ligase for PTENXinjiang Wang
Cell Biology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, Box 522, New York, NY 10021, USA
Cell 128:129-39. 2007..Therefore, NEDD4-1 is a potential proto-oncogene that negatively regulates PTEN via ubiquitination, a paradigm analogous to that of Mdm2 and p53... - Distinctive roles of PHAP proteins and prothymosin-alpha in a death regulatory pathwayXuejun Jiang
Howard Hughes Medical Institute, Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
Science 299:223-6. 2003..Thus, this chemical-biological combinatory approach has revealed the regulatory roles of oncoprotein ProT and tumor suppressor PHAP in apoptosis... - Mitochondrially localized EGFR is subjected to autophagic regulation and implicated in cell survivalXiaojing Yue
The Institute of Microbiology, Chinese Academy of Sciences, Beijing, China
Autophagy 4:641-9. 2008..Taken together, we conclude that EGFR mitochondrial localization is regulated by either autophagy or programmed cell death and is correlated with cell survival... - PHAPI, CAS, and Hsp70 promote apoptosome formation by preventing Apaf-1 aggregation and enhancing nucleotide exchange on Apaf-1Hyun Eui Kim
Howard Hughes Medical Institute, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA
Mol Cell 30:239-47. 2008..These studies indicated that PHAPI, CAS, and Hsp70 play an important regulatory role during apoptosis... - Three-dimensional structure of the apoptosome: implications for assembly, procaspase-9 binding, and activationDevrim Acehan
Department of Physiology and Biophysics, Boston University School of Medicine, 700 Albany Street, Boston, MA 02118, USA
Mol Cell 9:423-32. 2002..This complex promotes the efficient activation of procaspase-3. Therefore, the cleavage of procaspase-9 is not required to form an active cell death complex... - Assays and characterization of mammalian phosphatidylinositol 4,5-bisphosphate-sensitive phospholipase DXuejun Jiang
Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
Methods Enzymol 345:328-34. 2002
Research Grants
- Molecular Regulation of Apoptosome ActivityXuejun Jiang; Fiscal Year: 2007..This work should also shed light on designing novel cancer therapies by targeting this pathway. ..
- Molecular Regulation of Apoptosome ActivityXuejun Jiang; Fiscal Year: 2010..This work should also shed light on designing novel cancer therapies by targeting this pathway. ..
- Identification of Inhibitory Compounds for Apaf-1 by High Throughput ScreeningXUEJUN contact JIANG; Fiscal Year: 2010..They will also be important pharmacological tools for studying mechanisms and roles of cytochrome c-mediated apoptosis in various physiological and disease processes. ..