M Jasin

Summary

Affiliation: Memorial Sloan-Kettering Cancer Center
Country: USA

Publications

  1. ncbi Genetic manipulation of genomes with rare-cutting endonucleases
    M Jasin
    Cell Biology and Genetics Program, Sloan Kettering Institute and Cornell University Graduate School of Medical Sciences, NY 10021, USA
    Trends Genet 12:224-8. 1996
  2. ncbi BRCA2 is required for homology-directed repair of chromosomal breaks
    M E Moynahan
    Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA
    Mol Cell 7:263-72. 2001
  3. ncbi Repeat expansion by homologous recombination in the mouse germ line at palindromic sequences
    Z H Zhou
    Cell Biology Program, Sloan-Kettering Institute and Cornell University Graduate School of Medical Sciences, 1275 York Avenue, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 98:8326-33. 2001
  4. ncbi Double-strand breaks and tumorigenesis
    A J Pierce
    Cell Biology Program, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
    Trends Cell Biol 11:S52-9. 2001
  5. ncbi Mutations that affect meiosis in male mice influence the dynamics of the mid-preleptotene and bouquet stages
    B Liebe
    Max Planck Inst for Molecular Genetics, Ihnestr 73, D 14195 Berlin, Germany
    Exp Cell Res 312:3768-81. 2006
  6. ncbi Recombinational DNA double-strand breaks in mice precede synapsis
    S K Mahadevaiah
    Division of Developmental Genetics, National Institute for Medical Research, London, UK
    Nat Genet 27:271-6. 2001
  7. ncbi Chromosome synapsis defects and sexually dimorphic meiotic progression in mice lacking Spo11
    F Baudat
    Cell Biology Program Memorial Sloan Kettering Cancer Center New York, NY 10021, USA
    Mol Cell 6:989-98. 2000
  8. ncbi A mouse homolog of the Saccharomyces cerevisiae meiotic recombination DNA transesterase Spo11p
    S Keeney
    Molecular Biology Program, Cell Biology Program, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, New York, 10021, USA
    Genomics 61:170-82. 1999
  9. ncbi Mouse RAD54 affects DNA double-strand break repair and sister chromatid exchange
    M L Dronkert
    Department of Cell Biology and Genetics, Erasmus University Rotterdam, 3000 DR Rotterdam, The Netherlands
    Mol Cell Biol 20:3147-56. 2000
  10. ncbi XRCC3 promotes homology-directed repair of DNA damage in mammalian cells
    A J Pierce
    Cell Biology Program, Memorial Sloan Kettering Cancer Center and Cornell University Graduate School of Medical Sciences, New York, New York 10021, USA
    Genes Dev 13:2633-8. 1999

Collaborators

  • S Keeney
  • Harry Scherthan
  • W M Baarends
  • T K Pandita
  • Masayoshi Abe
  • J Schimenti
  • A J Pierce
  • R D Johnson
  • M E Moynahan
  • B Liebe
  • F Baudat
  • T Fukushima
  • Z H Zhou
  • S K Mahadevaiah
  • B Elliott
  • M L Dronkert
  • G Petukhova
  • T de Lange
  • M L Meistrich
  • R D Camerini-Otero
  • M Barchi
  • T Nakano
  • H Braselmann
  • M Bellani
  • A Fornace
  • C Morrison
  • W M Bonner
  • M Han
  • K Tatsumi
  • J Blanco-Rodríguez
  • F D Araujo
  • J M Turner
  • N Ellis
  • T Chiba
  • P K Dhar
  • E P Rogakou
  • M Takata
  • E Sonoda
  • S Takeda
  • P S Burgoyne
  • A Fujimori
  • P Hu
  • P de Boer
  • R Araki
  • M Berwick
  • J M Stark
  • H B Beverloo
  • R Kanaar
  • J H Hoeijmakers
  • J P Yuen
  • K Manova
  • L H Thompson
  • N Liu
  • N F Kaufer
  • W F Schwindinger
  • H M Fried
  • J R Warner

Detail Information

Publications16

  1. ncbi Genetic manipulation of genomes with rare-cutting endonucleases
    M Jasin
    Cell Biology and Genetics Program, Sloan Kettering Institute and Cornell University Graduate School of Medical Sciences, NY 10021, USA
    Trends Genet 12:224-8. 1996
    ..Thus, the use of rare-cutting endonucleases and the co-opting of cellular repair mechanisms might provide scientists with another tool for engineering changes into genomes...
  2. ncbi BRCA2 is required for homology-directed repair of chromosomal breaks
    M E Moynahan
    Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA
    Mol Cell 7:263-72. 2001
    ..We propose that impaired homology-directed repair caused by BRCA2 deficiency leads to chromosomal instability and, possibly, tumorigenesis, through lack of repair or misrepair of DNA damage...
  3. ncbi Repeat expansion by homologous recombination in the mouse germ line at palindromic sequences
    Z H Zhou
    Cell Biology Program, Sloan-Kettering Institute and Cornell University Graduate School of Medical Sciences, 1275 York Avenue, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 98:8326-33. 2001
    ..These results may have implications for instability observed at naturally occurring palindromic or quasipalindromic sequences...
  4. ncbi Double-strand breaks and tumorigenesis
    A J Pierce
    Cell Biology Program, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
    Trends Cell Biol 11:S52-9. 2001
    ..Although definitive proof has yet to be obtained, the current literature is highly suggestive of such a link...
  5. ncbi Mutations that affect meiosis in male mice influence the dynamics of the mid-preleptotene and bouquet stages
    B Liebe
    Max Planck Inst for Molecular Genetics, Ihnestr 73, D 14195 Berlin, Germany
    Exp Cell Res 312:3768-81. 2006
    ..Altogether, it appears that several pathways influence telomere dynamics in mammalian meiosis...
  6. ncbi Recombinational DNA double-strand breaks in mice precede synapsis
    S K Mahadevaiah
    Division of Developmental Genetics, National Institute for Medical Research, London, UK
    Nat Genet 27:271-6. 2001
    ..Loss of gamma-H2AX staining (which in irradiated somatic cells is temporally linked with DSB repair) is temporally and spatially correlated with synapsis, even when this synapsis is 'non-homologous'...
  7. ncbi Chromosome synapsis defects and sexually dimorphic meiotic progression in mice lacking Spo11
    F Baudat
    Cell Biology Program Memorial Sloan Kettering Cancer Center New York, NY 10021, USA
    Mol Cell 6:989-98. 2000
    ..Our results also support the view that mammalian checkpoint responses to meiotic recombination and/or synapsis defects are sexually dimorphic...
  8. ncbi A mouse homolog of the Saccharomyces cerevisiae meiotic recombination DNA transesterase Spo11p
    S Keeney
    Molecular Biology Program, Cell Biology Program, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, New York, 10021, USA
    Genomics 61:170-82. 1999
    ..Taken together, these results strongly suggest that this gene encodes the functional homolog of yeast Spo11p, which in turn suggests that the mechanism of meiotic recombination initiation is conserved between yeast and mammals...
  9. ncbi Mouse RAD54 affects DNA double-strand break repair and sister chromatid exchange
    M L Dronkert
    Department of Cell Biology and Genetics, Erasmus University Rotterdam, 3000 DR Rotterdam, The Netherlands
    Mol Cell Biol 20:3147-56. 2000
    ..Our results suggest that mRAD54 promotes gene conversion with predominant use of the sister chromatid as the repair template at the expense of error-prone SSA...
  10. ncbi XRCC3 promotes homology-directed repair of DNA damage in mammalian cells
    A J Pierce
    Cell Biology Program, Memorial Sloan Kettering Cancer Center and Cornell University Graduate School of Medical Sciences, New York, New York 10021, USA
    Genes Dev 13:2633-8. 1999
    ..These results establish that XRCC3-mediated homologous recombination can reverse DNA damage that would otherwise be mutagenic or lethal...
  11. ncbi Repair of double-strand breaks by homologous recombination in mismatch repair-defective mammalian cells
    B Elliott
    Cell Biology Program, Memorial Sloan Kettering Cancer Center and Cornell University Graduate School of Medical Sciences, New York, New York 10021, USA
    Mol Cell Biol 21:2671-82. 2001
    ..In cells with MMR defects, therefore, aberrant recombinational repair may be an additional mechanism that contributes to genomic instability and possibly tumorigenesis...
  12. ncbi Double-strand-break-induced homologous recombination in mammalian cells
    R D Johnson
    Cell Biology Program, Memorial Sloan-Kettering Cancer Center and Cornell University Graduate School of Medical Sciences, 1275 York Avenue, New York, NY 10021
    Biochem Soc Trans 29:196-201. 2001
    ..To date, four mammalian proteins have been demonstrated conclusively to be involved in DSB repair by homologous recombination: Rad54, XRCC2, XRCC3 and BRCA1. This paper summarizes results from a number of recent studies...
  13. ncbi Genetic analysis of the DNA-dependent protein kinase reveals an inhibitory role of Ku in late S-G2 phase DNA double-strand break repair
    T Fukushima
    CREST Research Project, Radiation Genetics, Faculty of Medicine, Kyoto University, Konoe Yoshida, Sakyo-ku, Kyoto 606-8501, Japan
    J Biol Chem 276:44413-8. 2001
    ..Our findings suggest that Ku can interfere with HR-mediated DSB repair, perhaps competing with HR for DSB recognition...
  14. ncbi Mammalian XRCC2 promotes the repair of DNA double-strand breaks by homologous recombination
    R D Johnson
    Cell Biology Program, Memorial Sloan Kettering Cancer Center and Cornell University Graduate School of Medical Sciences, New York, New York 10021, USA
    Nature 401:397-9. 1999
    ..The repair defect in XRCC2 mutant cells appears to be restricted to recombinational repair because NHEJ is normal. We conclude that XRCC2 is involved in the repair of DNA double-strand breaks by homologous recombination...
  15. ncbi Ku DNA end-binding protein modulates homologous repair of double-strand breaks in mammalian cells
    A J Pierce
    Cell Biology Program, Memorial Sloan Kettering Cancer Center, and Cornell University Graduate School of Medical Sciences, New York, New York 10021, USA
    Genes Dev 15:3237-42. 2001
    ..Neither sister-chromatid exchange nor gene-targeting frequencies show a dependence on these NHEJ proteins. A Ku-modulated two-ended versus one-ended chromosome break model is presented to explain these results...
  16. ncbi Cycloheximide resistance in yeast: the gene and its protein
    N F Kaufer
    Nucleic Acids Res 11:3123-35. 1983
    ..In confirmation of peptide analysis by Stocklein et al. (1) we find that resistance to cycloheximide is due to a transversion mutation resulting in the replacement of a glutamine by glutamic acid in position 37 of L29...