M Jasin

Summary

Affiliation: Memorial Sloan-Kettering Cancer Center
Country: USA

Publications

  1. ncbi request reprint Measuring recombination proficiency in mouse embryonic stem cells
    Andrew J Pierce
    Markey Cancer Center, University of Kentucky, Lexington, USA
    Methods Mol Biol 291:373-84. 2005
  2. ncbi request reprint Reduced repair of DNA double-strand breaks by homologous recombination in a DNA ligase I-deficient human cell line
    Julie Della Maria Goetz
    Radiation Oncology Research Laboratory, Department of Radiation Oncology and Greenebaum Cancer Center, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    DNA Repair (Amst) 4:649-54. 2005
  3. ncbi request reprint Homologous repair of DNA damage and tumorigenesis: the BRCA connection
    Maria Jasin
    Cell Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Oncogene 21:8981-93. 2002
  4. ncbi request reprint Chromosome breaks and genomic instability
    M Jasin
    Memorial Sloan Kettering Cancer Center, Cornell University Graduate School of Medical Sciences, New York, New York, USA
    Cancer Invest 18:78-86. 2000
  5. ncbi request reprint BRCA2 is required for homology-directed repair of chromosomal breaks
    M E Moynahan
    Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA
    Mol Cell 7:263-72. 2001
  6. pmc Ku DNA end-binding protein modulates homologous repair of double-strand breaks in mammalian cells
    A J Pierce
    Cell Biology Program, Memorial Sloan Kettering Cancer Center, and Cornell University Graduate School of Medical Sciences, New York, New York 10021, USA
    Genes Dev 15:3237-42. 2001
  7. ncbi request reprint Chromosome synapsis defects and sexually dimorphic meiotic progression in mice lacking Spo11
    F Baudat
    Cell Biology Program Memorial Sloan Kettering Cancer Center New York, NY 10021, USA
    Mol Cell 6:989-98. 2000
  8. ncbi request reprint Homology-directed dna repair, mitomycin-c resistance, and chromosome stability is restored with correction of a Brca1 mutation
    M E Moynahan
    Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, New York 10021, USA
    Cancer Res 61:4842-50. 2001
  9. pmc Repair of double-strand breaks by homologous recombination in mismatch repair-defective mammalian cells
    B Elliott
    Cell Biology Program, Memorial Sloan Kettering Cancer Center and Cornell University Graduate School of Medical Sciences, New York, New York 10021, USA
    Mol Cell Biol 21:2671-82. 2001
  10. ncbi request reprint Double-strand breaks and tumorigenesis
    A J Pierce
    Cell Biology Program, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
    Trends Cell Biol 11:S52-9. 2001

Research Grants

Collaborators

Detail Information

Publications61

  1. ncbi request reprint Measuring recombination proficiency in mouse embryonic stem cells
    Andrew J Pierce
    Markey Cancer Center, University of Kentucky, Lexington, USA
    Methods Mol Biol 291:373-84. 2005
    ..A fluorescence-based reporter is first gene targeted to the Hprt locus in a quantifiable way. A homing endonuclease expression vector is then introduced to generate a double-strand break, the repair of which is also quantifiable...
  2. ncbi request reprint Reduced repair of DNA double-strand breaks by homologous recombination in a DNA ligase I-deficient human cell line
    Julie Della Maria Goetz
    Radiation Oncology Research Laboratory, Department of Radiation Oncology and Greenebaum Cancer Center, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    DNA Repair (Amst) 4:649-54. 2005
    ..Thus, our results demonstrate that DNA ligase I-deficiency reduces recombinational repair of DNA double-strand breaks...
  3. ncbi request reprint Homologous repair of DNA damage and tumorigenesis: the BRCA connection
    Maria Jasin
    Cell Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Oncogene 21:8981-93. 2002
    ....
  4. ncbi request reprint Chromosome breaks and genomic instability
    M Jasin
    Memorial Sloan Kettering Cancer Center, Cornell University Graduate School of Medical Sciences, New York, New York, USA
    Cancer Invest 18:78-86. 2000
    ..This review summarizes those studies and discusses how disruption of homologous recombination pathways can create genetic instability...
  5. ncbi request reprint BRCA2 is required for homology-directed repair of chromosomal breaks
    M E Moynahan
    Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA
    Mol Cell 7:263-72. 2001
    ..We propose that impaired homology-directed repair caused by BRCA2 deficiency leads to chromosomal instability and, possibly, tumorigenesis, through lack of repair or misrepair of DNA damage...
  6. pmc Ku DNA end-binding protein modulates homologous repair of double-strand breaks in mammalian cells
    A J Pierce
    Cell Biology Program, Memorial Sloan Kettering Cancer Center, and Cornell University Graduate School of Medical Sciences, New York, New York 10021, USA
    Genes Dev 15:3237-42. 2001
    ..Neither sister-chromatid exchange nor gene-targeting frequencies show a dependence on these NHEJ proteins. A Ku-modulated two-ended versus one-ended chromosome break model is presented to explain these results...
  7. ncbi request reprint Chromosome synapsis defects and sexually dimorphic meiotic progression in mice lacking Spo11
    F Baudat
    Cell Biology Program Memorial Sloan Kettering Cancer Center New York, NY 10021, USA
    Mol Cell 6:989-98. 2000
    ..Our results also support the view that mammalian checkpoint responses to meiotic recombination and/or synapsis defects are sexually dimorphic...
  8. ncbi request reprint Homology-directed dna repair, mitomycin-c resistance, and chromosome stability is restored with correction of a Brca1 mutation
    M E Moynahan
    Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, New York 10021, USA
    Cancer Res 61:4842-50. 2001
    ..We conclude that the inability to properly repair strand breaks by homology-directed repair gives rise to defects in chromosome maintenance that promote genetic instability and, it is likely, tumorigenesis...
  9. pmc Repair of double-strand breaks by homologous recombination in mismatch repair-defective mammalian cells
    B Elliott
    Cell Biology Program, Memorial Sloan Kettering Cancer Center and Cornell University Graduate School of Medical Sciences, New York, New York 10021, USA
    Mol Cell Biol 21:2671-82. 2001
    ..In cells with MMR defects, therefore, aberrant recombinational repair may be an additional mechanism that contributes to genomic instability and possibly tumorigenesis...
  10. ncbi request reprint Double-strand breaks and tumorigenesis
    A J Pierce
    Cell Biology Program, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
    Trends Cell Biol 11:S52-9. 2001
    ..Although definitive proof has yet to be obtained, the current literature is highly suggestive of such a link...
  11. ncbi request reprint Double-strand-break-induced homologous recombination in mammalian cells
    R D Johnson
    Cell Biology Program, Memorial Sloan-Kettering Cancer Center and Cornell University Graduate School of Medical Sciences, 1275 York Avenue, New York, NY 10021
    Biochem Soc Trans 29:196-201. 2001
    ..To date, four mammalian proteins have been demonstrated conclusively to be involved in DSB repair by homologous recombination: Rad54, XRCC2, XRCC3 and BRCA1. This paper summarizes results from a number of recent studies...
  12. pmc Repeat expansion by homologous recombination in the mouse germ line at palindromic sequences
    Z H Zhou
    Cell Biology Program, Sloan-Kettering Institute and Cornell University Graduate School of Medical Sciences, 1275 York Avenue, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 98:8326-33. 2001
    ..These results may have implications for instability observed at naturally occurring palindromic or quasipalindromic sequences...
  13. pmc XRCC3 promotes homology-directed repair of DNA damage in mammalian cells
    A J Pierce
    Cell Biology Program, Memorial Sloan Kettering Cancer Center and Cornell University Graduate School of Medical Sciences, New York, New York 10021, USA
    Genes Dev 13:2633-8. 1999
    ..These results establish that XRCC3-mediated homologous recombination can reverse DNA damage that would otherwise be mutagenic or lethal...
  14. ncbi request reprint Double-strand breaks and translocations in cancer
    B Elliott
    Cell Biology Program, Memorial Sloan Kettering Cancer Center and Cornell University, Graduate School of Medical Sciences, New York, NewYork 10021, USA
    Cell Mol Life Sci 59:373-85. 2002
    ..The analysis of translocation breakpoints in a number of cancers and the development of model translocation systems are beginning to shed light on specific DSB repair pathway(s) responsible for the improper repair of broken chromosomes...
  15. ncbi request reprint Genetic manipulation of genomes with rare-cutting endonucleases
    M Jasin
    Cell Biology and Genetics Program, Sloan Kettering Institute and Cornell University Graduate School of Medical Sciences, NY 10021, USA
    Trends Genet 12:224-8. 1996
    ..Thus, the use of rare-cutting endonucleases and the co-opting of cellular repair mechanisms might provide scientists with another tool for engineering changes into genomes...
  16. ncbi request reprint NHEJ deficiency and disease
    A J Pierce
    Cell Biology Program, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Mol Cell 8:1160-1. 2001
    ..Manifestation of some of these disease phenotypes, namely tumorigenesis, may require additional checkpoint deficiencies...
  17. ncbi request reprint A mouse homolog of the Saccharomyces cerevisiae meiotic recombination DNA transesterase Spo11p
    S Keeney
    Molecular Biology Program, Cell Biology Program, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, New York, 10021, USA
    Genomics 61:170-82. 1999
    ..Taken together, these results strongly suggest that this gene encodes the functional homolog of yeast Spo11p, which in turn suggests that the mechanism of meiotic recombination initiation is conserved between yeast and mammals...
  18. ncbi request reprint Mammalian XRCC2 promotes the repair of DNA double-strand breaks by homologous recombination
    R D Johnson
    Cell Biology Program, Memorial Sloan Kettering Cancer Center and Cornell University Graduate School of Medical Sciences, New York, New York 10021, USA
    Nature 401:397-9. 1999
    ..The repair defect in XRCC2 mutant cells appears to be restricted to recombinational repair because NHEJ is normal. We conclude that XRCC2 is involved in the repair of DNA double-strand breaks by homologous recombination...
  19. pmc Mechanisms of recombination between diverged sequences in wild-type and BLM-deficient mouse and human cells
    Jeannine R Larocque
    Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    Mol Cell Biol 30:1887-97. 2010
    ..BLM-deficient mouse and human cells suppress homeologous recombination to a similar extent as wild-type cells, unlike Sgs1-deficient Saccharomyces cerevisiae...
  20. ncbi request reprint The Fanconi anemia group A protein modulates homologous repair of DNA double-strand breaks in mammalian cells
    Yun gui Yang
    International Agency for Research on Cancer IARC, 150 cours Albert Thomas, F 69008 Lyon, France
    Carcinogenesis 26:1731-40. 2005
    ..These data identify the Fanca protein as an integral component in the early step of HDR of DSBs and thereby minimizing the genomic instability...
  21. pmc Fen-1 facilitates homologous recombination by removing divergent sequences at DNA break ends
    Koji Kikuchi
    Department of Radiation Genetics, Graduate School of Medicine, Kyoto University, Yoshidakonoe, Sakyo ku, Japan
    Mol Cell Biol 25:6948-55. 2005
    ..We conclude that Fen-1 eliminates heterologous sequences at DNA damage site and facilitates DNA repair by HR...
  22. pmc Surveillance of different recombination defects in mouse spermatocytes yields distinct responses despite elimination at an identical developmental stage
    Marco Barchi
    Molecular Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Mol Cell Biol 25:7203-15. 2005
    ..Thus, despite equivalent stages of spermatocyte elimination, different recombination-defective mutants manifest distinct responses, providing insight into surveillance mechanisms in male meiosis...
  23. pmc A model of oncogenic rearrangements: differences between chromosomal translocation mechanisms and simple double-strand break repair
    David M Weinstock
    Department of Medicine and Molecular Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA
    Blood 107:777-80. 2006
    ..Interestingly, in a direct comparison, the spectrum of translocation breakpoint junctions differed from junctions derived from repair at a single chromosomal break, providing mechanistic insight into translocation formation...
  24. ncbi request reprint CDK-dependent phosphorylation of BRCA2 as a regulatory mechanism for recombinational repair
    Fumiko Esashi
    Cancer Research UK, London Research Institute, Clare Hall Laboratories, South Mimms, Hertfordshire EN6 3LD, UK
    Nature 434:598-604. 2005
    ....
  25. pmc Alternative pathways for the repair of RAG-induced DNA breaks
    David M Weinstock
    Department of Medicine, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
    Mol Cell Biol 26:131-9. 2006
    ..Thus, RAG-generated DSBs are typically repaired by the NHEJ pathway in ES cells, but in the absence of NHEJ components, a substantial fraction of breaks can be efficiently channeled into alternative pathways in these cells...
  26. ncbi request reprint Hypoxia-induced down-regulation of BRCA1 expression by E2Fs
    Ranjit S Bindra
    Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, CT 06520, USA
    Cancer Res 65:11597-604. 2005
    ..Furthermore, these findings provide a novel link between E2Fs and the transcriptional response to hypoxia and provide insight into the mechanisms by which the tumor microenvironment can contribute to genetic instability in cancer...
  27. pmc Suppression of the DNA repair defects of BRCA2-deficient cells with heterologous protein fusions
    Hiroshi Saeki
    Molecular Biology Program, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 103:8768-73. 2006
    ....
  28. pmc ATM promotes the obligate XY crossover and both crossover control and chromosome axis integrity on autosomes
    Marco Barchi
    Developmental Biology Program, Memorial Sloan Kettering Cancer Center, New York, New York, United States of America
    PLoS Genet 4:e1000076. 2008
    ..Together, these findings indicate that ATM plays a role in both crossover control and chromosome axis integrity and further suggests that ATM is important for coordinating these features of meiotic chromosome dynamics...
  29. ncbi request reprint Structural requirements for the BARD1 tumor suppressor in chromosomal stability and homology-directed DNA repair
    Marsha Laufer
    Institute for Cancer Genetics, Department of Pathology and Cell Biology, Columbia University College of Physicians and Surgeons, 1130 St Nicholas Avenue, New York, NY 10032, USA
    J Biol Chem 282:34325-33. 2007
    ..However, none of these was found to affect the HDR activity of BARD1, suggesting that any increased cancer risk conferred by these mutations is not because of defects in this repair mechanism...
  30. pmc Meiotic crossover hotspots contained in haplotype block boundaries of the mouse genome
    Liisa Kauppi
    Molecular Biology and Developmental Biology Programs, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 104:13396-401. 2007
    ..As increasing amounts of single-nucleotide polymorphism data emerge, this approach will be useful for investigating the recombination landscape of the mouse genome...
  31. pmc Interplay between human DNA repair proteins at a unique double-strand break in vivo
    Amélie Rodrigue
    Genome Stability Laboratory, Laval University Cancer Research Center, Quebec City, Quebec, Canada
    EMBO J 25:222-31. 2006
    ..We propose that RAD51C ensures a tight regulation of RAD51 assembly during DSB repair and plays a direct role in repairing DSBs in vivo...
  32. pmc Positional stability of single double-strand breaks in mammalian cells
    Evi Soutoglou
    National Cancer Institute, NIH, Bethesda, MD 20892, USA
    Nat Cell Biol 9:675-82. 2007
    ..These results support a contact-first model in which chromosome translocations predominantly form among spatially proximal DSBs...
  33. ncbi request reprint Immunology. Antibodies get a break
    Jayanta Chaudhuri
    Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Science 315:335-6. 2007
  34. ncbi request reprint Modeling oncogenic translocations: distinct roles for double-strand break repair pathways in translocation formation in mammalian cells
    David M Weinstock
    Department of Medicine, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
    DNA Repair (Amst) 5:1065-74. 2006
    ..Although SSA can efficiently mediate translocations between identical repeats, its contribution to translocation formation is likely very limited because of sequence divergence between repetitive elements in the genome...
  35. ncbi request reprint Control of BRCA2 cellular and clinical functions by a nuclear partner, PALB2
    Bing Xia
    Dana Farber Cancer Institute and Harvard Medical School, 44 Binney Street, Boston, Massachusetts 02115, USA
    Mol Cell 22:719-29. 2006
    ..Thus, PALB2 licenses key cellular biochemical properties of BRCA2 and ensures its tumor suppression function...
  36. ncbi request reprint Chromosomal translocation mechanisms at intronic alu elements in mammalian cells
    Beth Elliott
    Molecular Biology Program, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, New York 10021, USA
    Mol Cell 17:885-94. 2005
    ..These results emphasize the fluidity of mammalian DSB repair pathway usage. The intron-based system is highly adaptable to addressing a number of issues regarding molecular mechanisms of genomic rearrangements in mammalian cells...
  37. pmc Distinct DNA-damage-dependent and -independent responses drive the loss of oocytes in recombination-defective mouse mutants
    Monica Di Giacomo
    Molecular Biology Program, Memorial Sloan Kettering Cancer Center and Weill Graduate School of Medical Sciences of Cornell University, 1275 York Avenue, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 102:737-42. 2005
    ..The absence of ATM caused defects in folliculogenesis that were similar to those in Dmc1 mutants and that could be suppressed by Spo11 mutation, implying that oocyte death in Atm-deficient animals is a response to defective DSB repair...
  38. pmc Seeking new meiotic genes
    Marco Barchi
    Cell Biology Program, Memorial Sloan Kettering Cancer Center and Weill Graduate School of Medical Sciences of Cornell University, 1275 York Avenue, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 100:15287-9. 2003
  39. pmc BARD1 participates with BRCA1 in homology-directed repair of chromosome breaks
    Ulrica K Westermark
    Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Mol Cell Biol 23:7926-36. 2003
    ..The tumor suppressor activity of BRCA1 may require the participation of BARD1 to maintain chromosome integrity through the homologous-repair pathway...
  40. pmc Evidence for replicative repair of DNA double-strand breaks leading to oncogenic translocation and gene amplification
    Michael J Difilippantonio
    Genetics Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Exp Med 196:469-80. 2002
    ..Thus, mice deficient in NHEJ provide excellent models to study the etiology of unbalanced translocations and amplification events during tumorigenesis...
  41. pmc Eme1 is involved in DNA damage processing and maintenance of genomic stability in mammalian cells
    Jacinth Abraham
    Advanced Medical Discovery Institute, Ontario Cancer Institute, 620 University Avenue, Suite 706, Toronto, Ontario M5G 2C1, Canada
    EMBO J 22:6137-47. 2003
    ..Most importantly, Eme1 deficiency led to spontaneous genomic instability. These results reveal that mammalian Eme1 plays a key role in DNA repair and the maintenance of genome integrity...
  42. pmc An xrcc4 defect or Wortmannin stimulates homologous recombination specifically induced by double-strand breaks in mammalian cells
    Fabien Delacôte
    UMR CEA CNRS 217, CEA, DSV, DRR, 60 68 avenue du General Leclerc, F 92265 Fontenay aux Roses Cedex, France
    Nucleic Acids Res 30:3454-63. 2002
    ....
  43. ncbi request reprint Variant XRCC3 implicated in cancer is functional in homology-directed repair of double-strand breaks
    Felipe D Araujo
    Cell Biology Program, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
    Oncogene 21:4176-80. 2002
    ..These results suggest that the increased cancer risk associated with this variant may not be due to an intrinsic HDR defect...
  44. ncbi request reprint Rad51 overexpression promotes alternative double-strand break repair pathways and genome instability
    Christine Richardson
    Department of Pathology, Institute of Cancer Genetics, Columbia University College of Physicians and Surgeons, 1150 St Nicholas Avenue, New York, NY 10032, USA
    Oncogene 23:546-53. 2004
    ..Increased Rad51 also promoted aneuploidy and multiple chromosomal rearrangements. These data provide a link between elevated Rad51 protein levels, genome instability, and tumor progression...
  45. pmc Mouse strains with an active H2-Ea meiotic recombination hot spot exhibit increased levels of H2-Ea-specific DNA breaks in testicular germ cells
    Jian Qin
    Program in Molecular and Computational Biology, University of Southern California, Los Angeles, California 90089 1340, USA
    Mol Cell Biol 24:1655-66. 2004
    ..The recombination-related breaks in the hot spot likely reflect SPO11-induced double-strand breaks and/or recombination intermediates containing free 3' hydroxyl groups...
  46. ncbi request reprint Ablation of PARP-1 does not interfere with the repair of DNA double-strand breaks, but compromises the reactivation of stalled replication forks
    Yun gui Yang
    International Agency for Research on Cancer, 150 cours Albert Thomas, Lyon 69008, France
    Oncogene 23:3872-82. 2004
    ..These data indicate that PARP-1 is dispensable in HR induced by DSBs, but is involved in the repair and reactivation of stalled replication forks...
  47. pmc Collaboration of homologous recombination and nonhomologous end-joining factors for the survival and integrity of mice and cells
    Chrystelle Couedel
    Molecular Biology Program, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Genes Dev 18:1293-304. 2004
    ..The substantially increased DNA damage response in the double mutants implies a cooperation of the two DSB repair pathways for survival and genomic integrity in the animal...
  48. ncbi request reprint ATP hydrolysis by mammalian RAD51 has a key role during homology-directed DNA repair
    Jeremy M Stark
    Cell Biology Program, Memorial Sloan Kettering Cancer Center and Cornell University Graduate School of Medical Sciences, New York, New York 10021
    J Biol Chem 277:20185-94. 2002
    ..Thus, ATP hydrolysis by RAD51 has a key role in various types of DNA repair in mammalian cells...
  49. ncbi request reprint Involvement of mammalian Mus81 in genome integrity and tumor suppression
    John Peter McPherson
    Ontario Cancer Institute, 620 University Avenue, Suite 706, Toronto, Ontario, Canada M5G 2C1
    Science 304:1822-6. 2004
    ..These studies demonstrate a critical role for the proper biallelic expression of the mammalian Mus81 in the maintenance of genomic integrity and tumor suppression...
  50. pmc Genetic steps of mammalian homologous repair with distinct mutagenic consequences
    Jeremy M Stark
    Molecular Biology Program, Memorial Sloan Kettering Cancer Center, 1275 York Ave, New York, NY 10021, USA
    Mol Cell Biol 24:9305-16. 2004
    ..These results imply that the proper genetic interplay of repair factors is essential to limit the mutagenic potential of DSB repair...
  51. pmc Extensive loss of heterozygosity is suppressed during homologous repair of chromosomal breaks
    Jeremy M Stark
    Cell Biology Program, Memorial Sloan Kettering Cancer Center and Cornell University Graduate School of Medical Sciences, New York, New York 10021, USA
    Mol Cell Biol 23:733-43. 2003
    ..These results indicate that extensive LOH is normally suppressed during DSB-induced allelic recombination in dividing mammalian cells...
  52. pmc A forward chemical genetic screen reveals an inhibitor of the Mre11-Rad50-Nbs1 complex
    Aude Dupré
    Columbia University, Institute for Cancer Genetics, Irving Cancer Research Center, 1130 St Nicholas Avenue, Room 602, New York, New York 10032, USA
    Nat Chem Biol 4:119-25. 2008
    ..Consistent with its ability to target the MRN complex, mirin abolishes the G2/M checkpoint and homology-dependent repair in mammalian cells...
  53. pmc Human Fanconi anemia monoubiquitination pathway promotes homologous DNA repair
    Koji Nakanishi
    Molecular Biology Program, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 102:1110-5. 2005
    ..e., single-strand annealing. These results suggest an early role for the FANC proteins in homologous DSB repair pathway choice...
  54. ncbi request reprint Mice deficient for the type II topoisomerase-like DNA transesterase Spo11 show normal immunoglobulin somatic hypermutation and class switching
    Ulf Klein
    Institute for Cancer Genetics, Columbia University, New York, USA
    Eur J Immunol 32:316-21. 2002
    ..Furthermore, Spo11(-/-) mice showed normal serum levels of all Ig isotypes. These results indicate that Spo11 is not required for Ig hypermutation or class switch recombination...
  55. doi request reprint Distinct effects of DNA-PKcs and Artemis inactivation on signal joint formation in vivo
    Cedric Touvrey
    CEA, DSV, DRDC, Laboratoire d Immunochimie, INSERM U548, Universite Joseph Fourier, Grenoble F 38054, France
    Mol Immunol 45:3383-91. 2008
    ..In addition, these data suggest that Artemis might be the nuclease responsible for nucleotide loss from signal ends during the repair process...
  56. pmc RECQL5/Recql5 helicase regulates homologous recombination and suppresses tumor formation via disruption of Rad51 presynaptic filaments
    Yiduo Hu
    Department of Genetics, Case Comprehensive Cancer Centre, University Hospitals of Cleveland and Case Western Reserve University, Cleveland, Ohio 44106, USA
    Genes Dev 21:3073-84. 2007
    ..Together, our results identify RECQL5 as an important tumor suppressor that may act by preventing inappropriate HR events via Rad51 presynaptic filament disruption...
  57. ncbi request reprint Gene conversion is strongly induced in human cells by double-strand breaks and is modulated by the expression of BCL-x(L)
    Claudia Wiese
    Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, USA
    Cancer Res 62:1279-83. 2002
    ..This is the first study to highlight a function for BCL-x(L) in modulating DSB repair in human cells...
  58. ncbi request reprint Assaying double-strand break repair pathway choice in mammalian cells using a targeted endonuclease or the RAG recombinase
    David M Weinstock
    Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York, USA
    Methods Enzymol 409:524-40. 2006
    ..These reporters can be used to assess the effects of genetic background, dominant-negative constructs, or physiological conditions on DSB repair in a wide variety of mammalian cells...
  59. ncbi request reprint Homologous recombination deficiency leads to profound genetic instability in cells derived from Xrcc2-knockout mice
    Bryan Deans
    Medical Research Council, Radiation and Genome Stability Unit, Harwell, Oxfordshire, United Kingdom
    Cancer Res 63:8181-7. 2003
    ....
  60. pmc Molecular cross-talk among chromosome fragility syndromes
    Jordi Surralles
    Group of Mutagenesis, Department of Genetics and Microbiology, Universitat Autonoma de Barcelona, 08193 Bellaterra, Barcelona, Spain
    Genes Dev 18:1359-70. 2004
  61. pmc Formation of NHEJ-derived reciprocal chromosomal translocations does not require Ku70
    David M Weinstock
    Department of Medicine, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
    Nat Cell Biol 9:978-81. 2007
    ..Surprisingly, translocations are increased in cells deficient for the nonhomologous end-joining (NHEJ) protein Ku70, implicating non-canonical joining pathways in their etiology...

Research Grants23

  1. Double-strand break repair in mammalian cells
    Maria Jasin; Fiscal Year: 2006
    ....
  2. Double-strand break repair in mammalian cells
    Maria Jasin; Fiscal Year: 2007
    ..The roles of a gene encoding a Rad51 paralog (Xrcc2) and other Rad52 epistasis group members (Rad52 and Rad54) will be investigated, as well as that of a hypomorphic Brca2 allele. ..
  3. Role of Spo11 and recombination in mouse meiosis
    Maria Jasin; Fiscal Year: 2007
    ..This project will address fundamental questions about how mammals control meiotic recombination and respond when there are problems. ..
  4. Role of Spo11 and recombination in mouse meiosis
    Maria Jasin; Fiscal Year: 2010
    ..This project will address fundamental questions about how mammals control meiotic recombination and respond when there are problems. ..
  5. Role of Spo11 and recombination in mouse meiosis
    Maria Jasin; Fiscal Year: 2005
    ..We will further explore this relationship by examining spindle formation in cultured Spo11-/- oocytes. We will also explicitly test whether Spo11 is required for meiotic crossing over by assaying chiasma formation in mutant oocytes. ..
  6. RADIATION RESISTANT AND SENSITIVE CELLS DNA BREAK REPAIR
    Maria Jasin; Fiscal Year: 2001
    ..The understanding that is gained has a long-range impact on health, medicine, and basic science. ..
  7. Double-strand break repair in mammalian cells
    Maria Jasin; Fiscal Year: 2010
    ..The roles of a gene encoding a Rad51 paralog (Xrcc2) and other Rad52 epistasis group members (Rad52 and Rad54) will be investigated, as well as that of a hypomorphic Brca2 allele. ..