W R Jarnagin

Summary

Affiliation: Memorial Sloan-Kettering Cancer Center
Country: USA

Publications

  1. ncbi Genome wide analysis and clinical correlation of chromosomal and transcriptional mutations in cancers of the biliary tract
    George Miller
    Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    J Exp Clin Cancer Res 28:62. 2009
  2. ncbi Combined hepatocellular and cholangiocarcinoma: demographic, clinical, and prognostic factors
    William R Jarnagin
    Department of Surgery, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
    Cancer 94:2040-6. 2002
  3. ncbi Improvement in perioperative outcome after hepatic resection: analysis of 1,803 consecutive cases over the past decade
    William R Jarnagin
    Departments of Surgery and Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Ann Surg 236:397-406; discussion 406-7. 2002
  4. ncbi A prospective randomized trial of acute normovolemic hemodilution compared to standard intraoperative management in patients undergoing major hepatic resection
    William R Jarnagin
    Department of Surgery, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, C 887, New York, NY 10065, USA
    Ann Surg 248:360-9. 2008
  5. ncbi Regional chemotherapy for unresectable primary liver cancer: results of a phase II clinical trial and assessment of DCE-MRI as a biomarker of survival
    W R Jarnagin
    Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Ann Oncol 20:1589-95. 2009
  6. ncbi A clinical scoring system predicts the yield of diagnostic laparoscopy in patients with potentially resectable hepatic colorectal metastases
    W R Jarnagin
    Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Cancer 91:1121-8. 2001
  7. ncbi Treatment of cholangiocarcinoma with oncolytic herpes simplex virus combined with external beam radiation therapy
    W R Jarnagin
    Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Cancer Gene Ther 13:326-34. 2006
  8. ncbi Papillary phenotype confers improved survival after resection of hilar cholangiocarcinoma
    William R Jarnagin
    Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Ann Surg 241:703-12; discussion 712-4. 2005
  9. ncbi Patterns of initial disease recurrence after resection of gallbladder carcinoma and hilar cholangiocarcinoma: implications for adjuvant therapeutic strategies
    William R Jarnagin
    Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Cancer 98:1689-700. 2003
  10. ncbi Surgical management of cholangiocarcinoma
    William R Jarnagin
    Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Semin Liver Dis 24:189-99. 2004

Research Grants

  1. Hepatic Arterial Flouridine and IV Bevacizumab for Primary Hepatic Malignancy
    William Jarnagin; Fiscal Year: 2007

Detail Information

Publications101 found, 100 shown here

  1. ncbi Genome wide analysis and clinical correlation of chromosomal and transcriptional mutations in cancers of the biliary tract
    George Miller
    Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    J Exp Clin Cancer Res 28:62. 2009
    ..The pathogenesis of biliary cancers is ill-defined. This study investigates changes in gene expression and copy number in biliary cancers and correlates these changes with anatomical site of origin, histopathology and outcome...
  2. ncbi Combined hepatocellular and cholangiocarcinoma: demographic, clinical, and prognostic factors
    William R Jarnagin
    Department of Surgery, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
    Cancer 94:2040-6. 2002
    ....
  3. ncbi Improvement in perioperative outcome after hepatic resection: analysis of 1,803 consecutive cases over the past decade
    William R Jarnagin
    Departments of Surgery and Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Ann Surg 236:397-406; discussion 406-7. 2002
    ..To assess the nature of changes in the field of hepatic resectional surgery and their impact on perioperative outcome...
  4. ncbi A prospective randomized trial of acute normovolemic hemodilution compared to standard intraoperative management in patients undergoing major hepatic resection
    William R Jarnagin
    Department of Surgery, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, C 887, New York, NY 10065, USA
    Ann Surg 248:360-9. 2008
    ....
  5. ncbi Regional chemotherapy for unresectable primary liver cancer: results of a phase II clinical trial and assessment of DCE-MRI as a biomarker of survival
    W R Jarnagin
    Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Ann Oncol 20:1589-95. 2009
    ....
  6. ncbi A clinical scoring system predicts the yield of diagnostic laparoscopy in patients with potentially resectable hepatic colorectal metastases
    W R Jarnagin
    Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Cancer 91:1121-8. 2001
    ....
  7. ncbi Treatment of cholangiocarcinoma with oncolytic herpes simplex virus combined with external beam radiation therapy
    W R Jarnagin
    Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Cancer Gene Ther 13:326-34. 2006
    ..5 gene, resulting in treatment synergy; this effect is cell type dependent. Combined XRT and oncolytic viral therapy is a potentially important treatment strategy that may enhance the therapeutic ratios of both individual therapies...
  8. ncbi Papillary phenotype confers improved survival after resection of hilar cholangiocarcinoma
    William R Jarnagin
    Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Ann Surg 241:703-12; discussion 712-4. 2005
    ..The current study compares outcome after resection of papillary hilar cholangiocarcinoma to that of the more common nodular-sclerosing subtype...
  9. ncbi Patterns of initial disease recurrence after resection of gallbladder carcinoma and hilar cholangiocarcinoma: implications for adjuvant therapeutic strategies
    William R Jarnagin
    Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Cancer 98:1689-700. 2003
    ....
  10. ncbi Surgical management of cholangiocarcinoma
    William R Jarnagin
    Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Semin Liver Dis 24:189-99. 2004
    ..Adjuvant therapy (chemotherapy and radiation therapy) has not been shown clearly to reduce recurrence risk...
  11. ncbi Management of small hepatocellular carcinoma: a review of transplantation, resection, and ablation
    William R Jarnagin
    Memorial Sloan Kettering Cancer Center, New York, NY, USA
    Ann Surg Oncol 17:1226-33. 2010
    ....
  12. ncbi A prospective analysis of staging laparoscopy in patients with primary and secondary hepatobiliary malignancies
    W R Jarnagin
    Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    J Gastrointest Surg 4:34-43. 2000
    ..Eighty-three percent of patients subjected to laparotomy after laparoscopy underwent a potentially curative resection compared to 66% of those who were not staged laparoscopically...
  13. ncbi Operative repair of bile duct injuries involving the hepatic duct confluence
    W R Jarnagin
    Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Arch Surg 134:769-75. 1999
    ..In this review, we discuss the approach to patients with proximal bile duct injuries, with emphasis on preoperative evaluation and the technical aspects of biliary reconstruction...
  14. ncbi Staging, resectability, and outcome in 225 patients with hilar cholangiocarcinoma
    W R Jarnagin
    Department of Surgery, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
    Ann Surg 234:507-17; discussion 517-9. 2001
    ..To analyze resectability and survival in patients with hilar cholangiocarcinoma according to a proposed preoperative staging scheme that fully integrates local, tumor-related factors...
  15. ncbi Cholangiocarcinoma of the extrahepatic bile ducts
    W R Jarnagin
    Department of Surgery, Memorial Sloan Kettering Cancer Center and Weill Medical College of Cornell University, New York, New York 10021, USA
    Semin Surg Oncol 19:156-76. 2000
    ..This review focuses on cholangiocarcinoma of the extrahepatic bile ducts...
  16. ncbi Differential cell cycle-regulatory protein expression in biliary tract adenocarcinoma: correlation with anatomic site, pathologic variables, and clinical outcome
    William R Jarnagin
    Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    J Clin Oncol 24:1152-60. 2006
    ..This clinicopathologic study characterizes differences in cell cycle-regulatory protein expression across the spectrum of BTA...
  17. ncbi Neoadjuvant interleukin-12 immunogene therapy protects against cancer recurrence after liver resection in an animal model
    W R Jarnagin
    Departments of Surgery and Pathology, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Ann Surg 231:762-71. 2000
    ..To evaluate the neoadjuvant use of a herpes simplex viral (HSV) amplicon vector expressing the murine interleukin-12 (IL-12) gene...
  18. ncbi Caudate hepatectomy for cancer: a single institution experience with 150 patients
    William G Hawkins
    Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA
    J Am Coll Surg 200:345-52. 2005
    ..Although caudate resection of the liver can be performed safely, concomitant major vascular reconstruction substantially increases the mortality of the procedure...
  19. ncbi Downstaging in pancreatic cancer: a matched analysis of patients resected following systemic treatment of initially locally unresectable disease
    K A Bickenbach
    Department of Surgery, Memorial Sloan Kettering Cancer Center, 1275 York Ave, New York, NY, USA
    Ann Surg Oncol 19:1663-9. 2012
    ..The objective of this study was to evaluate outcome of initially unresectable patients who respond to multimodality therapy and undergo resection...
  20. ncbi Intrahepatic cholangiocarcinoma: resectability, recurrence pattern, and outcomes
    S M Weber
    Hepatobiliary Service, Memorial Sloan-Kettering Cancer Center, New York, NY, USA
    J Am Coll Surg 193:384-91. 2001
    ..Although complete resection improved survival, recurrence was common. The majority of recurrences were local or regional, which may help guide future adjuvant therapy strategies...
  21. ncbi Recent advances in hepatic resection
    R P DeMatteo
    Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Semin Surg Oncol 19:200-7. 2000
    ..We present a summary of our experience with these advances...
  22. ncbi Neoadjuvant treatment of hepatic malignancy: an oncolytic herpes simplex virus expressing IL-12 effectively treats the parent tumor and protects against recurrence-after resection
    W R Jarnagin
    Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Cancer Gene Ther 10:215-23. 2003
    ....
  23. ncbi Results of hepatic resection for sarcoma metastatic to liver
    R P DeMatteo
    Department of Surgery, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
    Ann Surg 234:540-7; discussion 547-8. 2001
    ..Hepatectomy should be considered when complete gross resection is possible, especially when the time to the development of liver metastasis exceeds 2 years...
  24. ncbi The role of staging laparoscopy in hepatobiliary malignancy: prospective analysis of 401 cases
    Y Fong
    Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, New York 10021, USA
    Ann Surg Oncol 10:183-9. 2003
    ..Targeting laparoscopy to patients at high risk for unresectable disease requires consideration of disease-specific factors; however, the surgeons' preoperative impression of resectability is also important...
  25. ncbi Intrahepatic biliary enteric bypass provides effective palliation in selected patients with malignant obstruction at the hepatic duct confluence
    W R Jarnagin
    Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, New York 10021, USA
    Am J Surg 175:453-60. 1998
    ..Patients with gallbladder cancer, because of their poor survival, are probably better palliated by percutaneous biliary stenting...
  26. ncbi Rates and patterns of recurrence for percutaneous radiofrequency ablation and open wedge resection for solitary colorectal liver metastasis
    R R White
    Department of Surgical Oncology, Memorial Sloan Kettering Cancer Center, New York, NY, USA
    J Gastrointest Surg 11:256-63. 2007
    ..The purpose of this study was to compare rates and patterns of disease progression following percutaneous, image-guided radiofrequency ablation (RFA) and nonanatomic wedge resection for solitary colorectal liver metastases...
  27. ncbi Outcome after hepatectomy for multiple (four or more) colorectal metastases in the era of effective chemotherapy
    Peter Kornprat
    Department of Surgery, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, New York 10021, USA
    Ann Surg Oncol 14:1151-60. 2007
    ..Despite an unknown benefit, hepatic resection is playing an increasing role in patients with extensive disease...
  28. ncbi Assessing the optimal duration of chemotherapy in patients with colorectal liver metastases
    Rebekah R White
    Department of Surgical Oncology, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    J Surg Oncol 97:601-4. 2008
    ..The purpose of this retrospective analysis was to evaluate time to maximal response in patients receiving systemic +/- hepatic arterial infusion (HAI) chemotherapy alone for the treatment of CLM...
  29. ncbi Synchronous hepatic metastases from colon cancer: changing treatment strategies and results of surgical intervention
    Bridget N Fahy
    Department of Surgery, The Methodist Hospital, Houston, TX 77030, USA
    Ann Surg Oncol 16:361-70. 2009
    ..A multidisciplinary treatment approach which combines both medical and surgical modalities may be associated with improved survival...
  30. ncbi Clinical significance of intraoperative bile duct margin assessment for hilar cholangiocarcinoma
    Itaru Endo
    Department of Surgery, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA
    Ann Surg Oncol 15:2104-12. 2008
    ..Frozen section analysis of bile duct margins is often used to guide the extent of surgical resection for hilar cholangiocarcinoma (HCCA), but the usefulness of this practice is unknown...
  31. ncbi What is the yield of intraoperative ultrasonography during partial hepatectomy for malignant disease?
    W R Jarnagin
    Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    J Am Coll Surg 192:577-83. 2001
    ..This study was undertaken to reassess the yield of IOUS in light of recent improvements in preoperative staging...
  32. ncbi Operative blood loss independently predicts recurrence and survival after resection of hepatocellular carcinoma
    Steven C Katz
    Hepatopancreatobiliary Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA
    Ann Surg 249:617-23. 2009
    ..To determine if the degree of blood loss during resection of hepatocellular carcinoma (HCC) is predictive of recurrence and long-term survival...
  33. ncbi Perihepatic lymph node assessment in patients undergoing partial hepatectomy for malignancy
    Stephen R Grobmyer
    Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Ann Surg 244:260-4. 2006
    ..Routine sampling of perihepatic lymph nodes will therefore have a low yield in patients without some evidence of disease on preoperative CT or PET scans or at the time of exploration...
  34. ncbi Peritoneal washings are not predictive of occult peritoneal disease in patients with hilar cholangiocarcinoma
    R C Martin
    Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA
    J Am Coll Surg 193:620-5. 2001
    ..There was no association between percutaneous transhepatic biliary drainage and peritoneal tumor seeding...
  35. ncbi Resectable hilar cholangiocarcinoma: surgical treatment and long-term outcome
    William R Jarnagin
    Department of Surgery, Hepatobiliary Service, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
    Surg Today 34:885-90. 2004
    ..This review summarizes the state of the art in diagnosis, treatment, and outcome for patients with biliary obstruction at the hilus of the liver...
  36. ncbi Diabetes is associated with increased perioperative mortality but equivalent long-term outcome after hepatic resection for colorectal cancer
    Sarah A Little
    Department of Surgery, Hepatobiliary Service, Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA
    J Gastrointest Surg 6:88-94. 2002
    ..We conclude that the presence of diabetes is associated with a higher incidence of perioperative mortality. In patients with diabetes mellitus and parenchymal steatosis, major hepatic resection should be undertaken with caution...
  37. ncbi Adequate lymph node assessment for extrahepatic bile duct adenocarcinoma
    Kaori Ito
    Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    Ann Surg 251:675-81. 2010
    ..To examine the importance of adequate lymph node sampling in staging of extrahepatic bile duct cancer (EHBDCA)...
  38. ncbi Predictors and patterns of recurrence after resection of hepatocellular carcinoma
    Charles Cha
    Hepatobiliary Service, Memorial Sloan-Kettering Cancer Center, New York, NY, USA
    J Am Coll Surg 197:753-8. 2003
    ..The current study underscores the need for effective adjuvant therapy for patients with HCC treated with partial hepatectomy...
  39. ncbi Effect of postoperative morbidity on long-term survival after hepatic resection for metastatic colorectal cancer
    Hiromichi Ito
    Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York, USA
    Ann Surg 247:994-1002. 2008
    ..The objective of this study was to evaluate the impact of postoperative morbidity on the long-term outcome after liver resection for MCRC...
  40. ncbi Management of 155 patients with benign liver tumours
    C K Charny
    Department of Surgery, New York Presbyterian Hospital-Cornell Campus, New York, NY, USA
    Br J Surg 88:808-13. 2001
    ..Symptomatic patients with a small FNH or haemangioma can be observed because their symptoms are unlikely to be related to the liver tumour. Percutaneous needle biopsy rarely changes management...
  41. ncbi Intrahepatic cholangiocarcinoma: rising frequency, improved survival, and determinants of outcome after resection
    Itaru Endo
    Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Ann Surg 248:84-96. 2008
    ..This study analyzes changes in IHC frequency, demographics, and treatment outcome in a consecutive and single institutional cohort...
  42. ncbi Role of intraoperative thermoablation combined with resection in the treatment of hepatic metastasis from colorectal cancer
    Peter Kornprat
    Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Arch Surg 142:1087-92. 2007
    ..Thermoablation, either cryosurgical ablation (CSA) or radiofrequency ablation (RFA), combined with resection is effective in the treatment of extensive bilobar colorectal metastasis...
  43. ncbi Current status of hepatic resection
    Peter J Allen
    Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, New York, USA
    Adv Surg 37:29-49. 2003
    ..Advances in laparoscopic equipment and techniques will undoubtedly expand the use of these techniques and is the next frontier in hepatic resectional surgery...
  44. ncbi Outcome of partial hepatectomy for large (> 10 cm) hepatocellular carcinoma
    Kui-Hin Liau
    Hepatobiliary Service, Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, New York 10021, USA
    Cancer 104:1948-55. 2005
    ..Minimizing intraoperative blood loss appears to be critical for favorable long-term outcome in patients with large HCC...
  45. ncbi Resection of hepatocellular carcinoma in patients otherwise eligible for transplantation
    Charles H Cha
    Hepatobiliary Service, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
    Ann Surg 238:315-21; discussion 321-3. 2003
    ..Resection should be considered the standard therapy for patients with HCC who have adequate liver reserve...
  46. ncbi Resection of recurrent ovarian or fallopian tube carcinoma involving the liver
    Sam S Yoon
    Hepatobiliary Service, Department of Surgery, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
    Gynecol Oncol 91:383-8. 2003
    ....
  47. ncbi Role of laparoscopy in the evaluation of biliary tract cancer
    Carlos U Corvera
    Department of Surgery, Hepatobiliary Service, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, C-887, New York, NY 10021, USA
    Surg Oncol Clin N Am 11:877-91. 2002
    ..These patients and patients with primary gallbladder carcinoma have a high incidence of metastatic disease and should undergo laparoscopic staging before attempting at resection...
  48. ncbi Preoperative CA 19-9 and the yield of staging laparoscopy in patients with radiographically resectable pancreatic adenocarcinoma
    Shishir K Maithel
    Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    Ann Surg Oncol 15:3512-20. 2008
    ..Factors associated with the likelihood of subradiographic unresectable disease have not been clearly defined...
  49. ncbi Increased use of parenchymal-sparing surgery for bilateral liver metastases from colorectal cancer is associated with improved mortality without change in oncologic outcome: trends in treatment over time in 440 patients
    Jason S Gold
    Department of Surgery, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
    Ann Surg 247:109-17. 2008
    ..We aimed to assess the evolution of the technical approach over time and correlations with morbidity, mortality, and oncologic outcome...
  50. ncbi Malignant Progression in IPMN: A Cohort Analysis of Patients Initially Selected for Resection or Observation
    J LaFemina
    Department of Surgical Oncology, Memorial Sloan Kettering Cancer Center, New York, NY, USA
    Ann Surg Oncol 20:440-7. 2013
    ..The relative risk of carcinoma in regions remote from the radiographically identified cyst remains poorly defined. This study describes the natural history of IPMN in patients initially selected for resection or surveillance...
  51. ncbi Incidence and management of pleural effusions after diaphragm peritonectomy or resection for advanced mullerian cancer
    Eric L Eisenhauer
    Gynecology Service, Department of Surgery, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, MRI-1026, New York, NY 10021, USA
    Gynecol Oncol 103:871-7. 2006
    ..Most were managed conservatively without requiring a chest tube or thoracentesis. The incidence of symptomatic effusions was not high enough to recommend routine chest tube placement at the time of diaphragm peritonectomy or resection...
  52. ncbi Effect on outcome of recurrence patterns after hepatectomy for colorectal metastases
    Michael D'Angelica
    Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA
    Ann Surg Oncol 18:1096-103. 2011
    ..Despite improvements in surgery and chemotherapy, most patients develop recurrence after hepatectomy for metastatic colorectal cancer. Data are lacking on the effect of these patterns on outcome...
  53. ncbi Survival after hepatic resection for metastatic colorectal cancer: trends in outcomes for 1,600 patients during two decades at a single institution
    Michael G House
    Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA
    J Am Coll Surg 210:744-52, 752-5. 2010
    ..This study analyzes factors associated with differences in long-term outcomes after hepatic resection for metastatic colorectal cancer over time...
  54. ncbi A matched case-control study of preoperative biliary drainage in patients with pancreatic adenocarcinoma: routine drainage is not justified
    James J Mezhir
    Department of Surgery, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA
    J Gastrointest Surg 13:2163-9. 2009
    ..Preoperative biliary drainage (PBD) prior to pancreaticoduodenectomy (PD) continues to be routine in many centers despite retrospective and randomized data showing that PBD increases perioperative infectious complications...
  55. ncbi A novel prognostic nomogram is more accurate than conventional staging systems for predicting survival after resection of hepatocellular carcinoma
    Clifford S Cho
    Hepatobiliary Service, Memorial Sloan Kettering Cancer Center, New York, NY, USA
    J Am Coll Surg 206:281-91. 2008
    ..Numerous staging systems have been devised for purposes of risk classification; we sought to identify the optimal staging system to predict postoperative survival...
  56. ncbi Autologous versus allogeneic transfusions: no difference in perioperative outcome after partial hepatectomy. Autologous transfusion on hepatectomy outcome
    James O Park
    Department of Surgery, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, C897, New York, NY 10021, USA
    J Gastrointest Surg 11:1286-93. 2007
    ..In patients undergoing hepatic resection, autologous blood transfusion did not demonstrably improve perioperative outcome when compared to a matched cohort of patients receiving a similar number of allogeneic units...
  57. ncbi Allergies, obesity, other risk factors and survival from pancreatic cancer
    Sara H Olson
    Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    Int J Cancer 127:2412-9. 2010
    ..62, 95% CI: 0.76-3.44). The mechanisms underlying the association between history of allergies and improved survival are unknown. These novel results need to be confirmed in other studies...
  58. ncbi Improved optimal cytoreduction rates for stages IIIC and IV epithelial ovarian, fallopian tube, and primary peritoneal cancer: a change in surgical approach
    Dennis S Chi
    Gynecology Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Gynecol Oncol 94:650-4. 2004
    ....
  59. ncbi Surgical management of hepatic malignancy
    David A Kooby
    Department of Surgery, Memorial Sloan-Kettering Cancer Center, 1275 York Ave, New York, NY 10021, USA
    Cancer Invest 22:283-303. 2004
    ..As better adjuvant and neo-adjuvant therapies emerge, the results of resection are likely to improve and the indications for its application perhaps will extend to patients currently considered to have unresectable disease...
  60. ncbi Analysis of the extent of resection for adenocarcinoma of the gallbladder
    Michael D'Angelica
    Hepatobiliary Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
    Ann Surg Oncol 16:806-16. 2009
    ..Major hepatic resections, including major hepatectomy and CBD excision, are appropriate when necessary to clear disease but are not mandatory in all cases...
  61. ncbi Predicting the risk of perioperative transfusion for patients undergoing elective hepatectomy
    Camelia S Sima
    Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    Ann Surg 250:914-21. 2009
    ..To develop 2 instruments that predict the probability of perioperative red blood cell transfusion in patients undergoing elective liver resection for primary and secondary tumors...
  62. ncbi Response to neoadjuvant chemotherapy does not predict overall survival for patients with synchronous colorectal hepatic metastases
    David J Gallagher
    Department of Medicine, Gastrointestinal Oncology Service, Division of Solid Tumor Oncology, Memorial Sloan Kettering Cancer Center and Joan and Sanford Weill Medical College of Cornell University, New York, NY, USA
    Ann Surg Oncol 16:1844-51. 2009
    ..We investigated the relation between response to neoadjuvant chemotherapy and overall survival (OS) in patients with colorectal liver metastases (CLM)...
  63. ncbi Influence of transfusions on perioperative and long-term outcome in patients following hepatic resection for colorectal metastases
    David A Kooby
    Department of Surgery, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
    Ann Surg 237:860-9; discussion 869-70. 2003
    ..Blood conservation methods should be used to avoid transfusion, especially in patents currently requiring limited amounts of transfused blood products...
  64. ncbi Conversion to resectability using hepatic artery infusion plus systemic chemotherapy for the treatment of unresectable liver metastases from colorectal carcinoma
    Nancy E Kemeny
    Memorial Sloan Kettering Cancer Center, Weill Medical College of Cornell University, 1275 York Ave, New York, NY 10065, USA
    J Clin Oncol 27:3465-71. 2009
    ..Future randomized trials should compare HAI plus systemic chemotherapy with systemic therapy alone to assess the additional value of HAI therapy in converting patients with hepatic metastases to resectability...
  65. ncbi Actual 10-year survival after resection of colorectal liver metastases defines cure
    James S Tomlinson
    Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    J Clin Oncol 25:4575-80. 2007
    ..There is now sufficient follow-up on a significant number of patients to address the curative intent of resecting CLM...
  66. ncbi Randomized phase II trial of adjuvant hepatic arterial infusion and systemic chemotherapy with or without bevacizumab in patients with resected hepatic metastases from colorectal cancer
    Nancy E Kemeny
    Memorial Sloan Kettering Cancer Center, Weill Medical College, NY, USA
    J Clin Oncol 29:884-9. 2011
    ..Add systemic bevacizumab (Bev) to adjuvant hepatic arterial infusion (HAI) plus systemic therapy after liver resection to increase recurrence-free survival (RFS)...
  67. ncbi Evolving techniques in the treatment of liver colorectal metastases: role of laparoscopy, radiofrequency ablation, microwave coagulation, hepatic arterial chemotherapy, indications and contraindications for resection, role of transplantation, and timing o
    Bridget N Fahy
    Department of Surgery, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
    Surg Clin North Am 86:1005-22. 2006
    ....
  68. ncbi A selective approach to the resection of cystic lesions of the pancreas: results from 539 consecutive patients
    Peter J Allen
    Memorial Sloan Kettering Cancer Center, USA
    Ann Surg 244:572-82. 2006
    ..To define a group of patients with pancreatic cysts who do not require resection...
  69. ncbi Lack of evidence for increased operative morbidity after hepatectomy with perioperative use of bevacizumab: a matched case-control study
    Michael D'Angelica
    Department of Surgery, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, New York 10021, USA
    Ann Surg Oncol 14:759-65. 2007
    ..Perioperative bev is now commonly used in patients undergoing hepatic resection. Little is known, however, about the safety of perioperative bev use in the setting of hepatic resection...
  70. ncbi Distal partial gastrectomy and gastrojejunal anastomosis for recurrent ovarian cancer
    Dennis S Chi
    Gynecology Service, Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA
    Gynecol Oncol 104:33-6. 2007
  71. ncbi Randomized clinical trials in hepatocellular carcinoma and biliary cancer
    Robert C G Martin
    Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Surg Oncol Clin N Am 11:193-205, x. 2002
    ....
  72. ncbi Management of primary liver sarcomas
    Juürgen Weitz
    Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York, USA
    Cancer 109:1391-6. 2007
    ..Primary hepatic sarcoma is a rare entity. The objectives of the study were to define treatment and long-term outcome and to identify prognostic factors...
  73. ncbi Profile of plasma angiogenic factors before and after hepatectomy for colorectal cancer liver metastases
    Sam S Yoon
    Department of Surgery, Division of Surgical Oncology, Massachusetts General Hospital, Harvard Medical School, Yawkey 7B 7926, 55 Fruit Street, Boston, Massachusetts 02114, USA
    Ann Surg Oncol 13:353-62. 2006
    ..Circulating angiogenic factors in patients with colorectal cancer liver metastases may promote tumor growth and contribute to liver regeneration after partial hepatectomy...
  74. ncbi The impact of margins on outcome after hepatic resection for colorectal metastasis
    Chandrakanth Are
    Hepatobiliary Division, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Ann Surg 246:295-300. 2007
    ..To analyze the impact of margin width on long-term outcome after hepatic resection for colorectal metastasis...
  75. ncbi Perioperative transfusion risk assessment with elective hepatectomy
    Cami S Sima
    Memorial Sloan Kettering, Cancer Center New York, NY
    Ann Surg 253:630-1. 2011
    ..Supplemental digital content is available in the text...
  76. ncbi Gallbladder carcinoma
    G Miller
    Hepatobiliary Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
    Eur J Surg Oncol 34:306-12. 2008
    ..In such cases, reoperation and definitive resection is appropriate and effective for patients with invasive lesions...
  77. ncbi Impact of steatosis on perioperative outcome following hepatic resection
    David A Kooby
    Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, New York 10021, USA
    J Gastrointest Surg 7:1034-44. 2003
    ..Steatosis alone should not preclude aggressive hepatic resection for neoplasms when indicated; however, patients with marked steatosis undergoing large resections should still be approached with due caution...
  78. ncbi Adjuncts to liver surgery: is acute normovolemic hemodilution useful for major hepatic resections?
    Shishir K Maithel
    Department of Surgery, Hepatopancreatobiliary Service, Memorial Sloan Kettering Cancer Center, 1275 York Avenue C 887, New York, NY 10065, USA
    Adv Surg 43:259-68. 2009
    ..However, given the relatively low transfusion rate overall, future efforts should be directed at preoperatively identifying patients most likely to benefit from ANH...
  79. ncbi Natural history of patients with subcentimeter pulmonary nodules undergoing hepatic resection for metastatic colorectal cancer
    Shishir K Maithel
    Department of Surgery, Division of Surgical Oncology, Emory University, Atlanta, GA, USA
    J Am Coll Surg 210:31-8. 2010
    ..CT imaging frequently detects subcentimeter pulmonary nodules (SPN) in patients undergoing resection of colorectal cancer liver metastases. Their clinical significance is unknown...
  80. ncbi Major hepatectomy with simultaneous pancreatectomy for advanced hepatobiliary cancer
    Robert C G Martin
    Department of Surgery, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
    J Am Coll Surg 198:570-6. 2004
    ..CONCLUSIONS: MHP is associated with a high morbidity and mortality and should only be considered in highly selected patients when a significant potential oncologic benefit is possible...
  81. ncbi CT angiography for delineation of celiac and superior mesenteric artery variants in patients undergoing hepatobiliary and pancreatic surgery
    Corinne B Winston
    Department of Radiology, Memorial Sloan Kettering Cancer Center, 160 E 53rd St, 8th Fl, New York, NY 10022, USA
    AJR Am J Roentgenol 189:W13-9. 2007
    ..CONCLUSION: Variant hepatic and celiac arterial anatomy is common. CTA can be used to identify common and uncommon variants that are important for the surgical management of patients with pancreatic and hepatobiliary neoplasms...
  82. ncbi Perihepatic lymph node micrometastases impact outcome after partial hepatectomy for colorectal metastases
    Joseph J Bennett
    Division of Hepatobiliary Surgery, Department of Surgery, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA
    Ann Surg Oncol 15:1130-6. 2008
    ..This study uses standard pathologic analysis and immunohistochemistry (IHC) to determine the impact of occult metastatic disease to perihepatic LN in patients with colorectal cancer undergoing hepatectomy...
  83. ncbi Major hepatectomy at interval debulking for stage IV ovarian carcinoma: a case report
    Dennis S Chi
    Gynecology Service, Department of Surgery, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
    Gynecol Oncol 87:138-42. 2002
    ..CONCLUSION: Interval debulking with hepatic resection may be a promising approach for patients left with bulky parenchymal liver metastasis after primary cytoreductive surgery...
  84. ncbi The addition of extensive upper abdominal surgery to achieve optimal cytoreduction improves survival in patients with stages IIIC-IV epithelial ovarian cancer
    Eric L Eisenhauer
    Gynecology Service, Department of Surgery, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, MRI-1026, New York, NY 10021, USA
    Gynecol Oncol 103:1083-90. 2006
    ..This initial maximal surgical effort was associated with improved survival in patients who would have otherwise been suboptimally cytoreduced...
  85. ncbi Incidence and management of pancreatic leaks after splenectomy with distal pancreatectomy performed during primary cytoreductive surgery for advanced ovarian, peritoneal and fallopian tube cancer
    Siobhan M Kehoe
    Gynecology Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, MRI 1026, New York, NY 10021, USA
    Gynecol Oncol 112:496-500. 2009
    ..To determine the incidence, management, and outcome of patients diagnosed with a pancreatic leak after a distal pancreatectomy during primary surgical cytoreduction for ovarian, peritoneal, or tubal cancer...
  86. ncbi Staging laparoscopy in patients with extrahepatic biliary carcinoma. Analysis of 100 patients
    Sharon M Weber
    Department of Surgery, Hepatobiliary Service, Memorial Sloan-Kettering Cancer Center, New York, New York 10021, USA
    Ann Surg 235:392-9. 2002
    ..All patients with potentially resectable primary gallbladder cancer and patients with T2/T3 hilar cholangiocarcinoma should undergo staging laparoscopy before surgical exploration...
  87. ncbi Hepatic metastasectomy in children
    Wendy T Su
    Department of Surgery, Division of Pediatric Surgery, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Cancer 109:2089-92. 2007
    ..We reviewed our institutional experience to assess operative mortality and morbidity, technique of resection, local control, and survival in pediatric patients undergoing liver resection for metastases...
  88. ncbi Outcome of patients with fibrolamellar hepatocellular carcinoma
    Francesco Stipa
    Department of Surgery, San Giovanni Hospital, Rome, Italy
    Cancer 106:1331-8. 2006
    ..These tumors have a relatively indolent tumor biology, and late recurrences are common. Repeat resections for recurrence should be considered given the lack of other effective treatment options...
  89. ncbi The use of fresh frozen plasma after major hepatic resection for colorectal metastasis: is there a standard for transfusion?
    Robert C G Martin
    Hepatobiliary Service, Memorial Sloan Kettering Cancer Center, Department of Surgery, New York, NY 10021, USA
    J Am Coll Surg 196:402-9. 2003
    ..Transfusion of fresh frozen plasma (FFP) might be required after major hepatectomy because of blood loss or coagulopathy, but there are no standard criteria for the use of FFP in this setting...
  90. ncbi Outcomes after resection of synchronous or metachronous hepatic and pulmonary colorectal metastases
    George Miller
    Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    J Am Coll Surg 205:231-8. 2007
    ..But the benefits of resection and appropriate selection criteria in patients who develop both hepatic and pulmonary metastases are ill defined...
  91. ncbi Partial hepatectomy for metastases from noncolorectal, nonneuroendocrine carcinoma
    Jurgen Weitz
    Hepatobiliary Service, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Ann Surg 241:269-76. 2005
    ..To define perioperative and long-term outcome and prognostic factors in patients undergoing hepatectomy for liver metastases arising from noncolorectal and nonneuroendocrine (NCNN) carcinoma...
  92. ncbi The role of aggressive regional therapy for colorectal liver metastases
    Rebekah R White
    Surgical Oncology Fellow, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Cancer Invest 25:458-63. 2007
    ..This article reviews the roles of HAI chemotherapy in an aggressive approach toward colorectal liver metastases...
  93. ncbi Clinical and pathologic features of proximal biliary strictures masquerading as hilar cholangiocarcinoma
    Carlos U Corvera
    Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA
    J Am Coll Surg 201:862-9. 2005
    ..The treatment approach should continue to be resection for presumed malignancy...
  94. ncbi Combined portal vein embolization and neoadjuvant chemotherapy as a treatment strategy for resectable hepatic colorectal metastases
    Anne M Covey
    Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    Ann Surg 247:451-5. 2008
    ....
  95. ncbi Histologic grade is correlated with outcome after resection of hepatic neuroendocrine neoplasms
    Clifford S Cho
    Section of Surgical Oncology, University of Wisconsin School of Medicine and Public Health, H4 724 Clinical Sciences Center, 600 Highland Avenue, Madison, WI 53792 7375, USA
    Cancer 113:126-34. 2008
    ..Consequently, guidelines for treatment remain unclear. Current pathologic classification systems do not permit meaningful discrimination of hepatic neuroendocrine neoplasms...
  96. ncbi Diagnostic laparoscopy prior to planned hepatic resection for colorectal metastases
    Stephen R Grobmyer
    Department of Surgery, Division of Hepatobiliary Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA
    Arch Surg 139:1326-30. 2004
    ..The yield of laparoscopy increases with increasing CRS. Preventing celiotomy with laparoscopy is associated with a decreased length of hospital stay and earlier initiation of postoperative chemotherapy...
  97. ncbi Jaundice predicts advanced disease and early mortality in patients with gallbladder cancer
    William G Hawkins
    Memorial Sloan-Kettering Cancer Center, New York, New York 10021, USA
    Ann Surg Oncol 11:310-5. 2004
    ..These data do not support routine operative exploration of patients with jaundice secondary to gallbladder cancer...
  98. ncbi A nomogram for predicting disease-specific survival after hepatic resection for metastatic colorectal cancer
    Michael W Kattan
    Department of Quantitative Health Sciences, Cleveland Clinic, Cleveland, Ohio, USA
    Ann Surg 247:282-7. 2008
    ..By using a nomogram we are trying to improve on the current practice of using prognostic scores for evaluating risks of therapeutic failure...
  99. ncbi Volumetric analysis predicts hepatic dysfunction in patients undergoing major liver resection
    Margo Shoup
    Departments of Surgery, Memorial Sloan-Kettering Cancer Center, New York, NY, USA
    J Gastrointest Surg 7:325-30. 2003
    ..Preoperative assessment of future liver volume remaining distinguishes which patients undergoing liver resection will most likely benefit from preoperative liver enhancement techniques such as portal vein embolization...
  100. ncbi Differential diagnosis of proximal biliary obstruction
    Chandrakanth Are
    Department of Surgery, Memorial Sloan Kettering Cancer Center, New York City, NY 10021, USA
    Surgery 140:756-63. 2006
    ..The combination of vascular invasion and lobar atrophy significantly increases the diagnostic likelihood of HCCA. The absence of these findings should raise awareness of the possibility of an alternative diagnosis...
  101. ncbi Full-thickness diaphragmatic resection for stage IV ovarian carcinoma using the EndoGIA stapling device followed by diaphragmatic reconstruction using a Gore-tex graft: a case report and review of the literature
    Margrit M Juretzka
    Gynecology Service, Department of Surgery, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
    Gynecol Oncol 100:618-20. 2006
    ..Use of the stapler expeditiously assists in removal of the specimen with minimal blood loss. In cases where large defects cannot be repaired primarily, a Gore-tex patch should be used...

Research Grants2

  1. Hepatic Arterial Flouridine and IV Bevacizumab for Primary Hepatic Malignancy
    William Jarnagin; Fiscal Year: 2007
    ..Furthermore, several important clinical issues are addressed by the proposed correlative studies, the results of which would be of broad general interest in clinical oncology. ..