Prasad Jallepalli

Summary

Affiliation: Memorial Sloan-Kettering Cancer Center
Country: USA

Publications

  1. pmc Plk1 self-organization and priming phosphorylation of HsCYK-4 at the spindle midzone regulate the onset of division in human cells
    Mark E Burkard
    Molecular Biology Program, Memorial Sloan Kettering Cancer Center, New York, New York, United States of America
    PLoS Biol 7:e1000111. 2009
  2. pmc Cohesin acetylation speeds the replication fork
    Marie Emilie Terret
    Molecular Biology Program, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, New York 10065, USA
    Nature 462:231-4. 2009
  3. pmc Vertebrate cells genetically deficient for Cdc14A or Cdc14B retain DNA damage checkpoint proficiency but are impaired in DNA repair
    Annamaria Mocciaro
    Zentrum fur Molekulare Biologie der Universitat Heidelberg, DKFZ ZMBH Allianz, 69117 Heidelberg, Germany
    J Cell Biol 189:631-9. 2010
  4. pmc Mps1 directs the assembly of Cdc20 inhibitory complexes during interphase and mitosis to control M phase timing and spindle checkpoint signaling
    John Maciejowski
    Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    J Cell Biol 190:89-100. 2010
  5. ncbi request reprint Cell biology. Aneuploidy in the balance
    Prasad V Jallepalli
    Molecular Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Science 317:904-5. 2007
  6. ncbi request reprint Inactivation of hCDC4 can cause chromosomal instability
    Harith Rajagopalan
    The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, USA
    Nature 428:77-81. 2004
  7. ncbi request reprint Multiple roles for separase auto-cleavage during the G2/M transition
    Maura Papi
    Molecular Biology Program, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
    Nat Cell Biol 7:1029-35. 2005
  8. ncbi request reprint Meiosis: separase strikes twice
    Marie Emilie Terret
    Nat Cell Biol 8:910-1. 2006
  9. pmc Requirements for Cdk7 in the assembly of Cdk1/cyclin B and activation of Cdk2 revealed by chemical genetics in human cells
    Stephane Larochelle
    Molecular Biology Program, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
    Mol Cell 25:839-50. 2007

Research Grants

  1. Regulation of Chromosome Segregation in Human Cells
    Prasad Jallepalli; Fiscal Year: 2005
  2. Regulation of Chromosome Segregation in Human Cells
    Prasad Jallepalli; Fiscal Year: 2006
  3. Regulation of Chromosome Segregation in Human Cells
    Prasad Jallepalli; Fiscal Year: 2007
  4. Regulation of Chromosome Segregation in Human Cells
    Prasad Jallepalli; Fiscal Year: 2009
  5. Regulation of Chromosome Segregation in Human Cells
    Prasad V Jallepalli; Fiscal Year: 2010

Collaborators

  • Jun Qin
  • C Lengauer
  • Robert P Fisher
  • Marie Emilie Terret
  • John Maciejowski
  • Kevan M Shokat
  • Chao Zhang
  • Annamaria Mocciaro
  • Mark E Burkard
  • Eli Berdougo
  • Stephane Larochelle
  • Maura Papi
  • Harith Rajagopalan
  • David Gillespie
  • Kelly A George
  • Elmar Schiebel
  • Elizabeth Black
  • Kang Zeng
  • Paola Vagnarelli
  • William Earnshaw
  • Rebecca Sherwood
  • Karl R Clauser
  • Michael B Yaffe
  • Steven A Carr
  • Drew M Lowery
  • Sadia Rahman
  • VerĂ³nica Rodriguez-Bravo
  • Michael Repka
  • Nora M Barboza
  • Karl A Merrick
  • Lara Wohlbold
  • Catherine L Randall
  • Sonali Ganguly
  • Bert Vogelstein
  • Carlo Rago
  • Victor E Velculescu
  • Kenneth W Kinzler

Detail Information

Publications9

  1. pmc Plk1 self-organization and priming phosphorylation of HsCYK-4 at the spindle midzone regulate the onset of division in human cells
    Mark E Burkard
    Molecular Biology Program, Memorial Sloan Kettering Cancer Center, New York, New York, United States of America
    PLoS Biol 7:e1000111. 2009
    ..Our findings illuminate two key mechanisms governing the initiation of cytokinesis in human cells and illustrate the power of chemical genetics to probe such regulation both in time and space...
  2. pmc Cohesin acetylation speeds the replication fork
    Marie Emilie Terret
    Molecular Biology Program, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, New York 10065, USA
    Nature 462:231-4. 2009
    ..Loss of this regulatory mechanism leads to the spontaneous accrual of DNA damage and may contribute to the abnormalities of the Roberts' syndrome cohesinopathy...
  3. pmc Vertebrate cells genetically deficient for Cdc14A or Cdc14B retain DNA damage checkpoint proficiency but are impaired in DNA repair
    Annamaria Mocciaro
    Zentrum fur Molekulare Biologie der Universitat Heidelberg, DKFZ ZMBH Allianz, 69117 Heidelberg, Germany
    J Cell Biol 189:631-9. 2010
    ..Surprisingly, however, irradiation-induced gamma-H2A.X foci and DNA double-strand breaks persist longer in Cdc14A-KO or Cdc14B-KO cells than controls, suggesting that Cdc14 phosphatases are required for efficient DNA repair...
  4. pmc Mps1 directs the assembly of Cdc20 inhibitory complexes during interphase and mitosis to control M phase timing and spindle checkpoint signaling
    John Maciejowski
    Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    J Cell Biol 190:89-100. 2010
    ....
  5. ncbi request reprint Cell biology. Aneuploidy in the balance
    Prasad V Jallepalli
    Molecular Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Science 317:904-5. 2007
  6. ncbi request reprint Inactivation of hCDC4 can cause chromosomal instability
    Harith Rajagopalan
    The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, USA
    Nature 428:77-81. 2004
    ..Our data suggest that chromosomal instability is caused by specific genetic alterations in a large fraction of human cancers and can occur before malignant conversion...
  7. ncbi request reprint Multiple roles for separase auto-cleavage during the G2/M transition
    Maura Papi
    Molecular Biology Program, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
    Nat Cell Biol 7:1029-35. 2005
    ..We conclude that separase auto-cleavage coordinates multiple aspects of the G2/M programme in human cells, thus contributing to the timing and efficiency of chromosome segregation...
  8. ncbi request reprint Meiosis: separase strikes twice
    Marie Emilie Terret
    Nat Cell Biol 8:910-1. 2006
  9. pmc Requirements for Cdk7 in the assembly of Cdk1/cyclin B and activation of Cdk2 revealed by chemical genetics in human cells
    Stephane Larochelle
    Molecular Biology Program, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
    Mol Cell 25:839-50. 2007
    ..Therefore, by combining chemical genetics and homologous gene replacement in somatic cells, we reveal different modes of CDK activation by Cdk7 at two distinct execution points in the cell cycle...

Research Grants6

  1. Regulation of Chromosome Segregation in Human Cells
    Prasad Jallepalli; Fiscal Year: 2005
    ..Such information is essential to developing more effective cancer therapies that attack the CIN phenotype found in most cancer cells. ..
  2. Regulation of Chromosome Segregation in Human Cells
    Prasad Jallepalli; Fiscal Year: 2006
    ..Such information is essential to developing more effective cancer therapies that attack the CIN phenotype found in most cancer cells. ..
  3. Regulation of Chromosome Segregation in Human Cells
    Prasad Jallepalli; Fiscal Year: 2007
    ..Such information is essential to developing more effective cancer therapies that attack the CIN phenotype found in most cancer cells. ..
  4. Regulation of Chromosome Segregation in Human Cells
    Prasad Jallepalli; Fiscal Year: 2009
    ..Such information is essential to developing more effective cancer therapies that attack the CIN phenotype found in most cancer cells. ..
  5. Regulation of Chromosome Segregation in Human Cells
    Prasad V Jallepalli; Fiscal Year: 2010
    ..As these kinases are overproduced in tumors and being evaluated as targets for anti-neoplastic therapy, our studies have strong relevance to ongoing efforts to expand and improve the cancer pharmacopeia. ..