Prasad Jallepalli

Summary

Affiliation: Memorial Sloan-Kettering Cancer Center
Country: USA

Publications

  1. ncbi request reprint Cell biology. Aneuploidy in the balance
    Prasad V Jallepalli
    Molecular Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Science 317:904-5. 2007
  2. ncbi request reprint Inactivation of hCDC4 can cause chromosomal instability
    Harith Rajagopalan
    The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, USA
    Nature 428:77-81. 2004
  3. ncbi request reprint Multiple roles for separase auto-cleavage during the G2/M transition
    Maura Papi
    Molecular Biology Program, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
    Nat Cell Biol 7:1029-35. 2005
  4. ncbi request reprint Meiosis: separase strikes twice
    Marie Emilie Terret
    Nat Cell Biol 8:910-1. 2006
  5. pmc Requirements for Cdk7 in the assembly of Cdk1/cyclin B and activation of Cdk2 revealed by chemical genetics in human cells
    Stephane Larochelle
    Molecular Biology Program, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
    Mol Cell 25:839-50. 2007

Research Grants

  1. Regulation of Chromosome Segregation in Human Cells
    Prasad Jallepalli; Fiscal Year: 2007
  2. Regulation of Chromosome Segregation in Human Cells
    Prasad Jallepalli; Fiscal Year: 2009
  3. Regulation of Chromosome Segregation in Human Cells
    Prasad V Jallepalli; Fiscal Year: 2010

Collaborators

  • C Lengauer
  • Robert P Fisher
  • Marie Emilie Terret
  • Stephane Larochelle
  • Maura Papi
  • Harith Rajagopalan
  • Kevan M Shokat
  • Nora M Barboza
  • Karl A Merrick
  • Lara Wohlbold
  • Chao Zhang
  • Catherine L Randall
  • Sonali Ganguly
  • Eli Berdougo
  • Bert Vogelstein
  • Carlo Rago
  • Victor E Velculescu
  • Kenneth W Kinzler

Detail Information

Publications5

  1. ncbi request reprint Cell biology. Aneuploidy in the balance
    Prasad V Jallepalli
    Molecular Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Science 317:904-5. 2007
  2. ncbi request reprint Inactivation of hCDC4 can cause chromosomal instability
    Harith Rajagopalan
    The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, USA
    Nature 428:77-81. 2004
    ..Our data suggest that chromosomal instability is caused by specific genetic alterations in a large fraction of human cancers and can occur before malignant conversion...
  3. ncbi request reprint Multiple roles for separase auto-cleavage during the G2/M transition
    Maura Papi
    Molecular Biology Program, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
    Nat Cell Biol 7:1029-35. 2005
    ..We conclude that separase auto-cleavage coordinates multiple aspects of the G2/M programme in human cells, thus contributing to the timing and efficiency of chromosome segregation...
  4. ncbi request reprint Meiosis: separase strikes twice
    Marie Emilie Terret
    Nat Cell Biol 8:910-1. 2006
  5. pmc Requirements for Cdk7 in the assembly of Cdk1/cyclin B and activation of Cdk2 revealed by chemical genetics in human cells
    Stephane Larochelle
    Molecular Biology Program, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
    Mol Cell 25:839-50. 2007
    ..Therefore, by combining chemical genetics and homologous gene replacement in somatic cells, we reveal different modes of CDK activation by Cdk7 at two distinct execution points in the cell cycle...

Research Grants6

  1. Regulation of Chromosome Segregation in Human Cells
    Prasad Jallepalli; Fiscal Year: 2007
    ..Such information is essential to developing more effective cancer therapies that attack the CIN phenotype found in most cancer cells. ..
  2. Regulation of Chromosome Segregation in Human Cells
    Prasad Jallepalli; Fiscal Year: 2009
    ..Such information is essential to developing more effective cancer therapies that attack the CIN phenotype found in most cancer cells. ..
  3. Regulation of Chromosome Segregation in Human Cells
    Prasad V Jallepalli; Fiscal Year: 2010
    ..As these kinases are overproduced in tumors and being evaluated as targets for anti-neoplastic therapy, our studies have strong relevance to ongoing efforts to expand and improve the cancer pharmacopeia. ..