MORGAN A HUSE

Summary

Affiliation: Memorial Sloan-Kettering Cancer Center
Country: USA

Publications

  1. pmc Inhibitory signaling blocks activating receptor clustering and induces cytoskeletal retraction in natural killer cells
    Thushara P Abeyweera
    Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    J Cell Biol 192:675-90. 2011
  2. pmc A cascade of protein kinase C isozymes promotes cytoskeletal polarization in T cells
    Emily J Quann
    Immunology Program, Memorial Sloan Kettering Cancer Center, New York, New York, USA
    Nat Immunol 12:647-54. 2011
  3. pmc Microtubule-organizing center polarity and the immunological synapse: protein kinase C and beyond
    Morgan Huse
    Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA
    Front Immunol 3:235. 2012
  4. pmc The variable hinge region of novel PKCs determines localization to distinct regions of the immunological synapse
    Roshni Basu
    Immunology Program, Memorial Sloan Kettering Cancer Center, New York, New York, United States of America
    PLoS ONE 9:e95531. 2014
  5. doi request reprint Building tolerance by dismantling synapses: inhibitory receptor signaling in natural killer cells
    Morgan Huse
    Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    Immunol Rev 251:143-53. 2013
  6. pmc Photochemical approaches to T-cell activation
    Morgan Huse
    Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    Immunology 130:151-7. 2010

Collaborators

  • Emily J Quann
  • Roshni Basu
  • Thushara P Abeyweera
  • Yuedan Chen
  • Gregoire Altan-Bonnet
  • Xin Liu
  • Ernesto Merino

Detail Information

Publications7

  1. pmc Inhibitory signaling blocks activating receptor clustering and induces cytoskeletal retraction in natural killer cells
    Thushara P Abeyweera
    Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    J Cell Biol 192:675-90. 2011
    ..These results suggest a cell biological basis for ITIM receptor signaling and establish an experimental framework for analyzing it...
  2. pmc A cascade of protein kinase C isozymes promotes cytoskeletal polarization in T cells
    Emily J Quann
    Immunology Program, Memorial Sloan Kettering Cancer Center, New York, New York, USA
    Nat Immunol 12:647-54. 2011
    ..Our results establish a previously uncharacterized role for PKC proteins in T cell polarity...
  3. pmc Microtubule-organizing center polarity and the immunological synapse: protein kinase C and beyond
    Morgan Huse
    Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA
    Front Immunol 3:235. 2012
    ..Particular attention will be paid to both novel and atypical members of the protein kinase C family, which are now known to play important roles in both the establishment and the maintenance of the polarized state...
  4. pmc The variable hinge region of novel PKCs determines localization to distinct regions of the immunological synapse
    Roshni Basu
    Immunology Program, Memorial Sloan Kettering Cancer Center, New York, New York, United States of America
    PLoS ONE 9:e95531. 2014
    ..Together, these results suggest a model whereby the V3 linker controls nPKC sub-compartmentalization after initial C1 domain-mediated accumulation at the IS. ..
  5. doi request reprint Building tolerance by dismantling synapses: inhibitory receptor signaling in natural killer cells
    Morgan Huse
    Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    Immunol Rev 251:143-53. 2013
    ..In this review, we discuss these new advances and how they might relate to what is known about the biochemistry of inhibitory signaling in NK cells and other cell types...
  6. pmc Photochemical approaches to T-cell activation
    Morgan Huse
    Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    Immunology 130:151-7. 2010
    ..Here, I review these efforts and outline future directions for this exciting area of research...

Research Grants1

  1. Mechanistic Analysis of T Cell Polarity by Photoactivation of Single Cells
    MORGAN A HUSE; Fiscal Year: 2010
    ..This proposal seeks to determine how this polarization process takes place in T cells, which could contribute to strategies for controlling T cell polarity and function in therapeutic contexts. ..