Jane Houldsworth

Summary

Affiliation: Memorial Sloan-Kettering Cancer Center
Country: USA

Publications

  1. ncbi request reprint Genetics and biology of male germ cell tumors
    Jane Houldsworth
    Cell Biology Program, Memorial Sloan Kettering Cancer Center, Box 391, 1275 York Avenue, New York, NY 10021, USA
    Chest Surg Clin N Am 12:629-43. 2002
  2. ncbi request reprint Biology and genetics of adult male germ cell tumors
    Jane Houldsworth
    Cell Biology Program and Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    J Clin Oncol 24:5512-8. 2006
  3. ncbi request reprint Constitutive gene expression predisposes morphogen-mediated cell fate responses of NT2/D1 and 27X-1 human embryonal carcinoma cells
    Rajendrakumar S V Chadalavada
    Cell Biology Program, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
    Stem Cells 25:771-8. 2007
  4. ncbi request reprint Down-regulation of stem cell genes, including those in a 200-kb gene cluster at 12p13.31, is associated with in vivo differentiation of human male germ cell tumors
    James E Korkola
    Cell Biology Program and Departments of Medicine, Epidemiology and Biostatistics, and Pathology, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
    Cancer Res 66:820-7. 2006
  5. pmc Role of promoter hypermethylation in Cisplatin treatment response of male germ cell tumors
    Sanjay Koul
    Department of Pathology, College of Physicians and Surgeons of Columbia University, 630 West 168th Street, New York, NY 10032, USA
    Mol Cancer 3:16. 2004
  6. doi request reprint Molecular events in germ cell tumours: linking chromosome-12 gain, acquisition of pluripotency and response to cisplatin
    James E Korkola
    Cell Biology Division, Memorial Sloan Kettering Cancer Center, New York, NY, USA
    BJU Int 104:1334-8. 2009
  7. pmc Identification and validation of a gene expression signature that predicts outcome in adult men with germ cell tumors
    James E Korkola
    Cell Biology Program, Sloan Kettering Institute for Cancer Research, New York, USA
    J Clin Oncol 27:5240-7. 2009
  8. ncbi request reprint Gene expression-based classification of nonseminomatous male germ cell tumors
    James E Korkola
    Cell Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Oncogene 24:5101-7. 2005
  9. pmc Inactivation of the PRDM1/BLIMP1 gene in diffuse large B cell lymphoma
    Laura Pasqualucci
    Institute for Cancer Genetics and 2The Herbert Irving Comprehensive Cancer Center, Columbia University, New York, NY 10032, USA
    J Exp Med 203:311-7. 2006
  10. ncbi request reprint Transcriptional program of bone morphogenetic protein-2-induced epithelial and smooth muscle differentiation of pluripotent human embryonal carcinoma cells
    Rajendrakumar S V Chadalavada
    Cell Biology Program, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, Box 391, New York, NY 10021, USA
    Funct Integr Genomics 5:59-69. 2005

Collaborators

Detail Information

Publications26

  1. ncbi request reprint Genetics and biology of male germ cell tumors
    Jane Houldsworth
    Cell Biology Program, Memorial Sloan Kettering Cancer Center, Box 391, 1275 York Avenue, New York, NY 10021, USA
    Chest Surg Clin N Am 12:629-43. 2002
    ..With the advent of expression profiling and genome-scanning technologies, it may be possible to identify molecular markers of germ cell tumor outcome and molecular networks important in human development and chemotherapeutic response...
  2. ncbi request reprint Biology and genetics of adult male germ cell tumors
    Jane Houldsworth
    Cell Biology Program and Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    J Clin Oncol 24:5512-8. 2006
    ....
  3. ncbi request reprint Constitutive gene expression predisposes morphogen-mediated cell fate responses of NT2/D1 and 27X-1 human embryonal carcinoma cells
    Rajendrakumar S V Chadalavada
    Cell Biology Program, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
    Stem Cells 25:771-8. 2007
    ..This study also demonstrates that EC cells can serve as robust models to investigate early lineage choices during both embryonic and extra-embryonic human development...
  4. ncbi request reprint Down-regulation of stem cell genes, including those in a 200-kb gene cluster at 12p13.31, is associated with in vivo differentiation of human male germ cell tumors
    James E Korkola
    Cell Biology Program and Departments of Medicine, Epidemiology and Biostatistics, and Pathology, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
    Cancer Res 66:820-7. 2006
    ..Furthermore, the differential expression of core stem cell genes may explain the differences in pluripotency between embryonal carcinomas and seminomas...
  5. pmc Role of promoter hypermethylation in Cisplatin treatment response of male germ cell tumors
    Sanjay Koul
    Department of Pathology, College of Physicians and Surgeons of Columbia University, 630 West 168th Street, New York, NY 10032, USA
    Mol Cancer 3:16. 2004
    ..Male germ cell tumor (GCT) is a highly curable malignancy, which exhibits exquisite sensitivity to cisplatin treatment. The genetic pathway(s) that determine the chemotherapy sensitivity in GCT remain largely unknown...
  6. doi request reprint Molecular events in germ cell tumours: linking chromosome-12 gain, acquisition of pluripotency and response to cisplatin
    James E Korkola
    Cell Biology Division, Memorial Sloan Kettering Cancer Center, New York, NY, USA
    BJU Int 104:1334-8. 2009
    ....
  7. pmc Identification and validation of a gene expression signature that predicts outcome in adult men with germ cell tumors
    James E Korkola
    Cell Biology Program, Sloan Kettering Institute for Cancer Research, New York, USA
    J Clin Oncol 27:5240-7. 2009
    ..Currently, patients are risk-stratified on the basis of clinical presentation and serum tumor markers. The introduction of molecular markers could improve outcome prediction...
  8. ncbi request reprint Gene expression-based classification of nonseminomatous male germ cell tumors
    James E Korkola
    Cell Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Oncogene 24:5101-7. 2005
    ..Thus, the expression-based classifier accurately assigned a single predominant histology to mixed NSGCTs, and identified transcripts differentially expressed between histologic components with relevance to NSGCT differentiation...
  9. pmc Inactivation of the PRDM1/BLIMP1 gene in diffuse large B cell lymphoma
    Laura Pasqualucci
    Institute for Cancer Genetics and 2The Herbert Irving Comprehensive Cancer Center, Columbia University, New York, NY 10032, USA
    J Exp Med 203:311-7. 2006
    ..These findings point to a role for BLIMP1 as a tumor suppressor gene, whose inactivation may contribute to lymphomagenesis by blocking post-GC differentiation of B cells toward plasma cells...
  10. ncbi request reprint Transcriptional program of bone morphogenetic protein-2-induced epithelial and smooth muscle differentiation of pluripotent human embryonal carcinoma cells
    Rajendrakumar S V Chadalavada
    Cell Biology Program, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, Box 391, New York, NY 10021, USA
    Funct Integr Genomics 5:59-69. 2005
    ..This study suggests that BMP-2-induced differentiation of NT2/D1 cells provides a powerful assay to study early human epithelial and smooth muscle development...
  11. doi request reprint Testicular mixed germ cell tumors: a morphological and immunohistochemical study using stem cell markers, OCT3/4, SOX2 and GDF3, with emphasis on morphologically difficult-to-classify areas
    Anuradha Gopalan
    Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    Mod Pathol 22:1066-74. 2009
    ..Embryonal carcinoma-like high-grade' nuclear details are the most important morphological criterion for the diagnosis of embryonal carcinoma in difficult-to-classify areas...
  12. doi request reprint Pathway activation in large B-cell non-Hodgkin lymphoma cell lines by doxorubicin reveals prognostic markers of in vivo response
    Jane Houldsworth
    Cell Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Leuk Lymphoma 49:2170-80. 2008
    ..Thus, the response of DLBCL in vivo and in vitro is defined by several distinct molecular and genetic pathways which is, perhaps, not surprising given the heterogeneous clinical, morphologic and genetic nature of DLBCL...
  13. ncbi request reprint Cell of origin, germinal center versus nongerminal center, determined by immunohistochemistry on tissue microarray, does not correlate with outcome in patients with relapsed and refractory DLBCL
    Craig H Moskowitz
    Lymphoma and Hematology Services of the Division of Hematological Oncology, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Blood 106:3383-5. 2005
    ..The cell of origin as determined by IHC does not predict outcome in transplantation-eligible patients with relapsed or primary refractory DLBCL...
  14. pmc Array comparative genomic hybridization reveals genomic copy number changes associated with outcome in diffuse large B-cell lymphomas
    Weiyi Chen
    Cell Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Blood 107:2477-85. 2006
    ..Overall, array-CGH identified relatively small genomic regions associated with outcome, which, along with follow-up expression studies, may reveal target genes important in DLBCL clinical behavior...
  15. ncbi request reprint Expression of the AID protein in normal and neoplastic B cells
    Laura Pasqualucci
    Institute for Cancer Genetics, Department of Pathology, Columbia University, 1150 St Nicholas Ave, New York, NY 10032, USA
    Blood 104:3318-25. 2004
    ....
  16. ncbi request reprint Differential expression patterns of c-REL protein in classic and nodular lymphocyte predominant Hodgkin lymphoma
    Qianxun Xiao
    Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Appl Immunohistochem Mol Morphol 12:211-5. 2004
    ..Our results demonstrate that there is differential c-REL protein expression in cHL in comparison with NLPHL and suggest that c-REL may play a role in the pathogenesis of classic Hodgkin lymphoma...
  17. ncbi request reprint Chemotherapy for teratoma with malignant transformation
    Alessia C Donadio
    Memorial Sloan Kettering Cancer Center, 1275 York Ave, New York, NY 10021, USA
    J Clin Oncol 21:4285-91. 2003
    ..We report that chemotherapy has a role in selected patients with MT, determined by cell type...
  18. ncbi request reprint MUC-1 mucin protein expression in B-cell lymphomas
    Julie Teruya-Feldstein
    Department of Pathology, Cell Biology and Immunology Programs, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
    Appl Immunohistochem Mol Morphol 11:28-32. 2003
    ..For all cases, MUC-1 mucin expression correlated with a previous history of lymphoma (p=0.003)...
  19. pmc Reduced proficiency in homologous recombination underlies the high sensitivity of embryonal carcinoma testicular germ cell tumors to Cisplatin and poly (adp-ribose) polymerase inhibition
    Francesca Cavallo
    Department of Biomedicine and Prevention, Section of Anatomy, University of Rome Tor Vergata, Rome, Italy
    PLoS ONE 7:e51563. 2012
    ....
  20. ncbi request reprint Mutations of the BCL6 proto-oncogene disrupt its negative autoregulation in diffuse large B-cell lymphoma
    Laura Pasqualucci
    Institute for Cancer Genetics and the Department of Pathology, Columbia University, New York, NY 10032, USA
    Blood 101:2914-23. 2003
    ..This study establishes a novel mechanism for BCL6 deregulation and reveals a broader involvement of this gene in DLBCL pathogenesis...
  21. pmc Characteristic promoter hypermethylation signatures in male germ cell tumors
    Sanjay Koul
    Department of Pathology, College of Physicians and Surgeons of Columbia University, 630 West 168th Street, New York, NY, 10032, USA
    Mol Cancer 1:8. 2002
    ..GCTs exhibit pluripotentiality and are highly sensitive to cisplatin therapy. The molecular basis of germ cell (GC) transformation, differentiation, and exquisite treatment response is poorly understood...
  22. ncbi request reprint Similar patterns of genomic alterations characterize primary mediastinal large-B-cell lymphoma and diffuse large-B-cell lymphoma
    Nallasivam Palanisamy
    Laboratory of Cancer Genetics, Cell Biology Program, Sloan Kettering Institute for Cancer Research, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Genes Chromosomes Cancer 33:114-22. 2002
    ..Based on these data, we conclude that PMLBCL is a distinct entity among GC-derived high-grade DLBCLs...
  23. ncbi request reprint Relationship between REL amplification, REL function, and clinical and biologic features in diffuse large B-cell lymphomas
    Jane Houldsworth
    Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Blood 103:1862-8. 2004
    ..Nonetheless, these data indicate that DLBCLs are heterogeneous with respect to REL and thus nuclear factor-kappaB (NF-kappaB) activity...
  24. ncbi request reprint Expression profiling of lineage differentiation in pluripotential human embryonal carcinoma cells
    Jane Houldsworth
    Cell Biology, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Cell Growth Differ 13:257-64. 2002
    ..Global analysis of gene expression allows monitoring cell fate and differentiation of EC cells in vitro and may provide insight into human embryonal stem cell development...
  25. pmc Members of the glutathione and ABC-transporter families are associated with clinical outcome in patients with diffuse large B-cell lymphoma
    Charalambos Andreadis
    Abramson Cancer Center, University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA 19104, USA
    Blood 109:3409-16. 2007
    ....
  26. ncbi request reprint Lack of A563G (I188V) missense mutation in RIZ/ PRDM2 in human diffuse large B-cell lymphomas
    Wayne Tam
    Genes Chromosomes Cancer 46:416-8. 2007