Jason P Holland

Summary

Affiliation: Memorial Sloan-Kettering Cancer Center
Country: USA

Publications

  1. doi request reprint In vitro kinetic studies on the mechanism of oxygen-dependent cellular uptake of copper radiopharmaceuticals
    Jason P Holland
    Department of Chemistry, University of Oxford, Oxford, OX1 3TA, UK
    Phys Med Biol 54:2103-19. 2009
  2. pmc Standardized methods for the production of high specific-activity zirconium-89
    Jason P Holland
    Memorial Sloan Kettering Cancer Center, Department of Radiology, New York, NY 10065, USA
    Nucl Med Biol 36:729-39. 2009
  3. pmc Cerenkov luminescence imaging of medical isotopes
    Alessandro Ruggiero
    Nuclear Medicine Service, Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA
    J Nucl Med 51:1123-30. 2010
  4. pmc Magnitude of enhanced permeability and retention effect in tumors with different phenotypes: 89Zr-albumin as a model system
    Carola Heneweer
    Program in Molecular Pharmacology and Chemistry, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA
    J Nucl Med 52:625-33. 2011
  5. pmc Imaging tumor burden in the brain with 89Zr-transferrin
    Michael J Evans
    Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA
    J Nucl Med 54:90-5. 2013
  6. pmc Annotating MYC status with 89Zr-transferrin imaging
    Jason P Holland
    Radiochemistry Service, Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York, USA
    Nat Med 18:1586-91. 2012
  7. pmc Targeting the internal epitope of prostate-specific membrane antigen with 89Zr-7E11 immuno-PET
    Alessandro Ruggiero
    Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York, USA
    J Nucl Med 52:1608-15. 2011
  8. doi request reprint In vitro and in vivo evaluations of a hydrophilic 64Cu-bis(thiosemicarbazonato)-glucose conjugate for hypoxia imaging
    Simon R Bayly
    Siemens Oxford Molecular Imaging Laboratory, Inorganic Chemistry Laboratory, University of Oxford, Oxford, United Kingdom
    J Nucl Med 49:1862-8. 2008
  9. pmc 89Zr-DFO-J591 for immunoPET of prostate-specific membrane antigen expression in vivo
    Jason P Holland
    Radiochemistry Service, Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA
    J Nucl Med 51:1293-300. 2010
  10. pmc Intraoperative imaging of positron emission tomographic radiotracers using Cerenkov luminescence emissions
    Jason P Holland
    Radiochemistry Service, Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    Mol Imaging 10:177-86, 1-3. 2011

Collaborators

Detail Information

Publications21

  1. doi request reprint In vitro kinetic studies on the mechanism of oxygen-dependent cellular uptake of copper radiopharmaceuticals
    Jason P Holland
    Department of Chemistry, University of Oxford, Oxford, OX1 3TA, UK
    Phys Med Biol 54:2103-19. 2009
    ..Further understanding of the mechanism of hypoxia selectivity may facilitate the development of new imaging and radiotherapeutic agents with increased specificity for tumour hypoxia...
  2. pmc Standardized methods for the production of high specific-activity zirconium-89
    Jason P Holland
    Memorial Sloan Kettering Cancer Center, Department of Radiology, New York, NY 10065, USA
    Nucl Med Biol 36:729-39. 2009
    ..The detailed methods described can be easily translated to other radiochemistry facilities and will facilitate the use of (89)Zr in both basic science and clinical investigations...
  3. pmc Cerenkov luminescence imaging of medical isotopes
    Alessandro Ruggiero
    Nuclear Medicine Service, Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA
    J Nucl Med 51:1123-30. 2010
    ..Here, we report the use of the inherent optical emissions from the decay of radiopharmaceuticals for Cerenkov luminescence imaging (CLI) of tumors in vivo and correlate the results with those obtained from concordant immuno-PET studies...
  4. pmc Magnitude of enhanced permeability and retention effect in tumors with different phenotypes: 89Zr-albumin as a model system
    Carola Heneweer
    Program in Molecular Pharmacology and Chemistry, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA
    J Nucl Med 52:625-33. 2011
    ..This study investigated the influence of different tumor phenotypes on the EPR effect, hypothesizing that a baseline level of uptake must be exceeded to visualize high and specific uptake of a targeted macromolecular radiotracer...
  5. pmc Imaging tumor burden in the brain with 89Zr-transferrin
    Michael J Evans
    Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA
    J Nucl Med 54:90-5. 2013
    ..Therefore, we reasoned that applying a radiolabeled derivative of transferrin ((89)Zr-labeled transferrin) may be an effective strategy to more thoroughly identify tumor tissue in the brain, regardless of the tumor's genetic background...
  6. pmc Annotating MYC status with 89Zr-transferrin imaging
    Jason P Holland
    Radiochemistry Service, Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York, USA
    Nat Med 18:1586-91. 2012
    ..These preclinical data establish (89)Zr-transferrin as a sensitive tool for noninvasive measurement of oncogene-driven TFRC expression in prostate and potentially other cancers, with prospective near-term clinical application...
  7. pmc Targeting the internal epitope of prostate-specific membrane antigen with 89Zr-7E11 immuno-PET
    Alessandro Ruggiero
    Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York, USA
    J Nucl Med 52:1608-15. 2011
    ..The ability of (89)Zr-DFO-7E11 to delineate tumor response to therapy was also investigated, because it binds to the intracellular epitope of PSMA, which becomes available only on membrane disruption in dead or dying cells...
  8. doi request reprint In vitro and in vivo evaluations of a hydrophilic 64Cu-bis(thiosemicarbazonato)-glucose conjugate for hypoxia imaging
    Simon R Bayly
    Siemens Oxford Molecular Imaging Laboratory, Inorganic Chemistry Laboratory, University of Oxford, Oxford, United Kingdom
    J Nucl Med 49:1862-8. 2008
    ..Here we report our initial biological experiments with 64Cu-ATSE/A-G and compare the results with those obtained for 64Cu-ATSM and 18F-FDG...
  9. pmc 89Zr-DFO-J591 for immunoPET of prostate-specific membrane antigen expression in vivo
    Jason P Holland
    Radiochemistry Service, Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA
    J Nucl Med 51:1293-300. 2010
    ....
  10. pmc Intraoperative imaging of positron emission tomographic radiotracers using Cerenkov luminescence emissions
    Jason P Holland
    Radiochemistry Service, Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    Mol Imaging 10:177-86, 1-3. 2011
    ..Overall, these results strongly support the continued development of CLI as a preclinical and possible clinical tool for use in molecular imaging and surgical procedures for accurately defining tumor margins...
  11. doi request reprint Spectroelectrochemical and computational studies on the mechanism of hypoxia selectivity of copper radiopharmaceuticals
    Jason P Holland
    Chemistry Research Laboratory, Department of Chemistry, University of Oxford, 12 Mansfield Road, Oxford, OX1 3TA UK
    Chemistry 14:5890-907. 2008
    ..The one-electron reduction potential, rate of reoxidation of the copper(I) anionic species and ease of protonation are dependent on the structure of the ligand, which also governs their observed behaviour in vivo...
  12. ncbi request reprint Macrocyclic diamide ligand systems: potential chelators for 64Cu- and 68Ga-based positron emission tomography imaging agents
    Peter J Barnard
    Department of Chemistry, Inorganic Chemistry Laboratory, University of Oxford, South Parks Road, Oxford OX1 3QR, UK
    Inorg Chem 48:7117-26. 2009
    ..In vivo biodistribution studies for the (64)Cu labeled complex, (64)Cu-1, in male Lewis rats, showed that the activity is cleared rapidly from the blood within 1-2 h post-administration...
  13. doi request reprint Monitoring afatinib treatment in HER2-positive gastric cancer with 18F-FDG and 89Zr-trastuzumab PET
    Yelena Y Janjigian
    Gastrointestinal Oncology Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    J Nucl Med 54:936-43. 2013
    ....
  14. pmc Imaging and treating tumor vasculature with targeted radiolabeled carbon nanotubes
    Alessandro Ruggiero
    Department of Medicine and Radiology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    Int J Nanomedicine 5:783-802. 2010
    ..These data have implications that support further imaging and radiotherapy studies using a SWCNT-based platform and focusing on the tumor vessels as the target...
  15. ncbi request reprint Nitrite reduction by copper complexes
    John G Woollard-Shore
    Chemistry Research Laboratory, Department of Chemistry, University of Oxford, 12 Mansfield Road, Oxford, United Kingdom OX1 3TA
    Dalton Trans 39:1576-85. 2010
    ..Overall the results suggest that further investigations into the design and use of copper complexes as nitrite reduction catalysts are warranted...
  16. ncbi request reprint Unconventional nuclides for radiopharmaceuticals
    Jason P Holland
    Radiochemistry Service, Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    Mol Imaging 9:1-20. 2010
    ..In particular, the properties and safety considerations associated with the increasingly prevalent PET nuclides 64Cu, 68Ga, 86Y, 89Zr, and 124I are discussed...
  17. pmc Measuring the pharmacodynamic effects of a novel Hsp90 inhibitor on HER2/neu expression in mice using Zr-DFO-trastuzumab
    Jason P Holland
    Radiochemistry Service, Department of Radiology, Memorial Sloan Kettering Cancer Center, Sloan Kettering Cancer Center, New York, New York, United States of America
    PLoS ONE 5:e8859. 2010
    ..In addition, pharmacodynamic studies on HER2/neu expression levels in response to therapeutic doses of PU-H71 (a specific inhibitor of heat-shock protein 90 [Hsp90]) were conducted...
  18. doi request reprint Fluorinated quinazolinones as potential radiotracers for imaging kinesin spindle protein expression
    Jason P Holland
    Division of Nuclear Medicine and Molecular Imaging, Massachusetts General Hospital, Department of Radiology, Harvard Medical School, 55 Fruit St, White 427, Boston, MA 02114, USA
    Bioorg Med Chem 21:496-507. 2013
    ....
  19. doi request reprint Clickable bifunctional radiometal chelates for peptide labeling
    Artem Y Lebedev
    Radiochemistry Service, Department of Radiology, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA
    Chem Commun (Camb) 46:1706-8. 2010
    ..Novel synthetic methods for producing an array of chelates for use in "click"-radiolabeling of peptides are described, and their reactivity with regards to subsequent conjugation and radiolabeling is discussed...
  20. pmc Imaging androgen receptor signaling with a radiotracer targeting free prostate-specific antigen
    David Ulmert
    Department of Surgery, Howard Hughes Medical Institute, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA
    Cancer Discov 2:320-7. 2012
    ..Finally, we demonstrate that (89)Zr-5A10 can detect osseous prostate cancer lesions, a context where bone scans fail to discriminate malignant and nonmalignant signals...
  21. ncbi request reprint Evaluation of exchange-correlation functionals for time-dependent density functional theory calculations on metal complexes
    Jason P Holland
    Department of Chemistry, Chemistry Research Laboratory, University of Oxford, 12 Mansfield Road, Oxford OX1 3TA, United Kingdom
    J Comput Chem 31:1008-14. 2010
    ..3 and 7.3%, and epsilon(SF) around 0.930. These studies illustrate the power of modern TD-DFT calculations for exploring excited state transitions of metal complexes. (c) 2009 Wiley Periodicals, Inc. J Comput Chem, 2010...