Research Topics
| Jason P HollandSummaryAffiliation: Memorial Sloan-Kettering Cancer Center Country: USA Publications
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Detail Information
Publications
In vitro kinetic studies on the mechanism of oxygen-dependent cellular uptake of copper radiopharmaceuticalsJason P Holland
Department of Chemistry, University of Oxford, Oxford, OX1 3TA, UK
Phys Med Biol 54:2103-19. 2009..Further understanding of the mechanism of hypoxia selectivity may facilitate the development of new imaging and radiotherapeutic agents with increased specificity for tumour hypoxia...
Standardized methods for the production of high specific-activity zirconium-89Jason P Holland
Memorial Sloan Kettering Cancer Center, Department of Radiology, New York, NY 10065, USA
Nucl Med Biol 36:729-39. 2009..The detailed methods described can be easily translated to other radiochemistry facilities and will facilitate the use of (89)Zr in both basic science and clinical investigations...- Cerenkov luminescence imaging of medical isotopesAlessandro Ruggiero
Nuclear Medicine Service, Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA
J Nucl Med 51:1123-30. 2010..Here, we report the use of the inherent optical emissions from the decay of radiopharmaceuticals for Cerenkov luminescence imaging (CLI) of tumors in vivo and correlate the results with those obtained from concordant immuno-PET studies... - Magnitude of enhanced permeability and retention effect in tumors with different phenotypes: 89Zr-albumin as a model systemCarola Heneweer
Program in Molecular Pharmacology and Chemistry, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA
J Nucl Med 52:625-33. 2011..This study investigated the influence of different tumor phenotypes on the EPR effect, hypothesizing that a baseline level of uptake must be exceeded to visualize high and specific uptake of a targeted macromolecular radiotracer... - Annotating MYC status with 89Zr-transferrin imagingJason P Holland
Radiochemistry Service, Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York, USA
Nat Med 18:1586-91. 2012..These preclinical data establish (89)Zr-transferrin as a sensitive tool for noninvasive measurement of oncogene-driven TFRC expression in prostate and potentially other cancers, with prospective near-term clinical application... - Targeting the internal epitope of prostate-specific membrane antigen with 89Zr-7E11 immuno-PETAlessandro Ruggiero
Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York, USA
J Nucl Med 52:1608-15. 2011..The ability of (89)Zr-DFO-7E11 to delineate tumor response to therapy was also investigated, because it binds to the intracellular epitope of PSMA, which becomes available only on membrane disruption in dead or dying cells... - In vitro and in vivo evaluations of a hydrophilic 64Cu-bis(thiosemicarbazonato)-glucose conjugate for hypoxia imagingSimon R Bayly
Siemens Oxford Molecular Imaging Laboratory, Inorganic Chemistry Laboratory, University of Oxford, Oxford, United Kingdom
J Nucl Med 49:1862-8. 2008..Here we report our initial biological experiments with 64Cu-ATSE/A-G and compare the results with those obtained for 64Cu-ATSM and 18F-FDG... - 89Zr-DFO-J591 for immunoPET of prostate-specific membrane antigen expression in vivoJason P Holland
Radiochemistry Service, Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA
J Nucl Med 51:1293-300. 2010.... - Macrocyclic diamide ligand systems: potential chelators for 64Cu- and 68Ga-based positron emission tomography imaging agentsPeter J Barnard
Department of Chemistry, Inorganic Chemistry Laboratory, University of Oxford, South Parks Road, Oxford OX1 3QR, UK
Inorg Chem 48:7117-26. 2009..In vivo biodistribution studies for the (64)Cu labeled complex, (64)Cu-1, in male Lewis rats, showed that the activity is cleared rapidly from the blood within 1-2 h post-administration... - Intraoperative imaging of positron emission tomographic radiotracers using Cerenkov luminescence emissionsJason P Holland
Radiochemistry Service, Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
Mol Imaging 10:177-86, 1-3. 2011..Overall, these results strongly support the continued development of CLI as a preclinical and possible clinical tool for use in molecular imaging and surgical procedures for accurately defining tumor margins... - Spectroelectrochemical and computational studies on the mechanism of hypoxia selectivity of copper radiopharmaceuticalsJason P Holland
Chemistry Research Laboratory, Department of Chemistry, University of Oxford, 12 Mansfield Road, Oxford, OX1 3TA UK
Chemistry 14:5890-907. 2008..The one-electron reduction potential, rate of reoxidation of the copper(I) anionic species and ease of protonation are dependent on the structure of the ligand, which also governs their observed behaviour in vivo... - Nitrite reduction by copper complexesJohn G Woollard-Shore
Chemistry Research Laboratory, Department of Chemistry, University of Oxford, 12 Mansfield Road, Oxford, United Kingdom OX1 3TA
Dalton Trans 39:1576-85. 2010..Overall the results suggest that further investigations into the design and use of copper complexes as nitrite reduction catalysts are warranted... - Imaging and treating tumor vasculature with targeted radiolabeled carbon nanotubesAlessandro Ruggiero
Department of Medicine and Radiology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
Int J Nanomedicine 5:783-802. 2010..These data have implications that support further imaging and radiotherapy studies using a SWCNT-based platform and focusing on the tumor vessels as the target... - Imaging tumor burden in the brain with 89Zr-transferrinMichael J Evans
Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA
J Nucl Med 54:90-5. 2013..Therefore, we reasoned that applying a radiolabeled derivative of transferrin ((89)Zr-labeled transferrin) may be an effective strategy to more thoroughly identify tumor tissue in the brain, regardless of the tumor's genetic background... 
Unconventional nuclides for radiopharmaceuticalsJason P Holland
Radiochemistry Service, Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
Mol Imaging 9:1-20. 2010..In particular, the properties and safety considerations associated with the increasingly prevalent PET nuclides 64Cu, 68Ga, 86Y, 89Zr, and 124I are discussed...- Measuring the pharmacodynamic effects of a novel Hsp90 inhibitor on HER2/neu expression in mice using Zr-DFO-trastuzumabJason P Holland
Radiochemistry Service, Department of Radiology, Memorial Sloan Kettering Cancer Center, Sloan Kettering Cancer Center, New York, New York, United States of America
PLoS ONE 5:e8859. 2010..In addition, pharmacodynamic studies on HER2/neu expression levels in response to therapeutic doses of PU-H71 (a specific inhibitor of heat-shock protein 90 [Hsp90]) were conducted... - Clickable bifunctional radiometal chelates for peptide labelingArtem Y Lebedev
Radiochemistry Service, Department of Radiology, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA
Chem Commun (Camb) 46:1706-8. 2010..Novel synthetic methods for producing an array of chelates for use in "click"-radiolabeling of peptides are described, and their reactivity with regards to subsequent conjugation and radiolabeling is discussed... - Imaging androgen receptor signaling with a radiotracer targeting free prostate-specific antigenDavid Ulmert
Department of Surgery, Howard Hughes Medical Institute, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA
Cancer Discov 2:320-7. 2012.... - Evaluation of exchange-correlation functionals for time-dependent density functional theory calculations on metal complexesJason P Holland
Department of Chemistry, Chemistry Research Laboratory, University of Oxford, 12 Mansfield Road, Oxford OX1 3TA, United Kingdom
J Comput Chem 31:1008-14. 2010..3 and 7.3%, and epsilon(SF) around 0.930. These studies illustrate the power of modern TD-DFT calculations for exploring excited state transitions of metal complexes. (c) 2009 Wiley Periodicals, Inc. J Comput Chem, 2010...