Cyrus V Hedvat

Summary

Affiliation: Memorial Sloan-Kettering Cancer Center
Country: USA

Publications

  1. ncbi request reprint Myeloid ELF1-like factor is a potent activator of interleukin-8 expression in hematopoietic cells
    Cyrus V Hedvat
    Laboratory of Molecular Aspects of Hematopoiesis, Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    J Biol Chem 279:6395-400. 2004
  2. doi request reprint Digital microscopy: past, present, and future
    Cyrus V Hedvat
    Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    Arch Pathol Lab Med 134:1666-70. 2010
  3. ncbi request reprint Expression of p63 in diffuse large B-cell lymphoma
    Cyrus V Hedvat
    Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Appl Immunohistochem Mol Morphol 13:237-42. 2005
  4. pmc The ETS protein MEF is regulated by phosphorylation-dependent proteolysis via the protein-ubiquitin ligase SCFSkp2
    Yan Liu
    Division of Hematologic Oncology, Department of Medicine, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, Box 575, New York, NY 10021, USA
    Mol Cell Biol 26:3114-23. 2006
  5. ncbi request reprint Insights into extramedullary tumour cell growth revealed by expression profiling of human plasmacytomas and multiple myeloma
    Cyrus V Hedvat
    Laboratory of Molecular Aspects of Hematopoiesis, Sloan Kettering Institute, New York, NY, USA
    Br J Haematol 122:728-44. 2003
  6. ncbi request reprint Patterns of expression of cell cycle/apoptosis genes along the spectrum of thyroid carcinoma progression
    Benjamin Saltman
    Department of Otolaryngology, Columbia University College of Physicians and Surgeons, New York, NY 10021, USA
    Surgery 140:899-905; discussion 905-6. 2006
  7. ncbi request reprint Wilms Tumor Gene (WT1) and p53 expression in endometrial carcinomas: a study of 130 cases using a tissue microarray
    Jakob Dupont
    Developmental Chemotherapy Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
    Gynecol Oncol 94:449-55. 2004
  8. ncbi request reprint Expression of cancer-testis antigens in endometrial carcinomas using a tissue microarray
    Dhananjay A Chitale
    Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Mod Pathol 18:119-26. 2005
  9. ncbi request reprint Tissue microarray molecular profiling of early, node-negative adenocarcinoma of the rectum: a comprehensive analysis
    Axel Hoos
    Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Clin Cancer Res 8:3841-9. 2002
  10. ncbi request reprint Differential expression patterns of c-REL protein in classic and nodular lymphocyte predominant Hodgkin lymphoma
    Qianxun Xiao
    Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Appl Immunohistochem Mol Morphol 12:211-5. 2004

Research Grants

Collaborators

Detail Information

Publications18

  1. ncbi request reprint Myeloid ELF1-like factor is a potent activator of interleukin-8 expression in hematopoietic cells
    Cyrus V Hedvat
    Laboratory of Molecular Aspects of Hematopoiesis, Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    J Biol Chem 279:6395-400. 2004
    ..MEF overexpression is sufficient to induce IL-8 protein expression, and reduction in MEF expression (using RNA interference) results in decreased IL-8 levels. These data demonstrates that MEF is an important regulator of IL-8 expression...
  2. doi request reprint Digital microscopy: past, present, and future
    Cyrus V Hedvat
    Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    Arch Pathol Lab Med 134:1666-70. 2010
    ....
  3. ncbi request reprint Expression of p63 in diffuse large B-cell lymphoma
    Cyrus V Hedvat
    Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Appl Immunohistochem Mol Morphol 13:237-42. 2005
    ..Even though in univariate analysis p63 expression did not correlate with overall survival, the association of p63 with increased proliferative index suggests its involvement in DLBCL tumor progression...
  4. pmc The ETS protein MEF is regulated by phosphorylation-dependent proteolysis via the protein-ubiquitin ligase SCFSkp2
    Yan Liu
    Division of Hematologic Oncology, Department of Medicine, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, Box 575, New York, NY 10021, USA
    Mol Cell Biol 26:3114-23. 2006
    ..The tight regulation of MEF levels during the cell cycle contributes to its effects on regulating cell cycle entry and cell proliferation...
  5. ncbi request reprint Insights into extramedullary tumour cell growth revealed by expression profiling of human plasmacytomas and multiple myeloma
    Cyrus V Hedvat
    Laboratory of Molecular Aspects of Hematopoiesis, Sloan Kettering Institute, New York, NY, USA
    Br J Haematol 122:728-44. 2003
    ..Defining how malignant plasma cell growth is regulated in the bone marrow versus at extramedullary sites will help to delineate the mechanisms underlying the dependence of tumour cell growth on angiogenesis and cell adhesion...
  6. ncbi request reprint Patterns of expression of cell cycle/apoptosis genes along the spectrum of thyroid carcinoma progression
    Benjamin Saltman
    Department of Otolaryngology, Columbia University College of Physicians and Surgeons, New York, NY 10021, USA
    Surgery 140:899-905; discussion 905-6. 2006
    ..The aim of this study is to determine to what extent cell cycle/apoptosis regulators contribute to cancer progression...
  7. ncbi request reprint Wilms Tumor Gene (WT1) and p53 expression in endometrial carcinomas: a study of 130 cases using a tissue microarray
    Jakob Dupont
    Developmental Chemotherapy Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
    Gynecol Oncol 94:449-55. 2004
    ..We studied a large number of endometrial carcinomas to determine the range of tumors that express WT1; this could have prognostic and therapeutic significance...
  8. ncbi request reprint Expression of cancer-testis antigens in endometrial carcinomas using a tissue microarray
    Dhananjay A Chitale
    Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Mod Pathol 18:119-26. 2005
    ..CT antigens CT7, MAGE-A3 and MAGE-A4, but not NY-ESO-1, are expressed in high-grade endometrial carcinomas, and expression of MAGE-A4 is correlated with the presence of overexpressed p53...
  9. ncbi request reprint Tissue microarray molecular profiling of early, node-negative adenocarcinoma of the rectum: a comprehensive analysis
    Axel Hoos
    Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Clin Cancer Res 8:3841-9. 2002
    ..This study evaluates such molecular phenotypes with regard to cell cycle regulation and proliferation and determines their significance for patient outcome...
  10. ncbi request reprint Differential expression patterns of c-REL protein in classic and nodular lymphocyte predominant Hodgkin lymphoma
    Qianxun Xiao
    Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Appl Immunohistochem Mol Morphol 12:211-5. 2004
    ..Our results demonstrate that there is differential c-REL protein expression in cHL in comparison with NLPHL and suggest that c-REL may play a role in the pathogenesis of classic Hodgkin lymphoma...
  11. ncbi request reprint Expression of cancer/testis (CT) antigens MAGE-A1, MAGE-A3, MAGE-A4, CT-7, and NY-ESO-1 in malignant gammopathies is heterogeneous and correlates with site, stage and risk status of disease
    Madhav V Dhodapkar
    Laboratory of Tumor Immunology and Immunotherapy, The Rockefeller University, New York, NY 10021, USA
    Cancer Immun 3:9. 2003
    ..These data suggest that CT antigens may have important biological implications in malignant gammopathies and that CT-7 may be a suitable target for T cell-based and possibly antibody-mediated immunotherapy of myeloma...
  12. ncbi request reprint Application of tissue microarray technology to the study of non-Hodgkin's and Hodgkin's lymphoma
    Cyrus V Hedvat
    Laboratory of Cancer Genetics, Cell Biology Program, Department of Pathology and Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Hum Pathol 33:968-74. 2002
    ..This extensive expression profile of B-cell NHLs and HL tissues discloses the ability of TMAs to rapidly screen a large series of cases and represents the first report of method validation for this technique in the study of lymphoma...
  13. pmc Regulatory T cell infiltration predicts outcome following resection of colorectal cancer liver metastases
    Steven C Katz
    Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA
    Ann Surg Oncol 20:946-55. 2013
    ..While CD4 and CD8 T cells have been correlated with outcome following CRCLM resection, the role of regulatory T cells (Treg) is not well defined...
  14. doi request reprint PIK3CA mutation associates with improved outcome in breast cancer
    Kevin Kalinsky
    Breast Cancer Medicine Service, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA
    Clin Cancer Res 15:5049-59. 2009
    ..The prognostic implication of these activating mutations remains uncertain as moderately sized studies have yielded variable outcomes. Our aim was to determine the prognostic implications of PIK3CA mutations in breast cancer...
  15. ncbi request reprint Doxorubicin and dexamethasone followed by thalidomide and dexamethasone is an effective well tolerated initial therapy for multiple myeloma
    Hani Hassoun
    Division of Hematologic Oncology, Department of Medicine, Hematology Service, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Br J Haematol 132:155-61. 2006
    ..AD-TD administered with low dose aspirin for deep vein thrombosis prophylaxis was well tolerated and yielded a high response rate with minimal treatment-related morbidity...
  16. ncbi request reprint p63 expression profiles in human normal and tumor tissues
    Charles J Di Como
    Division of Molecular Pathology, Department of Pathology, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Clin Cancer Res 8:494-501. 2002
    ..The p63 gene, located on chromosome 3q27-28, is a member of the p53 gene family. The product encoded by the p63 gene has been reported to be essential for normal development...
  17. ncbi request reprint Melan-A (A103) and inhibin expression in ovarian neoplasms
    Davis X Yao
    Department of Pathology, New York Presbyterian Hospital Weill Medical College of Cornell University, New York, New York, U S A
    Appl Immunohistochem Mol Morphol 11:244-9. 2003
    ..Thus, adding A103 to a panel of markers including inhibin may be a valuable adjunct in the differential diagnoses of SCSTs and their distinction from other ovarian neoplasms...
  18. pmc Akt phosphorylates the transcriptional repressor bmi1 to block its effects on the tumor-suppressing ink4a-arf locus
    Yan Liu
    Molecular Pharmacology and Chemistry Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    Sci Signal 5:ra77. 2012
    ....

Research Grants1

  1. ROLE OF MYELOID ELF-1 LIKE FACTOR IN HEMATOPOIESIS
    Cyrus Hedvat; Fiscal Year: 2005
    ..Experience in the analysis of mouse models, the use of emerging microarray technology to study and diagnose disease, and clinical diagnostic development will lead to an independent career as a physician scientist. ..