Cole M Haynes

Summary

Affiliation: Memorial Sloan-Kettering Cancer Center
Country: USA

Publications

  1. ncbi The matrix peptide exporter HAF-1 signals a mitochondrial UPR by activating the transcription factor ZC376.7 in C. elegans
    Cole M Haynes
    Kimmel Center for Biology and Medicine of the Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, NY 10016, USA
    Mol Cell 37:529-40. 2010
  2. ncbi The mitochondrial UPR - protecting organelle protein homeostasis
    Cole M Haynes
    Cell Biology Program, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, Box 390, New York, NY 10065, USA
    J Cell Sci 123:3849-55. 2010
  3. ncbi ClpP mediates activation of a mitochondrial unfolded protein response in C. elegans
    Cole M Haynes
    Kimmel Center for Biology and Medicine of Skirball Institute and Department of Cell Biology, New York University School of Medicine, New York, NY 10016, USA
    Dev Cell 13:467-80. 2007
  4. ncbi Mitochondrial import efficiency of ATFS-1 regulates mitochondrial UPR activation
    Amrita M Nargund
    Cell Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    Science 337:587-90. 2012
  5. ncbi Signaling the mitochondrial unfolded protein response
    Mark W Pellegrino
    Cell Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    Biochim Biophys Acta 1833:410-6. 2013
  6. ncbi Protective coupling of mitochondrial function and protein synthesis via the eIF2α kinase GCN-2
    Brooke M Baker
    Cell Biology Program, Memorial Sloan Kettering Cancer Center, New York, New York, United States of America
    PLoS Genet 8:e1002760. 2012
  7. ncbi Ubiquitin-like protein 5 positively regulates chaperone gene expression in the mitochondrial unfolded protein response
    Cristina Benedetti
    Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, New York 10016, USA
    Genetics 174:229-39. 2006
  8. ncbi Flavonol activation defines an unanticipated ligand-binding site in the kinase-RNase domain of IRE1
    R Luke Wiseman
    Kimmel Center for Biology and Medicine of the Skirball Institute, New York University School of Medicine, New York, NY 10016, USA
    Mol Cell 38:291-304. 2010
  9. ncbi Thioredoxin-related Protein 32 is an arsenite-regulated Thiol Reductase of the proteasome 19 S particle
    R Luke Wiseman
    Kimmel Center for Biology and Medicine of the Skirball Institute, New York University School of Medicine, New York, New York 10016, USA
    J Biol Chem 284:15233-45. 2009
  10. ncbi Mitochondrial protein quality control during biogenesis and aging
    Brooke M Baker
    Sloan Kettering Institute, Cell Biology Program, New York, NY 10065, USA
    Trends Biochem Sci 36:254-61. 2011

Collaborators

  • D Ron
  • Heather P Harding
  • R Luke Wiseman
  • Oliver Florey
  • Brooke M Baker
  • Amrita M Nargund
  • Mark W Pellegrino
  • Cristina Benedetti
  • Ariel Stanhill
  • Tiffany Sun
  • Christopher J Fiorese
  • Guangwei Min
  • Yun Yang
  • Juliya Kalinina
  • Matthew C Steele
  • Enid Martinez
  • Xiang-Peng Kong
  • Cecile M Pickart
  • Yuhong Zhang
  • Xiang Peng Kong

Detail Information

Publications12

  1. ncbi The matrix peptide exporter HAF-1 signals a mitochondrial UPR by activating the transcription factor ZC376.7 in C. elegans
    Cole M Haynes
    Kimmel Center for Biology and Medicine of the Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, NY 10016, USA
    Mol Cell 37:529-40. 2010
    ....
  2. ncbi The mitochondrial UPR - protecting organelle protein homeostasis
    Cole M Haynes
    Cell Biology Program, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, Box 390, New York, NY 10065, USA
    J Cell Sci 123:3849-55. 2010
    ..Here, we review the current knowledge of this mitochondrial unfolded protein response (UPR(mt)), compare it with the better understood UPR of the endoplasmic reticulum and highlight its potential impact on development and disease...
  3. ncbi ClpP mediates activation of a mitochondrial unfolded protein response in C. elegans
    Cole M Haynes
    Kimmel Center for Biology and Medicine of Skirball Institute and Department of Cell Biology, New York University School of Medicine, New York, NY 10016, USA
    Dev Cell 13:467-80. 2007
    ..As ClpP is known to function in the bacterial heat-shock response, our findings suggest that eukaryotes utilize component(s) from the protomitochondrial symbiont to signal the UPR(mt)...
  4. ncbi Mitochondrial import efficiency of ATFS-1 regulates mitochondrial UPR activation
    Amrita M Nargund
    Cell Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    Science 337:587-90. 2012
    ..Our results show that cells monitor mitochondrial import efficiency via ATFS-1 to coordinate the level of mitochondrial dysfunction with the protective transcriptional response...
  5. ncbi Signaling the mitochondrial unfolded protein response
    Mark W Pellegrino
    Cell Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    Biochim Biophys Acta 1833:410-6. 2013
    ..Here, we review the current understanding of UPR(mt) signal transduction and the impact of the UPR(mt) on diseased cells. This article is part of a Special Issue entitled: Protein Import and Quality Control in Mitochondria and Plastids...
  6. ncbi Protective coupling of mitochondrial function and protein synthesis via the eIF2α kinase GCN-2
    Brooke M Baker
    Cell Biology Program, Memorial Sloan Kettering Cancer Center, New York, New York, United States of America
    PLoS Genet 8:e1002760. 2012
    ..These findings are consistent with translational control and stress-dependent chaperone induction acting in complementary arms of the UPR(mt)...
  7. ncbi Ubiquitin-like protein 5 positively regulates chaperone gene expression in the mitochondrial unfolded protein response
    Cristina Benedetti
    Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, New York 10016, USA
    Genetics 174:229-39. 2006
    ..Induction of mitochondrial stress promotes accumulation of GFP-tagged UBL-5 in nuclei of transgenic worms, suggesting that UBL-5 effects a nuclear step required for mounting a response to the threat of mitochondrial protein misfolding...
  8. ncbi Flavonol activation defines an unanticipated ligand-binding site in the kinase-RNase domain of IRE1
    R Luke Wiseman
    Kimmel Center for Biology and Medicine of the Skirball Institute, New York University School of Medicine, New York, NY 10016, USA
    Mol Cell 38:291-304. 2010
    ....
  9. ncbi Thioredoxin-related Protein 32 is an arsenite-regulated Thiol Reductase of the proteasome 19 S particle
    R Luke Wiseman
    Kimmel Center for Biology and Medicine of the Skirball Institute, New York University School of Medicine, New York, New York 10016, USA
    J Biol Chem 284:15233-45. 2009
    ..These findings reveal a previously undescribed thiol reductase at the proteasome's regulatory particle...
  10. ncbi Mitochondrial protein quality control during biogenesis and aging
    Brooke M Baker
    Sloan Kettering Institute, Cell Biology Program, New York, NY 10065, USA
    Trends Biochem Sci 36:254-61. 2011
    ..Here, we review mitochondrial protein quality control with a focus on organelle biogenesis and aging...
  11. ncbi An arsenite-inducible 19S regulatory particle-associated protein adapts proteasomes to proteotoxicity
    Ariel Stanhill
    Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, New York 10016, USA
    Mol Cell 23:875-85. 2006
    ..These features include enhanced cleavage of peptide substrates and suggest that AIRAP adapts the cell's core protein degradation machinery to counteract proteotoxicity induced by an environmental toxin...
  12. ncbi Autophagy machinery mediates macroendocytic processing and entotic cell death by targeting single membranes
    Oliver Florey
    Cell Biology Program, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA
    Nat Cell Biol 13:1335-43. 2011
    ..These data demonstrate that proteins of the autophagy pathway can target single-membrane vacuoles in cells in the absence of pathogenic organisms...