Anna Katerina Hadjantonakis


Affiliation: Memorial Sloan-Kettering Cancer Center
Country: USA


  1. Simon C, Zhang L, Wu T, Cai W, Saiz N, Nowotschin S, et al. A Gata4 nuclear GFP transcriptional reporter to study endoderm and cardiac development in the mouse. Biol Open. 2018;7: pubmed publisher
    ..As such, this Gata4H2B-GFP allele will be a useful tool for studying Gata4 expression and transcriptional regulation.This article has an associated First Person interview with the first author of the paper. ..
  2. Nowotschin S, Setty M, Kuo Y, Liu V, Garg V, Sharma R, et al. The emergent landscape of the mouse gut endoderm at single-cell resolution. Nature. 2019;: pubmed publisher
    ..We observed the regionalized identity of cells along the anterior-posterior axis of the emergent gut tube, reflecting their embryonic or extra-embryonic origin, and their coordinate patterning into organ-specific territories. ..
  3. Nowotschin S, Garg V, Piliszek A, Hadjantonakis A. Ex Utero Culture and Imaging of Mouse Embryos. Methods Mol Biol. 2019;1920:163-182 pubmed publisher
  4. Nowotschin S, Hadjantonakis A. Lights, Camera, Action! Visualizing the Cellular Choreography of Mouse Gastrulation. Dev Cell. 2018;47:684-685 pubmed publisher
    ..Recent work reports a technical tour de force toward the in toto visualization of mouse early post-implantation embryo development at an unprecedented spatio-temporal resolution. ..
  5. Simon C, Hadjantonakis A. Top to Tail: Anterior-Posterior Patterning Precedes Regional Nervous System Identity. Cell. 2018;175:905-907 pubmed publisher
    ..This contrasts with the prevailing view that neural identity comes first, providing a new window on the origins of the brain and spinal cord. ..
  6. Morgani S, Saiz N, Garg V, Raina D, Simon C, Kang M, et al. A Sprouty4 reporter to monitor FGF/ERK signaling activity in ESCs and mice. Dev Biol. 2018;441:104-126 pubmed publisher
    ..This tool will provide new insights into the dynamics of the FGF/ERK signaling pathway during mammalian development. ..
  7. Viotti M, Foley A, Hadjantonakis A. Gutsy moves in mice: cellular and molecular dynamics of endoderm morphogenesis. Philos Trans R Soc Lond B Biol Sci. 2014;369: pubmed publisher
    ..Here, we review findings that have uncovered complex cell movements within the endodermal layer, before and during gastrulation, leading to the conclusion that cells from primitive endoderm contribute descendants directly to gut. ..
  8. Xenopoulos P, Kang M, Puliafito A, Di Talia S, Hadjantonakis A. Heterogeneities in Nanog Expression Drive Stable Commitment to Pluripotency in the Mouse Blastocyst. Cell Rep. 2015;10:1508-1520 pubmed publisher
    ..We propose that the rapid timescale of early mammalian embryonic development prevents fluctuations in cell fate. ..
  9. Saiz N, Plusa B, Hadjantonakis A. Single cells get together: High-resolution approaches to study the dynamics of early mouse development. Semin Cell Dev Biol. 2015;47-48:92-100 pubmed publisher
    ..In this review we highlight how the application of live imaging and single-cell resolution analysis pipelines is providing an unprecedented level of insight on the processes that shape the earliest stages of mammalian development. ..

More Information


  1. Hadjantonakis A, Papaioannou V. Dynamic in vivo imaging and cell tracking using a histone fluorescent protein fusion in mice. BMC Biotechnol. 2004;4:33 pubmed
    ..It is therefore attractive for use in multidimensional studies of in vivo cell behavior and cell fate. ..
  2. Freyer L, Schroter C, Saiz N, Schrode N, Nowotschin S, Martinez Arias A, et al. A loss-of-function and H2B-Venus transcriptional reporter allele for Gata6 in mice. BMC Dev Biol. 2015;15:38 pubmed publisher
  3. Garg V, Morgani S, Hadjantonakis A. Capturing Identity and Fate Ex Vivo: Stem Cells from the Mouse Blastocyst. Curr Top Dev Biol. 2016;120:361-400 pubmed publisher
    ..Here we outline our current understanding of the derivation, maintenance, and properties of these in vitro stem cell models representing the preimplantation embryonic lineages. ..
  4. Nowotschin S, Hadjantonakis A. Use of KikGR a photoconvertible green-to-red fluorescent protein for cell labeling and lineage analysis in ES cells and mouse embryos. BMC Dev Biol. 2009;9:49 pubmed publisher
  5. Freyer L, Hsu C, Nowotschin S, Pauli A, Ishida J, Kuba K, et al. Loss of Apela Peptide in Mice Causes Low Penetrance Embryonic Lethality and Defects in Early Mesodermal Derivatives. Cell Rep. 2017;20:2116-2130 pubmed publisher
    ..Double-mutant analyses showed that loss of Apela signaling impacts early Aplnr-expressing mesodermal populations independently of the alternative ligand Apelin, leading to lethal cardiac defects in some Apela null embryos. ..
  6. Morgani S, Nichols J, Hadjantonakis A. The many faces of Pluripotency: in vitro adaptations of a continuum of in vivo states. BMC Dev Biol. 2017;17:7 pubmed publisher
    ..Furthermore, we speculate on embryonic stage-specific characteristics that could be utilized to identify novel, developmentally relevant, pluripotent states. ..
  7. Kang M, Garg V, Hadjantonakis A. Lineage Establishment and Progression within the Inner Cell Mass of the Mouse Blastocyst Requires FGFR1 and FGFR2. Dev Cell. 2017;41:496-510.e5 pubmed publisher
    ..These data lead us to propose a model whereby unique and additive activities of FGFR1 and FGFR2 within the ICM coordinate establishment of two distinct lineages. ..
  8. Hadjantonakis A, Arias A. Single-Cell Approaches: Pandora's Box of Developmental Mechanisms. Dev Cell. 2016;38:574-8 pubmed publisher
    ..By bridging scales, single-cell approaches should, in principle, galvanize our understanding of how individual cells adopt distinct fates as they build complex tissues. ..
  9. Schrode N, Saiz N, Di Talia S, Hadjantonakis A. GATA6 levels modulate primitive endoderm cell fate choice and timing in the mouse blastocyst. Dev Cell. 2014;29:454-67 pubmed publisher
    ..This study provides a framework for quantitative analyses of mammalian embryos and establishes GATA6 as a nodal point in the gene regulatory network driving ICM lineage specification. ..