Philip H Gutin

Summary

Affiliation: Memorial Sloan-Kettering Cancer Center
Country: USA

Publications

  1. pmc Safety and efficacy of bevacizumab with hypofractionated stereotactic irradiation for recurrent malignant gliomas
    Philip H Gutin
    Department of Neurosurgery, The Brain Tumor Center, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA
    Int J Radiat Oncol Biol Phys 75:156-63. 2009
  2. doi request reprint Patterns of failure after concurrent bevacizumab and hypofractionated stereotactic radiation therapy for recurrent high-grade glioma
    Lauren Q Shapiro
    Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, New York, USA
    Int J Radiat Oncol Biol Phys 85:636-42. 2013
  3. ncbi request reprint Effect of brain tumor neovasculature defined by rCBV on BOLD fMRI activation volume in the primary motor cortex
    Bob L Hou
    Functional MRI Laboratory, Box 506, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
    Neuroimage 32:489-97. 2006
  4. doi request reprint Abbreviated course of radiation therapy with concurrent temozolomide for high-grade glioma in patients of advanced age or poor functional status
    Marsha Reyngold
    Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA
    J Neurooncol 110:369-74. 2012
  5. ncbi request reprint Adenovirus-mediated expression of a dominant negative Ku70 fragment radiosensitizes human tumor cells under aerobic and hypoxic conditions
    Fuqiu He
    Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Cancer Res 67:634-42. 2007
  6. ncbi request reprint Magnetic resonance spectroscopy imaging in radiotherapy planning for recurrent glioma
    Ase M Ballangrud
    Department of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Med Phys 38:2724-30. 2011
  7. doi request reprint Functional MRI in the presurgical evaluation of patients with brain tumors: characterization of the statistical threshold
    Connie Y Chang
    Department of Radiology, Functional MRI Laboratory, Memorial Sloan Kettering Cancer Center, New York, NY, USA
    Stereotact Funct Neurosurg 88:35-41. 2010
  8. ncbi request reprint Intensity-modulated radiotherapy in high-grade gliomas: clinical and dosimetric results
    Ashwatha Narayana
    Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Int J Radiat Oncol Biol Phys 64:892-7. 2006
  9. ncbi request reprint Hypofractionated stereotactic radiotherapy using intensity-modulated radiotherapy in patients with one or two brain metastases
    Ashwatha Narayana
    Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, Weill Medical College of Cornell University, New York, NY, USA
    Stereotact Funct Neurosurg 85:82-7. 2007
  10. pmc Antiangiogenic agents in the treatment of recurrent or newly diagnosed glioblastoma: analysis of single-agent and combined modality approaches
    Kathryn Beal
    Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
    Radiat Oncol 6:2. 2011

Collaborators

Detail Information

Publications35

  1. pmc Safety and efficacy of bevacizumab with hypofractionated stereotactic irradiation for recurrent malignant gliomas
    Philip H Gutin
    Department of Neurosurgery, The Brain Tumor Center, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA
    Int J Radiat Oncol Biol Phys 75:156-63. 2009
    ..The objectives of this study were to determine the safety and activity of this combination in malignant gliomas...
  2. doi request reprint Patterns of failure after concurrent bevacizumab and hypofractionated stereotactic radiation therapy for recurrent high-grade glioma
    Lauren Q Shapiro
    Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, New York, USA
    Int J Radiat Oncol Biol Phys 85:636-42. 2013
    ..The objective of this study was to characterize the patterns of failure after this treatment regimen...
  3. ncbi request reprint Effect of brain tumor neovasculature defined by rCBV on BOLD fMRI activation volume in the primary motor cortex
    Bob L Hou
    Functional MRI Laboratory, Box 506, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
    Neuroimage 32:489-97. 2006
    ..The nature of the relationship between the resulting activation volumes and adjacent tumor characteristics is complex, but is found to be dependent on the tumor grade and type, as well as the distance of the tumor to the PMC...
  4. doi request reprint Abbreviated course of radiation therapy with concurrent temozolomide for high-grade glioma in patients of advanced age or poor functional status
    Marsha Reyngold
    Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA
    J Neurooncol 110:369-74. 2012
    ..Grade 3-4 hematologic toxicity occurred in 11 patients. Abbreviated RT with concurrent TMZ provides a clinical benefit, is safe and tolerable in patients of advanced age or poor functional status...
  5. ncbi request reprint Adenovirus-mediated expression of a dominant negative Ku70 fragment radiosensitizes human tumor cells under aerobic and hypoxic conditions
    Fuqiu He
    Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Cancer Res 67:634-42. 2007
    ..If radiation-resistant tumor cells could be sensitized by down-regulating the cellular level/activity of Ku/DNA-PK, this approach could be evaluated as an adjuvant to radiation therapy...
  6. ncbi request reprint Magnetic resonance spectroscopy imaging in radiotherapy planning for recurrent glioma
    Ase M Ballangrud
    Department of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Med Phys 38:2724-30. 2011
    ..The purpose of this study was to investigate how incorporation of magnetic resonance spectroscopy imaging (MRSI) into radiotherapy planning would increase the target volume for patients with recurrent glioma...
  7. doi request reprint Functional MRI in the presurgical evaluation of patients with brain tumors: characterization of the statistical threshold
    Connie Y Chang
    Department of Radiology, Functional MRI Laboratory, Memorial Sloan Kettering Cancer Center, New York, NY, USA
    Stereotact Funct Neurosurg 88:35-41. 2010
    ..It is imperative to evaluate functional MRI data with a wide range of statistical parameters, especially in the assessment of tumor patients...
  8. ncbi request reprint Intensity-modulated radiotherapy in high-grade gliomas: clinical and dosimetric results
    Ashwatha Narayana
    Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Int J Radiat Oncol Biol Phys 64:892-7. 2006
    ..To report preliminary clinical and dosimetric data from intensity-modulated radiotherapy (IMRT) for malignant gliomas...
  9. ncbi request reprint Hypofractionated stereotactic radiotherapy using intensity-modulated radiotherapy in patients with one or two brain metastases
    Ashwatha Narayana
    Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, Weill Medical College of Cornell University, New York, NY, USA
    Stereotact Funct Neurosurg 85:82-7. 2007
    ....
  10. pmc Antiangiogenic agents in the treatment of recurrent or newly diagnosed glioblastoma: analysis of single-agent and combined modality approaches
    Kathryn Beal
    Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
    Radiat Oncol 6:2. 2011
    ..Further research is needed to determine the role of antiangiogenic therapy in frontline treatment and to identify the optimal schedule and partnering agents for use in combination therapy...
  11. doi request reprint A phase 2 trial of stereotactic radiosurgery boost after surgical resection for brain metastases
    Cameron Brennan
    Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York Department of Neurosurgery, Memorial Sloan Kettering Cancer Center, New York, New York
    Int J Radiat Oncol Biol Phys 88:130-6. 2014
    ..To evaluate local control after surgical resection and postoperative stereotactic radiosurgery (SRS) for brain metastases...
  12. doi request reprint Radiotherapy and concomitant temozolomide may improve survival of elderly patients with glioblastoma
    Christopher A Barker
    Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    J Neurooncol 109:391-7. 2012
    ..Survival of elderly patients with GBM may be prolonged with the use of concomitant TMZ during RT. An ongoing randomized study will determine the benefit of this approach in a prospective fashion...
  13. doi request reprint Intraparenchymal and intratumoral interstitial infusion of anti-glioma monoclonal antibody 8H9
    Neal Luther
    Department of Neurological Surgery, Weill Cornell Medical College, New York, New York 10021, USA
    Neurosurgery 63:1166-74; discussion 1174. 2008
    ..Interstitial delivery of murine immunoglobulin G1 monoclonal antibody (MAb) 8H9 was investigated in a rodent model for the potential treatment of infiltrative gliomas...
  14. ncbi request reprint Accuracy and feasibility of cone-beam computed tomography for stereotactic radiosurgery setup
    Jenghwa Chang
    Medical Physics Department, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, New York 10021, USA
    Med Phys 34:2077-84. 2007
    ..34 mm, SD = 0.33 mm). In conclusion, CBCT can be used to guide SRS treatment setup with accuracy comparable to the currently used frame-based stereotactic radiosurgery systems provided that intra-treatment patient motion is prevented...
  15. doi request reprint Interstitial infusion of glioma-targeted recombinant immunotoxin 8H9scFv-PE38
    Neal Luther
    Department of Neurologic Surgery, Weill Medical College of Cornell University, Room A 969, 1300 York Avenue, New York, NY, USA
    Mol Cancer Ther 9:1039-46. 2010
    ..Interstitial infusion of 8H9scFv-PE38 shows potential for the treatment of hemispherical and brain stem glioma. Mol Cancer Ther; 9(4); 1039-46. (c)2010 AACR...
  16. doi request reprint Surrogate markers predict angiogenic potential and survival in patients with glioblastoma multiforme
    Jeffrey P Greenfield
    Department of Neurological Surgery, NewYork Presbyterian Hospital, Weill Cornell Medical Center, New York, New York, USA
    Neurosurgery 64:819-26; discussion 826-7. 2009
    ..In addition, we report on a novel in vitro assay to assess the proangiogenic activity within the plasma samples obtained from glioma patients...
  17. doi request reprint Neurosurgery for brain tumors: update on recent technical advances
    Jonathan H Sherman
    Department of Neurosurgery, Memorial Sloan Kettering Cancer Center, 200 East 72nd Street, Apt 18A, New York, NY 10021, USA
    Curr Neurol Neurosci Rep 11:313-9. 2011
    ..The following review analyzes the recent literature in an effort to describe how these modalities can and should be used in the treatment of patients with intracranial pathology...
  18. ncbi request reprint Intensity-modulated stereotactic radiotherapy of paraspinal tumors: a preliminary report
    Mark H Bilsky
    Neurosurgery Service, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
    Neurosurgery 54:823-30; discussion 830-1. 2004
    ..In this article, we report our initial clinical experience in treating 16 paraspinal tumors with IMRT in which the planning target volume was 2 mm or greater from the spinal cord...
  19. ncbi request reprint Reorganization of the cortical control of movement due to radiation necrosis. Case report
    Bob L Hou
    Functional Magnetic Resonance Imaging Laboratory, and Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    J Neurosurg 104:147-9. 2006
    ..This is similar to the consequences of invasion by glial tumors into the PMC...
  20. ncbi request reprint Discordance between functional magnetic resonance imaging during silent speech tasks and intraoperative speech arrest
    Nicole Petrovich
    Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    J Neurosurg 103:267-74. 2005
    ....
  21. doi request reprint Prophylactic antiepileptic drug therapy in patients undergoing supratentorial meningioma resection: a systematic analysis of efficacy
    Ricardo J Komotar
    Department of Neurological Surgery, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA
    J Neurosurg 115:483-90. 2011
    ....
  22. doi request reprint Temporal relationship of post-operative radiotherapy with temozolomide and oncologic outcome for glioblastoma
    Daniel E Spratt
    Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, Box 22, New York, NY, 10065, USA
    J Neurooncol 116:357-63. 2014
    ..Our data does not support the OS benefit previously seen in delayed RT when correcting for important covariates. We demonstrate a survival detriment with delaying RT post-surgery greater than 6 weeks on multivariate analysis. ..
  23. ncbi request reprint Isolated translocation of Wernicke's area to the right hemisphere in a 62-year-man with a temporo-parietal glioma
    Nicole M Petrovich
    Department of Radiology, Advanced Neuroimaging Laboratory, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    AJNR Am J Neuroradiol 25:130-3. 2004
    ..The current case exemplifies how preoperative fMRI can identify unexpected language organization as a result of tumor growth, affording surgery to patients who may otherwise be deemed inoperable...
  24. doi request reprint Prostate-specific membrane antigen as a potential novel vascular target for treatment of glioblastoma multiforme
    A Gabriella Wernicke
    Department of Radiation Oncology, Weill Cornell Medical College of Cornell University, Stich Radiation Center, 525 E 68th St, New York, NY 10065, USA
    Arch Pathol Lab Med 135:1486-9. 2011
    ..Prostate-specific membrane antigen (PSMA) is expressed in endothelium of vessels in malignant solid tumors but not in normal vessels...
  25. pmc Tracking normalization of brain tumor vasculature by magnetic imaging and proangiogenic biomarkers
    Adilia Hormigo
    Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Cancer Cell 11:6-8. 2007
    ....
  26. ncbi request reprint Brachytherapy for brain tumors
    Todd W Vitaz
    Neurosurgical Service Memorial Sloan Kettering Cancer Center, New York, NY, USA
    J Neurooncol 73:71-86. 2005
    ..This article reviews brachytherapy's rationale, radiobiology, complications, indications, and results from numerous studies that have focused on its application for brain tumors with emphasis on its application for glial tumors...
  27. ncbi request reprint The effect of prior surgery on blood oxygen level-dependent functional MR imaging in the preoperative assessment of brain tumors
    Michael J J Kim
    Department of Radiology, Functional MRI Laboratory, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    AJNR Am J Neuroradiol 26:1980-5. 2005
    ....
  28. doi request reprint Genomic analysis of non-NF2 meningiomas reveals mutations in TRAF7, KLF4, AKT1, and SMO
    Victoria E Clark
    Department of Neurosurgery, Yale Program in Brain Tumor Research, Yale School of Medicine, New Haven, CT 06510, USA
    Science 339:1077-80. 2013
    ..Collectively, these findings identify distinct meningioma subtypes, suggesting avenues for targeted therapeutics...
  29. ncbi request reprint Meningioma resection in the elderly: nationwide inpatient sample, 1998-2002
    Brian T Bateman
    College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
    Neurosurgery 57:866-72; discussion 866-72. 2005
    ..To address this issue, we studied the effect of advanced age on outcome after meningioma resection using the Nationwide Inpatient Sample...
  30. ncbi request reprint Chordoid glioma: report of a case with unusual histologic features, ultrastructural study and review of the literature
    Jeffrey J Raizer
    Department of Neurology, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    J Neurooncol 63:39-47. 2003
    ..Treatment and long term outcome are limited but chordoid gliomas appear to be indolent lesions that may be cured with gross total resection...
  31. ncbi request reprint Surgery of brain metastases--is there still a place for it?
    Ashok Modha
    Neurosurgery Service, Memorial Sloan Kettering Cancer Center and Department of Neurological Surgery, Weill Medical College of Cornell University, New York, NY 10021, USA
    J Neurooncol 75:21-9. 2005
    ..A short description of surgical planning, operative techniques and tools, followed by a discussion on complication avoidance before, during, and after surgery is included...
  32. ncbi request reprint Diagnosis and treatment of atypical and anaplastic meningiomas: a review
    Ashok Modha
    Memorial Sloan Kettering Cancer Center, Department of Neurological Surgery, Weill Medical College of Cornell University, New York, New York, USA
    Neurosurgery 57:538-50; discussion 538-50. 2005
    ..In addition, the role of stereotactic radiosurgery is increasing, along with a possible role for brachytherapy. There are no effective chemotherapeutic agents available. A treatment algorithm is suggested...
  33. ncbi request reprint Diffusion-tensor MR tractography of somatotopic organization of corticospinal tracts in the internal capsule: initial anatomic results in contradistinction to prior reports
    Andrei I Holodny
    Functional MRI Laboratory, Department of Radiology, Memorial Sloan Kettering Cancer Center, 1275 York Ave, New York, NY 10021, USA
    Radiology 234:649-53. 2005
    ..The present data confirm recent results that the CST is located more posteriorly. In the majority of cases, however, the CST is organized somatotopically...
  34. doi request reprint Intracranial and spinal metastases from eccrine mucinous carcinoma: case report
    Rishi N Sheth
    Department of Neurosurgery, Memorial Sloan Kettering Cancer Center, New York, New York, USA
    Neurosurgery 67:E861-2. 2010
    ..MECs tend to recur locally, and their spread to distant organs is very uncommon. This article describes the first case of MEC metastasizing to the brain and the spine...
  35. ncbi request reprint Adenovirus-mediated heat-activated antisense Ku70 expression radiosensitizes tumor cells in vitro and in vivo
    Gloria C Li
    Department of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Cancer Res 63:3268-74. 2003
    ..Taken together, our results suggest that adenovirus-mediated, heat-activated antisense Ku70 expression may provide a novel approach to radiosensitize human tumors...