Research Topics
Genomes and GenesSpecies | Philip H GutinSummaryAffiliation: Memorial Sloan-Kettering Cancer Center Country: USA Publications
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Publications
Safety and efficacy of bevacizumab with hypofractionated stereotactic irradiation for recurrent malignant gliomasPhilip H Gutin
Department of Neurosurgery, The Brain Tumor Center, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA
Int J Radiat Oncol Biol Phys 75:156-63. 2009..The objectives of this study were to determine the safety and activity of this combination in malignant gliomas...
Effect of brain tumor neovasculature defined by rCBV on BOLD fMRI activation volume in the primary motor cortexBob L Hou
Functional MRI Laboratory, Box 506, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
Neuroimage 32:489-97. 2006..The nature of the relationship between the resulting activation volumes and adjacent tumor characteristics is complex, but is found to be dependent on the tumor grade and type, as well as the distance of the tumor to the PMC...- Adenovirus-mediated expression of a dominant negative Ku70 fragment radiosensitizes human tumor cells under aerobic and hypoxic conditionsFuqiu He
Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
Cancer Res 67:634-42. 2007..If radiation-resistant tumor cells could be sensitized by down-regulating the cellular level/activity of Ku/DNA-PK, this approach could be evaluated as an adjuvant to radiation therapy... - Functional MRI in the presurgical evaluation of patients with brain tumors: characterization of the statistical thresholdConnie Y Chang
Department of Radiology, Functional MRI Laboratory, Memorial Sloan Kettering Cancer Center, New York, NY, USA
Stereotact Funct Neurosurg 88:35-41. 2010..It is imperative to evaluate functional MRI data with a wide range of statistical parameters, especially in the assessment of tumor patients... - Intensity-modulated radiotherapy in high-grade gliomas: clinical and dosimetric resultsAshwatha Narayana
Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
Int J Radiat Oncol Biol Phys 64:892-7. 2006..To report preliminary clinical and dosimetric data from intensity-modulated radiotherapy (IMRT) for malignant gliomas... - Magnetic resonance spectroscopy imaging in radiotherapy planning for recurrent gliomaAse M Ballangrud
Department of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
Med Phys 38:2724-30. 2011..The purpose of this study was to investigate how incorporation of magnetic resonance spectroscopy imaging (MRSI) into radiotherapy planning would increase the target volume for patients with recurrent glioma... - Hypofractionated stereotactic radiotherapy using intensity-modulated radiotherapy in patients with one or two brain metastasesAshwatha Narayana
Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, Weill Medical College of Cornell University, New York, NY, USA
Stereotact Funct Neurosurg 85:82-7. 2007.... 
Antiangiogenic agents in the treatment of recurrent or newly diagnosed glioblastoma: analysis of single-agent and combined modality approachesKathryn Beal
Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
Radiat Oncol 6:2. 2011..Further research is needed to determine the role of antiangiogenic therapy in frontline treatment and to identify the optimal schedule and partnering agents for use in combination therapy...- Intraparenchymal and intratumoral interstitial infusion of anti-glioma monoclonal antibody 8H9Neal Luther
Department of Neurological Surgery, Weill Cornell Medical College, New York, New York 10021, USA
Neurosurgery 63:1166-74; discussion 1174. 2008..Interstitial delivery of murine immunoglobulin G1 monoclonal antibody (MAb) 8H9 was investigated in a rodent model for the potential treatment of infiltrative gliomas... - Interstitial infusion of glioma-targeted recombinant immunotoxin 8H9scFv-PE38Neal Luther
Department of Neurologic Surgery, Weill Medical College of Cornell University, Room A 969, 1300 York Avenue, New York, NY, USA
Mol Cancer Ther 9:1039-46. 2010..Interstitial infusion of 8H9scFv-PE38 shows potential for the treatment of hemispherical and brain stem glioma. Mol Cancer Ther; 9(4); 1039-46. (c)2010 AACR... - Accuracy and feasibility of cone-beam computed tomography for stereotactic radiosurgery setupJenghwa Chang
Medical Physics Department, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, New York 10021, USA
Med Phys 34:2077-84. 2007..34 mm, SD = 0.33 mm). In conclusion, CBCT can be used to guide SRS treatment setup with accuracy comparable to the currently used frame-based stereotactic radiosurgery systems provided that intra-treatment patient motion is prevented... - Surrogate markers predict angiogenic potential and survival in patients with glioblastoma multiformeJeffrey P Greenfield
Department of Neurological Surgery, NewYork Presbyterian Hospital, Weill Cornell Medical Center, New York, New York, USA
Neurosurgery 64:819-26; discussion 826-7. 2009..In addition, we report on a novel in vitro assay to assess the proangiogenic activity within the plasma samples obtained from glioma patients... - Neurosurgery for brain tumors: update on recent technical advancesJonathan H Sherman
Department of Neurosurgery, Memorial Sloan Kettering Cancer Center, 200 East 72nd Street, Apt 18A, New York, NY 10021, USA
Curr Neurol Neurosci Rep 11:313-9. 2011..The following review analyzes the recent literature in an effort to describe how these modalities can and should be used in the treatment of patients with intracranial pathology... - Intensity-modulated stereotactic radiotherapy of paraspinal tumors: a preliminary reportMark H Bilsky
Neurosurgery Service, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
Neurosurgery 54:823-30; discussion 830-1. 2004..In this article, we report our initial clinical experience in treating 16 paraspinal tumors with IMRT in which the planning target volume was 2 mm or greater from the spinal cord... - Reorganization of the cortical control of movement due to radiation necrosis. Case reportBob L Hou
Functional Magnetic Resonance Imaging Laboratory, and Department of Radiology, Memorial Sloan-Kettering Cancer Center, New York, New York 10021, USA
J Neurosurg 104:147-9. 2006..This is similar to the consequences of invasion by glial tumors into the PMC... - Discordance between functional magnetic resonance imaging during silent speech tasks and intraoperative speech arrestNicole Petrovich
Department of Radiology, Memorial Sloan-Kettering Cancer Center, New York, New York 10021, USA
J Neurosurg 103:267-74. 2005..The control fMR imaging study showed that vocalized speech fMR imaging shifts the location of the fMR imaging prediction to include the motor strip and may be more appropriate for neurosurgical planning... - Prophylactic antiepileptic drug therapy in patients undergoing supratentorial meningioma resection: a systematic analysis of efficacyRicardo J Komotar
Department of Neurological Surgery, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA
J Neurosurg 115:483-90. 2011.... - Prostate-specific membrane antigen as a potential novel vascular target for treatment of glioblastoma multiformeA Gabriella Wernicke
Department of Radiation Oncology, Weill Cornell Medical College of Cornell University, Stich Radiation Center, 525 E 68th St, New York, NY 10065, USA
Arch Pathol Lab Med 135:1486-9. 2011..Prostate-specific membrane antigen (PSMA) is expressed in endothelium of vessels in malignant solid tumors but not in normal vessels... - Isolated translocation of Wernicke's area to the right hemisphere in a 62-year-man with a temporo-parietal gliomaNicole M Petrovich
Department of Radiology, Advanced Neuroimaging Laboratory, Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA
AJNR Am J Neuroradiol 25:130-3. 2004..The current case exemplifies how preoperative fMRI can identify unexpected language organization as a result of tumor growth, affording surgery to patients who may otherwise be deemed inoperable... - Brachytherapy for brain tumorsTodd W Vitaz
Neurosurgical Service Memorial Sloan Kettering Cancer Center, New York, NY, USA
J Neurooncol 73:71-86. 2005..This article reviews brachytherapy's rationale, radiobiology, complications, indications, and results from numerous studies that have focused on its application for brain tumors with emphasis on its application for glial tumors... - The effect of prior surgery on blood oxygen level-dependent functional MR imaging in the preoperative assessment of brain tumorsMichael J J Kim
Department of Radiology, Functional MRI Laboratory, Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA
AJNR Am J Neuroradiol 26:1980-5. 2005.... - Tracking normalization of brain tumor vasculature by magnetic imaging and proangiogenic biomarkersAdilia Hormigo
Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
Cancer Cell 11:6-8. 2007.... - Abbreviated course of radiation therapy with concurrent temozolomide for high-grade glioma in patients of advanced age or poor functional statusMarsha Reyngold
Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA
J Neurooncol 110:369-74. 2012..Grade 3-4 hematologic toxicity occurred in 11 patients. Abbreviated RT with concurrent TMZ provides a clinical benefit, is safe and tolerable in patients of advanced age or poor functional status... - Intracranial and spinal metastases from eccrine mucinous carcinoma: case reportRishi N Sheth
Department of Neurosurgery, Memorial Sloan Kettering Cancer Center, New York, New York, USA
Neurosurgery 67:E861-2. 2010..MECs tend to recur locally, and their spread to distant organs is very uncommon. This article describes the first case of MEC metastasizing to the brain and the spine... - Meningioma resection in the elderly: nationwide inpatient sample, 1998-2002Brian T Bateman
College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
Neurosurgery 57:866-72; discussion 866-72. 2005..To address this issue, we studied the effect of advanced age on outcome after meningioma resection using the Nationwide Inpatient Sample... - Surgery of brain metastases--is there still a place for it?Ashok Modha
Neurosurgery Service, Memorial Sloan Kettering Cancer Center and Department of Neurological Surgery, Weill Medical College of Cornell University, New York, NY 10021, USA
J Neurooncol 75:21-9. 2005..A short description of surgical planning, operative techniques and tools, followed by a discussion on complication avoidance before, during, and after surgery is included... - Diagnosis and treatment of atypical and anaplastic meningiomas: a reviewAshok Modha
Memorial Sloan-Kettering Cancer Center, Department of Neurological Surgery, Weill Medical College of Cornell University, New York, New York, USA
Neurosurgery 57:538-50; discussion 538-50. 2005..In addition, the role of stereotactic radiosurgery is increasing, along with a possible role for brachytherapy. There are no effective chemotherapeutic agents available. A treatment algorithm is suggested... - Diffusion-tensor MR tractography of somatotopic organization of corticospinal tracts in the internal capsule: initial anatomic results in contradistinction to prior reportsAndrei I Holodny
Functional MRI Laboratory, Department of Radiology, Memorial Sloan Kettering Cancer Center, 1275 York Ave, New York, NY 10021, USA
Radiology 234:649-53. 2005..The present data confirm recent results that the CST is located more posteriorly. In the majority of cases, however, the CST is organized somatotopically... - Chordoid glioma: report of a case with unusual histologic features, ultrastructural study and review of the literatureJeffrey J Raizer
Department of Neurology, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
J Neurooncol 63:39-47. 2003..Treatment and long term outcome are limited but chordoid gliomas appear to be indolent lesions that may be cured with gross total resection... - Radiotherapy and concomitant temozolomide may improve survival of elderly patients with glioblastomaChristopher A Barker
Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
J Neurooncol 109:391-7. 2012..Survival of elderly patients with GBM may be prolonged with the use of concomitant TMZ during RT. An ongoing randomized study will determine the benefit of this approach in a prospective fashion... - Adenovirus-mediated heat-activated antisense Ku70 expression radiosensitizes tumor cells in vitro and in vivoGloria C Li
Department of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
Cancer Res 63:3268-74. 2003..Taken together, our results suggest that adenovirus-mediated, heat-activated antisense Ku70 expression may provide a novel approach to radiosensitize human tumors...