Barry M Gumbiner

Summary

Affiliation: Memorial Sloan-Kettering Cancer Center
Country: USA

Publications

  1. ncbi Propagation and localization of Wnt signaling
    B M Gumbiner
    Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Curr Opin Genet Dev 8:430-5. 1998
  2. ncbi Cadherin conformations associated with dimerization and adhesion
    Hitomi Tsuiji
    Department of Cell Biology, University of Virginia School of Medicine, Charlottesville, Virginia 22903, USA
    J Biol Chem 282:12871-82. 2007
  3. pmc Apical membrane localization of the adenomatous polyposis coli tumor suppressor protein and subcellular distribution of the beta-catenin destruction complex in polarized epithelial cells
    A Reinacher-Schick
    Cellular Biochemistry and Biophysics Program, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    J Cell Biol 152:491-502. 2001
  4. pmc E-cadherin suppresses cellular transformation by inhibiting beta-catenin signaling in an adhesion-independent manner
    C J Gottardi
    Cellular Biochemistry and Biophysics Program, Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA
    J Cell Biol 153:1049-60. 2001
  5. ncbi Carcinogenesis: a balance between beta-catenin and APC
    B M Gumbiner
    Cellular Biochemistry and Biophysics Program, Memorial Sloan Kettering Cancer Center, Box 564, 1275 York Avenue, New York, New York 10021, USA
    Curr Biol 7:R443-6. 1997
  6. pmc Regulation of cadherin adhesive activity
    B M Gumbiner
    Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    J Cell Biol 148:399-404. 2000
  7. ncbi Zygotic Wnt activity is required for Brachyury expression in the early Xenopus laevis embryo
    Alin Vonica
    Cellular Biochemistry and Biophysics Program, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Dev Biol 250:112-27. 2002
  8. ncbi Translocation of beta-catenin into the nucleus independent of interactions with FG-rich nucleoporins
    Eun Kyung Suh
    Neuroscience Program, Weill Graduate School of Medical Sciences of Cornell University, New York, NY 10021, USA
    Exp Cell Res 290:447-56. 2003
  9. pmc The Xenopus Nieuwkoop center and Spemann-Mangold organizer share molecular components and a requirement for maternal Wnt activity
    Alin Vonica
    The Laboratory of Vertebrate Embryology, The Rockefeller University, P O Box 32, 1230 York Avenue, New York, NY 10021, USA
    Dev Biol 312:90-102. 2007
  10. ncbi Signal transduction of beta-catenin
    B M Gumbiner
    Cellular Biochemistry and Biophysics Program, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Curr Opin Cell Biol 7:634-40. 1995

Collaborators

  • Lawrence Shapiro
  • Carien M Niessen
  • KATHLEEN JANEE GREEN
  • RAYMOND E KELLER
  • Ian G Macara
  • L Liu
  • Cara J Gottardi
  • Alin Vonica
  • Xuejun Chen
  • Paul Skoglund
  • Hitomi Tsuiji
  • Sreekala Mahadevaiyer
  • Michael Perrais
  • Yi Qin
  • Alice S T Wong
  • Eun Kyung Suh
  • Arthur C Huen
  • Titus J Boggon
  • S Chappuis-Flament
  • A Reinacher-Schick
  • Ana Rolo
  • Kathleen Schwartz
  • Chong Xu
  • Caitlyn Molino
  • Mirna Perez-Moreno
  • Xiao Chen
  • Liang Xu
  • R W Nelson
  • Christopher Capaldo
  • John Murray
  • Leslie J Bannon
  • Anne K Mongiu
  • Lisa M Godsel
  • Jung K Park
  • Ellen Wong
  • Evangeline V Amargo
  • David P Kelsell
  • Tracie Y Hudson
  • Irene M Leigh
  • Sophie Chappuis-Flament
  • E Wong
  • L D Hicks
  • C M Kay

Detail Information

Publications29

  1. ncbi Propagation and localization of Wnt signaling
    B M Gumbiner
    Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Curr Opin Genet Dev 8:430-5. 1998
    ..Wnt signals are distributed through tissues by vesicular transport of Wnt proteins, localized in embryos by directed transport of cytoplasmic Wnt-signaling components, and propagated asymmetrically during cell division...
  2. ncbi Cadherin conformations associated with dimerization and adhesion
    Hitomi Tsuiji
    Department of Cell Biology, University of Virginia School of Medicine, Charlottesville, Virginia 22903, USA
    J Biol Chem 282:12871-82. 2007
    ..Thus, the EC2-EC5 domains either reflect, or are involved in, cadherin dimerization and organization at the cell surface...
  3. pmc Apical membrane localization of the adenomatous polyposis coli tumor suppressor protein and subcellular distribution of the beta-catenin destruction complex in polarized epithelial cells
    A Reinacher-Schick
    Cellular Biochemistry and Biophysics Program, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    J Cell Biol 152:491-502. 2001
    ....
  4. pmc E-cadherin suppresses cellular transformation by inhibiting beta-catenin signaling in an adhesion-independent manner
    C J Gottardi
    Cellular Biochemistry and Biophysics Program, Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA
    J Cell Biol 153:1049-60. 2001
    ..The existence of functionally distinct pools of cytosolic beta-catenin suggests that there are mechanisms to regulate beta-catenin signaling in addition to controlling its level of accumulation...
  5. ncbi Carcinogenesis: a balance between beta-catenin and APC
    B M Gumbiner
    Cellular Biochemistry and Biophysics Program, Memorial Sloan Kettering Cancer Center, Box 564, 1275 York Avenue, New York, New York 10021, USA
    Curr Biol 7:R443-6. 1997
    ..In a number of different types of cancer, signalling through beta-catenin is upregulated either by direct mutation of beta-catenin or loss of negative regulation by the APC tumor suppressor protein...
  6. pmc Regulation of cadherin adhesive activity
    B M Gumbiner
    Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    J Cell Biol 148:399-404. 2000
  7. ncbi Zygotic Wnt activity is required for Brachyury expression in the early Xenopus laevis embryo
    Alin Vonica
    Cellular Biochemistry and Biophysics Program, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Dev Biol 250:112-27. 2002
    ..Since Brachyury is considered to have a major role in mesoderm formation, it is possible that Wnts might play a role in mesoderm specification, in addition to patterning...
  8. ncbi Translocation of beta-catenin into the nucleus independent of interactions with FG-rich nucleoporins
    Eun Kyung Suh
    Neuroscience Program, Weill Graduate School of Medical Sciences of Cornell University, New York, NY 10021, USA
    Exp Cell Res 290:447-56. 2003
    ..Transport is blocked by a soluble form of the C-cadherin cytoplasmic domain, suggesting that masking of the nuclear targeting signal may be a mechanism of regulating beta-catenin subcellular localization...
  9. pmc The Xenopus Nieuwkoop center and Spemann-Mangold organizer share molecular components and a requirement for maternal Wnt activity
    Alin Vonica
    The Laboratory of Vertebrate Embryology, The Rockefeller University, P O Box 32, 1230 York Avenue, New York, NY 10021, USA
    Dev Biol 312:90-102. 2007
    ..We conclude that the maternal Wnt pathway generates the Nieuwkoop center in vitro and the organizer in vivo by activating a common set of genes, without the need of an intermediary signaling step...
  10. ncbi Signal transduction of beta-catenin
    B M Gumbiner
    Cellular Biochemistry and Biophysics Program, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Curr Opin Cell Biol 7:634-40. 1995
    ..The adenomatous polyposis coli tumor suppressor protein is also implicated in beta-catenin signaling...
  11. ncbi C-cadherin ectodomain structure and implications for cell adhesion mechanisms
    Titus J Boggon
    Department of Biochemistry, Columbia University College of Physicians and Surgeons, 630 West 168th Street, New York, NY 10032, USA
    Science 296:1308-13. 2002
    ....
  12. ncbi Catenins as mediators of the cytoplasmic functions of cadherins
    B M Gumbiner
    Cellular Biochemistry and Biophysics Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10021
    J Cell Sci Suppl 17:155-8. 1993
    ..The catenins may be involved in the regulation of cadherin function during tissue morphogenesis and tumorigenesis...
  13. ncbi Adhesion signaling: how beta-catenin interacts with its partners
    C J Gottardi
    Cellular Biochemistry and Biophysics Program, Memorial Sloan-Kettering Cancer Center, New York, New York 10021, USA
    Curr Biol 11:R792-4. 2001
    ..Elucidation of the structures of beta-catenin complexes is beginning to clarify how beta-catenin uses the same surface to bind its various partners, and provides insights into how these interactions might be regulated...
  14. ncbi Beta-catenin directly induces expression of the Siamois gene, and can initiate signaling indirectly via a membrane-tethered form
    R W Nelson
    Cellular Biochemistry and Biophysics Program, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Ann N Y Acad Sci 857:86-98. 1998
    ..We propose that the membrane-tethered construct acts by titrating a cytoplasmic inhibitor of beta-catenin signaling...
  15. pmc Cadherin-mediated cell sorting not determined by binding or adhesion specificity
    Carien M Niessen
    Cellular Biochemistry and Biophysics Program, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    J Cell Biol 156:389-399. 2002
    ..These results show that cadherins are far more promiscuous in their adhesive-binding capacity than had been expected and that the ability to sort out must be determined by mechanisms other than simple adhesive-binding specificity...
  16. pmc Multiple cadherin extracellular repeats mediate homophilic binding and adhesion
    S Chappuis-Flament
    Cellular Biochemistry and Biophysics Program, Memorial Sloan-Kettering Cancer Center, 1275 York Ave, New York, NY 10021, USA
    J Cell Biol 154:231-43. 2001
    ..PROC: Natl. Acad. Sci. USA. 96:11820-11824; Sivasankar, S., B. Gumbiner, and D. Leckband. 2001. Biophys J. 80:1758-68). We propose new models for how the cadherin extracellular repeats may contribute to adhesive specificity and function...
  17. ncbi Structural elements necessary for oligomerization, trafficking, and cell sorting function of paraxial protocadherin
    Xuejun Chen
    Department of Cell Biology, University of Virginia Health Sciences Center, Charlottesville, Virginia 22908, USA
    J Biol Chem 282:32128-37. 2007
    ..Therefore, protein oligomerization and/or protein interactions via the extracellular and transmembrane domains of PAPC are required for its cell sorting function...
  18. pmc E-cadherin homophilic ligation inhibits cell growth and epidermal growth factor receptor signaling independently of other cell interactions
    Michael Perrais
    Department of Cell Biology, University of Virginia, Charlottesville, VA 22908 0732, USA
    Mol Biol Cell 18:2013-25. 2007
    ..Thus, E-cadherin homophilic binding independent of other cell contacts directly transduces growth inhibition by a beta-catenin-dependent mechanism that inhibits selective signaling functions of growth factor receptors...
  19. pmc Paraxial protocadherin mediates cell sorting and tissue morphogenesis by regulating C-cadherin adhesion activity
    Xuejun Chen
    Department of Cell Biology, University of Virginia Health Sciences Center, Charlottesville, VA 22908, USA
    J Cell Biol 174:301-13. 2006
    ..Thus, spatial regulation of classical cadherin adhesive function by local expression of a protocadherin is a novel mechanism for controlling cell sorting and tissue morphogenesis...
  20. pmc The mammalian Scribble polarity protein regulates epithelial cell adhesion and migration through E-cadherin
    Yi Qin
    Center for Cell Signaling, Department of Microbiology, University of Virginia School of Medicine, Charlottesville, VA 22908, USA
    J Cell Biol 171:1061-71. 2005
    ..These results suggest that Scrib stabilizes the coupling between E-cadherin and the catenins and are consistent with the idea that mammalian Scrib could behave as a tumor suppressor by regulating epithelial cell adhesion and migration...
  21. ncbi Regulation of cadherin-mediated adhesion in morphogenesis
    Barry M Gumbiner
    Department of Cell Biology, University of Virginia, School of Medicine, PO Box 800732, Charlottesville, Virginia 22908 0732, USA
    Nat Rev Mol Cell Biol 6:622-34. 2005
    ..Signal-transduction pathways impinge on the catenins (cytoplasmic cadherin-associated proteins), which transduce changes across the membrane to alter the state of the cadherin adhesive bond...
  22. ncbi Coordinate gene regulation by two different catenins
    Barry M Gumbiner
    Department of Cell Biology, School of Medicine, University of Virginia, Post Office Box 800732, Charlottesville, Virginia 22908, USA
    Dev Cell 8:795-6. 2005
    ..These findings raise the exciting possibility that these two related proteins function in parallel to mediate cadherin-associated regulation of gene expression...
  23. pmc Distinct molecular forms of beta-catenin are targeted to adhesive or transcriptional complexes
    Cara J Gottardi
    Department of Cell Biology, University of Virginia School of Medicine, Charlottesville, VA 22908, USA
    J Cell Biol 167:339-49. 2004
    ..This model explains how cells can control whether beta-catenin is used independently in cell adhesion and nuclear signaling, or competitively so that the two processes are coordinated and interrelated...
  24. ncbi Role for ICAT in beta-catenin-dependent nuclear signaling and cadherin functions
    Cara J Gottardi
    Department of Cell Biology, School of Medicine, University of Virginia, Charlottesville, VA 22908 0732, USA
    Am J Physiol Cell Physiol 286:C747-56. 2004
    ....
  25. pmc Adhesion-independent mechanism for suppression of tumor cell invasion by E-cadherin
    Alice S T Wong
    Dept of Cell Biology, School of Medicine, University of Virginia, PO Box 800732, Charlottesville, VA 22903, USA
    J Cell Biol 161:1191-203. 2003
    ..However, alteration in the beta-catenin/TCF transcriptional regulation of target genes is not required for the invasion suppressor activity of E-cadherin, suggesting the involvement of other beta-catenin-binding proteins...
  26. pmc Intermediate filament-membrane attachments function synergistically with actin-dependent contacts to regulate intercellular adhesive strength
    Arthur C Huen
    Department of Pathology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
    J Cell Biol 159:1005-17. 2002
    ..These data provide direct in vitro evidence that IF-membrane attachments regulate adhesive strength and suggest furthermore that actin- and IF-based junctions act synergistically to strengthen adhesion...
  27. pmc Convergence and extension at gastrulation require a myosin IIB-dependent cortical actin network
    Paul Skoglund
    Department of Biology, University of Virginia, Charlottesville, VA 22903, USA
    Development 135:2435-44. 2008
    ..These findings bridge the gap between a molecular-scale motor protein and tissue-scale embryonic morphogenesis...
  28. ncbi Crosstalk between different adhesion molecules
    Xuejun Chen
    Department of Cell Biology, University of Virginia Health Sciences Center, P O Box 800732, 1300 Jefferson Park Ave, Charlottesville, VA 22908, USA
    Curr Opin Cell Biol 18:572-8. 2006
    ..Furthermore, protocadherins can interact with extracellular matrix proteins or function by regulating classical cadherins...
  29. pmc Characterization of a 60S complex of the adenomatous polyposis coli tumor suppressor protein
    Sreekala Mahadevaiyer
    Department of Cell Biology, University of Virginia Health Sciences Center, 1300 Jefferson Park Avenue, Charlottesville, VA 22908, USA
    Biochim Biophys Acta 1773:120-30. 2007
    ....