Jose G Guillem

Summary

Affiliation: Memorial Sloan-Kettering Cancer Center
Country: USA

Publications

  1. pmc Pilot study of PET imaging of 124I-iodoazomycin galactopyranoside (IAZGP), a putative hypoxia imaging agent, in patients with colorectal cancer and head and neck cancer
    Joseph A O'Donoghue
    Department of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    EJNMMI Res 3:42. 2013
  2. ncbi request reprint Neither FDG-PET Nor CT can distinguish between a pathological complete response and an incomplete response after neoadjuvant chemoradiation in locally advanced rectal cancer: a prospective study
    Jose G Guillem
    Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    Ann Surg 258:289-95. 2013
  3. ncbi request reprint Contemporary applications of transanal endoscopic microsurgery: technical innovations and limitations
    Jose G Guillem
    Department of Surgery, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, Rm C 1077, New York, NY 10021, USA
    Clin Colorectal Cancer 5:268-73. 2005
  4. ncbi request reprint ASCO/SSO review of current role of risk-reducing surgery in common hereditary cancer syndromes
    Jose G Guillem
    Department of Surgery, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, Room C 1077, New York, New York 10021, USA
    Ann Surg Oncol 13:1296-321. 2006
  5. ncbi request reprint ASCO/SSO review of current role of risk-reducing surgery in common hereditary cancer syndromes
    Jose G Guillem
    Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    J Clin Oncol 24:4642-60. 2006
  6. pmc A prospective pathologic analysis using whole-mount sections of rectal cancer following preoperative combined modality therapy: implications for sphincter preservation
    Jose G Guillem
    Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Ann Surg 245:88-93. 2007
  7. pmc Single-amplicon MSH2 A636P mutation testing in Ashkenazi Jewish patients with colorectal cancer: role in presurgical management
    Jose G Guillem
    Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Ann Surg 245:560-5. 2007
  8. doi request reprint cT3N0 rectal cancer: potential overtreatment with preoperative chemoradiotherapy is warranted
    Jose G Guillem
    Department of Surgery, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
    J Clin Oncol 26:368-73. 2008
  9. ncbi request reprint Anal neoplasms
    Harvey G Moore
    Colorectal Surgery Service, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
    Surg Clin North Am 82:1233-51. 2002
  10. ncbi request reprint Clinical examination following preoperative chemoradiation for rectal cancer is not a reliable surrogate end point
    Jose G Guillem
    Colorectal Service, Memorial Sloan Kettering Cancer Center, 1275 York Ave, Room C 1077, New York, NY 10021, USA
    J Clin Oncol 23:3475-9. 2005

Detail Information

Publications93

  1. pmc Pilot study of PET imaging of 124I-iodoazomycin galactopyranoside (IAZGP), a putative hypoxia imaging agent, in patients with colorectal cancer and head and neck cancer
    Joseph A O'Donoghue
    Department of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    EJNMMI Res 3:42. 2013
    ....
  2. ncbi request reprint Neither FDG-PET Nor CT can distinguish between a pathological complete response and an incomplete response after neoadjuvant chemoradiation in locally advanced rectal cancer: a prospective study
    Jose G Guillem
    Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    Ann Surg 258:289-95. 2013
    ..To prospectively compare the ability of flourodeoxyglucose-positron emission tomography (FDG-PET) and computed tomography (CT) to identify a pathological complete response (pCR) in patients with rectal cancer treated by chemoradiation...
  3. ncbi request reprint Contemporary applications of transanal endoscopic microsurgery: technical innovations and limitations
    Jose G Guillem
    Department of Surgery, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, Rm C 1077, New York, NY 10021, USA
    Clin Colorectal Cancer 5:268-73. 2005
    ..This report summarizes the recent literature concerning TEM, comprehensively analyzes the authors' experience with TEM, and describes recent technical innovations and indications...
  4. ncbi request reprint ASCO/SSO review of current role of risk-reducing surgery in common hereditary cancer syndromes
    Jose G Guillem
    Department of Surgery, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, Room C 1077, New York, New York 10021, USA
    Ann Surg Oncol 13:1296-321. 2006
    ..Clinical interventions have been formulated for mutation carriers within affected families. The primary interventions for mutation carriers of highly penetrant syndromes are surgical...
  5. ncbi request reprint ASCO/SSO review of current role of risk-reducing surgery in common hereditary cancer syndromes
    Jose G Guillem
    Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    J Clin Oncol 24:4642-60. 2006
    ....
  6. pmc A prospective pathologic analysis using whole-mount sections of rectal cancer following preoperative combined modality therapy: implications for sphincter preservation
    Jose G Guillem
    Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Ann Surg 245:88-93. 2007
    ....
  7. pmc Single-amplicon MSH2 A636P mutation testing in Ashkenazi Jewish patients with colorectal cancer: role in presurgical management
    Jose G Guillem
    Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Ann Surg 245:560-5. 2007
    ..This study summarizes our initial experience with prospective, single-amplicon (mutation-specific) A636P testing in Ashkenazi Jewish patients at risk for Hereditary Nonpolyposis Colorectal Cancer (HNPCC)...
  8. doi request reprint cT3N0 rectal cancer: potential overtreatment with preoperative chemoradiotherapy is warranted
    Jose G Guillem
    Department of Surgery, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
    J Clin Oncol 26:368-73. 2008
    ..We therefore determined the accuracy of pre-CMT ERUS or magnetic resonance imaging (MRI) staging, to explore the validity of a nonpreoperative CMT approach for cT3N0 disease...
  9. ncbi request reprint Anal neoplasms
    Harvey G Moore
    Colorectal Surgery Service, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
    Surg Clin North Am 82:1233-51. 2002
    ..The prognosis for anorectal melanoma, as well as for small cell and undifferentiated tumors, continues to be poor. Fortunately, these are relatively rare tumors...
  10. ncbi request reprint Clinical examination following preoperative chemoradiation for rectal cancer is not a reliable surrogate end point
    Jose G Guillem
    Colorectal Service, Memorial Sloan Kettering Cancer Center, 1275 York Ave, Room C 1077, New York, NY 10021, USA
    J Clin Oncol 23:3475-9. 2005
    ..However, because the accuracy of this approach has not been established, we conducted a prospective analysis to determine the operating surgeon's ability to assess response using DRE...
  11. ncbi request reprint Value of immunohistochemical detection of DNA mismatch repair proteins in predicting germline mutation in hereditary colorectal neoplasms
    Jinru Shia
    Department of Pathology, Memorial Sloan Kettering, Cancer Center, New York, NY 10021, USA
    Am J Surg Pathol 29:96-104. 2005
    ....
  12. ncbi request reprint Prognostic implications of the distribution of lymph node metastases in rectal cancer after neoadjuvant chemoradiotherapy
    Tobias Leibold
    Department of Surgery, Memorial Sloan Kettering Cancer Center, 1275 York Ave, Room C 1077, New York, NY 10021, USA
    J Clin Oncol 26:2106-11. 2008
    ..The aim of this study was to examine the prognostic significance of location of involved lymph nodes in rectal cancer patients after preoperative chemoradiotherapy...
  13. doi request reprint Evaluation of ¹⁸F-FDG-PET for early detection of suboptimal response of rectal cancer to preoperative chemoradiotherapy: a prospective analysis
    Tobias Leibold
    Department of Surgery Colorectal Service, Memorial Sloan Kettering Cancer Center, New York, NY, USA
    Ann Surg Oncol 18:2783-9. 2011
    ..We prospectively evaluated tumor response with (18)F-fluorodeoxyglucose (FDG) positron emission tomography (PET) early in the course of preoperative CRT...
  14. doi request reprint Response to neoadjuvant therapy in patients with early age-of-onset rectal cancer
    Emily Steinhagen
    Department of Surgery, Colorectal Service, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA
    Dis Colon Rectum 56:58-63. 2013
    ..The response to neoadjuvant treatment in patients ≤ 50 years of age is not known. Factors affecting the response to neoadjuvant therapy in this age group have not been evaluated...
  15. ncbi request reprint Predictors of recurrence in patients with T2 and early T3, N0 adenocarcinoma of the rectum treated by surgery alone
    Aviram Nissan
    Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    J Clin Oncol 24:4078-84. 2006
    ..The aim of this study was to identify predictors of recurrence in this group of patients to enhance treatment selection...
  16. ncbi request reprint Sequential preoperative fluorodeoxyglucose-positron emission tomography assessment of response to preoperative chemoradiation: a means for determining longterm outcomes of rectal cancer
    Jose G Guillem
    Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA
    J Am Coll Surg 199:1-7. 2004
    ..Our goal was to determine the prognostic significance of FDG-PET assessment of rectal cancer response to preoperative chemoradiation...
  17. doi request reprint Squamous-cell carcinoma of the anal canal: predictors of treatment outcome
    Ramin Roohipour
    Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Dis Colon Rectum 51:147-53. 2008
    ..The incidence of anal canal squamous-cell carcinoma is increasing. Limited data exist on predictors of treatment failure. This study was designed to identify predictors for relapse/persistence after first-line therapy...
  18. ncbi request reprint Expression of p27 in residual rectal cancer after preoperative chemoradiation predicts long-term outcome
    Harvey G Moore
    Department of Surgery, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, Room C 1077, New York, NY 10021, USA
    Ann Surg Oncol 11:955-61. 2004
    ..Although numerous studies have focused on identifying molecular markers of prognosis in the primary rectal cancer before CMT, our aim was to identify markers of prognosis in residual rectal cancer after preoperative CMT...
  19. ncbi request reprint Patterns of morphologic alteration in residual rectal carcinoma following preoperative chemoradiation and their association with long-term outcome
    Jinru Shia
    Department of Pathology, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
    Am J Surg Pathol 28:215-23. 2004
    ..Our results demonstrate distinct morphologic features in treated rectal carcinomas that are prognostically relevant...
  20. ncbi request reprint Value of histopathology in predicting microsatellite instability in hereditary nonpolyposis colorectal cancer and sporadic colorectal cancer
    Jinru Shia
    Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY 10002, USA
    Am J Surg Pathol 27:1407-17. 2003
    ..Using a stepwise logistic regression model, a formula was generated that could be used to calculate the probability of a colorectal carcinoma being MSI-H based on morphologic features...
  21. doi request reprint FDG-PET assessment of rectal cancer response to neoadjuvant chemoradiotherapy is not associated with long-term prognosis: a prospective evaluation
    Jeannine A Ruby
    Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA
    Dis Colon Rectum 55:378-86. 2012
    ..At present there is no defined role for routine FDG-PET in the preoperative evaluation of nonmetastatic rectal cancer...
  22. ncbi request reprint Squamous-cell carcinoma of the rectum: a rare but curable tumor
    Caio S R Nahas
    Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Dis Colon Rectum 50:1393-400. 2007
    ..This study was designed to evaluate one institution's experience with treatment outcomes for rectal squamous-cell carcinoma...
  23. doi request reprint Effects of obesity in rectal cancer surgery
    Hueylan Chern
    Colorectal Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    J Am Coll Surg 211:55-60. 2010
    ..In this study, we evaluate whether higher body mass index (BMI) compromises surgical resection in patients with locally advanced, mid-to-low rectal cancer after neoadjuvant therapy, adversely affecting long-term oncologic outcomes...
  24. ncbi request reprint Management and outcome of perianal Paget's disease: a 6-decade institutional experience
    Daniel R Perez
    1Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York 2Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York
    Dis Colon Rectum 57:747-51. 2014
    ..It is often noninvasive but frequently recurs locally. Invasive disease can metastasize to distant sites...
  25. ncbi request reprint Locoregional lymphadenectomy in the surgical management of anorectal melanoma
    Daniel R Perez
    Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA
    Ann Surg Oncol 20:2339-44. 2013
    ..Understanding the significance of lymphatic dissemination might assist in stratifying patients for either organ preservation or radical surgery...
  26. ncbi request reprint Identification of patients with high-risk stage II colon cancer for adjuvant therapy
    Hak Mien Quah
    Colorectal Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York, USA
    Dis Colon Rectum 51:503-7. 2008
    ..The purpose of this study was to assess the prognostic significance of commonly reported clinicopathologic features of Stage II colon cancer to identify high-risk patients...
  27. ncbi request reprint A pathologic complete response of rectal cancer to preoperative combined-modality therapy results in improved oncological outcome compared with those who achieve no downstaging on the basis of preoperative endorectal ultrasonography
    Francesco Stipa
    Department of Surgery Colorectal Service, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, Room C 1077, New York, New York 10021, USA
    Ann Surg Oncol 13:1047-53. 2006
    ..However, the prognostic significance of pCR remains unclear...
  28. ncbi request reprint A636P testing in Ashkenazi Jews
    Jose G Guillem
    Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Fam Cancer 3:223-7. 2004
    ..In addition, we summarize our initial experience with a prospective A636P testing protocol aimed at Ashkenazi Jewish patients at high or intermediate risk for harboring the A636P mutation...
  29. ncbi request reprint Rectus flap reconstruction decreases perineal wound complications after pelvic chemoradiation and surgery: a cohort study
    David B Chessin
    Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Ann Surg Oncol 12:104-10. 2005
    ..Our purpose was to determine the effect of rectus abdominus myocutaneous (RAM) flap reconstruction on perineal wound morbidity in this population...
  30. ncbi request reprint Complications after preoperative combined modality therapy and radical resection of locally advanced rectal cancer: a 14-year experience from a specialty service
    David B Chessin
    Colorectal Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    J Am Coll Surg 200:876-82; discussion 882-4. 2005
    ..But its impact on postoperative complications has not been adequately evaluated. Our aims were to evaluate our comprehensive experience and identify factors predictive of complications in this patient population...
  31. ncbi request reprint Ten-year results of preoperative radiation followed by sphincter preservation for rectal cancer: increased local failure rate in nonresponders
    Ramesh Rengan
    Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Clin Colorectal Cancer 5:413-21. 2006
    ..The primary objective of this study was to determine the long-term outcome of sphincter preservation with preoperative radiation therapy (RT) and surgical resection in the treatment of distal rectal adenocarcinoma...
  32. ncbi request reprint Immunohistochemistry as first-line screening for detecting colorectal cancer patients at risk for hereditary nonpolyposis colorectal cancer syndrome: a 2-antibody panel may be as predictive as a 4-antibody panel
    Jinru Shia
    Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, USA
    Am J Surg Pathol 33:1639-45. 2009
    ..Such a cost-effective approach carries significant implication, as immunohistochemistry is being widely used as first-line screening for HNPCC...
  33. pmc Outcome of primary tumor in patients with synchronous stage IV colorectal cancer receiving combination chemotherapy without surgery as initial treatment
    George A Poultsides
    Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    J Clin Oncol 27:3379-84. 2009
    ....
  34. ncbi request reprint Limitations of early rectal cancer nodal staging may explain failure after local excision
    Ron G Landmann
    Colorectal Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York, USA
    Dis Colon Rectum 50:1520-5. 2007
    ..The limitations of endorectal ultrasound in accurately staging nodal disease in early rectal lesions may, in part, explain the relatively high recurrence rates seen after local excision...
  35. doi request reprint A predictive model for lymph node yield in colon cancer resection specimens
    Garrett M Nash
    Department of Surgery, Colorectal Service, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA
    Ann Surg 253:318-22. 2011
    ..To develop a predictive model of lymph node yield in a series of colon cancer resection specimens with detailed anatomic and surgical technique data...
  36. ncbi request reprint Carcinoid of the rectum risk stratification (CaRRs): a strategy for preoperative outcome assessment
    Bridget N Fahy
    Department of Surgery, Division of Colorectal Surgery, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
    Ann Surg Oncol 14:1735-43. 2007
    ..Predicting rectal carcinoid behavior based exclusively on tumor size is imprecise. We sought to identify factors associated with outcome and incorporate them into a pre-operative risk stratification scheme...
  37. pmc Long-term oncologic outcome following preoperative combined modality therapy and total mesorectal excision of locally advanced rectal cancer
    Jose G Guillem
    Department of Surgery Colorectal Service, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Ann Surg 241:829-36; discussion 836-8. 2005
    ....
  38. ncbi request reprint Operative salvage for locoregional recurrent colon cancer after curative resection: an analysis of 100 cases
    Wilbur B Bowne
    Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Dis Colon Rectum 48:897-909. 2005
    ..This investigation was undertaken to review our experience with surgical resection for patients with locoregional recurrence colon cancer, determine predictors of respectability, and define prognostic factors associated with survival...
  39. ncbi request reprint Surgical salvage of recurrent rectal cancer after transanal excision
    Martin R Weiser
    Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Dis Colon Rectum 48:1169-75. 2005
    ..This study examines surgical salvage of locally recurrent rectal cancer following transanal excision of early tumors...
  40. ncbi request reprint Rate of pathologic complete response with increased interval between preoperative combined modality therapy and rectal cancer resection
    Harvey G Moore
    Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Dis Colon Rectum 47:279-86. 2004
    ..Prolongation of the interval between preoperative combined modality therapy and surgery (RT-surgery interval) as a means of increasing pathologic complete response rate has not been fully examined...
  41. pmc What is the significance of the circumferential margin in locally advanced rectal cancer after neoadjuvant chemoradiotherapy?
    Atthaphorn Trakarnsanga
    Colorectal Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA
    Ann Surg Oncol 20:1179-84. 2013
    ..However, its significance in the setting of long-course neoadjuvant chemoradiotherapy (nCRT) is not well defined...
  42. doi request reprint Significance of acellular mucin pools in rectal carcinoma after neoadjuvant chemoradiotherapy
    Jinru Shia
    Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, USA
    Am J Surg Pathol 35:127-34. 2011
    ....
  43. pmc Challenging the feasibility and clinical significance of current guidelines on lymph node examination in rectal cancer in the era of neoadjuvant therapy
    Anand Govindarajan
    Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    J Clin Oncol 29:4568-73. 2011
    ..We sought to examine the feasibility and clinical significance of current guidelines on nodal assessment in patients with rectal cancer (RC) treated with neoadjuvant radiation...
  44. ncbi request reprint Can differences in bowel function after surgery for rectal cancer be identified by the European Organization for Research and Treatment of Cancer quality of life instrument?
    Heather B Neuman
    Department of Surgery, Memorial Sloan Kettering Cancer Center, 1275 York Ave, New York, New York 10021, USA
    Ann Surg Oncol 14:1727-34. 2007
    ....
  45. doi request reprint Sphincter preservation in low rectal cancer is facilitated by preoperative chemoradiation and intersphincteric dissection
    Martin R Weiser
    Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Ann Surg 249:236-42. 2009
    ....
  46. ncbi request reprint Predictive clinicopathologic factors for limited response of T3 rectal cancer to combined modality therapy
    Anne Y Lin
    Colorectal Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Int J Colorectal Dis 23:243-9. 2008
    ..The aim of this study was to identify pretreatment factors associated with poor tumor response to neoadjuvant chemoradiation...
  47. doi request reprint Long-term survival after transanal excision of T1 rectal cancer
    Garrett M Nash
    Department of Surgery, Colorectal Service, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA
    Dis Colon Rectum 52:577-82. 2009
    ..However, the impact of transanal excision on cancer mortality has not been adequately studied. The purpose of this study was to compare oncologic outcomes of transanal excision with those of radical resection...
  48. doi request reprint Anastomotic leak following low anterior resection in stage IV rectal cancer is associated with poor survival
    James D Smith
    Colorectal Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA
    Ann Surg Oncol 20:2641-6. 2013
    ..We measured the incidence of anastomotic leak and its association with clinical outcome...
  49. ncbi request reprint Oncologic outcomes of salvage surgery for epidermoid carcinoma of the anus initially managed with combined modality therapy
    Robert P Akbari
    Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York, USA
    Dis Colon Rectum 47:1136-44. 2004
    ..Primary chemoradiation failure for epidermoid carcinoma of the anus is treated by surgical resection. This study evaluates the outcome of salvage surgery at one institution...
  50. ncbi request reprint Feasibility of ex vivo FDG PET of the colon
    Marc J Gollub
    Department of Radiology, Memorial Sloan Kettering Cancer Center, 1275 York Ave, New York, NY 10023, USA
    Radiology 252:232-9. 2009
    ....
  51. ncbi request reprint Positron emission tomography detection of distant metastatic or synchronous disease in patients with locally advanced rectal cancer receiving preoperative chemoradiation
    Caio S R Nahas
    Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA
    Ann Surg Oncol 15:704-11. 2008
    ....
  52. doi request reprint Recurrence rates and prognostic factors in ypN0 rectal cancer after neoadjuvant chemoradiation and total mesorectal excision
    Anand Govindarajan
    Department of Colorectal Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA
    Ann Surg Oncol 18:3666-72. 2011
    ..Patients with pathologically node-negative tumors have an improved prognosis, but recurrence patterns and independent prognostic factors in these patients have been incompletely characterized...
  53. pmc T1 adenocarcinoma of the rectum: transanal excision or radical surgery?
    David J Bentrem
    Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Ann Surg 242:472-7; discussion 477-9. 2005
    ..We performed a retrospective evaluation of patients with T1 rectal cancers treated by either transanal excision or radical resection at our institution to assess patient selection, cancer recurrence, and survival...
  54. ncbi request reprint Adequacy of 1-cm distal margin after restorative rectal cancer resection with sharp mesorectal excision and preoperative combined-modality therapy
    Harvey G Moore
    Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Ann Surg Oncol 10:80-5. 2003
    ..To further define the subset of rectal cancer patients suitable for this approach, we determined the adequacy of a distal margin of < or = 1 cm in patients with locally advanced rectal cancer requiring preoperative CMT...
  55. pmc Long-term prognostic significance of extent of rectal cancer response to preoperative radiation and chemotherapy
    Leyo Ruo
    Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Ann Surg 236:75-81. 2002
    ....
  56. ncbi request reprint Sacral resection for recurrent rectal cancer: analysis of morbidity and treatment results
    Genevieve B Melton
    Division of Colorectal Surgery, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Dis Colon Rectum 49:1099-107. 2006
    ..Composite sacropelvic resection for locally advanced recurrent rectal cancer is a high-risk procedure that benefits select patients. We reviewed our recent institutional experience to evaluate case selection, morbidity, and outcomes...
  57. doi request reprint Nonoperative management of rectal cancer with complete clinical response after neoadjuvant therapy
    James D Smith
    Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    Ann Surg 256:965-72. 2012
    ....
  58. doi request reprint Pulmonary recurrence predominates after combined modality therapy for rectal cancer: an original retrospective study
    Peirong Ding
    Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    Ann Surg 256:111-6. 2012
    ..To characterize patterns of recurrence in locally advanced rectal cancer treated with combined modality therapy (CMT): neoadjuvant chemoradiation + total mesorectal excision + adjuvant chemotherapy...
  59. doi request reprint Whole-mount pathologic analysis of rectal cancer following neoadjuvant therapy: implications of margin status on long-term oncologic outcome
    James J Mezhir
    Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    Ann Surg 256:274-9. 2012
    ..We set out to determine the long-term oncologic impact of resection margins in patients with locally advanced rectal cancer using a comprehensive pathologic whole-mount section analysis...
  60. doi request reprint Treatment for patients with rectal cancer and a clinical complete response to neoadjuvant therapy: a decision analysis
    Heather B Neuman
    Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA
    Dis Colon Rectum 52:863-71. 2009
    ..Therefore, the objective was to develop a decision-analytic model to evaluate the relative benefits of surgery vs. observation in rectal cancer patients who achieve clinical complete response after neoadjuvant chemoradiation...
  61. ncbi request reprint Colorectal cancer pelvic recurrences: determinants of resectability
    Harvey G Moore
    Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York, USA
    Dis Colon Rectum 47:1599-606. 2004
    ....
  62. ncbi request reprint MSH6 germline mutations are rare in colorectal cancer families
    Paolo Peterlongo
    Cell Biology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Int J Cancer 107:571-9. 2003
    ..Altogether, our results indicate that disease-causing germline mutations of MSH6 are rare in HNPCC and HNPCC-like families...
  63. doi request reprint Close distal margin and rectal cancer recurrence after sphincter-preserving rectal resection
    Garrett M Nash
    Department of Surgery, Colorectal Service, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA
    Dis Colon Rectum 53:1365-73. 2010
    ..Negative surgical margins are important for local control of rectal cancer treated with sphincter-preserving surgery. However, the association of rectal cancer recurrence with close distal margin is not well established...
  64. ncbi request reprint Surgeon volume compared to hospital volume as a predictor of outcome following primary colon cancer resection
    Deborah Schrag
    Health Outcomes Research Group, Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    J Surg Oncol 83:68-78; discussion 78-9. 2003
    ..However, the importance of surgeon case volume as a determinant of outcome has been less well studied, and it is unclear whether hospital or surgeon volume is the more powerful predictor of outcomes...
  65. doi request reprint Individualized prediction of colon cancer recurrence using a nomogram
    Martin R Weiser
    Department of Surgery, Memorial Sloan Kettering Cancer Center, 1275 York Ave, New York, NY 10021, USA
    J Clin Oncol 26:380-5. 2008
    ..Although easy to implement, there remains significant heterogeneity within each stage grouping. In the era of multimodality treatment, a more refined tool is needed to predict recurrence...
  66. ncbi request reprint Association of statin use with a pathologic complete response to neoadjuvant chemoradiation for rectal cancer
    Matthew S Katz
    Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Int J Radiat Oncol Biol Phys 62:1363-70. 2005
    ..To assess whether 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors, or statins, might enhance the efficacy of neoadjuvant chemoradiation in rectal cancer...
  67. ncbi request reprint The emerging role of 18F-fluorodeoxyglucose positron emission tomography in the management of primary and recurrent rectal cancer
    David B Chessin
    Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    J Am Coll Surg 201:948-56. 2005
  68. ncbi request reprint Carcinoid of the rectum risk stratification (CaRRS): a strategy for preoperative outcome assessment
    Bridget N Fahy
    Department of Surgery, Division of Colorectal Surgery, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
    Ann Surg Oncol 14:396-404. 2007
    ..Predicting rectal carcinoid behavior exclusively on the basis of tumor size is imprecise. We sought to identify factors associated with outcome and incorporate them into a preoperative risk stratification scheme...
  69. ncbi request reprint Combined CT colonography and 18F-FDG PET of colon polyps: potential technique for selective detection of cancer and precancerous lesions
    Marc J Gollub
    Department of Radiology, Memorial Sloan Kettering Cancer Center, 1275 York Ave, Rm C276F, New York, NY 10021, USA
    AJR Am J Roentgenol 188:130-8. 2007
    ..The purpose of this study was to determine the feasibility of imaging the colon with fused CT colonography (CTC) and 18F-FDG PET and to correlate the findings with the histologic features of polyps...
  70. ncbi request reprint Residual mesorectal lymph node involvement following neoadjuvant combined-modality therapy: rationale for radical resection?
    Francesco Stipa
    Colorectal Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York, USA
    Ann Surg Oncol 11:187-91. 2004
    ....
  71. ncbi request reprint Prognostic significance of depth of gross or microscopic perirectal fat invasion in T3 N0 M0 rectal cancers following sharp mesorectal excision and no adjuvant therapy
    Antonio I Picon
    Department of Surgery, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, NY 10021, New York, USA
    Int J Colorectal Dis 18:487-92. 2003
    ..Our aim was to determine the prognostic significance of gross perirectal fat invasion, or depth of microscopic perirectal fat invasion, in T3 N0 rectal cancers following sharp mesorectal excision and no adjuvant therapy...
  72. doi request reprint Systematic immunohistochemistry screening for Lynch syndrome in early age-of-onset colorectal cancer patients undergoing surgical resection
    Emily Steinhagen
    Department of Surgery, Colorectal Service, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    J Am Coll Surg 214:61-7. 2012
    ..Our study describes the impact of routine immunohistochemistry (IHC) analysis of tumor tissue for loss of MMR protein expression in early age-of-onset CRC patients undergoing resection...
  73. ncbi request reprint Differential expression of alpha-methylacyl-coenzyme A racemase in colorectal carcinoma bears clinical and pathologic significance
    Anne Lin
    Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Hum Pathol 38:850-6. 2007
    ..Further investigation on interaction between AMACR and other known colorectal cancer development pathways may provide new insights on colorectal carcinogenesis...
  74. ncbi request reprint Radical resection of rectal cancer primary tumor provides effective local therapy in patients with stage IV disease
    Garrett M Nash
    Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Ann Surg Oncol 9:954-60. 2002
    ..We have reviewed stage IV rectal cancer patients to evaluate the effectiveness of radical surgery without radiation as local therapy...
  75. ncbi request reprint Is nonsmall cell type high-grade neuroendocrine carcinoma of the tubular gastrointestinal tract a distinct disease entity?
    Jinru Shia
    Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Am J Surg Pathol 32:719-31. 2008
    ..These tumors are clinically aggressive. Prospective studies using defined diagnostic criteria are needed to determine their biologic characteristics and optimal management...
  76. ncbi request reprint Increased endocrine cells in treated rectal adenocarcinomas: a possible reflection of endocrine differentiation in tumor cells induced by chemotherapy and radiotherapy
    Jinru Shia
    Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Am J Surg Pathol 26:863-72. 2002
    ..The possible mechanism for the increased endocrine cells in treated rectal adenocarcinomas may be related to induction of endocrine differentiation in tumor cells by cytotoxic insult...
  77. ncbi request reprint Elective bowel resection for incurable stage IV colorectal cancer: prognostic variables for asymptomatic patients
    Leyo Ruo
    Colorectal Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    J Am Coll Surg 196:722-8. 2003
    ..The extent of distant metastases was objectively measured by several methods to identify potential prognostic variables that may help guide patient selection in this population...
  78. pmc The role of abdominoperineal resection as surgical therapy for anorectal melanoma
    Jen Jen Yeh
    Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Ann Surg 244:1012-7. 2006
    ..1) Characterize changes in the surgical treatment of anorectal melanoma over time. 2) Determine if the extent of surgical resection is associated with outcome. 3) Identify prognostic factors correlating with survival...
  79. ncbi request reprint A636P is associated with early-onset colon cancer in Ashkenazi Jews
    Jose G Guillem
    Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    J Am Coll Surg 196:222-5. 2003
    ..This study seeks to characterize the proportion of individuals of Ashkenazi heritage with very early-onset colon cancer (diagnosed at age 40 or younger) that could be attributed to MSH2*1906C>G...
  80. ncbi request reprint Multimodality management of locally advanced rectal cancer
    Harvey G Moore
    Colorectal Service, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Am Surg 69:612-9. 2003
    ..Efforts are currently directed at identifying the subset of locally advanced rectal cancer patients who may be adequately treated with a resection alone thereby avoiding the added morbidity of adjuvant radiation and chemotherapy...
  81. ncbi request reprint Predictors of survival in recurrent rectal cancer after resection and intraoperative radiotherapy
    Margo Shoup
    Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Dis Colon Rectum 45:585-92. 2002
    ..This study was designed to determine predictors of survival after surgery and intraoperative radiotherapy for recurrent rectal cancer...
  82. doi request reprint Immunohistochemical expression of folate receptor alpha in colorectal carcinoma: patterns and biological significance
    Jinru Shia
    Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Hum Pathol 39:498-505. 2008
    ..The significance of such an association as well as the prognostic value of FRalpha expression deserves further exploration...
  83. pmc Long-term results of local excision for rectal cancer
    Philip B Paty
    Department of Surgery, Pathology, and Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Ann Surg 236:522-29; discussion 529-30. 2002
    ..To review the authors' experience with local excision of early rectal cancers to assess the effectiveness of initial treatment and of salvage surgery...
  84. pmc Hospital and surgeon procedure volume as predictors of outcome following rectal cancer resection
    Deborah Schrag
    Health Outcomes Research Group, Department of Epidemiology and Biostatistics, Department of Medicine, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Ann Surg 236:583-92. 2002
    ..To compare surgeon and hospital procedure volume as predictors of outcomes for patients with rectal cancer...
  85. ncbi request reprint Assessing the predictive value of clinical complete response to neoadjuvant therapy for rectal cancer: an analysis of 488 patients
    Spiros P Hiotis
    Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, 10021, USA
    J Am Coll Surg 194:131-5; discussion 135-6. 2002
    ..Some investigators have proposed that such patients should simply be observed and not undergo resection...
  86. ncbi request reprint A case-controlled study of 18-fluorodeoxyglucose positron emission tomography in the detection of pelvic recurrence in previously irradiated rectal cancer patients
    Harvey G Moore
    Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    J Am Coll Surg 197:22-8. 2003
    ....
  87. ncbi request reprint Long-term follow-up of patients with familial adenomatous polyposis undergoing pancreaticoduodenal surgery
    Leyo Ruo
    Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    J Gastrointest Surg 6:671-5. 2002
    ..Good long-term prognosis can be expected in completely resected patients although subsequent proliferative and/or neoplastic lesions may still be detected in the gastrointestinal tract with prolonged follow-up...
  88. ncbi request reprint Surgical issues in rectal cancer: a 2004 update
    David B Chessin
    Colorectal Service, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Clin Colorectal Cancer 4:233-40. 2004
    ..Our aim is to outline some of the important surgical issues surrounding the management of patients with early-stage (T1/T2 N0) or locally advanced (T3/T4 and/or N1) rectal cancer...
  89. ncbi request reprint Surgical treatment of rectal cancer: radical resection
    Seung Yong Jeong
    Colorectal Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, Room C 1077, New York, NY 10021, USA
    Surg Oncol Clin N Am 15:95-107, vi-vii. 2006
    ..This article reviews the surgical management of primary rectal cancer and discusses major surgical considerations in the treatment of this disease...
  90. ncbi request reprint Long-term outcome of perianal Paget's disease
    Martin D McCarter
    Colorectal Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Dis Colon Rectum 46:612-6. 2003
    ..This study summarizes the history and treatment of all patients diagnosed with perianal Paget's disease at a single institution...
  91. ncbi request reprint Primary adenocarcinoma of the anus treated with combined modality therapy
    Kathryn P Beal
    Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Dis Colon Rectum 46:1320-4. 2003
    ..The purpose of this study was to determine the local control and survival of patients with adenocarcinoma of the anus who received combined modality therapy as a component of their treatment...
  92. ncbi request reprint Symptom control in patients with locally recurrent rectal cancer
    Thomas J Miner
    Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Ann Surg Oncol 10:72-9. 2003
    ..Although resection of locally recurrent rectal cancer has been associated with improved survival, clinical outcomes after such repeat surgery have been incompletely characterized...
  93. ncbi request reprint Abdominoperineal resection for rectal cancer: historic perspective and current issues
    David B Chessin
    Colorectal Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, Room C 1083, New York, NY 10021, USA
    Surg Oncol Clin N Am 14:569-86, vii. 2005

Research Grants3

  1. PET IMAGING IN MULTIMODALITY MANAGEMENT OF RECTAL CANCER
    Jose Guillem; Fiscal Year: 1999
    ..abstract_text> ..
  2. PET IMAGING IN MULTIMODALITY MANAGEMENT OF RECTAL CANCER
    Jose Guillem; Fiscal Year: 2000
    ..abstract_text> ..
  3. PET IMAGING IN MULTIMODALITY MANAGEMENT OF RECTAL CANCER
    Jose Guillem; Fiscal Year: 2001
    ..abstract_text> ..