JONATHAN D GOLDBERG

Summary

Affiliation: Memorial Sloan-Kettering Cancer Center
Country: USA

Publications

  1. ncbi Structural basis for activation of ARF GTPase: mechanisms of guanine nucleotide exchange and GTP-myristoyl switching
    J Goldberg
    Cellular Biochemistry and Biophysics Program Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Cell 95:237-48. 1998
  2. ncbi Structural and functional analysis of the ARF1-ARFGAP complex reveals a role for coatomer in GTP hydrolysis
    J Goldberg
    Cellular Biochemistry and Biophysics Program, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Cell 96:893-902. 1999
  3. ncbi Decoding of sorting signals by coatomer through a GTPase switch in the COPI coat complex
    J Goldberg
    Cellular Biochemistry and Biophysics Program, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Cell 100:671-9. 2000
  4. ncbi Structure of the guanine nucleotide exchange factor Sec7 domain of human arno and analysis of the interaction with ARF GTPase
    E Mossessova
    Memorial Sloan Kettering Cancer Center, Sloan Kettering Division, Graduate School of Medical Sciences, Cornell University, New York, New York 10021, USA
    Cell 92:415-23. 1998
  5. ncbi Study of quadrant high-dose intraoperative radiation therapy for early-stage breast cancer
    V Sacchini
    Breast Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, MRI 1026, New York, New York 10021, USA
    Br J Surg 95:1105-10. 2008
  6. ncbi Three-dimensional structure of the catalytic subunit of protein serine/threonine phosphatase-1
    J Goldberg
    Howard Hughes Medical Institute, Rockefeller University, New York, New York 10021, USA
    Nature 376:745-53. 1995
  7. ncbi Structural basis for the autoinhibition of calcium/calmodulin-dependent protein kinase I
    J Goldberg
    Howard Hughes Medical Institute, The Rockefeller University, New York, 10021, USA
    Cell 84:875-87. 1996
  8. ncbi Structure of the Ku heterodimer bound to DNA and its implications for double-strand break repair
    J R Walker
    Cellular Biochemistry and Biophysics Program, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Nature 412:607-14. 2001

Research Grants

  1. STRUCTURAL STUDY OF ARF GTPASE REGULATORS AND EFFECTORS
    Jonathan Goldberg; Fiscal Year: 2003
  2. Structural Study of ARF-GTPase Regulators and Effectors
    Jonathan Goldberg; Fiscal Year: 2007

Collaborators

  • V Sacchini
  • J R Walker
  • E Mossessova
  • R A Corpina
  • J M Gulbis

Detail Information

Publications8

  1. ncbi Structural basis for activation of ARF GTPase: mechanisms of guanine nucleotide exchange and GTP-myristoyl switching
    J Goldberg
    Cellular Biochemistry and Biophysics Program Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Cell 95:237-48. 1998
    ..The transition controls the exposure of the myristoylated N terminus, explaining how ARF GTPases couple the GDP-GTP conformational switch to membrane binding...
  2. ncbi Structural and functional analysis of the ARF1-ARFGAP complex reveals a role for coatomer in GTP hydrolysis
    J Goldberg
    Cellular Biochemistry and Biophysics Program, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Cell 96:893-902. 1999
    ..Thus, a tripartite complex controls the GTP hydrolysis reaction triggering disassembly of COPI vesicle coats...
  3. ncbi Decoding of sorting signals by coatomer through a GTPase switch in the COPI coat complex
    J Goldberg
    Cellular Biochemistry and Biophysics Program, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Cell 100:671-9. 2000
    ....
  4. ncbi Structure of the guanine nucleotide exchange factor Sec7 domain of human arno and analysis of the interaction with ARF GTPase
    E Mossessova
    Memorial Sloan Kettering Cancer Center, Sloan Kettering Division, Graduate School of Medical Sciences, Cornell University, New York, New York 10021, USA
    Cell 92:415-23. 1998
    ....
  5. ncbi Study of quadrant high-dose intraoperative radiation therapy for early-stage breast cancer
    V Sacchini
    Breast Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, MRI 1026, New York, New York 10021, USA
    Br J Surg 95:1105-10. 2008
    ..The aim of this study was to determine the feasibility of using quadrant high-dose intraoperative radiation therapy (IORT) for the treatment of early-stage breast cancer...
  6. ncbi Three-dimensional structure of the catalytic subunit of protein serine/threonine phosphatase-1
    J Goldberg
    Howard Hughes Medical Institute, Rockefeller University, New York, New York 10021, USA
    Nature 376:745-53. 1995
    ..The fold of the catalytic domain is expected to be closely preserved in protein phosphatases 2A and 2B (calcineurin)...
  7. ncbi Structural basis for the autoinhibition of calcium/calmodulin-dependent protein kinase I
    J Goldberg
    Howard Hughes Medical Institute, The Rockefeller University, New York, 10021, USA
    Cell 84:875-87. 1996
    ..The structure provides a view of an intact calmodulin target and suggests that substantial structural changes will accompany kinase activation by calmodulin binding to the regulatory region...
  8. ncbi Structure of the Ku heterodimer bound to DNA and its implications for double-strand break repair
    J R Walker
    Cellular Biochemistry and Biophysics Program, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Nature 412:607-14. 2001
    ..These features seem well designed to structurally support broken DNA ends and to bring the DNA helix into phase across the junction during end processing and ligation...

Research Grants9

  1. STRUCTURAL STUDY OF ARF GTPASE REGULATORS AND EFFECTORS
    Jonathan Goldberg; Fiscal Year: 2003
    ..abstract_text> ..
  2. Structural Study of ARF-GTPase Regulators and Effectors
    Jonathan Goldberg; Fiscal Year: 2007
    ..8 Angstroms resolution in-house, which we are working to improve. These studies will provide insight to the processes of GTP-dependent assembly of vesicular coat complexes and coat-controlled GTP hydrolysis triggering disassembly. ..