Gabrielle L Goldberg

Summary

Affiliation: Memorial Sloan-Kettering Cancer Center
Country: USA

Publications

  1. ncbi Enhanced immune reconstitution by sex steroid ablation following allogeneic hemopoietic stem cell transplantation
    Gabrielle L Goldberg
    Department of Pathology and Immunology, Central and Eastern Clinical School, Monash University, Melbourne, Australia
    J Immunol 178:7473-84. 2007
  2. ncbi Sex steroid ablation enhances hematopoietic recovery following cytotoxic antineoplastic therapy in aged mice
    Jarrod A Dudakov
    Immune Regeneration Laboratory, Monash Immunology and Stem Cell Laboratories, Monash University, Wellington Road, Clayton VIC 3800, Australia
    J Immunol 183:7084-94. 2009
  3. ncbi Sex steroid ablation enhances immune reconstitution following cytotoxic antineoplastic therapy in young mice
    Gabrielle L Goldberg
    Immune Regeneration Laboratory, Monash Immunology and Stem Cell Laboratories, Monash University, Clayton, Australia
    J Immunol 184:6014-24. 2010
  4. ncbi Withdrawal of sex steroids reverses age- and chemotherapy-related defects in bone marrow lymphopoiesis
    Jarrod A Dudakov
    Immune Regeneration Laboratory, Monash Immunology and Stem Cell Laboratories, Monash University, Clayton, Australia
    J Immunol 182:6247-60. 2009
  5. ncbi Sex steroid ablation enhances lymphoid recovery following autologous hematopoietic stem cell transplantation
    Gabrielle L Goldberg
    Department of Immunology, Central and Eastern Clinical School, Monash University, Melbourne, Australia
    Transplantation 80:1604-13. 2005
  6. ncbi Effects of castration on thymocyte development in two different models of thymic involution
    Tracy S P Heng
    Department of Immunology, Monash University, Central and Eastern Clinical School, Alfred Hospital, Prahran, Australia
    J Immunol 175:2982-93. 2005
  7. ncbi Controlling the thymic microenvironment
    Daniel H D Gray
    Department of Immunology, Central and Eastern Clinical School, Monash University, Melbourne, 3181, Australia
    Curr Opin Immunol 17:137-43. 2005
  8. ncbi Keratinocyte growth factor (KGF) is required for postnatal thymic regeneration
    Onder Alpdogan
    Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Blood 107:2453-60. 2006
  9. ncbi Activation of thymic regeneration in mice and humans following androgen blockade
    Jayne S Sutherland
    Department of Immunology, Monash University Medical School, Prahran, Victoria, Australia
    J Immunol 175:2741-53. 2005
  10. ncbi Clinical strategies to enhance T cell reconstitution
    Gabrielle L Goldberg
    Department of Immunology, Laboratory of the Immunology of Bone Marrow Transplantation, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Semin Immunol 19:289-96. 2007

Collaborators

Detail Information

Publications12

  1. ncbi Enhanced immune reconstitution by sex steroid ablation following allogeneic hemopoietic stem cell transplantation
    Gabrielle L Goldberg
    Department of Pathology and Immunology, Central and Eastern Clinical School, Monash University, Melbourne, Australia
    J Immunol 178:7473-84. 2007
    ..These results indicate that sex steroid ablation can profoundly enhance thymic and hemopoietic recovery following allogeneic HSCT without increasing GVHD and maintaining GVT...
  2. ncbi Sex steroid ablation enhances hematopoietic recovery following cytotoxic antineoplastic therapy in aged mice
    Jarrod A Dudakov
    Immune Regeneration Laboratory, Monash Immunology and Stem Cell Laboratories, Monash University, Wellington Road, Clayton VIC 3800, Australia
    J Immunol 183:7084-94. 2009
    ..Taken together, these results provide the basis for the use of SSA in the clinic to enhance treatment outcomes from cytotoxic antineoplastic therapy...
  3. ncbi Sex steroid ablation enhances immune reconstitution following cytotoxic antineoplastic therapy in young mice
    Gabrielle L Goldberg
    Immune Regeneration Laboratory, Monash Immunology and Stem Cell Laboratories, Monash University, Clayton, Australia
    J Immunol 184:6014-24. 2010
    ..In conclusion, SSA enhances T cell recovery following cyclophosphamide treatment of mice, at the level of the thymocytes and their stromal niches. This provides a new approach to immune reconstitution following antineoplastic therapy...
  4. ncbi Withdrawal of sex steroids reverses age- and chemotherapy-related defects in bone marrow lymphopoiesis
    Jarrod A Dudakov
    Immune Regeneration Laboratory, Monash Immunology and Stem Cell Laboratories, Monash University, Clayton, Australia
    J Immunol 182:6247-60. 2009
    ..Since SSA has been achieved clinically for over 25 years, this provides a novel, rational basis for approaching the need for immune recovery in many clinical conditions...
  5. ncbi Sex steroid ablation enhances lymphoid recovery following autologous hematopoietic stem cell transplantation
    Gabrielle L Goldberg
    Department of Immunology, Central and Eastern Clinical School, Monash University, Melbourne, Australia
    Transplantation 80:1604-13. 2005
    ....
  6. ncbi Effects of castration on thymocyte development in two different models of thymic involution
    Tracy S P Heng
    Department of Immunology, Monash University, Central and Eastern Clinical School, Alfred Hospital, Prahran, Australia
    J Immunol 175:2982-93. 2005
    ..By improving our understanding of the kinetics of thymic recovery, this study will allow more appropriate timing of therapy to achieve maximal reconstitution, especially in the elderly...
  7. ncbi Controlling the thymic microenvironment
    Daniel H D Gray
    Department of Immunology, Central and Eastern Clinical School, Monash University, Melbourne, 3181, Australia
    Curr Opin Immunol 17:137-43. 2005
    ..Elucidation of the molecular players involved and their context within the organ is the challenge for the field today. This knowledge could then be translated to clinical restoration of thymic function and T-cell reconstitution...
  8. ncbi Keratinocyte growth factor (KGF) is required for postnatal thymic regeneration
    Onder Alpdogan
    Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Blood 107:2453-60. 2006
    ..We conclude that KGF plays a critical role in postnatal thymic regeneration and may be useful in treating immune deficiency conditions...
  9. ncbi Activation of thymic regeneration in mice and humans following androgen blockade
    Jayne S Sutherland
    Department of Immunology, Monash University Medical School, Prahran, Victoria, Australia
    J Immunol 175:2741-53. 2005
    ..Collectively these studies represent a fundamentally new approach to treating immunodeficiency states in humans...
  10. ncbi Clinical strategies to enhance T cell reconstitution
    Gabrielle L Goldberg
    Department of Immunology, Laboratory of the Immunology of Bone Marrow Transplantation, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Semin Immunol 19:289-96. 2007
    ....
  11. ncbi Tumor immunotherapy across MHC barriers using allogeneic T-cell precursors
    Johannes L Zakrzewski
    Department Immunology, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, New York 10021, USA
    Nat Biotechnol 26:453-61. 2008
    ..We conclude that ex vivo generated MHC-disparate T-cell precursors from any donor can be used universally for 'off-the-shelf' immunotherapy, and can be further enhanced by genetic engineering for targeted immunotherapy...
  12. ncbi Enhancing T cell reconstitution after hematopoietic stem cell transplantation: a brief update of the latest trends
    Johannes L Zakrzewski
    Department of Medicine and Immunology, Memorial Sloan Kettering Cancer Center, Zuckerman Research Center, New York, NY 10021, USA
    Blood Cells Mol Dis 40:44-7. 2008
    ..The translation of most of these strategies into clinical trials is likely and in some cases Phase I/II studies are already underway...