MICHAEL STEPHEN GLICKMAN
Affiliation: Memorial Sloan-Kettering Cancer Center
- Converting cancer therapies into cures: lessons from infectious diseasesMichael S Glickman
Infectious Diseases Service and Immunology Program, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA
Cell 148:1089-98. 2012..A remaining challenge in both fields is identifying drugs that eliminate drug-tolerant "persister" cells (infectious disease) or tumor-initiating/stem cells (cancer) to prevent late relapse and shorten treatment duration...
- The mmaA2 gene of Mycobacterium tuberculosis encodes the distal cyclopropane synthase of the alpha-mycolic acidMichael S Glickman
Division of Infectious Diseases, Immunology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
J Biol Chem 278:7844-9. 2003..These results expand our knowledge of the biosynthesis of the Mtb cell envelope and will allow further elucidation of the relationship between Mtb pathogenesis and the fine structure of mycolic acids...
- Bacterial DNA repair by non-homologous end joiningStewart Shuman
Sloan Kettering Institute, 1275 York Avenue, New York, New York 10021, USA
Nat Rev Microbiol 5:852-61. 2007..Although still a young field, bacterial NHEJ promises to teach us a great deal about the nexus of DNA repair and bacterial pathogenesis...
- Delayed protection by ESAT-6-specific effector CD4+ T cells after airborne M. tuberculosis infectionAlena M Gallegos
Infectious Diseases Service, Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10032, USA
J Exp Med 205:2359-68. 2008..Our results demonstrate that pathogen-specific Th1 cells can provide protection against inhaled M. tuberculosis, but only after the first week of infection...
- The pathways and outcomes of mycobacterial NHEJ depend on the structure of the broken DNA endsJideofor Aniukwu
Molecular Biology Program, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
Genes Dev 22:512-27. 2008..We conclude that the mechanisms of mycobacterial NHEJ are many and the outcomes depend on the initial structures of the DSBs and the available ensemble of end-processing and end-sealing components, which are not limited to Ku and LigD...
- Mycobacterial nonhomologous end joining mediates mutagenic repair of chromosomal double-strand DNA breaksNicolas C Stephanou
Immunology Program, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
J Bacteriol 189:5237-46. 2007..These findings demonstrate that prokaryotic NHEJ is specifically required for DSB repair in late stationary phase and can mediate mutagenic repair of homing endonuclease-generated chromosomal DSBs...
- Mycobacterial UvrD1 is a Ku-dependent DNA helicase that plays a role in multiple DNA repair events, including double-strand break repairKrishna Murari Sinha
Molecular Biology, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
J Biol Chem 282:15114-25. 2007..The physical and functional interactions of bacterial Ku and UvrD1 highlight the potential for cross-talk between components of nonhomologous end joining and nucleotide excision repair pathways...
- Trans-cyclopropanation of mycolic acids on trehalose dimycolate suppresses Mycobacterium tuberculosis -induced inflammation and virulenceVivek Rao
Immunology Program, Sloan-Kettering Institute, Memorial Sloan-Kettering Cancer Center, New York, New York 10021, USA
J Clin Invest 116:1660-7. 2006..tuberculosis-induced inflammation and virulence. In addition, cyclopropane stereochemistries on mycolic acids interact directly with host cells to both positively and negatively influence host innate immune activation...
- Crystal structure and nonhomologous end-joining function of the ligase component of Mycobacterium DNA ligase DDavid Akey
Department of Molecular and Cellular Biology, University of California, Berkeley, California 94720, USA
J Biol Chem 281:13412-23. 2006..We surmise that the signature error-prone quality of bacterial NHEJ in vivo arises from a dynamic balance between the end-remodeling and end-sealing steps...
- Regulation of Mycobacterium tuberculosis cell envelope composition and virulence by intramembrane proteolysisHideki Makinoshima
Immunology Program, Sloan-Kettering Institute, New York, New York 10021, USA
Nature 436:406-9. 2005..tuberculosis...
- Mechanism of nonhomologous end-joining in mycobacteria: a low-fidelity repair system driven by Ku, ligase D and ligase CChunling Gong
Immunology and Molecular Biology Programs, Sloan Kettering Institute, and Division of Infectious Diseases, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
Nat Struct Mol Biol 12:304-12. 2005..Another ATP-dependent DNA ligase (LigC) provides a backup mechanism for LigD-independent error-prone repair of blunt-end DSBs. We speculate that NHEJ allows mycobacteria to evade genotoxic host defense...
- Mycobacterium tuberculosis controls host innate immune activation through cyclopropane modification of a glycolipid effector moleculeVivek Rao
Division of Infectious Diseases, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
J Exp Med 201:535-43. 2005....
- Efficient allelic exchange and transposon mutagenesis in Mycobacterium avium by specialized transductionJoel Otero
Howard Hughes Medical Institute, Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
Appl Environ Microbiol 69:5039-44. 2003..avium. In combination with the forthcoming M. avium genome sequence, these tools will allow the distinct physiologic and pathogenic properties of M. avium to be dissected in molecular detail...
- Crystal structures of mycolic acid cyclopropane synthases from Mycobacterium tuberculosisChih Chin Huang
Department of Biochemistry and Biophysics, Texas A and M University, College Station, Texas 77843 2128, USA
J Biol Chem 277:11559-69. 2002..These structures provide a foundation for rational-drug design, which may lead to the development of new inhibitors effective against persistent bacteria...
- CELL ENVELOPE BIOSYNTHESIS IN M TUBERCULOSISMichael Glickman; Fiscal Year: 2002..Isolation and characterization of such mutants will likely yield important insights into the role of the mycobacterial cell envelope in the pathogenesis of Tuberculosis and the interaction of the tubercle bacillus with host cells. ..
- DNA Ligases in Mycobacterial DNA repair & PathogenesisMichael Glickman; Fiscal Year: 2009..abstract_text> ..
- Cyclopropane Synthetases and M.tuerculosis VirulenceMichael Glickman; Fiscal Year: 2007..This knowledge may validate this new antibiotic target in Mtb and lead to new vaccine strategies. ..
- Molecular Analysis of the Rip1 Virulence Pathway of M. tuberculosisMICHAEL STEPHEN GLICKMAN; Fiscal Year: 2010..Finally, we will define the molecular basis for site one cleavage of anti-sigma factors by genetically ablating candidate site one proteases and testing anti-sigma factor cleavage in these mutant strains. . ..
- Cyclopropane Synthetases and M.tuberculosis PathogenesisMICHAEL STEPHEN GLICKMAN; Fiscal Year: 2010..The experiments in this application are designed to validate this enzyme family as a target for antibiotic development and to understand their role in causing disease. ..
- Cyclopropane Synthetases and M.tuberculosis PathogenesisMichael Glickman; Fiscal Year: 2009..The experiments in this application are designed to validate this enzyme family as a target for antibiotic development and to understand their role in causing disease. ..
- Molecular analysis of mycobacterial NHEJMICHAEL STEPHEN GLICKMAN; Fiscal Year: 2010..tuberculosis, cause of the disease Tuberculosis. These studies will advance our understanding of how mycobacteria resist elimination by the host and may lead to novel drug strategies for infections caused by mycobacteria. ..
- Cyclopropane Synthetases and M.tuerculosis VirulenceMichael Glickman; Fiscal Year: 2006..This knowledge may validate this new antibiotic target in Mtb and lead to new vaccine strategies. ..