MICHAEL STEPHEN GLICKMAN

Summary

Affiliation: Memorial Sloan-Kettering Cancer Center
Country: USA

Publications

  1. pmc Mycobacterium tuberculosis controls host innate immune activation through cyclopropane modification of a glycolipid effector molecule
    Vivek Rao
    Division of Infectious Diseases, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    J Exp Med 201:535-43. 2005
  2. pmc A dual role for mycobacterial RecO in RecA-dependent homologous recombination and RecA-independent single-strand annealing
    Richa Gupta
    Division of Infectious Diseases, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA
    Nucleic Acids Res 41:2284-95. 2013
  3. pmc Catalytic and non-catalytic roles for the mono-ADP-ribosyltransferase Arr in the mycobacterial DNA damage response
    Christina L Stallings
    Department of Molecular Microbiology Washington University School of Medicine, St Louis, Missouri, United States of America
    PLoS ONE 6:e21807. 2011
  4. pmc Converting cancer therapies into cures: lessons from infectious diseases
    Michael S Glickman
    Infectious Diseases Service and Immunology Program, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA
    Cell 148:1089-98. 2012
  5. ncbi request reprint The mmaA2 gene of Mycobacterium tuberculosis encodes the distal cyclopropane synthase of the alpha-mycolic acid
    Michael S Glickman
    Division of Infectious Diseases, Immunology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    J Biol Chem 278:7844-9. 2003
  6. ncbi request reprint Bacterial DNA repair by non-homologous end joining
    Stewart Shuman
    Sloan Kettering Institute, 1275 York Avenue, New York, New York 10021, USA
    Nat Rev Microbiol 5:852-61. 2007
  7. pmc Delayed protection by ESAT-6-specific effector CD4+ T cells after airborne M. tuberculosis infection
    Alena M Gallegos
    Infectious Diseases Service, Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10032, USA
    J Exp Med 205:2359-68. 2008
  8. pmc The pathways and outcomes of mycobacterial NHEJ depend on the structure of the broken DNA ends
    Jideofor Aniukwu
    Molecular Biology Program, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Genes Dev 22:512-27. 2008
  9. pmc Mycobacterial nonhomologous end joining mediates mutagenic repair of chromosomal double-strand DNA breaks
    Nicolas C Stephanou
    Immunology Program, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    J Bacteriol 189:5237-46. 2007
  10. ncbi request reprint Mycobacterial UvrD1 is a Ku-dependent DNA helicase that plays a role in multiple DNA repair events, including double-strand break repair
    Krishna Murari Sinha
    Molecular Biology, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    J Biol Chem 282:15114-25. 2007

Research Grants

  1. CELL ENVELOPE BIOSYNTHESIS IN M TUBERCULOSIS
    Michael Glickman; Fiscal Year: 2002
  2. DNA Ligases in Mycobacterial DNA repair & Pathogenesis
    Michael Glickman; Fiscal Year: 2009
  3. Molecular Analysis of the Rip1 Virulence Pathway of M. tuberculosis
    Michael Glickman; Fiscal Year: 2009
  4. Cyclopropane Synthetases and M. tuberculosis Virulence
    Michael Glickman; Fiscal Year: 2003
  5. DNA Ligases in Mycobacterial DNA repair & Pathogenesis
    Michael Glickman; Fiscal Year: 2005
  6. Cyclopropane Synthetases and M.tuberculosis Pathogenesis
    MICHAEL STEPHEN GLICKMAN; Fiscal Year: 2010
  7. Cyclopropane Synthetases and M.tuberculosis Pathogenesis
    Michael Glickman; Fiscal Year: 2009
  8. Molecular analysis of mycobacterial NHEJ
    MICHAEL STEPHEN GLICKMAN; Fiscal Year: 2010
  9. Cyclopropane Synthetases and M.tuberculosis Pathogenesis
    Michael Glickman; Fiscal Year: 2009
  10. DNA Ligases in Mycobacterial DNA repair & Pathogenesis
    Michael Glickman; Fiscal Year: 2009

Collaborators

  • Nagatoshi Fujiwara
  • Christina L Stallings
  • STEWART H SHUMAN
  • Dirk Schnappinger
  • Charles L Sawyers
  • Nicolas C Stephanou
  • Vivek Rao
  • Jideofor Aniukwu
  • Feng Gao
  • Richa Gupta
  • William R Jacobs
  • Alena M Gallegos
  • Krishna Murari Sinha
  • David Akey
  • Paola Bongiorno
  • Alexandra Martins
  • Hideki Makinoshima
  • Chunling Gong
  • Joel Otero
  • Chih Chin Huang
  • Sergey Korolev
  • Olga Koroleva
  • Mikhail Ryzhikov
  • Mihaela Unciuleac
  • Eric G Pamer
  • Sabine Ehrt
  • James M Berger
  • Bing Chen
  • Hui Zhu
  • Steven A Porcelli
  • James C Sacchettini
  • Clare V Smith

Detail Information

Publications16

  1. pmc Mycobacterium tuberculosis controls host innate immune activation through cyclopropane modification of a glycolipid effector molecule
    Vivek Rao
    Division of Infectious Diseases, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    J Exp Med 201:535-43. 2005
    ....
  2. pmc A dual role for mycobacterial RecO in RecA-dependent homologous recombination and RecA-independent single-strand annealing
    Richa Gupta
    Division of Infectious Diseases, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA
    Nucleic Acids Res 41:2284-95. 2013
    ....
  3. pmc Catalytic and non-catalytic roles for the mono-ADP-ribosyltransferase Arr in the mycobacterial DNA damage response
    Christina L Stallings
    Department of Molecular Microbiology Washington University School of Medicine, St Louis, Missouri, United States of America
    PLoS ONE 6:e21807. 2011
    ..Our findings establish an endogenous cellular function for a mono-ADP-ribosyltransferase apart from its role in mediating Rifampin resistance...
  4. pmc Converting cancer therapies into cures: lessons from infectious diseases
    Michael S Glickman
    Infectious Diseases Service and Immunology Program, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA
    Cell 148:1089-98. 2012
    ..A remaining challenge in both fields is identifying drugs that eliminate drug-tolerant "persister" cells (infectious disease) or tumor-initiating/stem cells (cancer) to prevent late relapse and shorten treatment duration...
  5. ncbi request reprint The mmaA2 gene of Mycobacterium tuberculosis encodes the distal cyclopropane synthase of the alpha-mycolic acid
    Michael S Glickman
    Division of Infectious Diseases, Immunology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    J Biol Chem 278:7844-9. 2003
    ..These results expand our knowledge of the biosynthesis of the Mtb cell envelope and will allow further elucidation of the relationship between Mtb pathogenesis and the fine structure of mycolic acids...
  6. ncbi request reprint Bacterial DNA repair by non-homologous end joining
    Stewart Shuman
    Sloan Kettering Institute, 1275 York Avenue, New York, New York 10021, USA
    Nat Rev Microbiol 5:852-61. 2007
    ..Although still a young field, bacterial NHEJ promises to teach us a great deal about the nexus of DNA repair and bacterial pathogenesis...
  7. pmc Delayed protection by ESAT-6-specific effector CD4+ T cells after airborne M. tuberculosis infection
    Alena M Gallegos
    Infectious Diseases Service, Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10032, USA
    J Exp Med 205:2359-68. 2008
    ..Our results demonstrate that pathogen-specific Th1 cells can provide protection against inhaled M. tuberculosis, but only after the first week of infection...
  8. pmc The pathways and outcomes of mycobacterial NHEJ depend on the structure of the broken DNA ends
    Jideofor Aniukwu
    Molecular Biology Program, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Genes Dev 22:512-27. 2008
    ..We conclude that the mechanisms of mycobacterial NHEJ are many and the outcomes depend on the initial structures of the DSBs and the available ensemble of end-processing and end-sealing components, which are not limited to Ku and LigD...
  9. pmc Mycobacterial nonhomologous end joining mediates mutagenic repair of chromosomal double-strand DNA breaks
    Nicolas C Stephanou
    Immunology Program, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    J Bacteriol 189:5237-46. 2007
    ..These findings demonstrate that prokaryotic NHEJ is specifically required for DSB repair in late stationary phase and can mediate mutagenic repair of homing endonuclease-generated chromosomal DSBs...
  10. ncbi request reprint Mycobacterial UvrD1 is a Ku-dependent DNA helicase that plays a role in multiple DNA repair events, including double-strand break repair
    Krishna Murari Sinha
    Molecular Biology, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    J Biol Chem 282:15114-25. 2007
    ..The physical and functional interactions of bacterial Ku and UvrD1 highlight the potential for cross-talk between components of nonhomologous end joining and nucleotide excision repair pathways...
  11. pmc Trans-cyclopropanation of mycolic acids on trehalose dimycolate suppresses Mycobacterium tuberculosis -induced inflammation and virulence
    Vivek Rao
    Immunology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    J Clin Invest 116:1660-7. 2006
    ..tuberculosis-induced inflammation and virulence. In addition, cyclopropane stereochemistries on mycolic acids interact directly with host cells to both positively and negatively influence host innate immune activation...
  12. ncbi request reprint Crystal structure and nonhomologous end-joining function of the ligase component of Mycobacterium DNA ligase D
    David Akey
    Department of Molecular and Cellular Biology, University of California, Berkeley, California 94720, USA
    J Biol Chem 281:13412-23. 2006
    ..We surmise that the signature error-prone quality of bacterial NHEJ in vivo arises from a dynamic balance between the end-remodeling and end-sealing steps...
  13. pmc Regulation of Mycobacterium tuberculosis cell envelope composition and virulence by intramembrane proteolysis
    Hideki Makinoshima
    Immunology Program, Sloan Kettering Institute, New York, New York 10021, USA
    Nature 436:406-9. 2005
    ..tuberculosis...
  14. ncbi request reprint Mechanism of nonhomologous end-joining in mycobacteria: a low-fidelity repair system driven by Ku, ligase D and ligase C
    Chunling Gong
    Immunology and Molecular Biology Programs, Sloan Kettering Institute, and Division of Infectious Diseases, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Nat Struct Mol Biol 12:304-12. 2005
    ..Another ATP-dependent DNA ligase (LigC) provides a backup mechanism for LigD-independent error-prone repair of blunt-end DSBs. We speculate that NHEJ allows mycobacteria to evade genotoxic host defense...
  15. pmc Efficient allelic exchange and transposon mutagenesis in Mycobacterium avium by specialized transduction
    Joel Otero
    Howard Hughes Medical Institute, Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Appl Environ Microbiol 69:5039-44. 2003
    ..avium. In combination with the forthcoming M. avium genome sequence, these tools will allow the distinct physiologic and pathogenic properties of M. avium to be dissected in molecular detail...
  16. ncbi request reprint Crystal structures of mycolic acid cyclopropane synthases from Mycobacterium tuberculosis
    Chih Chin Huang
    Department of Biochemistry and Biophysics, Texas A and M University, College Station, Texas 77843 2128, USA
    J Biol Chem 277:11559-69. 2002
    ..These structures provide a foundation for rational-drug design, which may lead to the development of new inhibitors effective against persistent bacteria...

Research Grants19

  1. CELL ENVELOPE BIOSYNTHESIS IN M TUBERCULOSIS
    Michael Glickman; Fiscal Year: 2002
    ..Isolation and characterization of such mutants will likely yield important insights into the role of the mycobacterial cell envelope in the pathogenesis of Tuberculosis and the interaction of the tubercle bacillus with host cells. ..
  2. DNA Ligases in Mycobacterial DNA repair & Pathogenesis
    Michael Glickman; Fiscal Year: 2009
    ..abstract_text> ..
  3. Molecular Analysis of the Rip1 Virulence Pathway of M. tuberculosis
    Michael Glickman; Fiscal Year: 2009
    ..Finally, we will define the molecular basis for site one cleavage of anti-sigma factors by genetically ablating candidate site one proteases and testing anti-sigma factor cleavage in these mutant strains. . ..
  4. Cyclopropane Synthetases and M. tuberculosis Virulence
    Michael Glickman; Fiscal Year: 2003
    ..This knowledge may validate this new antibiotic target in Mtb and lead to new vaccine strategies. ..
  5. DNA Ligases in Mycobacterial DNA repair & Pathogenesis
    Michael Glickman; Fiscal Year: 2005
    ..abstract_text> ..
  6. Cyclopropane Synthetases and M.tuberculosis Pathogenesis
    MICHAEL STEPHEN GLICKMAN; Fiscal Year: 2010
    ..The experiments in this application are designed to validate this enzyme family as a target for antibiotic development and to understand their role in causing disease. ..
  7. Cyclopropane Synthetases and M.tuberculosis Pathogenesis
    Michael Glickman; Fiscal Year: 2009
    ..The experiments in this application are designed to validate this enzyme family as a target for antibiotic development and to understand their role in causing disease. ..
  8. Molecular analysis of mycobacterial NHEJ
    MICHAEL STEPHEN GLICKMAN; Fiscal Year: 2010
    ..tuberculosis, cause of the disease Tuberculosis. These studies will advance our understanding of how mycobacteria resist elimination by the host and may lead to novel drug strategies for infections caused by mycobacteria. ..
  9. Cyclopropane Synthetases and M.tuberculosis Pathogenesis
    Michael Glickman; Fiscal Year: 2009
    ..The experiments in this application are designed to validate this enzyme family as a target for antibiotic development and to understand their role in causing disease. ..
  10. DNA Ligases in Mycobacterial DNA repair & Pathogenesis
    Michael Glickman; Fiscal Year: 2009
    ..abstract_text> ..
  11. DNA Ligases in Mycobacterial DNA repair & Pathogenesis
    Michael Glickman; Fiscal Year: 2007
    ..abstract_text> ..
  12. Cyclopropane Synthetases and M.tuerculosis Virulence
    Michael Glickman; Fiscal Year: 2007
    ..This knowledge may validate this new antibiotic target in Mtb and lead to new vaccine strategies. ..
  13. DNA Ligases in Mycobacterial DNA repair & Pathogenesis
    Michael Glickman; Fiscal Year: 2006
    ..abstract_text> ..
  14. Cyclopropane Synthetases and M.tuerculosis Virulence
    Michael Glickman; Fiscal Year: 2006
    ..This knowledge may validate this new antibiotic target in Mtb and lead to new vaccine strategies. ..
  15. Molecular Analysis of the Rip1 Virulence Pathway of M. tuberculosis
    MICHAEL STEPHEN GLICKMAN; Fiscal Year: 2010
    ..Finally, we will define the molecular basis for site one cleavage of anti-sigma factors by genetically ablating candidate site one proteases and testing anti-sigma factor cleavage in these mutant strains. . ..