Michael S Glickman

Summary

Affiliation: Memorial Sloan-Kettering Cancer Center
Country: USA

Publications

  1. pmc Trans-cyclopropanation of mycolic acids on trehalose dimycolate suppresses Mycobacterium tuberculosis -induced inflammation and virulence
    Vivek Rao
    Immunology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    J Clin Invest 116:1660-7. 2006
  2. ncbi The mmaA2 gene of Mycobacterium tuberculosis encodes the distal cyclopropane synthase of the alpha-mycolic acid
    Michael S Glickman
    Division of Infectious Diseases, Immunology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    J Biol Chem 278:7844-9. 2003
  3. pmc Mutational analysis of Mycobacterium UvrD1 identifies functional groups required for ATP hydrolysis, DNA unwinding, and chemomechanical coupling
    Krishna Murari Sinha
    Molecular Biology Program, Sloan Kettering Institute, New York, New York 10021, USA
    Biochemistry 48:4019-30. 2009
  4. pmc A dual role for mycobacterial RecO in RecA-dependent homologous recombination and RecA-independent single-strand annealing
    Richa Gupta
    Division of Infectious Diseases, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA
    Nucleic Acids Res 41:2284-95. 2013
  5. pmc Mycobacterial nonhomologous end joining mediates mutagenic repair of chromosomal double-strand DNA breaks
    Nicolas C Stephanou
    Immunology Program, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    J Bacteriol 189:5237-46. 2007
  6. pmc Domain requirements for DNA unwinding by mycobacterial UvrD2, an essential DNA helicase
    Krishna Murari Sinha
    Molecular Biology and Immunology Programs, Sloan Kettering Institute, New York, New York 10065, USA
    Biochemistry 47:9355-64. 2008
  7. pmc AdnAB: a new DSB-resecting motor-nuclease from mycobacteria
    Krishna Murari Sinha
    Molecular Biology Program, Sloan Kettering Institute, New York, New York 10065, USA
    Genes Dev 23:1423-37. 2009
  8. pmc Mycobacteria exploit three genetically distinct DNA double-strand break repair pathways
    Richa Gupta
    Immunology Program Molecular Biology Program, Sloan Kettering Institute, New York, NY 10065, USA
    Mol Microbiol 79:316-30. 2011
  9. pmc Mycobacterium tuberculosis lacking all mycolic acid cyclopropanation is viable but highly attenuated and hyperinflammatory in mice
    Daniel Barkan
    Division of Infectious Diseases, Memorial Sloan Kettering Cancer Center, New York, New York, USA
    Infect Immun 80:1958-68. 2012
  10. pmc M. tuberculosis intramembrane protease Rip1 controls transcription through three anti-sigma factor substrates
    Joseph G Sklar
    Immunology Program, Sloan Kettering Institute, New York, NY 10021, USA
    Mol Microbiol 77:605-17. 2010

Collaborators

Detail Information

Publications35

  1. pmc Trans-cyclopropanation of mycolic acids on trehalose dimycolate suppresses Mycobacterium tuberculosis -induced inflammation and virulence
    Vivek Rao
    Immunology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    J Clin Invest 116:1660-7. 2006
    ..tuberculosis-induced inflammation and virulence. In addition, cyclopropane stereochemistries on mycolic acids interact directly with host cells to both positively and negatively influence host innate immune activation...
  2. ncbi The mmaA2 gene of Mycobacterium tuberculosis encodes the distal cyclopropane synthase of the alpha-mycolic acid
    Michael S Glickman
    Division of Infectious Diseases, Immunology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    J Biol Chem 278:7844-9. 2003
    ..These results expand our knowledge of the biosynthesis of the Mtb cell envelope and will allow further elucidation of the relationship between Mtb pathogenesis and the fine structure of mycolic acids...
  3. pmc Mutational analysis of Mycobacterium UvrD1 identifies functional groups required for ATP hydrolysis, DNA unwinding, and chemomechanical coupling
    Krishna Murari Sinha
    Molecular Biology Program, Sloan Kettering Institute, New York, New York 10021, USA
    Biochemistry 48:4019-30. 2009
    ....
  4. pmc A dual role for mycobacterial RecO in RecA-dependent homologous recombination and RecA-independent single-strand annealing
    Richa Gupta
    Division of Infectious Diseases, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA
    Nucleic Acids Res 41:2284-95. 2013
    ....
  5. pmc Mycobacterial nonhomologous end joining mediates mutagenic repair of chromosomal double-strand DNA breaks
    Nicolas C Stephanou
    Immunology Program, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    J Bacteriol 189:5237-46. 2007
    ..These findings demonstrate that prokaryotic NHEJ is specifically required for DSB repair in late stationary phase and can mediate mutagenic repair of homing endonuclease-generated chromosomal DSBs...
  6. pmc Domain requirements for DNA unwinding by mycobacterial UvrD2, an essential DNA helicase
    Krishna Murari Sinha
    Molecular Biology and Immunology Programs, Sloan Kettering Institute, New York, New York 10065, USA
    Biochemistry 47:9355-64. 2008
    ..Attempts to disrupt the M. smegmatis uvrD2 gene were unsuccessful unless a second copy of uvrD2 was present elsewhere in the chromosome, indicating that UvrD2 is essential for growth of M. smegmatis...
  7. pmc AdnAB: a new DSB-resecting motor-nuclease from mycobacteria
    Krishna Murari Sinha
    Molecular Biology Program, Sloan Kettering Institute, New York, New York 10065, USA
    Genes Dev 23:1423-37. 2009
    ..AdnAB is a novel signature of the Actinomycetales taxon. Mycobacteria are exceptional in that they encode both AdnAB and RecBCD, suggesting the existence of alternative end-resecting motor-nuclease complexes...
  8. pmc Mycobacteria exploit three genetically distinct DNA double-strand break repair pathways
    Richa Gupta
    Immunology Program Molecular Biology Program, Sloan Kettering Institute, New York, NY 10065, USA
    Mol Microbiol 79:316-30. 2011
    ..These findings reveal distinctive features of mycobacterial DSB repair, most notably the dedication of the RecBCD and AdnAB helicase-nuclease machines to distinct repair pathways...
  9. pmc Mycobacterium tuberculosis lacking all mycolic acid cyclopropanation is viable but highly attenuated and hyperinflammatory in mice
    Daniel Barkan
    Division of Infectious Diseases, Memorial Sloan Kettering Cancer Center, New York, New York, USA
    Infect Immun 80:1958-68. 2012
    ..Taken together, our findings establish the immunomodulatory function of the mycolic acid modification pathway in pathogenesis and buttress this enzyme class as an attractive target for antimycobacterial drug development...
  10. pmc M. tuberculosis intramembrane protease Rip1 controls transcription through three anti-sigma factor substrates
    Joseph G Sklar
    Immunology Program, Sloan Kettering Institute, New York, NY 10021, USA
    Mol Microbiol 77:605-17. 2010
    ....
  11. pmc Redundant function of cmaA2 and mmaA2 in Mycobacterium tuberculosis cis cyclopropanation of oxygenated mycolates
    Daniel Barkan
    Division of Infectious Diseases, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA
    J Bacteriol 192:3661-8. 2010
    ..tuberculosis and indicate a substantial redundancy of function for MmaA2 and CmaA2, the latter of which can function as both a cis and trans cyclopropane synthase for the oxygenated mycolates...
  12. pmc Site-2 protease substrate specificity and coupling in trans by a PDZ-substrate adapter protein
    Jessica S Schneider
    Immunology Program, Sloan Kettering Institute, New York, NY 10021
    Proc Natl Acad Sci U S A 110:19543-8. 2013
    ..Our results support a model of S2P substrate specificity in which a substrate-specific adapter protein tethers the S2P to its substrate while holding the protease inactive through its PDZ domain. ..
  13. ncbi Function of site-2 proteases in bacteria and bacterial pathogens
    Jessica S Schneider
    Immunology Program, Memorial Sloan Kettering Cancer Center, 1275 York Ave, New York, NY 10065, USA Program in Immunology and Microbial Pathogenesis, Weill Cornell Graduate School of Biomedical Sciences, USA
    Biochim Biophys Acta 1828:2808-14. 2013
    ..This article is part of a Special Issue entitled: Intramembrane Proteases. ..
  14. pmc CarD is an essential regulator of rRNA transcription required for Mycobacterium tuberculosis persistence
    Christina L Stallings
    Immunology Program, Sloan Kettering Institute, New York, NY 10065, USA
    Cell 138:146-59. 2009
    ..These findings highlight a distinct molecular mechanism for regulating rRNA transcription in mycobacteria that is critical for M. tuberculosis pathogenesis...
  15. pmc An improved counterselectable marker system for mycobacterial recombination using galK and 2-deoxy-galactose
    Daniel Barkan
    Infectious Disease Division, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    Gene 470:31-6. 2011
    ..These results establish a new counterselectable marker system for use in mycobacteria that can shorten the time to generate unmarked mutations in M. smegmatis and M. tuberculosis...
  16. pmc Mycolic acid cyclopropanation is essential for viability, drug resistance, and cell wall integrity of Mycobacterium tuberculosis
    Daniel Barkan
    Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    Chem Biol 16:499-509. 2009
    ..These results demonstrate that mycolic acid methyltransferases are a promising antibiotic target and that a family of virulence factors can be chemically inhibited with effects not anticipated from studies of each individual enzyme...
  17. pmc Structure and function of CarD, an essential mycobacterial transcription factor
    Devendra B Srivastava
    Laboratory of Molecular Biophysics, The Rockefeller University, New York, NY 10065, USA
    Proc Natl Acad Sci U S A 110:12619-24. 2013
    ..Thus, CarD uses an unusual mechanism for regulating transcription, sensing the DNA conformation where transcription bubble formation initiates. ..
  18. pmc Characterization of Mycobacterium smegmatis PolD2 and PolD1 as RNA/DNA polymerases homologous to the POL domain of bacterial DNA ligase D
    Hui Zhu
    Molecular Biology Program, Sloan Kettering Institute, New York, NY 10065, USA
    Biochemistry 51:10147-58. 2012
    ..Whereas our results document the existence and characteristics of new stand-alone members of the LigD POL family of RNA/DNA polymerases, they imply that other polymerases can perform fill-in synthesis during mycobacterial NHEJ...
  19. pmc The pathways and outcomes of mycobacterial NHEJ depend on the structure of the broken DNA ends
    Jideofor Aniukwu
    Molecular Biology Program, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Genes Dev 22:512-27. 2008
    ..We conclude that the mechanisms of mycobacterial NHEJ are many and the outcomes depend on the initial structures of the DSBs and the available ensemble of end-processing and end-sealing components, which are not limited to Ku and LigD...
  20. pmc Inhibition of mycobacterial infection by the tumor suppressor PTEN
    Guochang Huang
    Cell Biology Program, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA
    J Biol Chem 287:23196-202. 2012
    ..The relationship of PTEN-PI3K-Akt mTOR status and susceptibility to mycobacterial infection suggests that the interaction of mycobacterial pathogens with cancer cells may be influenced by genetic alterations in the tumor cells...
  21. pmc Delayed protection by ESAT-6-specific effector CD4+ T cells after airborne M. tuberculosis infection
    Alena M Gallegos
    Infectious Diseases Service, Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10032, USA
    J Exp Med 205:2359-68. 2008
    ..Our results demonstrate that pathogen-specific Th1 cells can provide protection against inhaled M. tuberculosis, but only after the first week of infection...
  22. ncbi Mycobacterial UvrD1 is a Ku-dependent DNA helicase that plays a role in multiple DNA repair events, including double-strand break repair
    Krishna Murari Sinha
    Molecular Biology, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    J Biol Chem 282:15114-25. 2007
    ..The physical and functional interactions of bacterial Ku and UvrD1 highlight the potential for cross-talk between components of nonhomologous end joining and nucleotide excision repair pathways...
  23. ncbi The Rip1 Protease of Mycobacterium tuberculosis Controls the SigD Regulon
    Jessica S Schneider
    Immunology Program, Memorial Sloan Kettering Cancer Center, New York, New York, USA Program in Immunology and Microbial Pathogenesis, Weill Cornell Graduate School, New York, New York, USA
    J Bacteriol 196:2638-45. 2014
    ..In the absence of Rip1, proteolytic maturation of RsdA is impaired. These findings identify RsdA/SigD as a fourth arm of the branched pathway controlled by Rip1 in M. tuberculosis. ..
  24. ncbi Deficiency of Double-Strand DNA Break Repair Does Not Impair Mycobacterium tuberculosis Virulence in Multiple Animal Models of Infection
    Brook E Heaton
    Immunology Program, Sloan Kettering Institute, New York, New York, USA
    Infect Immun 82:3177-85. 2014
    ..tuberculosis pathogenesis. ..
  25. ncbi Bacterial DNA repair by non-homologous end joining
    Stewart Shuman
    Sloan Kettering Institute, 1275 York Avenue, New York, New York 10021, USA
    Nat Rev Microbiol 5:852-61. 2007
    ..Although still a young field, bacterial NHEJ promises to teach us a great deal about the nexus of DNA repair and bacterial pathogenesis...
  26. doi The mechanism of action of BCG therapy for bladder cancer--a current perspective
    Gil Redelman-Sidi
    Sloan Kettering Cancer Center, 1275 York Avenue, Box 9, New York, NY 10065, USA
    Nat Rev Urol 11:153-62. 2014
    ..Several gaps still exist in our knowledge that should be addressed in future efforts to understand this biotherapy of cancer. ..
  27. pmc Oncogenic activation of Pak1-dependent pathway of macropinocytosis determines BCG entry into bladder cancer cells
    Gil Redelman-Sidi
    Infectious Diseases Service, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    Cancer Res 73:1156-67. 2013
    ..These results reveal that oncogenic activation of macropinocytosis determines BCG uptake by bladder cancer cells, implying that tumor responsiveness to BCG may be governed by the specific mutations present in the treated cancer cell...
  28. pmc Converting cancer therapies into cures: lessons from infectious diseases
    Michael S Glickman
    Infectious Diseases Service and Immunology Program, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA
    Cell 148:1089-98. 2012
    ..A remaining challenge in both fields is identifying drugs that eliminate drug-tolerant "persister" cells (infectious disease) or tumor-initiating/stem cells (cancer) to prevent late relapse and shorten treatment duration...
  29. pmc Mycobacterium tuberculosis controls host innate immune activation through cyclopropane modification of a glycolipid effector molecule
    Vivek Rao
    Division of Infectious Diseases, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    J Exp Med 201:535-43. 2005
    ....
  30. pmc Regulation of Mycobacterium tuberculosis cell envelope composition and virulence by intramembrane proteolysis
    Hideki Makinoshima
    Immunology Program, Sloan Kettering Institute, New York, New York 10021, USA
    Nature 436:406-9. 2005
    ..tuberculosis...
  31. ncbi Site-2 proteases in prokaryotes: regulated intramembrane proteolysis expands to microbial pathogenesis
    Hideki Makinoshima
    Immunology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Microbes Infect 8:1882-8. 2006
    ..In this review we will discuss the biochemical functions and physiologic roles of S2P proteases in bacteria and highlight recent data implicating S2P family members in host-pathogen interactions...
  32. ncbi Mechanism of nonhomologous end-joining in mycobacteria: a low-fidelity repair system driven by Ku, ligase D and ligase C
    Chunling Gong
    Immunology and Molecular Biology Programs, Sloan Kettering Institute, and Division of Infectious Diseases, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Nat Struct Mol Biol 12:304-12. 2005
    ..Another ATP-dependent DNA ligase (LigC) provides a backup mechanism for LigD-independent error-prone repair of blunt-end DSBs. We speculate that NHEJ allows mycobacteria to evade genotoxic host defense...
  33. ncbi Crystal structure and nonhomologous end-joining function of the ligase component of Mycobacterium DNA ligase D
    David Akey
    Department of Molecular and Cellular Biology, University of California, Berkeley, California 94720, USA
    J Biol Chem 281:13412-23. 2006
    ..We surmise that the signature error-prone quality of bacterial NHEJ in vivo arises from a dynamic balance between the end-remodeling and end-sealing steps...
  34. pmc Efficient allelic exchange and transposon mutagenesis in Mycobacterium avium by specialized transduction
    Joel Otero
    Howard Hughes Medical Institute, Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Appl Environ Microbiol 69:5039-44. 2003
    ..avium. In combination with the forthcoming M. avium genome sequence, these tools will allow the distinct physiologic and pathogenic properties of M. avium to be dissected in molecular detail...
  35. ncbi Crystal structures of mycolic acid cyclopropane synthases from Mycobacterium tuberculosis
    Chih Chin Huang
    Department of Biochemistry and Biophysics, Texas A and M University, College Station, Texas 77843 2128, USA
    J Biol Chem 277:11559-69. 2002
    ..These structures provide a foundation for rational-drug design, which may lead to the development of new inhibitors effective against persistent bacteria...