Filippo Giancotti

Summary

Affiliation: Memorial Sloan-Kettering Cancer Center
Country: USA

Publications

  1. ncbi request reprint Targeting integrin beta4 for cancer and anti-angiogenic therapy
    Filippo G Giancotti
    Cell Biology Program, Sloan Kettering Institute for Cancer Research, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, Box 216, New York, NY 10021, USA
    Trends Pharmacol Sci 28:506-11. 2007
  2. pmc EGF-R signaling through Fyn kinase disrupts the function of integrin alpha6beta4 at hemidesmosomes: role in epithelial cell migration and carcinoma invasion
    A Mariotti
    Cellular Biochemistry and Biophysics Program, Department of Surgery, Sloan Kettering Institute for Cancer Research, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    J Cell Biol 155:447-58. 2001
  3. pmc Compartmentalization of integrin alpha6beta4 signaling in lipid rafts
    Laurent Gagnoux-Palacios
    Cell Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    J Cell Biol 162:1189-96. 2003
  4. doi request reprint Mechanisms governing metastatic dormancy and reactivation
    Filippo G Giancotti
    Cell Biology Program, Sloan Kettering Institute for Cancer Research and Metastasis Research Center, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA Electronic address
    Cell 155:750-64. 2013
  5. pmc The BMP inhibitor Coco reactivates breast cancer cells at lung metastatic sites
    Hua Gao
    Cell Biology Program, Sloan Kettering Institute for Cancer Research, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    Cell 150:764-79. 2012
  6. ncbi request reprint Integrin signaling: specificity and control of cell survival and cell cycle progression
    F G Giancotti
    Cellular Biochemistry and Biophysics Program, Memorial Sloan Kettering Cancer Center, Cornell University, New York, NY 10021, USA
    Curr Opin Cell Biol 9:691-700. 1997
  7. ncbi request reprint Positional control of cell fate through joint integrin/receptor protein kinase signaling
    Filippo G Giancotti
    Cellular Biochemistry and Biophysics Program, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Annu Rev Cell Dev Biol 19:173-206. 2003
  8. ncbi request reprint Integrin signaling
    F G Giancotti
    Cellular Biochemistry and Biophysics Program, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Science 285:1028-32. 1999
  9. pmc Cell cycle and adhesion defects in mice carrying a targeted deletion of the integrin beta4 cytoplasmic domain
    C Murgia
    Cellular Biochemistry and Biophysics Program, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    EMBO J 17:3940-51. 1998
  10. ncbi request reprint A requirement for caveolin-1 and associated kinase Fyn in integrin signaling and anchorage-dependent cell growth
    K K Wary
    Cellular Biochemistry and Biophysics Program, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Cell 94:625-34. 1998

Collaborators

Detail Information

Publications26

  1. ncbi request reprint Targeting integrin beta4 for cancer and anti-angiogenic therapy
    Filippo G Giancotti
    Cell Biology Program, Sloan Kettering Institute for Cancer Research, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, Box 216, New York, NY 10021, USA
    Trends Pharmacol Sci 28:506-11. 2007
    ..Therefore, I propose that a simultaneous blockade of beta4 and receptor-tyrosine-kinase signaling represents a rational approach to cancer and anti-angiogenic therapy...
  2. pmc EGF-R signaling through Fyn kinase disrupts the function of integrin alpha6beta4 at hemidesmosomes: role in epithelial cell migration and carcinoma invasion
    A Mariotti
    Cellular Biochemistry and Biophysics Program, Department of Surgery, Sloan Kettering Institute for Cancer Research, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    J Cell Biol 155:447-58. 2001
    ..These results suggest that disruption of hemidesmosomes mediated by Fyn is a prerequisite for normal keratinocyte migration and squamous carcinoma invasion...
  3. pmc Compartmentalization of integrin alpha6beta4 signaling in lipid rafts
    Laurent Gagnoux-Palacios
    Cell Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    J Cell Biol 162:1189-96. 2003
    ..Thus, compartmentalization in lipid rafts is necessary to couple the alpha6beta4 integrin to a palmitoylated SFK and promote EGF-dependent mitogenesis...
  4. doi request reprint Mechanisms governing metastatic dormancy and reactivation
    Filippo G Giancotti
    Cell Biology Program, Sloan Kettering Institute for Cancer Research and Metastasis Research Center, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA Electronic address
    Cell 155:750-64. 2013
    ..In spite of significant remaining uncertainties, these findings provide a framework to understand the logic of metastatic dormancy and reactivation and open new avenues for therapeutic intervention. ..
  5. pmc The BMP inhibitor Coco reactivates breast cancer cells at lung metastatic sites
    Hua Gao
    Cell Biology Program, Sloan Kettering Institute for Cancer Research, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    Cell 150:764-79. 2012
    ..These findings reveal that metastasis-initiating cells need to overcome organ-specific antimetastatic signals in order to undergo reactivation...
  6. ncbi request reprint Integrin signaling: specificity and control of cell survival and cell cycle progression
    F G Giancotti
    Cellular Biochemistry and Biophysics Program, Memorial Sloan Kettering Cancer Center, Cornell University, New York, NY 10021, USA
    Curr Opin Cell Biol 9:691-700. 1997
    ..The repertoire of integrins and composition of the extracellular matrix appear to dictate whether a cell will survive, proliferate or exit the cell cycle and differentiate in response to soluble factors...
  7. ncbi request reprint Positional control of cell fate through joint integrin/receptor protein kinase signaling
    Filippo G Giancotti
    Cellular Biochemistry and Biophysics Program, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Annu Rev Cell Dev Biol 19:173-206. 2003
    ..Research on integrin signaling is beginning to explain the complex and specific effects that the extracellular matrix exerts on cells...
  8. ncbi request reprint Integrin signaling
    F G Giancotti
    Cellular Biochemistry and Biophysics Program, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Science 285:1028-32. 1999
    ..Many integrin signals converge on cell cycle regulation, directing cells to live or die, to proliferate, or to exit the cell cycle and differentiate...
  9. pmc Cell cycle and adhesion defects in mice carrying a targeted deletion of the integrin beta4 cytoplasmic domain
    C Murgia
    Cellular Biochemistry and Biophysics Program, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    EMBO J 17:3940-51. 1998
    ....
  10. ncbi request reprint A requirement for caveolin-1 and associated kinase Fyn in integrin signaling and anchorage-dependent cell growth
    K K Wary
    Cellular Biochemistry and Biophysics Program, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Cell 94:625-34. 1998
    ..These findings reveal an unexpected function of caveolin-1 and Fyn in integrin signaling and anchorage-dependent cell growth...
  11. ncbi request reprint Integrin-specific activation of Rac controls progression through the G(1) phase of the cell cycle
    A Mettouchi
    Cellular Biochemistry and Biophysics Program, Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA
    Mol Cell 8:115-27. 2001
    ..This process is mediated by SOS and PI-3K and requires coordinate upstream signals through Shc and FAK. These results indicate that Rac is a crucial mediator of the integrin-specific control of cell cycle in endothelial cells...
  12. ncbi request reprint Tyrosine phosphorylation of the beta 4 integrin cytoplasmic domain mediates Shc signaling to extracellular signal-regulated kinase and antagonizes formation of hemidesmosomes
    M Dans
    Cellular Biochemistry and Biophysics Program, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    J Biol Chem 276:1494-502. 2001
    ..This event is required for subsequent tyrosine phosphorylation of Shc and signaling to ERK but not formation of hemidesmosomes...
  13. pmc Defective Rac-mediated proliferation and survival after targeted mutation of the beta1 integrin cytodomain
    Emilio Hirsch
    Dipartimento di Genetica, Biologia, e Biochimica, Universita di Torino, 10126 Torino, Italy
    J Cell Biol 157:481-92. 2002
    ..Altogether, our data provide the evidence for an epistatic interaction between the beta1 integrin cytoplasmic domain and Rac, and indicate that this anchorage-dependent signaling pathway is crucial for cell growth control...
  14. ncbi request reprint Tensin relief facilitates migration
    Yuliya Pylayeva
    Nat Cell Biol 9:877-9. 2007
  15. ncbi request reprint Beta 4 integrin amplifies ErbB2 signaling to promote mammary tumorigenesis
    Wenjun Guo
    Cell Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10021 USA
    Cell 126:489-502. 2006
    ..These results indicate that beta 4 integrin promotes tumor progression by amplifying ErbB2 signaling and identify beta 4 as a potential target for molecular therapy of breast cancer...
  16. pmc Merlin/NF-2 mediates contact inhibition of growth by suppressing recruitment of Rac to the plasma membrane
    Tomoyo Okada
    Cell Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    J Cell Biol 171:361-71. 2005
    ..These results provide a framework for understanding the tumor suppressor function of Merlin and indicate that Merlin mediates contact inhibition of growth by suppressing recruitment of Rac to matrix adhesions...
  17. ncbi request reprint Integrin beta4 signaling promotes tumor angiogenesis
    Sotiris N Nikolopoulos
    Cell Biology Program, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Cancer Cell 6:471-83. 2004
    ..These results provide genetic evidence that alpha6beta4 signaling promotes the onset of the invasive phase of pathological angiogenesis and hence identify a novel target for antiangiogenic therapy...
  18. ncbi request reprint A structural view of integrin activation and signaling
    Filippo G Giancotti
    Cellular Biochemistry and Biophysics Program, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
    Dev Cell 4:149-51. 2003
    ..Integrins connect the matrix to the cytoskeleton and propagate structural order between the two systems. A series of elegant structural papers now provides a compelling explanation of how integrins perform this basic function...
  19. ncbi request reprint Integrin signalling during tumour progression
    Wenjun Guo
    Cell Biology Program, Sloan Kettering Institute for Cancer Research, Memorial Sloan Kettering Cancer Center, Weill Graduate School of Medical Sciences, Sloan Kettering Institute Cornell University, New York, New York, USA
    Nat Rev Mol Cell Biol 5:816-26. 2004
    ..The effect of these integrins might be especially important in cancer cells that have activating mutations, or amplifications, of the genes that encode these RTKs...
  20. pmc Alpha 5 beta 1 integrin activates an NF-kappa B-dependent program of gene expression important for angiogenesis and inflammation
    Sharon Klein
    Cellular Biochemistry and Biophysics Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Mol Cell Biol 22:5912-22. 2002
    ..These results suggest that engagement of the alpha 5 beta 1 integrin promotes an NF-kappa B-dependent program of gene expression that coordinately regulates angiogenesis and inflammation...
  21. ncbi request reprint The c-Jun N-terminal kinase JNK functions upstream of Aurora B to promote entry into mitosis
    Kutluk Oktay
    New York Medical College, Valhalla, NY 10595, USA
    Cell Cycle 7:533-41. 2008
    ..Inhibition of JNK delays activation of cdc-2 and prevents downregulation of Cyclin B1. We conclude that JNK signaling promotes entry into mitosis by promoting expression of Aurora B and thereby phosphorylation of Histone-H3...
  22. ncbi request reprint Analysis of integrin signaling in genetically engineered mouse models of mammary tumor progression
    Yuliya Pylayeva
    Cell Biology Program, Memorial Sloan Kettering Cancer Center, and Sloan Kettering Division, Weill Graduate School of Medical Sciences, Cornell University, New York, New York, USA
    Methods Enzymol 426:439-61. 2007
    ..In this chapter, we describe a collection of cell biological and genetic methods that may aid in characterizing the roles of integrin signals in mammary tumorigenesis...
  23. ncbi request reprint Shedding light on Merlin's wizardry
    Tomoyo Okada
    Cell Biology Program, Sloan Kettering Institute for Cancer Research, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Trends Cell Biol 17:222-9. 2007
    ..Here, we review these recent findings and their relevance to the tumor suppressor function of Merlin...
  24. ncbi request reprint Netrin-integrin signaling in epithelial morphogenesis, axon guidance and vascular patterning
    Sotiris N Nikolopoulos
    Cell Biology Program, Sloan Kettering Institute for Cancer Research, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Cell Cycle 4:e131-5. 2005
    ..Here we discuss these recent findings and propose that integrins and classical netrin receptors cooperate to regulate multiple aspects of development...
  25. ncbi request reprint Development requires activation but not phosphorylation of beta1 integrins
    Yuliya Pylayeva
    Cell Biology Program, Memorial Sloan Kettering Cancer Center, New York, New York, USA
    Genes Dev 20:1057-60. 2006
  26. pmc Targeted deletion of the integrin beta4 signaling domain suppresses laminin-5-dependent nuclear entry of mitogen-activated protein kinases and NF-kappaB, causing defects in epidermal growth and migration
    Sotiris N Nikolopoulos
    Cell Biology Program, Memorial Sloan Kettering Cancer Center, Box 216, 1275 York Avenue, New York, New York 10021, USA
    Mol Cell Biol 25:6090-102. 2005
    ..These findings provide evidence that beta4 signaling promotes epidermal growth and wound healing through a previously unrecognized effect on nuclear translocation of NF-kappaB and mitogen-activated protein kinases...

Research Grants27

  1. Integrin alpha6beta4 Signaling in Prostate Carcinoma Growth and Invasion
    Filippo Giancotti; Fiscal Year: 2006
    ..We will study the expression of alpha6beta4 during human prostate cancer progression and test the effect of beta4 signaling-inhibitory antibodies in xenograft models. ..
  2. Role of the Adaptor Protein Shc in Integrin Signaling
    Filippo Giancotti; Fiscal Year: 2006
    ..DNA microarray analysis of polysome-bound mRNAs will be employed to study the role that matrix control of mRNA translation plays in coordinating cell growth and cell division. ..
  3. Molecular Analysis of the alpha6beta4 Integrin
    Filippo Giancotti; Fiscal Year: 2007
    ..By using both cell biology and genetics, we hope to achieve a better understanding of the signaling function of this important integrin. ..
  4. Role of the Adaptor Protein Shc in Integrin Signaling
    Filippo Giancotti; Fiscal Year: 2007
    ..DNA microarray analysis of polysome-bound mRNAs will be employed to study the role that matrix control of mRNA translation plays in coordinating cell growth and cell division. ..
  5. Integrin alpha6beta4 Signaling in Prostate Carcinoma Growth and Invasion
    Filippo Giancotti; Fiscal Year: 2007
    ..We will study the expression of alpha6beta4 during human prostate cancer progression and test the effect of beta4 signaling-inhibitory antibodies in xenograft models. ..
  6. INTEGRIN SIGNALING DURING BREAST TUMORIGENESIS
    Filippo Giancotti; Fiscal Year: 2009
    ..These studies will contribute to our understanding of the pathogenesis of breast cancer and to the identification of novel molecular targets for its therapy. ..
  7. Integrin alpha6beta4 Signaling in Prostate Carcinoma Growth and Invasion
    Filippo Giancotti; Fiscal Year: 2009
    ..We will study the expression of alpha6beta4 during human prostate cancer progression and test the effect of beta4 signaling-inhibitory antibodies in xenograft models. ..
  8. INTEGRIN SIGNALING DURING BREAST TUMORIGENESIS
    Filippo G Giancotti; Fiscal Year: 2010
    ..These studies will contribute to our understanding of the pathogenesis of breast cancer and to the identification of novel molecular targets for its therapy. ..
  9. Integrin alpha6beta4 Signaling in Prostate Carcinoma Growth and Invasion
    Filippo G Giancotti; Fiscal Year: 2010
    ..We will study the expression of alpha6beta4 during human prostate cancer progression and test the effect of beta4 signaling-inhibitory antibodies in xenograft models. ..
  10. Role of the Adaptor Protein Shc in Integrin Signaling
    Filippo Giancotti; Fiscal Year: 2005
    ..DNA microarray analysis of polysome-bound mRNAs will be employed to study the role that matrix control of mRNA translation plays in coordinating cell growth and cell division. ..
  11. Role of the Adaptor Protein Shc in Integrin Signaling
    Filippo Giancotti; Fiscal Year: 2004
    ..DNA microarray analysis of polysome-bound mRNAs will be employed to study the role that matrix control of mRNA translation plays in coordinating cell growth and cell division. ..
  12. Role of the Adaptor Protein Shc in Integrin Signaling
    Filippo Giancotti; Fiscal Year: 2003
    ..DNA microarray analysis of polysome-bound mRNAs will be employed to study the role that matrix control of mRNA translation plays in coordinating cell growth and cell division. ..
  13. MOLECULAR ANALYSIS OF THE ALPHA6-BETA4 INTEGRIN
    Filippo Giancotti; Fiscal Year: 1999
    ..We hope that these studies will help to clarify the function of alpha6beta4 in normal and neoplastic cells. ..
  14. ADAPTOR PROTEIN SHC AND INTEGRIN SIGNALING
    Filippo Giancotti; Fiscal Year: 1999
    ..We hope that these studies will increase our understanding of the mechanisms by which the extracellular matrix regulates cell survival and cell proliferation. ..
  15. MOLECULAR ANALYSIS OF THE ALPHA6-BETA4 INTEGRIN
    Filippo Giancotti; Fiscal Year: 2000
    ..We hope that these studies will help to clarify the function of alpha6beta4 in normal and neoplastic cells. ..
  16. ADAPTOR PROTEIN SHC AND INTEGRIN SIGNALING
    Filippo Giancotti; Fiscal Year: 2000
    ..We hope that these studies will increase our understanding of the mechanisms by which the extracellular matrix regulates cell survival and cell proliferation. ..
  17. MOLECULAR ANALYSIS OF THE ALPHA6-BETA4 INTEGRIN
    Filippo Giancotti; Fiscal Year: 2001
    ..We hope that these studies will help to clarify the function of alpha6beta4 in normal and neoplastic cells. ..
  18. ADAPTOR PROTEIN SHC AND INTEGRIN SIGNALING
    Filippo Giancotti; Fiscal Year: 2001
    ..We hope that these studies will increase our understanding of the mechanisms by which the extracellular matrix regulates cell survival and cell proliferation. ..
  19. MOLECULAR ANALYSIS OF THE ALPHA6-BETA4 INTEGRIN
    Filippo Giancotti; Fiscal Year: 2002
    ..We hope that these studies will help to clarify the function of alpha6beta4 in normal and neoplastic cells. ..
  20. ADAPTOR PROTEIN SHC AND INTEGRIN SIGNALING
    Filippo Giancotti; Fiscal Year: 2002
    ..We hope that these studies will increase our understanding of the mechanisms by which the extracellular matrix regulates cell survival and cell proliferation. ..
  21. Mechanism of Merlin-mediated contact inhibition and tumor suppression.
    Filippo G Giancotti; Fiscal Year: 2010
    ..It is expected that a mechanistic understanding of Merlin's function will shed light on contact inhibition and on the pathogenesis of NF2 mutant tumors. ..