Research Topics
Species | Filippo GiancottiSummaryAffiliation: Memorial Sloan-Kettering Cancer Center Country: USA Publications
Research Grants
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Detail Information
Publications
Targeting integrin beta4 for cancer and anti-angiogenic therapyFilippo G Giancotti
Cell Biology Program, Sloan Kettering Institute for Cancer Research, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, Box 216, New York, NY 10021, USA
Trends Pharmacol Sci 28:506-11. 2007..Therefore, I propose that a simultaneous blockade of beta4 and receptor-tyrosine-kinase signaling represents a rational approach to cancer and anti-angiogenic therapy...
The BMP inhibitor Coco reactivates breast cancer cells at lung metastatic sitesHua Gao
Cell Biology Program, Sloan Kettering Institute for Cancer Research, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
Cell 150:764-79. 2012..These findings reveal that metastasis-initiating cells need to overcome organ-specific antimetastatic signals in order to undergo reactivation...- Integrin signaling: specificity and control of cell survival and cell cycle progressionF G Giancotti
Cellular Biochemistry and Biophysics Program, Memorial Sloan Kettering Cancer Center, Cornell University, New York, NY 10021, USA
Curr Opin Cell Biol 9:691-700. 1997..The repertoire of integrins and composition of the extracellular matrix appear to dictate whether a cell will survive, proliferate or exit the cell cycle and differentiate in response to soluble factors... - Positional control of cell fate through joint integrin/receptor protein kinase signalingFilippo G Giancotti
Cellular Biochemistry and Biophysics Program, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
Annu Rev Cell Dev Biol 19:173-206. 2003..Research on integrin signaling is beginning to explain the complex and specific effects that the extracellular matrix exerts on cells... - Integrin signalingF G Giancotti
Cellular Biochemistry and Biophysics Program, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
Science 285:1028-32. 1999..Many integrin signals converge on cell cycle regulation, directing cells to live or die, to proliferate, or to exit the cell cycle and differentiate... 
Cell cycle and adhesion defects in mice carrying a targeted deletion of the integrin beta4 cytoplasmic domainC Murgia
Cellular Biochemistry and Biophysics Program, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
EMBO J 17:3940-51. 1998....- EGF-R signaling through Fyn kinase disrupts the function of integrin alpha6beta4 at hemidesmosomes: role in epithelial cell migration and carcinoma invasionA Mariotti
Cellular Biochemistry and Biophysics Program, Department of Surgery, Sloan Kettering Institute for Cancer Research, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
J Cell Biol 155:447-58. 2001..These results suggest that disruption of hemidesmosomes mediated by Fyn is a prerequisite for normal keratinocyte migration and squamous carcinoma invasion... - A requirement for caveolin-1 and associated kinase Fyn in integrin signaling and anchorage-dependent cell growthK K Wary
Cellular Biochemistry and Biophysics Program, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
Cell 94:625-34. 1998..These findings reveal an unexpected function of caveolin-1 and Fyn in integrin signaling and anchorage-dependent cell growth... - Tyrosine phosphorylation of the beta 4 integrin cytoplasmic domain mediates Shc signaling to extracellular signal-regulated kinase and antagonizes formation of hemidesmosomesM Dans
Cellular Biochemistry and Biophysics Program, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
J Biol Chem 276:1494-502. 2001..This event is required for subsequent tyrosine phosphorylation of Shc and signaling to ERK but not formation of hemidesmosomes... - Integrin-specific activation of Rac controls progression through the G(1) phase of the cell cycleA Mettouchi
Cellular Biochemistry and Biophysics Program, Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA
Mol Cell 8:115-27. 2001..This process is mediated by SOS and PI-3K and requires coordinate upstream signals through Shc and FAK. These results indicate that Rac is a crucial mediator of the integrin-specific control of cell cycle in endothelial cells... - Merlin/NF-2 mediates contact inhibition of growth by suppressing recruitment of Rac to the plasma membraneTomoyo Okada
Cell Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
J Cell Biol 171:361-71. 2005..These results provide a framework for understanding the tumor suppressor function of Merlin and indicate that Merlin mediates contact inhibition of growth by suppressing recruitment of Rac to matrix adhesions... - Beta 4 integrin amplifies ErbB2 signaling to promote mammary tumorigenesisWenjun Guo
Cell Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10021 USA
Cell 126:489-502. 2006..These results indicate that beta 4 integrin promotes tumor progression by amplifying ErbB2 signaling and identify beta 4 as a potential target for molecular therapy of breast cancer... - Tensin relief facilitates migrationYuliya Pylayeva
Nat Cell Biol 9:877-9. 2007 - Integrin beta4 signaling promotes tumor angiogenesisSotiris N Nikolopoulos
Cell Biology Program, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
Cancer Cell 6:471-83. 2004..These results provide genetic evidence that alpha6beta4 signaling promotes the onset of the invasive phase of pathological angiogenesis and hence identify a novel target for antiangiogenic therapy... - Integrin signalling during tumour progressionWenjun Guo
Cell Biology Program, Sloan Kettering Institute for Cancer Research, Memorial Sloan Kettering Cancer Center, Weill Graduate School of Medical Sciences, Sloan Kettering Institute Cornell University, New York, New York, USA
Nat Rev Mol Cell Biol 5:816-26. 2004..The effect of these integrins might be especially important in cancer cells that have activating mutations, or amplifications, of the genes that encode these RTKs... - A structural view of integrin activation and signalingFilippo G Giancotti
Cellular Biochemistry and Biophysics Program, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
Dev Cell 4:149-51. 2003..Integrins connect the matrix to the cytoskeleton and propagate structural order between the two systems. A series of elegant structural papers now provides a compelling explanation of how integrins perform this basic function... - Defective Rac-mediated proliferation and survival after targeted mutation of the beta1 integrin cytodomainEmilio Hirsch
Dipartimento di Genetica, Biologia, e Biochimica, Universita di Torino, 10126 Torino, Italy
J Cell Biol 157:481-92. 2002..Altogether, our data provide the evidence for an epistatic interaction between the beta1 integrin cytoplasmic domain and Rac, and indicate that this anchorage-dependent signaling pathway is crucial for cell growth control... - Netrin-integrin signaling in epithelial morphogenesis, axon guidance and vascular patterningSotiris N Nikolopoulos
Cell Biology Program, Sloan Kettering Institute for Cancer Research, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
Cell Cycle 4:e131-5. 2005..Here we discuss these recent findings and propose that integrins and classical netrin receptors cooperate to regulate multiple aspects of development... - The c-Jun N-terminal kinase JNK functions upstream of Aurora B to promote entry into mitosisKutluk Oktay
New York Medical College, Valhalla, NY 10595, USA
Cell Cycle 7:533-41. 2008..Inhibition of JNK delays activation of cdc-2 and prevents downregulation of Cyclin B1. We conclude that JNK signaling promotes entry into mitosis by promoting expression of Aurora B and thereby phosphorylation of Histone-H3... - Analysis of integrin signaling in genetically engineered mouse models of mammary tumor progressionYuliya Pylayeva
Cell Biology Program, Memorial Sloan Kettering Cancer Center, and Sloan Kettering Division, Weill Graduate School of Medical Sciences, Cornell University, New York, New York, USA
Methods Enzymol 426:439-61. 2007..In this chapter, we describe a collection of cell biological and genetic methods that may aid in characterizing the roles of integrin signals in mammary tumorigenesis... - Alpha 5 beta 1 integrin activates an NF-kappa B-dependent program of gene expression important for angiogenesis and inflammationSharon Klein
Cellular Biochemistry and Biophysics Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
Mol Cell Biol 22:5912-22. 2002..These results suggest that engagement of the alpha 5 beta 1 integrin promotes an NF-kappa B-dependent program of gene expression that coordinately regulates angiogenesis and inflammation... - Shedding light on Merlin's wizardryTomoyo Okada
Cell Biology Program, Sloan Kettering Institute for Cancer Research, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
Trends Cell Biol 17:222-9. 2007..Here, we review these recent findings and their relevance to the tumor suppressor function of Merlin... - Development requires activation but not phosphorylation of beta1 integrinsYuliya Pylayeva
Cell Biology Program, Memorial Sloan-Kettering Cancer Center, New York, New York, USA
Genes Dev 20:1057-60. 2006 - Targeted deletion of the integrin beta4 signaling domain suppresses laminin-5-dependent nuclear entry of mitogen-activated protein kinases and NF-kappaB, causing defects in epidermal growth and migrationSotiris N Nikolopoulos
Cell Biology Program, Memorial Sloan Kettering Cancer Center, Box 216, 1275 York Avenue, New York, New York 10021, USA
Mol Cell Biol 25:6090-102. 2005..These findings provide evidence that beta4 signaling promotes epidermal growth and wound healing through a previously unrecognized effect on nuclear translocation of NF-kappaB and mitogen-activated protein kinases...
Research Grants
- Molecular Analysis of the alpha6beta4 IntegrinFilippo Giancotti; Fiscal Year: 2007..By using both cell biology and genetics, we hope to achieve a better understanding of the signaling function of this important integrin. ..
- Role of the Adaptor Protein Shc in Integrin SignalingFilippo Giancotti; Fiscal Year: 2007..DNA microarray analysis of polysome-bound mRNAs will be employed to study the role that matrix control of mRNA translation plays in coordinating cell growth and cell division. ..
- Integrin alpha6beta4 Signaling in Prostate Carcinoma Growth and InvasionFilippo Giancotti; Fiscal Year: 2007..We will study the expression of alpha6beta4 during human prostate cancer progression and test the effect of beta4 signaling-inhibitory antibodies in xenograft models. ..
- INTEGRIN SIGNALING DURING BREAST TUMORIGENESISFilippo Giancotti; Fiscal Year: 2009..These studies will contribute to our understanding of the pathogenesis of breast cancer and to the identification of novel molecular targets for its therapy. ..
- INTEGRIN SIGNALING DURING BREAST TUMORIGENESISFilippo G Giancotti; Fiscal Year: 2010..These studies will contribute to our understanding of the pathogenesis of breast cancer and to the identification of novel molecular targets for its therapy. ..
- Integrin alpha6beta4 Signaling in Prostate Carcinoma Growth and InvasionFilippo G Giancotti; Fiscal Year: 2010..We will study the expression of alpha6beta4 during human prostate cancer progression and test the effect of beta4 signaling-inhibitory antibodies in xenograft models. ..
- MOLECULAR ANALYSIS OF THE ALPHA6-BETA4 INTEGRINFilippo Giancotti; Fiscal Year: 2002..We hope that these studies will help to clarify the function of alpha6beta4 in normal and neoplastic cells. ..
- ADAPTOR PROTEIN SHC AND INTEGRIN SIGNALINGFilippo Giancotti; Fiscal Year: 2002..We hope that these studies will increase our understanding of the mechanisms by which the extracellular matrix regulates cell survival and cell proliferation. ..
- Mechanism of Merlin-mediated contact inhibition and tumor suppression.Filippo G Giancotti; Fiscal Year: 2010..It is expected that a mechanistic understanding of Merlin's function will shed light on contact inhibition and on the pathogenesis of NF2 mutant tumors. ..