W L Gerald

Summary

Affiliation: Memorial Sloan-Kettering Cancer Center
Country: USA

Publications

  1. pmc Identification of novel androgen receptor target genes in prostate cancer
    Unnati Jariwala
    Department of Biochemistry and Molecular Biology, Keck School of Medicine, University of Southern California, Los Angeles, USA
    Mol Cancer 6:39. 2007
  2. pmc Stat3 is tyrosine-phosphorylated through the interleukin-6/glycoprotein 130/Janus kinase pathway in breast cancer
    Marjan Berishaj
    Department of Medicine, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021 USA
    Breast Cancer Res 9:R32. 2007
  3. pmc Specific gene expression profiles and chromosomal abnormalities are associated with infant disseminated neuroblastoma
    Cinzia Lavarino
    Developmental tumour biology laboratory, Hospital Sant Joan de Deu, Fundació Sant Joan de Déu, Barcelona, Spain
    BMC Cancer 9:44. 2009
  4. ncbi request reprint The EWS-WT1 gene fusion in desmoplastic small round cell tumor
    William L Gerald
    Department of Pathology, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
    Semin Cancer Biol 15:197-205. 2005
  5. ncbi request reprint Clinical, pathologic, and molecular spectrum of tumors associated with t(11;22)(p13;q12): desmoplastic small round-cell tumor and its variants
    W L Gerald
    Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    J Clin Oncol 16:3028-36. 1998
  6. ncbi request reprint Clinically critical impact of molecular genetic studies in pediatric solid tumors
    B H Kushner
    Department of Human Genetics, Pathology, Pediatrics, and Surgery, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Med Pediatr Oncol 33:530-5. 1999
  7. ncbi request reprint Synovial sarcoma mimicking desmoplastic small round-cell tumor: critical role for molecular diagnosis
    P Cole
    Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Med Pediatr Oncol 32:97-101. 1999
  8. pmc Genetic heterogeneity and clonal evolution in neuroblastoma
    J Mora
    Departments of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, NY, USA
    Br J Cancer 85:182-9. 2001
  9. pmc Characterization of the genomic breakpoint and chimeric transcripts in the EWS-WT1 gene fusion of desmoplastic small round cell tumor
    W L Gerald
    Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY 10021
    Proc Natl Acad Sci U S A 92:1028-32. 1995
  10. ncbi request reprint High-dose induction chemoradiotherapy followed by autologous bone marrow transplantation as consolidation therapy in rhabdomyosarcoma, extraosseous Ewing's sarcoma, and undifferentiated sarcoma
    F Boulad
    Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    J Clin Oncol 16:1697-706. 1998

Research Grants

  1. MOLECULAR CLASSIFICATION OF PROSTATE CANCER
    William Gerald; Fiscal Year: 2004

Detail Information

Publications77

  1. pmc Identification of novel androgen receptor target genes in prostate cancer
    Unnati Jariwala
    Department of Biochemistry and Molecular Biology, Keck School of Medicine, University of Southern California, Los Angeles, USA
    Mol Cancer 6:39. 2007
    ..The androgen receptor (AR) plays critical roles in both androgen-dependent and castrate-resistant prostate cancer (PCa). However, little is known about AR target genes that mediate the receptor's roles in disease progression...
  2. pmc Stat3 is tyrosine-phosphorylated through the interleukin-6/glycoprotein 130/Janus kinase pathway in breast cancer
    Marjan Berishaj
    Department of Medicine, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021 USA
    Breast Cancer Res 9:R32. 2007
    ..A number of different mechanisms responsible for Stat3 activation, including abnormal activation of receptor tyrosine kinases, Src, and Janus kinases (Jaks), have been implicated in breast cancer...
  3. pmc Specific gene expression profiles and chromosomal abnormalities are associated with infant disseminated neuroblastoma
    Cinzia Lavarino
    Developmental tumour biology laboratory, Hospital Sant Joan de Deu, Fundació Sant Joan de Déu, Barcelona, Spain
    BMC Cancer 9:44. 2009
    ..The aim of this study was to investigate chromosomal alterations and differential gene expression amongst infant disseminated NB subgroups...
  4. ncbi request reprint The EWS-WT1 gene fusion in desmoplastic small round cell tumor
    William L Gerald
    Department of Pathology, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
    Semin Cancer Biol 15:197-205. 2005
    ....
  5. ncbi request reprint Clinical, pathologic, and molecular spectrum of tumors associated with t(11;22)(p13;q12): desmoplastic small round-cell tumor and its variants
    W L Gerald
    Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    J Clin Oncol 16:3028-36. 1998
    ..We reviewed 109 cases of DSRCT to further characterize this entity better...
  6. ncbi request reprint Clinically critical impact of molecular genetic studies in pediatric solid tumors
    B H Kushner
    Department of Human Genetics, Pathology, Pediatrics, and Surgery, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Med Pediatr Oncol 33:530-5. 1999
    ..We present cases depicting the importance of including molecular diagnostic studies in the routine evaluation of pediatric solid tumors...
  7. ncbi request reprint Synovial sarcoma mimicking desmoplastic small round-cell tumor: critical role for molecular diagnosis
    P Cole
    Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Med Pediatr Oncol 32:97-101. 1999
    ..One alternative involves immunologic attack against markers derived from tumor-specific chromosomal defects such as those found in our patient...
  8. pmc Genetic heterogeneity and clonal evolution in neuroblastoma
    J Mora
    Departments of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, NY, USA
    Br J Cancer 85:182-9. 2001
    ..These findings suggest that NB exhibits a high degree of clonal heterogeneity and clonal evolution occurs during the course of therapy and clinical progression...
  9. pmc Characterization of the genomic breakpoint and chimeric transcripts in the EWS-WT1 gene fusion of desmoplastic small round cell tumor
    W L Gerald
    Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY 10021
    Proc Natl Acad Sci U S A 92:1028-32. 1995
    ..The chimeric products are predicted to modulate transcription at WT1 target sites and contribute to development of this unique tumor...
  10. ncbi request reprint High-dose induction chemoradiotherapy followed by autologous bone marrow transplantation as consolidation therapy in rhabdomyosarcoma, extraosseous Ewing's sarcoma, and undifferentiated sarcoma
    F Boulad
    Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    J Clin Oncol 16:1697-706. 1998
    ..Consolidation was with intensive chemotherapy and autologous bone marrow transplantation (ABMT)...
  11. ncbi request reprint Disaloganglioside GD2 loss following monoclonal antibody therapy is rare in neuroblastoma
    K Kramer
    Department of Pediatrics, Memorial Sloan-Kettering Cancer Center, New York, New York 10021, USA
    Med Pediatr Oncol 36:194-6. 2001
    ..CONCLUSIONS: The persistence of GD2 expression in refractory or recurrent NB suggests that complete antigen loss is an uncommon event and cannot account for treatment failure...
  12. pmc Phosphorylation of the androgen receptor by PIM1 in hormone refractory prostate cancer
    S Ha
    Department of Urology, New York University School of Medicine, New York, NY 10016, USA
    Oncogene 32:3992-4000. 2013
    ..Thus, AR phosphorylation by PIM1 at S213 impacts gene transcription and is highly prevalent in aggressive prostate cancer...
  13. pmc Molecular diagnosis of synovial sarcoma and characterization of a variant SYT-SSX2 fusion transcript
    I Fligman
    Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Am J Pathol 147:1592-9. 1995
    ..Thus, a diagnosis of SS may be confirmed in > 90% of cases using RT-PCR detection of the chimeric transcript resulting from the t(X;18), and the incidence of molecular variants appears low...
  14. ncbi request reprint Molecular genetics of neuroblastoma and the implications for clinical management: a review of the MSKCC experience
    J Mora
    Department of Pathology, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
    Oncologist 6:263-8. 2001
    ....
  15. pmc Comprehensive analysis of the 9p21 region in neuroblastoma suggests a role for genes mapping to 9p21-23 in the biology of favourable stage 4 tumours
    J Mora
    Department of Molecular Pathology, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Br J Cancer 91:1112-8. 2004
    ..The only well-characterised transcript among them was nuclear factor I-B3. Our results suggest a role for genes located telomeric of 9p21 in good risk NB...
  16. ncbi request reprint Neuroblastic and Schwannian stromal cells of neuroblastoma are derived from a tumoral progenitor cell
    J Mora
    Department of Pediatrics, Memorial Sloan-Kettering Cancer Center, New York, New York 10021, USA
    Cancer Res 61:6892-8. 2001
    ....
  17. ncbi request reprint Identifying site-specific metastasis genes and functions
    G P Gupta
    Cancer Biology and Genetics Program and Howard Hughes Medical Institute, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Cold Spring Harb Symp Quant Biol 70:149-58. 2005
    ..These findings improve our understanding of metastatic progression, facilitate the interpretation of primary tumor gene expression data, and open several important possibilities for future clinical application...
  18. ncbi request reprint An estrogen receptor-negative breast cancer subset characterized by a hormonally regulated transcriptional program and response to androgen
    A S Doane
    Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Oncogene 25:3994-4008. 2006
    ..This subset of BCs, characterized by a hormonally regulated transcriptional program and response to androgen, suggests the potential for therapeutic strategies targeting the androgen signaling pathway...
  19. ncbi request reprint Biological behavior of human breast cancer micrometastases
    N Klauber-DeMore
    Department of Surgery, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
    Clin Cancer Res 7:2434-9. 2001
    ..7%; P = not significant). CONCLUSIONS: Human breast cancer micrometastases have lower tumor proliferation rates and angiogenesis than breast cancer macrometastases. These characteristics may explain their differential growth patterns...
  20. ncbi request reprint Expression of TERT in early premalignant lesions and a subset of cells in normal tissues
    K A Kolquist
    Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Nat Genet 19:182-6. 1998
    ....
  21. ncbi request reprint A103: An anti-melan-a monoclonal antibody for the detection of malignant melanoma in paraffin-embedded tissues
    A A Jungbluth
    Ludwig Institute for Cancer Research, New York Branch, Memorial Sloan Kettering Cancer Center, New York 10021, USA
    Am J Surg Pathol 22:595-602. 1998
    ..This A103 immunoreactivity in benign and neoplastic tissues of nonmelanocytic origin, the basis of which is unclear, could also be of potential diagnostic value...
  22. doi request reprint Epidermal growth factor receptor activation in prostate cancer by three novel missense mutations
    C Q Cai
    Department of Pathology, New York University School of Medicine, New York, NY 10010, USA
    Oncogene 27:3201-10. 2008
    ..Molecules that regulate the mechanisms of their oncogenic activation represent novel targets for limiting tumor cell progression, and further elucidation of these mutations will have utility in prostate cancer treatment...
  23. pmc A gene expression signature predicts survival of patients with stage I non-small cell lung cancer
    Yan Lu
    Department of Surgery, Washington University School of Medicine, St Louis, Missouri, United States of America
    PLoS Med 3:e467. 2006
    ..As a consequence, it is not possible to select those high-risk patients for more aggressive therapies and assign less aggressive treatments to patients at low risk for recurrence...
  24. pmc Genes that mediate breast cancer metastasis to lung
    Andy J Minn
    Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Nature 436:518-24. 2005
    ..Others contribute to aggressive growth selectively in the lung. Many encode extracellular proteins and are of previously unknown relevance to cancer metastasis...
  25. ncbi request reprint Reassessment of id1 protein expression in human mammary, prostate, and bladder cancers using a monospecific rabbit monoclonal anti-id1 antibody
    Jonathan Perk
    Cancer Biology and Genetics Program and Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York, USA
    Cancer Res 66:10870-7. 2006
    ..These results suggest that further refinement of Id1 expression patterns in a variety of tumor types will be necessary to identify and study the functional roles played by Id1 in human neoplastic processes...
  26. ncbi request reprint Clinical presentation, treatment, and outcome of alveolar soft part sarcoma in children, adolescents, and young adults
    Mark L Kayton
    Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    J Pediatr Surg 41:187-93. 2006
    ..There are few reported series of these patients in the literature. To define the clinical presentation, treatment, and outcome of young people with this rare sarcoma, we reviewed our clinical experience...
  27. ncbi request reprint The RET oncogene is a critical component of transcriptional programs associated with retinoic acid-induced differentiation in neuroblastoma
    Orit Oppenheimer
    Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Mol Cancer Ther 6:1300-9. 2007
    ..The core set of RA-regulated genes includes critical molecular components of pathways necessary for neuroblastic tumor differentiation and have potential as therapeutic targets and molecular markers of response to differentiating agents...
  28. ncbi request reprint Differential expression of alpha-methylacyl-coenzyme A racemase in colorectal carcinoma bears clinical and pathologic significance
    Anne Lin
    Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Hum Pathol 38:850-6. 2007
    ..Further investigation on interaction between AMACR and other known colorectal cancer development pathways may provide new insights on colorectal carcinogenesis...
  29. ncbi request reprint The 2006 Fred Waldorf Stewart Award recipient Juan Rosai, MD
    David S Klimstra
    Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Am J Surg Pathol 31:649-51. 2007
  30. pmc Association of cysteine-rich secretory protein 3 and beta-microseminoprotein with outcome after radical prostatectomy
    Anders S Bjartell
    Departments of Surgery Urology, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Clin Cancer Res 13:4130-8. 2007
    ..We investigated whether these markers are related to biochemical recurrence and whether addition of the markers improves prediction of recurring disease...
  31. pmc Gene expression-based survival prediction in lung adenocarcinoma: a multi-site, blinded validation study
    Kerby Shedden
    Department of Statistics, 1085 South University, University of Michigan, Ann Arbor, Michigan 48109, USA
    Nat Med 14:822-7. 2008
    ..This study also provides the largest available set of microarray data with extensive pathological and clinical annotation for lung adenocarcinomas...
  32. pmc KLF6-SV1 overexpression accelerates human and mouse prostate cancer progression and metastasis
    Goutham Narla
    Department of Genetics and Genomic Sciences, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Clin Invest 118:2711-21. 2008
    ..Together, these findings demonstrate that KLF6-SV1 expression levels in PCa tumors at the time of diagnosis can predict the metastatic behavior of the tumor; thus, KLF-SV1 may represent a novel therapeutic target...
  33. pmc The role of SPINK1 in ETS rearrangement-negative prostate cancers
    Scott A Tomlins
    Michigan Center for Translational Pathology, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    Cancer Cell 13:519-28. 2008
    ..We identified the aggressive 22RV1 cell line as a SPINK1 outlier expression model and demonstrate that SPINK1 knockdown in 22RV1 attenuates invasion, suggesting a functional role in ETS rearrangement-negative prostate cancers...
  34. pmc TGFbeta primes breast tumors for lung metastasis seeding through angiopoietin-like 4
    David Padua
    Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Cell 133:66-77. 2008
    ....
  35. doi request reprint Lung adenocarcinoma: modification of the 2004 WHO mixed subtype to include the major histologic subtype suggests correlations between papillary and micropapillary adenocarcinoma subtypes, EGFR mutations and gene expression analysis
    Noriko Motoi
    Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Am J Surg Pathol 32:810-27. 2008
    ..Such an approach should be considered in future studies for validation in other datasets...
  36. doi request reprint Activator protein-1 transcription factors are associated with progression and recurrence of prostate cancer
    Xuesong Ouyang
    Center for Advanced Biotechnology and Medicine, University of Medicine and Dentistry, New Jersey Robert Wood Johnson Medical School, Piscataway, New Jersey, USA
    Cancer Res 68:2132-44. 2008
    ..This study provides a striking example of how accurate mouse models can provide insights on molecular processes involved in progression and recurrence of human cancer...
  37. ncbi request reprint EMP3, a myelin-related gene located in the critical 19q13.3 region, is epigenetically silenced and exhibits features of a candidate tumor suppressor in glioma and neuroblastoma
    Miguel Alaminos
    Cancer Epigenetics Laboratory, Molecular Pathology Programme, Spanish National Cancer Centre, Madrid, Spain
    Cancer Res 65:2565-71. 2005
    ..03) and death of disease (Kendall tau, P = 0.03; r = 0.19). Thus, EMP3 is a good candidate for being the long-sought tumor suppressor gene located at 19q13 in gliomas and neuroblastomas...
  38. pmc Endogenous human microRNAs that suppress breast cancer metastasis
    Sohail F Tavazoie
    Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Nature 451:147-52. 2008
    ..miR-335 and miR-126 are thus identified as metastasis suppressor microRNAs in human breast cancer...
  39. pmc Mutations in the EGFR kinase domain mediate STAT3 activation via IL-6 production in human lung adenocarcinomas
    Sizhi Paul Gao
    Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    J Clin Invest 117:3846-56. 2007
    ..Therefore, mutant EGFR could activate the gp130/JAK/STAT3 pathway by means of IL-6 upregulation in primary human lung adenocarcinomas, making this pathway a potential target for cancer treatment...
  40. ncbi request reprint Phase I study of targeted radioimmunotherapy for leptomeningeal cancers using intra-Ommaya 131-I-3F8
    Kim Kramer
    Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    J Clin Oncol 25:5465-70. 2007
    ..We tested the toxicity, pharmacokinetics, and dosimetry of intraventricular iodine-131-labeled monoclonal antibody 3F8 (131I-3F8) targeting GD2-positive CNS/LM disease in a phase I clinical trial...
  41. ncbi request reprint Control of androgen receptor signaling in prostate cancer by the cochaperone small glutamine rich tetratricopeptide repeat containing protein alpha
    Grant Buchanan
    Dame Roma Mitchell Cancer Research Laboratories, School of Medicine, The University of Adelaide Hanson Institute, Adelaide, South Australia, Australia
    Cancer Res 67:10087-96. 2007
    ..These findings implicate alphaSGT as a molecular rheostat of in vivo signaling competence by the AR, and provide new insight into the determinants of androgen sensitivity during prostate cancer progression...
  42. pmc Oncogenic cooperation and coamplification of developmental transcription factor genes in lung cancer
    Jude Kendall
    Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA
    Proc Natl Acad Sci U S A 104:16663-8. 2007
    ....
  43. ncbi request reprint Prognostic value of MYCN and ID2 overexpression in neuroblastoma
    Miguel Alaminos
    Department of Pathology, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, New York 10021, USA
    Pediatr Blood Cancer 45:909-15. 2005
    ..The molecular mechanisms driven by overexpression of the MYCN gene in neuroblastoma are not well known. Whether MYCN overexpression in the absence of genomic amplification, or ID2 overexpression has prognostic value remains controversial...
  44. pmc Temporally regulated neural crest transcription factors distinguish neuroectodermal tumors of varying malignancy and differentiation
    Timothy R Gershon
    Department of Neurology, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
    Neoplasia 7:575-84. 2005
    ..These findings suggest that PAX3, PAX7, AP-2alpha, and SOX10 are potential markers of prognosis and targets for therapeutic intervention...
  45. pmc Gene expression profiling predicts clinical outcome of prostate cancer
    Gennadi V Glinsky
    Sidney Kimmel Cancer Center, San Diego, California 92121, USA
    J Clin Invest 113:913-23. 2004
    ....
  46. pmc Gene expression analysis of human prostate carcinoma during hormonal therapy identifies androgen-responsive genes and mechanisms of therapy resistance
    Jeff Holzbeierlein
    Department of Urology, Genitourinary Oncology Service, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Am J Pathol 164:217-27. 2004
    ..The specific pathways of reactivation provide opportunities for classification of resistant tumors and targeted therapies...
  47. ncbi request reprint Value of histopathology in predicting microsatellite instability in hereditary nonpolyposis colorectal cancer and sporadic colorectal cancer
    Jinru Shia
    Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY 10002, USA
    Am J Surg Pathol 27:1407-17. 2003
    ..Using a stepwise logistic regression model, a formula was generated that could be used to calculate the probability of a colorectal carcinoma being MSI-H based on morphologic features...
  48. ncbi request reprint Genome-wide gene expression analysis of prostate carcinoma
    William L Gerald
    Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Semin Oncol 30:635-48. 2003
    ..It is clear that these novel technologies and approaches provide many opportunities for biologists and clinicians; however, there are many challenges in moving these discoveries forward...
  49. ncbi request reprint Genome-wide analysis of gene expression associated with MYCN in human neuroblastoma
    Miguel Alaminos
    Department of Pathology, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
    Cancer Res 63:4538-46. 2003
    ....
  50. ncbi request reprint Evolving significance of prognostic markers associated with new treatment strategies in neuroblastoma
    Jaume Mora
    Department of Oncology, Hospital Sant Joan de Deu de Barcelona, Passeig de Sant Joan de Deu num 2, Barcelona 08950, Spain
    Cancer Lett 197:119-24. 2003
    ..Distinct gene expression patterns between metastatic and non-metastatic NB tumors have been identified. Validation of these results and further mechanistic studies may shed new light on the biology of metastasis in human NB...
  51. ncbi request reprint Induction of BAIAP3 by the EWS-WT1 chimeric fusion implicates regulated exocytosis in tumorigenesis
    Rachel E Palmer
    Massachusetts General Hospital Cancer Center and Harvard Medical School, Charlestown, MA 02129, USA
    Cancer Cell 2:497-505. 2002
    ..BAIAP3 therefore encodes a transcriptional target of an oncogenic fusion protein that implicates the regulated exocytotic pathway in cancer cell proliferation...
  52. ncbi request reprint Evolving significance of prognostic markers associated with treatment improvement in patients with stage 4 neuroblastoma
    Jaume Mora
    Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York, USA
    Cancer 94:2756-65. 2002
    ....
  53. ncbi request reprint Comprehensive gene expression analysis of prostate cancer reveals distinct transcriptional programs associated with metastatic disease
    Eva Latulippe
    Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Cancer Res 62:4499-506. 2002
    ..These differentially expressed genes reflect critical cellular activities that contribute to clinical heterogeneity and provide diagnostic and therapeutic targets...
  54. ncbi request reprint Induction of the interleukin-2/15 receptor beta-chain by the EWS-WT1 translocation product
    Jenise C Wong
    Massachusetts General Hospital Cancer Center and Harvard Medical School, Charlestown, Massachusetts, MA 02129, USA
    Oncogene 21:2009-19. 2002
    ..These observations suggest that the transcriptional induction of a cytokine receptor by a tumor-associated translocation product enables a proliferative response of epithelial cancer cells to ligands secreted by the surrounding stroma...
  55. ncbi request reprint Origin of neuroblastic tumors: clues for future therapeutics
    Jaume Mora
    Department of Oncology, Hospital Sant Joan de Deu de Barcelona, Passeig de Sant Joan de Deu num 2, 08950 Barcelona, Spain
    Expert Rev Mol Diagn 4:293-302. 2004
    ..In order to identify the cellular origin of these tumors, the embryology of the sympathetic nervous system is first reviewed and any archeological rests of normal development in the tumors are then discussed...
  56. ncbi request reprint Utilization of bone marrow-derived endothelial cell precursors in spontaneous prostate tumors varies with tumor grade
    Haiqing Li
    Program of Cell Biology and Genetics, Weill Graduate School of Medical Sciences, Cornell University Medical College, New York, New York 10021, USA
    Cancer Res 64:6137-43. 2004
    ....
  57. ncbi request reprint Relationship of gene expression and chromosomal abnormalities in colorectal cancer
    Dafna Tsafrir
    Department of Physics of Complex Systems, Weizmann Institute of Science, Rehovot, Israel
    Cancer Res 66:2129-37. 2006
    ....
  58. ncbi request reprint Value of immunohistochemical detection of DNA mismatch repair proteins in predicting germline mutation in hereditary colorectal neoplasms
    Jinru Shia
    Department of Pathology, Memorial Sloan Kettering, Cancer Center, New York, NY 10021, USA
    Am J Surg Pathol 29:96-104. 2005
    ....
  59. pmc Distinct organ-specific metastatic potential of individual breast cancer cells and primary tumors
    Andy J Minn
    Cancer Biology and Genetics Program, Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    J Clin Invest 115:44-55. 2005
    ..These results suggest that the bone-specific metastatic phenotypes and gene expression signature identified in a mouse model may be clinically relevant...
  60. ncbi request reprint Positional gene expression analysis identifies 12q overexpression and amplification in a subset of neuroblastomas
    Wendy T Su
    Department of Surgery, Division of Pediatric Surgery, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Cancer Genet Cytogenet 154:131-7. 2004
    ..The expressed genes mapped closely to the complex amplicon reported in sarcomas, and they identify critical genes and pathways affected by 12q gene amplification...
  61. ncbi request reprint Interlaboratory comparability study of cancer gene expression analysis using oligonucleotide microarrays
    Kevin K Dobbin
    Cancer Diagnosis Program, National Cancer Institute NIH, Bethesda, MD 20894, USA
    Clin Cancer Res 11:565-72. 2005
    ..The findings indicate that under properly controlled conditions it is feasible to perform complete tumor microarray analysis, from tissue processing to hybridization and scanning, at multiple independent laboratories for a single study...
  62. ncbi request reprint EGFR gene amplification in breast cancer: correlation with epidermal growth factor receptor mRNA and protein expression and HER-2 status and absence of EGFR-activating mutations
    Rohit Bhargava
    Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Mod Pathol 18:1027-33. 2005
    ..Approximately 6% of breast carcinomas show EGFR amplification with EGFR protein overexpression and may be candidates for trials of EGFR-targeted antibodies or small inhibitory molecules...
  63. pmc Integration of gene expression profiling and clinical variables to predict prostate carcinoma recurrence after radical prostatectomy
    Andrew J Stephenson
    Department of Urology, Sidney Kimmel Center for Prostate and Urologic Cancers, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Cancer 104:290-8. 2005
    ..Gene expression profiling of prostate carcinoma offers an alternative means to distinguish aggressive tumor biology and may improve the accuracy of outcome prediction for patients with prostate carcinoma treated by radical prostatectomy...
  64. pmc Targeting AKT/mTOR and ERK MAPK signaling inhibits hormone-refractory prostate cancer in a preclinical mouse model
    Carolyn Waugh Kinkade
    Department of Urology, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    J Clin Invest 118:3051-64. 2008
    ..We therefore propose that combination therapy targeting AKT/mTOR and ERK MAPK signaling pathways may be an effective treatment for patients with advanced prostate cancer, in particular those with hormone-refractory disease...
  65. ncbi request reprint High expression of the Met receptor in prostate cancer metastasis to bone
    Beatrice S Knudsen
    Department ofPathology, Weill Medical College of Cornell University, New York, New York, USA
    Urology 60:1113-7. 2002
    ....
  66. ncbi request reprint Desmoplastic small cell tumor in the pancreas
    Tarek A Bismar
    Department of Pathology, Harper University Hospital, Wayne State University, Detroit, MI 48201, USA
    Am J Surg Pathol 28:808-12. 2004
    ..This case is also another demonstrative example of how DSCT may form a dominant mass in intraabdominal organs...
  67. ncbi request reprint Genomic medicine and neuroblastoma
    Orit Oppenheimer
    Departments of Pathology and Pediatrics, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Expert Rev Mol Diagn 3:39-54. 2003
    ..The goal of this review is to provide an overview of the disease and highlight diagnostic, prognostic and therapeutic advances in neuroblastoma. Recommendations and resources for the evaluation and treatment of this disease are outlined...
  68. ncbi request reprint Comparison of normal and tumor cells by laser capture microdissection
    Jaume Mora
    Department of Hematology and Oncology, Hospital Sant Joan de Deu de Barcelona, Barcelona, Spain
    Methods Enzymol 356:240-7. 2002
  69. ncbi request reprint Novel mutations of epidermal growth factor receptor in localized prostate cancer
    Diah A Douglas
    Department of Urology, New York University School of Medicine, New York, NY 10016, USA
    Front Biosci 11:2518-25. 2006
    ..Larger population-based studies are required to define the association between EGFR mutations and the ethnic background of patients...
  70. pmc Identification of a DNA-binding site and transcriptional target for the EWS-WT1(+KTS) oncoprotein
    Paul A Reynolds
    Massachusetts General Hospital Cancer Center and Harvard Medical School, Charlestown, MA 02129, USA
    Genes Dev 17:2094-107. 2003
    ..Together, these observations define the consequence of (KTS) insertion within WT1-derived zinc fingers, and identify a novel EWS-WT1 transcriptional target implicated in tumor invasiveness...
  71. pmc ID genes mediate tumor reinitiation during breast cancer lung metastasis
    Gaorav P Gupta
    Cancer Biology and Genetics Program, Molecular Cytology Core Facility, Human Oncology and Pathogenesis Program, Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 104:19506-11. 2007
    ..These results shed light on the proliferative mechanisms that initiate metastatic colonization, and they implicate Id1 and Id3 as mediators of this malignant function in the TN subgroup of breast cancers...
  72. pmc Combinatorial activities of Akt and B-Raf/Erk signaling in a mouse model of androgen-independent prostate cancer
    Hui Gao
    Center for Advanced Biotechnology and Medicine, Cancer Institute of New Jersey, and Department of Medicine, University of Medicine and Dentistry of New Jersey Robert Wood Johnson Medical School, 679 Hoes Lane, Piscataway, NJ 08854, USA
    Proc Natl Acad Sci U S A 103:14477-82. 2006
    ..We propose that androgen independence emerges by means of epithelial-stromal competition, in which activation of Akt and Erk promotes AR activity in the prostate epithelium while counteracting antagonistic effects of the stroma...
  73. pmc Breast cancer bone metastasis mediated by the Smad tumor suppressor pathway
    Yibin Kang
    Cancer Biology and Genetics Program and Howard Hughes Medical Institute, Molecular Cytology Laboratory, Memorial Sloan Kettering Cancer Center, NY 10021, USA
    Proc Natl Acad Sci U S A 102:13909-14. 2005
    ..Our findings provide functional evidence for a switch of the Smad pathway, from tumor-suppressor to prometastatic, in the development of breast cancer bone metastasis...
  74. ncbi request reprint Comprehensive analysis of tumoral DNA content reveals clonal ploidy heterogeneity as a marker with prognostic significance in locoregional neuroblastoma
    Jaume Mora
    Developmental Tumor Biology Laboratory, Hospital Sant Joan de Deu, Barcelona, Spain
    Genes Chromosomes Cancer 46:385-96. 2007
    ..02; progression-free survival, P = 0.01). These results provide strong evidence for clonal ploidy heterogeneity in LR NB and clonal evolution toward diploidy in progressing LR NB...
  75. ncbi request reprint Novel regions of allelic imbalance identified by genome-wide analysis of neuroblastoma
    Jaume Mora
    Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Cancer Res 62:1761-7. 2002
    ..Spontaneously remitting or quiescent tumors were intact at all of the regions described above...
  76. pmc Requirement of matrix metalloproteinase-9 for the transformation of human mammary epithelial cells by Stat3-C
    Tobias N Dechow
    Laboratory of Molecular Cell Biology, The Rockefeller University, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 101:10602-7. 2004
    ..These results demonstrate a relationship between activated Stat3 and MMP-9 in breast oncogenesis...
  77. ncbi request reprint Clustering of gene hypermethylation associated with clinical risk groups in neuroblastoma
    Miguel Alaminos
    Cancer Epigenetics Laboratory, Spanish National Cancer Centre CNIO, Melchor Fernandez Almagro 3, 28029 Madrid, Spain
    J Natl Cancer Inst 96:1208-19. 2004
    ..Transcriptional silencing of tumor suppressor genes mediated by hypermethylation of promoter CpG islands is a hallmark of human tumors. We addressed the clinical relevance of promoter hypermethylation in neuroblastoma...

Research Grants1

  1. MOLECULAR CLASSIFICATION OF PROSTATE CANCER
    William Gerald; Fiscal Year: 2004
    ..abstract_text> ..