Yuman Fong

Summary

Affiliation: Memorial Sloan-Kettering Cancer Center
Country: USA

Publications

  1. ncbi Preoperative Y-90 microsphere selective internal radiation treatment for tumor downsizing and future liver remnant recruitment: a novel approach to improving the safety of major hepatic resections
    Seza A Gulec
    Center for Cancer Care at Goshen Health System, Goshen, IN, USA
    World J Surg Oncol 7:6. 2009
  2. ncbi Insertion of the human sodium iodide symporter to facilitate deep tissue imaging does not alter oncolytic or replication capability of a novel vaccinia virus
    Dana Haddad
    Department of Biochemistry, University of Wuerzburg, Wuerzburg D 97074, Germany
    J Transl Med 9:36. 2011
  3. ncbi Genome wide analysis and clinical correlation of chromosomal and transcriptional mutations in cancers of the biliary tract
    George Miller
    Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    J Exp Clin Cancer Res 28:62. 2009
  4. ncbi Editorial on "Simultaneous resections of colorectal cancer and synchronous liver metastases: a multi-institutional analysis"
    Charlotte Ariyan
    Ann Surg Oncol 14:3295-6. 2007
  5. ncbi Evolution in surgery: influence of minimally invasive approaches on the hepatobiliary surgeon
    Yuman Fong
    Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA
    Surg Infect (Larchmt) 10:399-406. 2009
  6. ncbi Liver resection for colorectal metastases
    Y Fong
    Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    J Clin Oncol 15:938-46. 1997
  7. ncbi Evidence-based gallbladder cancer staging: changing cancer staging by analysis of data from the National Cancer Database
    Yuman Fong
    Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Ann Surg 243:767-71; discussion 771-4. 2006
  8. ncbi Gallbladder cancer: comparison of patients presenting initially for definitive operation with those presenting after prior noncurative intervention
    Y Fong
    Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Ann Surg 232:557-69. 2000
  9. ncbi Long-term survival is superior after resection for cancer in high-volume centers
    Yuman Fong
    Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Ann Surg 242:540-4; discussion 544-7. 2005
  10. ncbi Operative blood loss independently predicts recurrence and survival after resection of hepatocellular carcinoma
    Steven C Katz
    Hepatopancreatobiliary Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA
    Ann Surg 249:617-23. 2009

Research Grants

  1. CLINICAL AND BIOLOGICAL BASIS OF 18F-FDG PET IN CANCER
    Yuman Fong; Fiscal Year: 2001
  2. LIVER REGENERATION IN MAN--EFFECTS ON ADJUVANT THERAPY
    Yuman Fong; Fiscal Year: 1999
  3. Liver Regeneration in Man--Effects or Adjuvant Therapy
    Yuman Fong; Fiscal Year: 2005

Detail Information

Publications176 found, 100 shown here

  1. ncbi Preoperative Y-90 microsphere selective internal radiation treatment for tumor downsizing and future liver remnant recruitment: a novel approach to improving the safety of major hepatic resections
    Seza A Gulec
    Center for Cancer Care at Goshen Health System, Goshen, IN, USA
    World J Surg Oncol 7:6. 2009
    ..An intervention that would both accomplish tumor control and induce compensatory hypertrophy, with good patient tolerability, could improve clinical outcomes...
  2. ncbi Insertion of the human sodium iodide symporter to facilitate deep tissue imaging does not alter oncolytic or replication capability of a novel vaccinia virus
    Dana Haddad
    Department of Biochemistry, University of Wuerzburg, Wuerzburg D 97074, Germany
    J Transl Med 9:36. 2011
    ..This study aimed to determine if insertion of the human sodium iodide symporter (hNIS) cDNA as a marker for non-invasive imaging of virotherapy alters the replication and oncolytic capability of a novel vaccinia virus, GLV-1h153...
  3. ncbi Genome wide analysis and clinical correlation of chromosomal and transcriptional mutations in cancers of the biliary tract
    George Miller
    Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    J Exp Clin Cancer Res 28:62. 2009
    ..The pathogenesis of biliary cancers is ill-defined. This study investigates changes in gene expression and copy number in biliary cancers and correlates these changes with anatomical site of origin, histopathology and outcome...
  4. ncbi Editorial on "Simultaneous resections of colorectal cancer and synchronous liver metastases: a multi-institutional analysis"
    Charlotte Ariyan
    Ann Surg Oncol 14:3295-6. 2007
  5. ncbi Evolution in surgery: influence of minimally invasive approaches on the hepatobiliary surgeon
    Yuman Fong
    Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA
    Surg Infect (Larchmt) 10:399-406. 2009
    ..Those who understand, anticipate, and plan for these changes will have the greatest impact on future care of patients and education of the next generation of scholars...
  6. ncbi Liver resection for colorectal metastases
    Y Fong
    Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    J Clin Oncol 15:938-46. 1997
    ..The current study was performed to determine if liver resection for colorectal metastases is safe and effective and to evaluate predictors of outcome...
  7. ncbi Evidence-based gallbladder cancer staging: changing cancer staging by analysis of data from the National Cancer Database
    Yuman Fong
    Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Ann Surg 243:767-71; discussion 771-4. 2006
    ..Most notably, T2N0M0 tumors were moved from stage II to stage IB; T3N1M0 disease was moved from stage III to stage IIB; and T4NxM0 (x = any) tumors were moved from stage IVA to stage III...
  8. ncbi Gallbladder cancer: comparison of patients presenting initially for definitive operation with those presenting after prior noncurative intervention
    Y Fong
    Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Ann Surg 232:557-69. 2000
    ..To compare patients with gallbladder cancer presenting for therapy with and without prior operation elsewhere to determine if an initial noncurative procedure alters outcome...
  9. ncbi Long-term survival is superior after resection for cancer in high-volume centers
    Yuman Fong
    Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Ann Surg 242:540-4; discussion 544-7. 2005
    ..Whether long-term results after resection of visceral malignancies are superior at high-volume centers is largely unknown...
  10. ncbi Operative blood loss independently predicts recurrence and survival after resection of hepatocellular carcinoma
    Steven C Katz
    Hepatopancreatobiliary Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA
    Ann Surg 249:617-23. 2009
    ..To determine if the degree of blood loss during resection of hepatocellular carcinoma (HCC) is predictive of recurrence and long-term survival...
  11. ncbi Preoperative chemotherapy and the risk of hepatotoxicity and morbidity after liver resection for metastatic colorectal cancer: a single institution experience
    Patrick S Wolf
    Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    J Am Coll Surg 216:41-9. 2013
    ..This study investigates the effect of preoperative chemotherapy for CRCLM on nontumoral liver histology and perioperative outcomes in a contemporary cohort...
  12. ncbi Biliary sclerosis after hepatic arterial infusion pump chemotherapy for patients with colorectal cancer liver metastasis: incidence, clinical features, and risk factors
    Kaori Ito
    Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA
    Ann Surg Oncol 19:1609-17. 2012
    ..The most clinically important adverse event after HAIPC with floxuridine (FUDR) is biliary sclerosis (BS). Little is known about the etiology of BS...
  13. ncbi Perihepatic lymph node assessment in patients undergoing partial hepatectomy for malignancy
    Stephen R Grobmyer
    Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Ann Surg 244:260-4. 2006
    ..Routine sampling of perihepatic lymph nodes will therefore have a low yield in patients without some evidence of disease on preoperative CT or PET scans or at the time of exploration...
  14. ncbi Radiation-induced cellular DNA damage repair response enhances viral gene therapy efficacy in the treatment of malignant pleural mesothelioma
    Prasad S Adusumilli
    Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Ann Surg Oncol 14:258-69. 2007
    ..Such stress response is beneficial for oncolytic viral therapy. We hypothesized that a combination of RT and NV1066, an oncolytic herpes virus, might exert an additive or synergistic effect in the treatment of MPM...
  15. ncbi Accurate staging for gallbladder cancer: implications for surgical therapy and pathological assessment
    Hiromichi Ito
    Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Ann Surg 254:320-5. 2011
    ..This study evaluates the significance of tumor involvement of the liver in early T-stage tumors and lymph node (LN) metastases on outcome after R0 resection of gallbladder cancer (GBCA)...
  16. ncbi Imaging and therapy of malignant pleural mesothelioma using replication-competent herpes simplex viruses
    Prasad S Adusumilli
    Department of Surgery, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
    J Gene Med 8:603-15. 2006
    ..CONCLUSION: These findings support the continued investigation of oncolytic HSV as potential therapy for patients with therapy-resistant MPM...
  17. ncbi Real-time diagnostic imaging of tumors and metastases by use of a replication-competent herpes vector to facilitate minimally invasive oncological surgery
    Prasad S Adusumilli
    Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, New York 10021, USA
    FASEB J 20:726-8. 2006
    ..These studies form the basis for real-time, intraoperative diagnostic imaging of tumor and metastases by minimally invasive endoscopic technology...
  18. ncbi Imaging of dihydrofolate reductase fusion gene expression in xenografts of human liver metastases of colorectal cancer in living rats
    Philipp Mayer-Kuckuk
    Molecular Pharmacology and Therapeutics Program, Memorial Sloan-Kettering Cancer Center, New York, NY, USA
    Eur J Nucl Med Mol Imaging 30:1281-91. 2003
    ..It is concluded that the two examined nucleotide imaging methods are feasible techniques for monitoring of DHFR-HSV TK fusion protein expression in hepatic colorectal tumor tissue in living animals...
  19. ncbi Oncolytic vaccinia therapy of squamous cell carcinoma
    Zhenkun Yu
    Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA
    Mol Cancer 8:45. 2009
    ..We examined the therapeutic effects of an attenuated, replication-competent vaccinia virus (GLV-1h68) as an oncolytic agent against a panel of six human head and neck SCC cell lines...
  20. ncbi Intrahepatic cholangiocarcinoma: rising frequency, improved survival, and determinants of outcome after resection
    Itaru Endo
    Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Ann Surg 248:84-96. 2008
    ..This study analyzes changes in IHC frequency, demographics, and treatment outcome in a consecutive and single institutional cohort...
  21. ncbi Adequate lymph node assessment for extrahepatic bile duct adenocarcinoma
    Kaori Ito
    Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    Ann Surg 251:675-81. 2010
    ..To examine the importance of adequate lymph node sampling in staging of extrahepatic bile duct cancer (EHBDCA)...
  22. ncbi Particle embolization of recurrent hepatocellular carcinoma after hepatectomy
    Anne M Covey
    Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Cancer 106:2181-9. 2006
    ..The purpose of the current study was to review the authors' experience using bland hepatic arterial embolization to treat recurrent HCC after definitive surgical resection...
  23. ncbi Differential cell cycle-regulatory protein expression in biliary tract adenocarcinoma: correlation with anatomic site, pathologic variables, and clinical outcome
    William R Jarnagin
    Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    J Clin Oncol 24:1152-60. 2006
    ..This clinicopathologic study characterizes differences in cell cycle-regulatory protein expression across the spectrum of BTA...
  24. ncbi Use of positron emission tomography to target prostate cancer gene therapy by oncolytic herpes simplex virus
    Michael Mullerad
    Department of Urology, Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA
    Mol Imaging Biol 8:30-5. 2006
    ..002). This proof-of-concept study provides the mechanistic basis for selecting patients for targeted oncolytic viral therapy by means of a noninvasive molecular imaging method in the treatment of prostate cancer...
  25. ncbi CT-guided radiofrequency ablation as a salvage treatment of colorectal cancer hepatic metastases developing after hepatectomy
    Constantinos T Sofocleous
    Department of Interventional Radiology, Memorial Sloan Kettering Cancer Center, 1275 York Ave, New York, NY 10065, USA
    J Vasc Interv Radiol 22:755-61. 2011
    ..To evaluate the clinical outcomes of percutaneous radiofrequency (RF) ablation of colorectal cancer liver metastases (CLMs) that recur after hepatectomy...
  26. ncbi Imaging a Genetically Engineered Oncolytic Vaccinia Virus (GLV-1h99) Using a Human Norepinephrine Transporter Reporter Gene
    Peter Brader
    Departments of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York, USA
    Clin Cancer Res 15:3791-801. 2009
    ....
  27. ncbi Real-time intraoperative detection of breast cancer axillary lymph node metastases using a green fluorescent protein-expressing herpes virus
    David P Eisenberg
    Department of Surgery, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
    Ann Surg 243:824-30; discussion 830-2. 2006
    ..CONCLUSIONS: We introduce a novel, sensitive, and specific method of lymphatic mapping that utilizes NV1066-guided cancer cell-specific viral production of GFP to enable real-time intraoperative detection of lymphatic metastases...
  28. ncbi Comparison of adjuvant systemic chemotherapy with or without hepatic arterial infusional chemotherapy after hepatic resection for metastatic colorectal cancer
    Michael G House
    Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    Ann Surg 254:851-6. 2011
    ..The principle aim of this study was to compare outcomes in patients receiving modern systemic chemotherapy with or without HAI-FUDR...
  29. ncbi Real-time intraoperative detection of melanoma lymph node metastases using recombinant vaccinia virus GLV-1h68 in an immunocompetent animal model
    Kaitlyn J Kelly
    Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    Int J Cancer 124:911-8. 2009
    ..This assay is rapid, sensitive, specific and easy to perform and interpret. As a candidate gene therapy virus for killing cancer, GLV-1h68 may also have significant concomitant diagnostic utility in the staging of cancer patients...
  30. ncbi A novel genetically modified oncolytic vaccinia virus in experimental models is effective against a wide range of human cancers
    Dana Haddad
    Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA
    Ann Surg Oncol 19:S665-74. 2012
    ....
  31. ncbi Intraductal papillary neoplasm of the bile duct: a biliary equivalent to intraductal papillary mucinous neoplasm of the pancreas?
    Flavio G Rocha
    Hepatopancreatobiliary Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    Hepatology 56:1352-60. 2012
    ..Given their significant risk of harboring invasive carcinoma, they should be treated with complete resection...
  32. ncbi Resection of adrenocortical carcinoma liver metastasis: is it justified?
    Sebastien Gaujoux
    Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA
    Ann Surg Oncol 19:2643-51. 2012
    ..Adrenocortical carcinoma (ACC) liver metastases (LM) represent a therapeutic challenge, and it is unclear whether resection is justified. This study assesses long-term outcome and prognostic factors after liver resection for metastatic ACC...
  33. ncbi The Blumgart preoperative staging system for hilar cholangiocarcinoma: analysis of resectability and outcomes in 380 patients
    Kenichi Matsuo
    Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    J Am Coll Surg 215:343-55. 2012
    ..Complete resection of hilar cholangiocarcinoma (HCCA) is a critical determinant of long-term survival. This study validates a previously reported preoperative clinical T staging system for determining resectability of HCCA...
  34. ncbi Rt-PCR increases detection of submicroscopic peritoneal metastases in gastric cancer and has prognostic significance
    Joyce Wong
    Department of Surgery, Memorial Sloan Kettering Cancer Center, 275 York Avenue, New York, NY 10021, USA
    J Gastrointest Surg 16:889-96; discussion 896. 2012
    ..Conventional cytology examination, however, has low sensitivity. We hypothesize that real-time polymerase chain reaction (RT-PCR) may have increased sensitivity and provide more accurate staging information...
  35. ncbi Oncolytic vaccinia virotherapy of anaplastic thyroid cancer in vivo
    Shu Fu Lin
    Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    J Clin Endocrinol Metab 93:4403-7. 2008
    ..Anaplastic thyroid carcinoma (ATC) is a fatal disease with a median survival of only 6 months. Novel therapies are needed to improve dismal outcomes...
  36. ncbi Novel oncolytic agent GLV-1h68 is effective against malignant pleural mesothelioma
    Kaitlyn J Kelly
    Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    Hum Gene Ther 19:774-82. 2008
    ..GLV-1h68 was successfully used to treat MPM in vitro and in an orthotopic model (in vivo). These promising results warrant clinical investigation of GLV-1h68 as a novel agent in the treatment of MPM...
  37. ncbi 18F-FDG PET scanning correlates with tissue markers of poor prognosis and predicts mortality for patients after liver resection for colorectal metastases
    Christopher C Riedl
    Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    J Nucl Med 48:771-5. 2007
    ..The aim of the current study was to determine whether this biologic scan would correlate with other cellular characteristics and the clinical behavior of tumors...
  38. ncbi Synergy of a herpes oncolytic virus and paclitaxel for anaplastic thyroid cancer
    Shu Fu Lin
    Department of Surgery and Medicine, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Clin Cancer Res 14:1519-28. 2008
    ..We studied the application of oncolytic herpes simplex virus (G207 and NV1023) in combination with currently used chemotherapeutic drugs (paclitaxel and doxorubicin) for the treatment of ATC...
  39. ncbi 18F-fluorodeoxyglucose positron emission tomography influences management decisions in patients with biliary cancer
    Carlos U Corvera
    Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    J Am Coll Surg 206:57-65. 2008
    ..The role of PET in detecting disease recurrence after resection was also examined...
  40. ncbi Survival after hepatic resection for metastatic colorectal cancer: trends in outcomes for 1,600 patients during two decades at a single institution
    Michael G House
    Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA
    J Am Coll Surg 210:744-52, 752-5. 2010
    ..This study analyzes factors associated with differences in long-term outcomes after hepatic resection for metastatic colorectal cancer over time...
  41. ncbi Sensitivity of squamous cell carcinoma lymph node metastases to herpes oncolytic therapy
    Zhenkun Yu
    Head and Neck Service and Gastric, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Clin Cancer Res 14:1897-904. 2008
    ..We compared the efficacy of an attenuated oncolytic HSV-1 (NV1023) in treating a series of murine squamous carcinoma cell lines derived from serial implantation and harvest from metastatic lymph nodes. EXPERIMENTAL DESIGN and..
  42. ncbi Caudate hepatectomy for cancer: a single institution experience with 150 patients
    William G Hawkins
    Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA
    J Am Coll Surg 200:345-52. 2005
    ..Although caudate resection of the liver can be performed safely, concomitant major vascular reconstruction substantially increases the mortality of the procedure...
  43. ncbi Tumor hypoxia imaging in orthotopic liver tumors and peritoneal metastasis: a comparative study featuring dynamic 18F-MISO and 124I-IAZG PET in the same study cohort
    Christopher C Riedl
    Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Eur J Nucl Med Mol Imaging 35:39-46. 2008
    ....
  44. ncbi Phase I trial of systemic oxaliplatin combination chemotherapy with hepatic arterial infusion in patients with unresectable liver metastases from colorectal cancer
    Nancy Kemeny
    Gastrointestinal Oncology Service, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    J Clin Oncol 23:4888-96. 2005
    ..To determine the maximum-tolerated dose (MTD) of concurrent systemic oxaliplatin (Oxal) combinations plus hepatic arterial infusion (HAI) in patients with unresectable hepatic metastases from colorectal cancer...
  45. ncbi Invasive carcinoma arising in intraductal papillary mucinous neoplasms of the pancreas: a matched control study with conventional pancreatic ductal adenocarcinoma
    Adam C Yopp
    Division of Surgical Oncology, Department of Surgery, University of Texas Southwestern Medical Center, Dallas, TX, USA
    Ann Surg 253:968-74. 2011
    ....
  46. ncbi Clinical significance of intraoperative bile duct margin assessment for hilar cholangiocarcinoma
    Itaru Endo
    Department of Surgery, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA
    Ann Surg Oncol 15:2104-12. 2008
    ..Frozen section analysis of bile duct margins is often used to guide the extent of surgical resection for hilar cholangiocarcinoma (HCCA), but the usefulness of this practice is unknown...
  47. ncbi Radiation therapy potentiates effective oncolytic viral therapy in the treatment of lung cancer
    Prasad S Adusumilli
    Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, New York 10021, USA
    Ann Thorac Surg 80:409-16; discussion 416-7. 2005
    ....
  48. ncbi Combined portal vein embolization and neoadjuvant chemotherapy as a treatment strategy for resectable hepatic colorectal metastases
    Anne M Covey
    Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    Ann Surg 247:451-5. 2008
    ....
  49. ncbi Intraoperative localization of lymph node metastases with a replication-competent herpes simplex virus
    Prasad S Adusumilli
    Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, NY, USA
    J Thorac Cardiovasc Surg 132:1179-88. 2006
    ..Fluorescent filters that detect green fluorescent protein can be incorporated into operative scopes to precisely localize and biopsy lymph node metastases...
  50. ncbi Outcome after hepatectomy for multiple (four or more) colorectal metastases in the era of effective chemotherapy
    Peter Kornprat
    Department of Surgery, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, New York 10021, USA
    Ann Surg Oncol 14:1151-60. 2007
    ..Despite an unknown benefit, hepatic resection is playing an increasing role in patients with extensive disease...
  51. ncbi Lack of evidence for increased operative morbidity after hepatectomy with perioperative use of bevacizumab: a matched case-control study
    Michael D'Angelica
    Department of Surgery, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, New York 10021, USA
    Ann Surg Oncol 14:759-65. 2007
    ..Perioperative bev is now commonly used in patients undergoing hepatic resection. Little is known, however, about the safety of perioperative bev use in the setting of hepatic resection...
  52. ncbi Treatment of anaplastic thyroid carcinoma in vitro with a mutant vaccinia virus
    Shu Fu Lin
    Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Surgery 142:976-83; discussion 976-83. 2007
    ..Anaplastic thyroid carcinoma (ATC) is a fatal disease resistant to all conventional treatments. Novel therapies are needed to improve dismal outcomes...
  53. ncbi Cisplatin-induced GADD34 upregulation potentiates oncolytic viral therapy in the treatment of malignant pleural mesothelioma
    Prasad S Adusumilli
    Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, New York 10021, USA
    Cancer Biol Ther 5:48-53. 2006
    ..5-deficient oncolytic virus, NV1066. This provides a cellular basis for combination therapy with cisplatin and NV1066 to treat MPM and achieve synergistic efficacy, while minimizing dosage and toxicity...
  54. ncbi Detection of micrometastases in peritoneal washings of gastric cancer patients by the reverse transcriptase polymerase chain reaction
    Kimberly Moore Dalal
    Department of Surgery, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York NY, 10021, USA
    Gastric Cancer 11:206-13. 2008
    ..We studied the ability of quantitative reverse transcriptase polymerase chain reaction (RT-PCR) to detect peritoneal micrometastases in patients undergoing staging laparoscopy...
  55. ncbi Antiangiogenic therapy for primary liver cancer: correlation of changes in dynamic contrast-enhanced magnetic resonance imaging with tissue hypoxia markers and clinical response
    Adam C Yopp
    Department of Surgery, Division of Surgical Oncology, University of Texas Southwestern Medical Center, Dallas, TX, USA
    Ann Surg Oncol 18:2192-9. 2011
    ....
  56. ncbi An analysis of the utility of handheld PET probes for the intraoperative localization of malignant tissue
    Segundo Jaime Gonzalez
    Department of Surgery, Memorial Sloan Kettering Cancer Center, 1275 York Ave, New York, NY 10065, USA
    J Gastrointest Surg 15:358-66. 2011
    ..To solve this, two novel probes have been created to accurately detect the (18)F-FDG radiotracer intraoperatively...
  57. ncbi Nectin-1 expression by squamous cell carcinoma is a predictor of herpes oncolytic sensitivity
    Zhenkun Yu
    Head and Neck Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York, USA
    Mol Ther 15:103-13. 2007
    ..These results suggest that nectin-1 may be used as a marker to predict the sensitivity of a tumor to herpes oncolytic therapy...
  58. ncbi Detection of free peritoneal cancer cells in gastric cancer using cancer-specific Newcastle disease virus
    Joyce Wong
    Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    J Gastrointest Surg 14:7-14. 2010
    ..We evaluated a novel detection technique using Newcastle disease virus expressing the enhanced green fluorescent protein (NDV-GFP) gene...
  59. ncbi Utility of a herpes oncolytic virus for the detection of neural invasion by cancer
    Ziv Gil
    Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Neoplasia 10:347-53. 2008
    ..This method may improve the diagnosis and treatment of patients with neurotrophic cancers by reducing injury to normal nerves and facilitating identification of infiltrated nerves requiring resection...
  60. ncbi Estrogen enhances the efficacy of an oncolytic HSV-1 mutant in the treatment of estrogen receptor-positive breast cancer
    Brendon M Stiles
    Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA
    Int J Oncol 28:1429-39. 2006
    ..These data provide the mechanistic basis for the use of oncolytic HSV-1 in patients with hormone receptor-positive breast cancer, particularly if the disease progresses with conventional therapies...
  61. ncbi 5-fluorouracil and gemcitabine potentiate the efficacy of oncolytic herpes viral gene therapy in the treatment of pancreatic cancer
    David P Eisenberg
    Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York 10021, USA
    J Gastrointest Surg 9:1068-77; discussion 1077-9. 2005
    ..These data provide the cellular basis for the clinical investigation of combined oncolytic herpes virus therapy and chemotherapy in the treatment of pancreatic cancer...
  62. ncbi Liver angiomyolipomas: a clinical, radiologic, and pathologic analysis of 22 patients from a single center
    Jean M Butte
    Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA
    Surgery 150:557-67. 2011
    ..The spectrum of presentation, imaging and histologic features, and outcomes were analyzed in all patients treated at Memorial Sloan-Kettering Cancer Center...
  63. ncbi Effect of postoperative morbidity on long-term survival after hepatic resection for metastatic colorectal cancer
    Hiromichi Ito
    Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York, USA
    Ann Surg 247:994-1002. 2008
    ..The objective of this study was to evaluate the impact of postoperative morbidity on the long-term outcome after liver resection for MCRC...
  64. ncbi Conversion to resectability using hepatic artery infusion plus systemic chemotherapy for the treatment of unresectable liver metastases from colorectal carcinoma
    Nancy E Kemeny
    Memorial Sloan Kettering Cancer Center, Weill Medical College of Cornell University, 1275 York Ave, New York, NY 10065, USA
    J Clin Oncol 27:3465-71. 2009
    ..Future randomized trials should compare HAI plus systemic chemotherapy with systemic therapy alone to assess the additional value of HAI therapy in converting patients with hepatic metastases to resectability...
  65. ncbi CXCR4 expression predicts patient outcome and recurrence patterns after hepatic resection for colorectal liver metastases
    Adam C Yopp
    Department of Surgery, Division of Surgical Oncology, University of Texas Southwestern Medical Center, Dallas, TX, USA
    Ann Surg Oncol 19:S339-46. 2012
    ....
  66. ncbi Operative procedures for unresectable pancreatic cancer: does operative bypass decrease requirements for postoperative procedures and in-hospital days?
    John M Lyons
    Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    HPB (Oxford) 14:469-75. 2012
    ..The optimal surgical management of patients found to have unresectable pancreatic cancer at open exploration remains unknown...
  67. ncbi Improving the clinical risk score: an analysis of molecular biomarkers in the era of modern chemotherapy for resectable hepatic colorectal cancer metastases
    Shishir K Maithel
    Department of Surgery, Division of Surgical Oncology, Emory University, Atlanta, GA 10065, USA
    Surgery 151:162-70. 2012
    ..The prognostic relevance of variations in expression of specific tumor genes in colorectal cancer liver metastases (CRCLMs) in patients treated with resection and modern chemotherapy is not known...
  68. ncbi Up-regulation of GADD34 mediates the synergistic anticancer activity of mitomycin C and a gamma134.5 deleted oncolytic herpes virus (G207)
    Joseph J Bennett
    Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, New York 10021, USA
    FASEB J 18:1001-3. 2004
    ..5 HSV mutants in the treatment of cancer...
  69. ncbi The role of laparoscopic staging in patients with incidental gallbladder cancer
    Jean M Butte
    Departments of Surgery Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY, USA
    HPB (Oxford) 13:463-72. 2011
    ..The role of staging laparoscopy (SL) in patients with incidental gallbladder cancer (IGBC) is ill defined. This study evaluates the utility of SL with the aim of identifying variables associated with disseminated disease (DD)...
  70. ncbi Increased use of parenchymal-sparing surgery for bilateral liver metastases from colorectal cancer is associated with improved mortality without change in oncologic outcome: trends in treatment over time in 440 patients
    Jason S Gold
    Department of Surgery, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
    Ann Surg 247:109-17. 2008
    ..We aimed to assess the evolution of the technical approach over time and correlations with morbidity, mortality, and oncologic outcome...
  71. ncbi Transcatheter arterial embolization with only particles for the treatment of unresectable hepatocellular carcinoma
    Mary A Maluccio
    Department of Surgery, Indiana University, Bloomington, Indiana, USA
    J Vasc Interv Radiol 19:862-9. 2008
    ....
  72. ncbi Simple measurement of intra-abdominal fat for abdominal surgery outcome prediction
    Katherine Morris
    Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    Arch Surg 145:1069-73. 2010
    ..To assess the effect of increasing body mass index, intra-abdominal fat, and outer abdominal fat on outcome in patients undergoing major hepatectomy...
  73. ncbi Current utility of staging laparoscopy for pancreatic and peripancreatic neoplasms
    Rebekah White
    Department of Surgical Oncology, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    J Am Coll Surg 206:445-50. 2008
    ..The routine use of staging laparoscopy in patients with radiographically resectable pancreatic and peripancreatic neoplasms remains controversial...
  74. ncbi Use of an oncolytic virus secreting GM-CSF as combined oncolytic and immunotherapy for treatment of colorectal and hepatic adenocarcinomas
    Sandeep Malhotra
    Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA
    Surgery 141:520-9. 2007
    ..The purpose of this study was to compare NV1034 to NV1023, the parent HSV mutants lacking GM-CSF, to determine if such combined oncolytic and immunotherapy using a single vector has advantages over oncolytic therapy alone...
  75. ncbi Gallbladder cancer: differences in presentation, surgical treatment, and survival in patients treated at centers in three countries
    Jean M Butte
    Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    J Am Coll Surg 212:50-61. 2011
    ..This study analyzed GBCA patients treated at centers in 3 countries. The aim was to assess for location-specific differences in presentation and outcomes, which might suggest differences in pathogenesis or disease biology...
  76. ncbi Escherichia coli Nissle 1917 facilitates tumor detection by positron emission tomography and optical imaging
    Peter Brader
    Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Clin Cancer Res 14:2295-302. 2008
    ..Imaging bacteria specifically targeting and replicating within tumors using radiotracer techniques and optical imaging can provide confirmation of successful colonization of malignant tissue...
  77. ncbi A matched case-control study of preoperative biliary drainage in patients with pancreatic adenocarcinoma: routine drainage is not justified
    James J Mezhir
    Department of Surgery, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA
    J Gastrointest Surg 13:2163-9. 2009
    ..Preoperative biliary drainage (PBD) prior to pancreaticoduodenectomy (PD) continues to be routine in many centers despite retrospective and randomized data showing that PBD increases perioperative infectious complications...
  78. ncbi Prognostic impact of RT-PCR-based detection of peritoneal micrometastases in patients with pancreatic cancer undergoing curative resection
    Kaitlyn J Kelly
    Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA
    Ann Surg Oncol 16:3333-9. 2009
    ..The purpose of the current study was to determine the outcome RT-PCR positive/cytology-negative patients who underwent potentially curative resection...
  79. ncbi Virally directed fluorescent imaging improves diagnostic sensitivity in the detection of minimal residual disease after potentially curative cytoreductive surgery
    Prasad S Adusumilli
    Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York 10021, USA
    J Gastrointest Surg 9:1138-46; discussion 1146-7. 2005
    ..Virally directed fluorescent imaging, a novel molecular imaging technology, can be used for real-time visualization of minimal residual disease after cytoreductive surgery and can improve the completeness of cure-intended resection...
  80. ncbi Utilizing alpha-fetoprotein expression to enhance oncolytic viral therapy in hepatocellular carcinoma
    Richard H Pin
    Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, New York, USA
    Ann Surg 240:659-65; discussion 665-6. 2004
    ..0001). CONCLUSIONS: AFP-driven RR production by hepatoma cells significantly enhances herpes viral cytotoxicity and specificity in vitro and reduces tumor burden in vivo...
  81. ncbi Assessing the optimal duration of chemotherapy in patients with colorectal liver metastases
    Rebekah R White
    Department of Surgical Oncology, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    J Surg Oncol 97:601-4. 2008
    ..The purpose of this retrospective analysis was to evaluate time to maximal response in patients receiving systemic +/- hepatic arterial infusion (HAI) chemotherapy alone for the treatment of CLM...
  82. ncbi Extent of hepatic resection does not correlate with toxicity following adjuvant chemotherapy
    Waldemar F Carlo
    Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, New York 10021, USA
    J Surg Oncol 87:85-90. 2004
    ..79). CONCLUSIONS: A greater loss of healthy liver following resection of hepatic metastases from colorectal cancer does not seem to predispose to the development of toxicity from adjuvant HAI and systemic chemotherapy...
  83. ncbi Predictors and patterns of recurrence after resection of hepatocellular carcinoma
    Charles Cha
    Hepatobiliary Service, Memorial Sloan-Kettering Cancer Center, New York, NY, USA
    J Am Coll Surg 197:753-8. 2003
    ..The current study underscores the need for effective adjuvant therapy for patients with HCC treated with partial hepatectomy...
  84. ncbi Pathologic complete response to neoadjuvant FOLFOX in combination with bevacizumab in unresectable metastatic colorectal carcinoma
    Austin Duffy
    Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Clin Colorectal Cancer 7:140-3. 2008
    ..He underwent hepatic metastasectomy and was found to have had a complete pathologic response (pCR) to treatment. The literature regarding pCR with chemotherapy in CRC and the implications for further management is discussed herein...
  85. ncbi Phase I/II study of hepatic arterial therapy with floxuridine and dexamethasone in combination with intravenous irinotecan as adjuvant treatment after resection of hepatic metastases from colorectal cancer
    N Kemeny
    Memorial Sloan-Kettering Cancer Center, 1275 York Ave, New York, NY 10021, USA
    J Clin Oncol 21:3303-9. 2003
    ..This regimen seems to have comparable activity to fluorouracil and leucovorin, but further studies are needed to assess whether it improves local control or decreases extrahepatic recurrences...
  86. ncbi Selective use of diagnostic laparoscopy prior to planned hepatectomy for patients with hepatocellular carcinoma
    Jurgen Weitz
    Hepatobiliary Service and Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Surgery 135:273-81. 2004
    ..Laparoscopy may reduce the rate of unnecessary laparotomy in these patients. However, there are no criteria for selective use of laparoscopy...
  87. ncbi Diabetes is associated with increased perioperative mortality but equivalent long-term outcome after hepatic resection for colorectal cancer
    Sarah A Little
    Department of Surgery, Hepatobiliary Service, Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA
    J Gastrointest Surg 6:88-94. 2002
    ..We conclude that the presence of diabetes is associated with a higher incidence of perioperative mortality. In patients with diabetes mellitus and parenchymal steatosis, major hepatic resection should be undertaken with caution...
  88. ncbi Interleukin 12 secretion enhances antitumor efficacy of oncolytic herpes simplex viral therapy for colorectal cancer
    J J Bennett
    Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, New York 10021, USA
    Ann Surg 233:819-26. 2001
    ..The combination of oncolytic viral therapy and immunomodulatory strategies should be further investigated as treatment for colon cancer...
  89. ncbi Combination vascular delivery of herpes simplex oncolytic viruses and amplicon mediated cytokine gene transfer is effective therapy for experimental liver cancer
    J S Zager
    Department of Surgery, Hepatobiliary Division, Memorial Sloan-Kettering Cancer Center, New York, New York 10021, USA
    Mol Med 7:561-8. 2001
    ..CONCLUSIONS: Vascular regional delivery of oncolytic and amplicon HSV vectors can be used to induce improved anti-tumor efficacy by combining oncolytic and immunostimulatory strategies...
  90. ncbi Recent advancements in diagnosis and treatment of metastatic colorectal cancer to the liver
    Katherine T Morris
    Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, NY, USA
    Surg Oncol 15:129-34. 2006
  91. ncbi Second liver resections are safe and effective treatment for recurrent hepatic metastases from colorectal cancer: a bi-institutional analysis
    Henrik Petrowsky
    Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, New York 10021, USA
    Ann Surg 235:863-71. 2002
    ..Patients with a low tumor load are the best candidates for a repeat resection. In well-selected patients, further resection of the liver can provide prolonged survival after recurrence of colorectal liver metastases...
  92. ncbi Role of intraoperative thermoablation combined with resection in the treatment of hepatic metastasis from colorectal cancer
    Peter Kornprat
    Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Arch Surg 142:1087-92. 2007
    ..Thermoablation, either cryosurgical ablation (CSA) or radiofrequency ablation (RFA), combined with resection is effective in the treatment of extensive bilobar colorectal metastasis...
  93. ncbi Volumetric analysis predicts hepatic dysfunction in patients undergoing major liver resection
    Margo Shoup
    Departments of Surgery, Memorial Sloan-Kettering Cancer Center, New York, NY, USA
    J Gastrointest Surg 7:325-30. 2003
    ..Preoperative assessment of future liver volume remaining distinguishes which patients undergoing liver resection will most likely benefit from preoperative liver enhancement techniques such as portal vein embolization...
  94. ncbi Rates and patterns of recurrence for percutaneous radiofrequency ablation and open wedge resection for solitary colorectal liver metastasis
    R R White
    Department of Surgical Oncology, Memorial Sloan Kettering Cancer Center, New York, NY, USA
    J Gastrointest Surg 11:256-63. 2007
    ..The purpose of this study was to compare rates and patterns of disease progression following percutaneous, image-guided radiofrequency ablation (RFA) and nonanatomic wedge resection for solitary colorectal liver metastases...
  95. ncbi Gallbladder cancer (GBC): 10-year experience at Memorial Sloan-Kettering Cancer Centre (MSKCC)
    A Duffy
    Department of Medicine, Memorial Sloan Kettering Cancer Center MSKCC, New York, NY 10021, USA
    J Surg Oncol 98:485-9. 2008
    ..The incidence of gallbladder cancer (GBC) in the US is 1.2/100,000. This report examines the patterns of presentation, adjuvant treatment and survival of a large cohort of patients with GBC evaluated at MSKCC over a 10-year period...
  96. ncbi Intrahepatic cholangiocarcinoma: resectability, recurrence pattern, and outcomes
    S M Weber
    Hepatobiliary Service, Memorial Sloan-Kettering Cancer Center, New York, NY, USA
    J Am Coll Surg 193:384-91. 2001
    ..Although complete resection improved survival, recurrence was common. The majority of recurrences were local or regional, which may help guide future adjuvant therapy strategies...
  97. ncbi Phase I study of hepatic arterial infusion of floxuridine and dexamethasone with systemic irinotecan for unresectable hepatic metastases from colorectal cancer
    N Kemeny
    Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA
    J Clin Oncol 19:2687-95. 2001
    ..Although the main objective of this study was to evaluate the toxicity of the combined regimen, a high response rate (74%) was observed...
  98. ncbi Kinetics of liver volume changes in the first year after portal vein embolization
    Danton Corrêa
    Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    Arch Surg 145:351-4; discussion 354-5. 2010
    ..To determine the time course of liver hypertrophy after portal vein embolization (PVE)...
  99. ncbi T cell infiltrate predicts long-term survival following resection of colorectal cancer liver metastases
    Steven C Katz
    Hepatopancreatobiliary Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA
    Ann Surg Oncol 16:2524-30. 2009
    ..This study examines the correlation between TIL numbers and survival following hepatic resection...
  100. ncbi Response to neoadjuvant chemotherapy does not predict overall survival for patients with synchronous colorectal hepatic metastases
    David J Gallagher
    Department of Medicine, Gastrointestinal Oncology Service, Division of Solid Tumor Oncology, Memorial Sloan Kettering Cancer Center and Joan and Sanford Weill Medical College of Cornell University, New York, NY, USA
    Ann Surg Oncol 16:1844-51. 2009
    ..We investigated the relation between response to neoadjuvant chemotherapy and overall survival (OS) in patients with colorectal liver metastases (CLM)...
  101. ncbi Prognostic indicators of malignancy in adrenal pheochromocytomas: clinical, histopathologic, and cell cycle/apoptosis gene expression analysis
    Vivian E Strong
    Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Surgery 143:759-68. 2008
    ..Pheochromocytomas are malignant in approximately 10% of patients. The histologic differentiation between benign and malignant tumors is difficult, the latter diagnosed by the presence of metastatic disease or recurrence...

Research Grants10

  1. CLINICAL AND BIOLOGICAL BASIS OF 18F-FDG PET IN CANCER
    Yuman Fong; Fiscal Year: 2001
    ..abstract_text> ..
  2. LIVER REGENERATION IN MAN--EFFECTS ON ADJUVANT THERAPY
    Yuman Fong; Fiscal Year: 1999
    ....
  3. Liver Regeneration in Man--Effects or Adjuvant Therapy
    Yuman Fong; Fiscal Year: 2005
    ....