James Eastham

Summary

Affiliation: Memorial Sloan-Kettering Cancer Center
Country: USA

Publications

  1. pmc Validation study of a web-based assessment of functional recovery after radical prostatectomy
    Andrew J Vickers
    Department of Epidemiology and Biostatistics, Health Outcomes Group Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA
    Health Qual Life Outcomes 8:82. 2010
  2. pmc Feasibility study of a clinically-integrated randomized trial of modifications to radical prostatectomy
    Andrew J Vickers
    Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY 11215, USA
    Trials 13:23. 2012
  3. pmc Prostate-specific antigen at or before age 50 as a predictor of advanced prostate cancer diagnosed up to 25 years later: a case-control study
    David Ulmert
    Departments of Laboratory Medicine and Clinical Sciences in Malmö, Lund University, University Hospital UMAS, Malmo, Sweden
    BMC Med 6:6. 2008
  4. ncbi request reprint Bone health in men receiving androgen deprivation therapy for prostate cancer
    James A Eastham
    Department of Urology, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    J Urol 177:17-24. 2007
  5. doi request reprint Predicting an optimal outcome after radical prostatectomy: the trifecta nomogram
    James A Eastham
    Division of Urology, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    J Urol 179:2207-10; discussion 2210-1. 2008
  6. ncbi request reprint Surgery Insight: optimizing open nerve-sparing radical prostatectomy techniques for improved outcomes
    James A Eastham
    Division of Urology, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Nat Clin Pract Urol 4:561-9. 2007
  7. doi request reprint Do high-volume hospitals and surgeons provide better care in urologic oncology?
    James A Eastham
    Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Urol Oncol 27:417-21. 2009
  8. doi request reprint Trends in radical prostatectomy
    James Eastham
    Department of Urology, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA
    Int J Urol 16:151-60. 2009
  9. ncbi request reprint Prognostic significance of location of positive margins in radical prostatectomy specimens
    James A Eastham
    Department of Urology, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Urology 70:965-9. 2007
  10. ncbi request reprint Active surveillance for prostate cancer with selective delayed definitive therapy
    James A Eastham
    Department of Urology, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Clin Prostate Cancer 4:45-9. 2005

Detail Information

Publications99

  1. pmc Validation study of a web-based assessment of functional recovery after radical prostatectomy
    Andrew J Vickers
    Department of Epidemiology and Biostatistics, Health Outcomes Group Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA
    Health Qual Life Outcomes 8:82. 2010
    ..Logistical problems associated with using paper questionnaire limit their use in the clinic. We have implemented a web-interface ("STAR") for patient-reported outcomes after radical prostatectomy...
  2. pmc Feasibility study of a clinically-integrated randomized trial of modifications to radical prostatectomy
    Andrew J Vickers
    Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY 11215, USA
    Trials 13:23. 2012
    ..We aimed to determine the feasibility of implementing such a trial for radical prostatectomy...
  3. pmc Prostate-specific antigen at or before age 50 as a predictor of advanced prostate cancer diagnosed up to 25 years later: a case-control study
    David Ulmert
    Departments of Laboratory Medicine and Clinical Sciences in Malmö, Lund University, University Hospital UMAS, Malmo, Sweden
    BMC Med 6:6. 2008
    ..We aimed to determine whether this association holds for advanced cancers, defined as clinical stage T3 or higher, or skeletal metastasis at the time of the cancer diagnosis...
  4. ncbi request reprint Bone health in men receiving androgen deprivation therapy for prostate cancer
    James A Eastham
    Department of Urology, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    J Urol 177:17-24. 2007
    ..We explored androgen deprivation therapy related bone loss in prostate cancer, current treatments and emerging therapies...
  5. doi request reprint Predicting an optimal outcome after radical prostatectomy: the trifecta nomogram
    James A Eastham
    Division of Urology, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    J Urol 179:2207-10; discussion 2210-1. 2008
    ..We evaluated our series of open radical prostatectomy cases to determine the likelihood of this outcome and develop a nomogram predicting the trifecta...
  6. ncbi request reprint Surgery Insight: optimizing open nerve-sparing radical prostatectomy techniques for improved outcomes
    James A Eastham
    Division of Urology, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Nat Clin Pract Urol 4:561-9. 2007
    ..Here the role of surgical techniques in determining oncologic and quality of life outcomes after RP, focusing on open RP, are presented...
  7. doi request reprint Do high-volume hospitals and surgeons provide better care in urologic oncology?
    James A Eastham
    Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Urol Oncol 27:417-21. 2009
    ..This review highlights data indicating that high-volume surgeons and hospitals provide better care for radical prostatectomy...
  8. doi request reprint Trends in radical prostatectomy
    James Eastham
    Department of Urology, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA
    Int J Urol 16:151-60. 2009
    ..Here we will examine recent trends in radical prostatectomy, focusing on surgical technique...
  9. ncbi request reprint Prognostic significance of location of positive margins in radical prostatectomy specimens
    James A Eastham
    Department of Urology, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Urology 70:965-9. 2007
    ..In this study, we assessed the prognostic significance of sites of positive surgical margins (+SMs) in RP specimens...
  10. ncbi request reprint Active surveillance for prostate cancer with selective delayed definitive therapy
    James A Eastham
    Department of Urology, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Clin Prostate Cancer 4:45-9. 2005
    ..This review summarizes our current understanding of active surveillance with selective delayed definitive therapy...
  11. ncbi request reprint Multimodal treatment strategies combining neoadjuvant hormonal therapy and/or chemotherapy with radical prostatectomy in high-risk localised prostate cancer
    James A Eastham
    Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Expert Opin Investig Drugs 13:39-46. 2004
    ..These studies will help examine the role of multimodal treatment strategies in these high-risk patients...
  12. ncbi request reprint Prostate-specific antigen doubling time as a prognostic marker in prostate cancer
    James A Eastham
    Department of Urology at Memorial Sloan Kettering Cancer Center, New York, NY, USA
    Nat Clin Pract Urol 2:482-91. 2005
    ..PSA doubling time can also be used as a surrogate marker for prostate cancer-specific death. This review summarizes current knowledge regarding the role of PSA doubling time as a prognostic marker in men with prostate cancer...
  13. ncbi request reprint Variations among individual surgeons in the rate of positive surgical margins in radical prostatectomy specimens
    James A Eastham
    Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    J Urol 170:2292-5. 2003
    ..We examined variations in the rate of positive surgical margins among surgeons after controlling for the severity of disease and volume of cases per surgeon...
  14. ncbi request reprint Clinical stage T1c prostate cancer: pathologic outcomes following radical prostatectomy in black and white men
    James A Eastham
    Department of Urology, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Prostate 50:236-40. 2002
    ....
  15. pmc Local progression among men with conservatively treated localized prostate cancer: results from the Transatlantic Prostate Group
    James A Eastham
    Department of Urology, Memorial Sloan Kettering Cancer Center, New York, New York, USA
    Eur Urol 53:347-54. 2008
    ..Men with clinically detected localized prostate cancer treated without curative intent are at risk of complications from local tumor growth. We investigated rates of local progression and need for local therapy among such men...
  16. ncbi request reprint Variation of serum prostate-specific antigen levels: an evaluation of year-to-year fluctuations
    James A Eastham
    Memorial Sloan Kettering Cancer Center, New York, NY, USA
    JAMA 289:2695-700. 2003
    ..While PSA testing has resulted in an increase in prostate cancer detection, its routine use has been questioned because of a lack of specificity...
  17. ncbi request reprint Salvage radical prostatectomy for recurrence of prostate cancer after radiation therapy
    James A Eastham
    Memorial Sloan Kettering Cancer Center, 353 East 68th Street, New York, NY 10021, USA
    Curr Urol Rep 4:211-5. 2003
    ..This article reviews knowledge regarding radiation failure and the role of salvage radical prostatectomy for men with local recurrence after radiation therapy for prostate cancer...
  18. pmc Pretreatment prostate-specific antigen (PSA) velocity and doubling time are associated with outcome but neither improves prediction of outcome beyond pretreatment PSA alone in patients treated with radical prostatectomy
    Matthew Frank O'Brien
    Departmen of Surgery Urology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    J Clin Oncol 27:3591-7. 2009
    ..We assessed whether pretreatment PSA velocity (PSAV) or doubling time (PSADT) predicted outcome in men undergoing radical prostatectomy and whether any definition enhanced accuracy of an outcome prediction model...
  19. pmc Comparison of observed biochemical recurrence-free survival in patients with low PSA values undergoing radical prostatectomy and predictions of preoperative nomogram
    Ryan K Berglund
    Division of Urology, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Urology 73:1098-103. 2009
    ..5 ng/mL had outcomes different than predicted by a validated preoperative nomogram...
  20. ncbi request reprint A preoperative nomogram identifying decreased risk of positive pelvic lymph nodes in patients with prostate cancer
    Ilias Cagiannos
    Department of Urology, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
    J Urol 170:1798-803. 2003
    ..We developed a preoperative nomogram for prediction of lymph node metastases in patients with clinically localized prostate cancer...
  21. doi request reprint Magnetic resonance imaging for predicting prostate biopsy findings in patients considered for active surveillance of clinically low risk prostate cancer
    Hebert Alberto Vargas
    Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York, USA
    J Urol 188:1732-8. 2012
    ..We assessed the value of endorectal magnetic resonance imaging in predicting upgrading on confirmatory biopsy in men with low risk prostate cancer...
  22. pmc Preoperative nomogram predicting the 10-year probability of prostate cancer recurrence after radical prostatectomy
    Andrew J Stephenson
    Department of Urology, Sidney Kimmel Center for Prostate and Urologic Cancers, Memorial Sloan Kettering Cancer Center, New York, NY, USA
    J Natl Cancer Inst 98:715-7. 2006
    ..Thus, a new preoperative nomogram provides robust predictions of prostate cancer recurrence up to 10 years after radical prostatectomy...
  23. doi request reprint Radical prostatectomy in men aged >or=70 years: effect of age on upgrading, upstaging, and the accuracy of a preoperative nomogram
    Lee Richstone
    The Smith Institute for Urology, The North Shore LIJ Health System, NY, USA
    BJU Int 101:541-6. 2008
    ..To determine the effect of age on clinicopathological features, the accuracy of the preoperative nomogram, and survival after radical retropubic prostatectomy (RRP), as there are limited data on elderly men undergoing RRP...
  24. ncbi request reprint Radical prostatectomy for clinically localized, high risk prostate cancer: critical analysis of risk assessment methods
    Ofer Yossepowitch
    Urology Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    J Urol 178:493-9; discussion 499. 2007
    ..Of patients undergoing radical prostatectomy we identified those at high risk based on 8 previously described definitions. We examined pathological characteristics and prostate specific antigen outcomes...
  25. doi request reprint Oncologic outcome and patterns of recurrence after salvage radical prostatectomy
    Philippe Paparel
    Division of Urology, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Eur Urol 55:404-10. 2009
    ..Limited data on patterns of recurrence (local or metastatic) after salvage radical prostatectomy (SP) is available...
  26. pmc Is it necessary to remove the seminal vesicles completely at radical prostatectomy? decision curve analysis of European Society of Urologic Oncology criteria
    Fernando P Secin
    Department of Urology, Sidney Kimmel Center for Prostate and Urologic Cancers and Department of Epidemiology and Biostatistics AC, AJV, Memorial Sloan Kettering Cancer Center, New York, New York
    J Urol 181:609-13; discussion 614. 2009
    ..We applied the European Society of Urological Oncology algorithm to an independent data set to determine its predictive value...
  27. pmc Testosterone as a predictor of pathological stage in clinically localized prostate cancer
    Ginger Isom-Batz
    Department of Urology, Memorial Sloan Kettering Cancer Center, New York, New York, USA
    J Urol 173:1935-7. 2005
    ..We explored the relationship between preoperative total testosterone, and pathological stage and progression in patients with clinically localized prostate cancer treated with radical prostatectomy...
  28. pmc Preoperative nomograms incorporating magnetic resonance imaging and spectroscopy for prediction of insignificant prostate cancer
    Amita Shukla-Dave
    Department of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    BJU Int 109:1315-22. 2012
    ..Upon initial testing, the new MR models performed significantly better than a clinical model lacking detailed biopsy data...
  29. pmc Impact of socioeconomic factors on prostate cancer outcomes in black patients treated with surgery
    Atreya Dash
    Division of Urology, Memorial Sloan Kettering Cancer Center, New York, New York, USA
    Urology 72:641-6. 2008
    ..To determine whether socioeconomic factors affect prostate cancer outcomes, we studied a cohort of only black patients to minimize known confounding factors...
  30. doi request reprint Subjective characterization of nerve sparing predicts recovery of erectile function after radical prostatectomy: defining the utility of a nerve sparing grading system
    Daniel J Moskovic
    Urology Service, Department of Psychiatry and Behavioral Services, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    J Sex Med 8:255-60. 2011
    ..Radical prostatectomy (RP) is a common technique for managing prostate cancer. Concern regarding functional outcomes in patients prompted the development of nerve sparing to improve recovery of erectile function...
  31. ncbi request reprint Do margins matter? The prognostic significance of positive surgical margins in radical prostatectomy specimens
    Peter Swindle
    Department of Urology, Memorial Sloan Kettering Cancer Center, Sidney Kimmel Center for Prostate and Urologic Cancer, New York, New York 10021, USA
    J Urol 174:903-7. 2005
    ..We evaluated the prognostic significance of PSMs using multiple methods of analysis accounting for patients who received adjuvant therapy...
  32. ncbi request reprint Cancer and Leukemia Group B (CALGB) 90203: a randomized phase 3 study of radical prostatectomy alone versus estramustine and docetaxel before radical prostatectomy for patients with high-risk localized disease
    James A Eastham
    Memorial Sloan Kettering Cancer Center, New York, New York 94115, USA
    Urology 62:55-62. 2003
    ..The trial will enroll approximately 700 men during a 48-month period. Patients will be observed for 84 months after study closure. The power to detect a 36% decrease in 5-year recurrence rates is 90%...
  33. doi request reprint Impact of prior prostate radiation on complications after radical prostatectomy
    Geoffrey T Gotto
    Urology Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York and Department of Urology, Montefiore Medical Center FR, Bronx, New York, USA
    J Urol 184:136-42. 2010
    ..Salvage radical prostatectomy is associated with a higher complication rate than radical prostatectomy without prior radiotherapy but the magnitude of the increase is not well delineated...
  34. ncbi request reprint Clinically significant prostate cancer local recurrence after radiation therapy occurs at the site of primary tumor: magnetic resonance imaging and step-section pathology evidence
    Darko Pucar
    Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Int J Radiat Oncol Biol Phys 69:62-9. 2007
    ....
  35. pmc Pathological upgrading and up staging with immediate repeat biopsy in patients eligible for active surveillance
    Ryan K Berglund
    Division of Urology, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    J Urol 180:1964-7; discussion 1967-8. 2008
    ..We reviewed our experience with immediate repeat biopsy in patients eligible for active surveillance with selective delayed intervention...
  36. ncbi request reprint Counseling men with prostate cancer: a nomogram for predicting the presence of small, moderately differentiated, confined tumors
    Michael W Kattan
    Department of Urology, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
    J Urol 170:1792-7. 2003
    ....
  37. doi request reprint Pathological features of lymph node metastasis for predicting biochemical recurrence after radical prostatectomy for prostate cancer
    Sigrid V Carlsson
    Urology Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA
    J Urol 189:1314-8. 2013
    ..We explored the role of extranodal extension, size of the largest metastatic lymph node and the largest metastasis, and lymph node density as predictors of biochemical recurrence...
  38. ncbi request reprint Prostate biopsy techniques and indications: when, where, and how?
    Douglas S Scherr
    Department of Urology, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Semin Urol Oncol 20:18-31. 2002
    ..Here we review the current techniques and indications as well as pertinent pathologic and staging data obtained through TRUS and prostate biopsy...
  39. doi request reprint Long-term prediction of prostate cancer: prostate-specific antigen (PSA) velocity is predictive but does not improve the predictive accuracy of a single PSA measurement 15 years or more before cancer diagnosis in a large, representative, unscreened popula
    David Ulmert
    Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    J Clin Oncol 26:835-41. 2008
    ..We tested whether total prostate-specific antigen velocity (tPSAv) improves accuracy of a model using PSA level to predict long-term risk of prostate cancer diagnosis...
  40. ncbi request reprint Achieving optimal outcomes after radical prostatectomy
    Jeffery W Saranchuk
    Department of Urology, Sidney Kimmel Center for Prostate and Urologic Cancers, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
    J Clin Oncol 23:4146-51. 2005
    ..We sought to determine the frequency of optimal outcomes after radical prostatectomy and the time to such outcomes...
  41. ncbi request reprint Cancer-specific survival and predictors of prostate-specific antigen recurrence and survival in patients with seminal vesicle invasion after radical prostatectomy
    Fernando P Secin
    Department of Urology, Sidney Kimmel Center for Prostate and Urologic Cancers, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Cancer 106:2369-75. 2006
    ....
  42. pmc Long-term follow-up of 3-month neoadjuvant hormone therapy before radical prostatectomy in a randomized trial
    David S Yee
    Urology Service, Department of Surgery, and Health Outcomes Research Group, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    BJU Int 105:185-90. 2010
    ....
  43. ncbi request reprint International validation of a preoperative nomogram for prostate cancer recurrence after radical prostatectomy
    Markus Graefen
    Department of Urology, Division of Solid Tumor Oncology, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
    J Clin Oncol 20:3206-12. 2002
    ..We applied this nomogram to patients from seven different institutions spanning three continents...
  44. ncbi request reprint Does the time from biopsy to surgery affect biochemical recurrence after radical prostatectomy?
    Stephen A Boorjian
    Department of Urology, Memorial Sloan Kettering Cancer Center, New York, NY, USA
    BJU Int 96:773-6. 2005
    ....
  45. ncbi request reprint African-American race is a predictor of prostate cancer detection: incorporation into a pre-biopsy nomogram
    Brent V Yanke
    State University of New York Downstate Medical Center, New York, NY, USA
    BJU Int 98:783-7. 2006
    ....
  46. doi request reprint Testosterone in prostate cancer: the Bethesda consensus
    Bob Djavan
    Department of Urology, New York University School of Medicine, New York, NY, USA
    BJU Int 110:344-52. 2012
    ..This is especially important when PCa progresses from an endocrine to an intracrine status...
  47. ncbi request reprint Algorithms for prostate-specific antigen recurrence after treatment of localized prostate cancer
    Michael W Kattan
    Department of Urology, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Clin Prostate Cancer 1:221-6. 2003
    ..We believe these tools are useful and necessary for patient counseling, follow-up scheduling, and clinical trial design and analysis...
  48. pmc Diffusion-weighted endorectal MR imaging at 3 T for prostate cancer: tumor detection and assessment of aggressiveness
    Hebert Alberto Vargas
    Department of Radiology, Memorial Sloan Kettering Cancer Center, 1275 York Ave, Room C 278, New York, NY 10065, USA
    Radiology 259:775-84. 2011
    ....
  49. ncbi request reprint Radical prostatectomy: long-term cancer control and recovery of sexual and urinary function ("trifecta")
    Fernando J Bianco
    Department of Urology, Sidney Kimmel Center for Prostate and Urologic Cancers, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Urology 66:83-94. 2005
    ..Cancer control was good even for patients with adverse prognostic features. The probability of death from cancer was similar to other causes after disease progression. By 2 years, 60% of men were continent, potent, and cancer free...
  50. ncbi request reprint Morbidity and functional outcomes of salvage radical prostatectomy for locally recurrent prostate cancer after radiation therapy
    Andrew J Stephenson
    Department of Urology, Sidney Kimmel Center for Prostate and Urologic Cancers, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    J Urol 172:2239-43. 2004
    ..We report the morbidity associated with salvage RP in 100 consecutive patients...
  51. pmc Secondary therapy, metastatic progression, and cancer-specific mortality in men with clinically high-risk prostate cancer treated with radical prostatectomy
    Ofer Yossepowitch
    Department of Surgery, Urology Service, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Eur Urol 53:950-9. 2008
    ..We assessed how accurately these definitions identify patients likely to receive secondary cancer therapy, experience metastatic progression, or die of prostate cancer...
  52. pmc Postoperative nomogram predicting the 10-year probability of prostate cancer recurrence after radical prostatectomy
    Andrew J Stephenson
    Department of Urology, Sidney Kimmel Center for Prostate and Urologic Cancers, Memorial Sloan Kettering Cancer Center, New York, NY, USA
    J Clin Oncol 23:7005-12. 2005
    ..We have updated the nomogram by extending the predictions to 10 years after RP and have enabled the nomogram predictions to be adjusted for the disease-free interval that a patient has maintained after RP...
  53. ncbi request reprint Recovery of erectile function after salvage radical prostatectomy for locally recurrent prostate cancer after radiotherapy
    Timothy A Masterson
    Department of Urology, Sidney Kimmel Center for Prostate and Urologic Cancers, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Urology 66:623-6. 2005
    ..To analyze the feasibility of neurovascular bundle (NVB) preservation and peripheral nerve grafting during salvage radical prostatectomy (RP) for radiorecurrent prostate cancer and analyze their effect on the recovery of potency...
  54. doi request reprint Magnetic resonance imaging in the prediction of biochemical recurrence of prostate cancer after radical prostatectomy
    Michael H Fuchsjäger
    Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    BJU Int 104:315-20. 2009
    ..To investigate whether magnetic resonance imaging (MRI) findings, when converted into a scoring system, can predict the biochemical recurrence of prostate cancer after radical prostatectomy (RP)...
  55. ncbi request reprint Long-term oncologic results of salvage radical prostatectomy for locally recurrent prostate cancer after radiotherapy
    Fernando J Bianco
    Department of Urology, Sidney Kimmel Center for Prostate and Urologic Cancers, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Int J Radiat Oncol Biol Phys 62:448-53. 2005
    ..We report the long-term cancer control associated with salvage RP in a consecutive cohort of patients and identify the variables associated with disease progression and cancer survival...
  56. ncbi request reprint Role of salvage radical prostatectomy for recurrent prostate cancer after radiation therapy
    Andrew J Stephenson
    Department of Urology, Sidney Kimmel Center for Prostate and Urologic Cancers Memorial Sloan Kettering Cancer Center, 1275 York Ave, New York, NY 10021, USA
    J Clin Oncol 23:8198-203. 2005
    ..Salvage RP may favorably alter the natural history of biochemical recurrence after radiation therapy, but it must be instituted early in the course of recurrent disease to be effective...
  57. ncbi request reprint Risk-adjusted analysis of positive surgical margins following laparoscopic and retropubic radical prostatectomy
    Karim Touijer
    Department of Urology, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Eur Urol 52:1090-6. 2007
    ..To prospectively compare in a contemporary and contemporaneous series the positive surgical margin (PSM) rate between laparoscopic (LRP) and retropubic (RRP) radical prostatectomy at the same institution...
  58. pmc Evaluation of molecular forms of prostate-specific antigen and human kallikrein 2 in predicting biochemical failure after radical prostatectomy
    Sven Wenske
    Department of Surgery Urology Service, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Int J Cancer 124:659-63. 2009
    ..720 to 0.726, p=0.2). fPSA is routinely measured during prostate cancer detection. We suggest that the role of fPSA in aiding preoperative prediction should be investigated in further cohorts...
  59. ncbi request reprint Dietary manipulation, ethnicity, and serum PSA levels
    James A Eastham
    Department of Urology, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Urology 62:677-82. 2003
    ....
  60. doi request reprint The depth of the prostatic apex is an independent predictor of positive apical margins at radical prostatectomy
    Mika P Matikainen
    Urology Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA
    BJU Int 106:622-6. 2010
    ..e. open retropubic (RRP) vs laparoscopic (LRP), as apical dissection is expected to be more challenging at RP with a prostate situated deep in a narrow pelvis...
  61. ncbi request reprint Endorectal MR imaging before salvage prostatectomy: tumor localization and staging
    Evis Sala
    Department of Radiology, Memorial Sloan Kettering Cancer Center, 1275 York Ave, New York, NY 10021, USA
    Radiology 238:176-83. 2006
    ....
  62. pmc Risk assessment for biochemical recurrence prior to radical prostatectomy: significant enhancement contributed by human glandular kallikrein 2 (hK2) and free prostate specific antigen (PSA) in men with moderate PSA-elevation in serum
    Thomas Steuber
    Department of Urology, Memorial Sloan Kettering Cancer Center, New York, NY, USA
    Int J Cancer 118:1234-40. 2006
    ..Measurements of fPSA and hK2 improve on our ability to counsel patients prior to treatment as to their risk of BCR...
  63. doi request reprint Effect of repeated prostate biopsies on erectile function in men on active surveillance for prostate cancer
    Katharina Braun
    Urology Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York Department of Urology, University Hospital Ruhr University Bochum, Marienhospital Herne, Herne, Germany
    J Urol 191:744-9. 2014
    ..It has been hypothesized that serial biopsies can lead to reduced erectile function in patients on active surveillance and we explored this hypothesis in a longitudinally followed cohort...
  64. doi request reprint Cancer control and functional outcomes of salvage radical prostatectomy for radiation-recurrent prostate cancer: a systematic review of the literature
    Daher C Chade
    Urology Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA
    Eur Urol 61:961-71. 2012
    ..Prostate cancer (PCa) recurrence following definitive radiation therapy (RT) remains a vexing challenge for the practicing physician. Salvage radical prostatectomy (SRP) has not been recognized yet as a valuable therapeutic option...
  65. pmc The learning curve for surgical margins after open radical prostatectomy: implications for margin status as an oncological end point
    Andrew Vickers
    Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    J Urol 183:1360-5. 2010
    ..Surgical margin status is commonly used as an end point for surgical learning. We examined the surgical margin learning curve and investigated whether surgical margins are a good marker for oncological outcome...
  66. ncbi request reprint Race is not a predictor of prostate cancer detection on repeat prostate biopsy
    Brett S Carver
    Department of Urology, Louisiana State University Health Sciences Center and Overton Brooks Veterans Administration Medical Center, Shreveport, Louisiana, USA
    J Urol 172:1853-5. 2004
    ..We evaluated men undergoing repeat prostate biopsies for persistently increased serum prostate specific antigen (PSA) levels to determine if race was a predictor of cancer detection...
  67. doi request reprint Impact of ethnicity on surgical margins at radical prostatectomy
    Farhang Rabbani
    Urology Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    BJU Int 104:904-8. 2009
    ....
  68. pmc Predicting biochemical recurrence-free survival for patients with positive pelvic lymph nodes at radical prostatectomy
    Christian von Bodman
    Urology Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York, USA
    J Urol 184:143-8. 2010
    ..We evaluated predictors of freedom from biochemical recurrence in patients with pelvic lymph node metastasis at radical prostatectomy...
  69. pmc Clinical stage T1c prostate cancer: evaluation with endorectal MR imaging and MR spectroscopic imaging
    Jingbo Zhang
    Department of Radiology, Memorial Sloan Kettering Cancer Center, 1275 York Ave, Room C 278, New York, NY 10065, USA
    Radiology 253:425-34. 2009
    ....
  70. doi request reprint Comprehensive standardized report of complications of retropubic and laparoscopic radical prostatectomy
    Farhang Rabbani
    Urology Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    Eur Urol 57:371-86. 2010
    ..The lack of standardized reporting of the complications of radical prostatectomy in the literature has made it difficult to compare incidences across institutions and across different surgical approaches...
  71. pmc Metastasis after radical prostatectomy or external beam radiotherapy for patients with clinically localized prostate cancer: a comparison of clinical cohorts adjusted for case mix
    Michael J Zelefsky
    Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    J Clin Oncol 28:1508-13. 2010
    ..We assessed the effect of radical prostatectomy (RP) and external beam radiotherapy (EBRT) on distant metastases (DM) rates in patients with localized prostate cancer treated with RP or EBRT at a single specialized cancer center...
  72. ncbi request reprint Analysis of clinical stage T2 prostate cancer: do current subclassifications represent an improvement?
    Ilias Cagiannos
    Department of Urology, Memorial Sloan Kettering Cancer Center, New York, NY 11021, USA
    J Clin Oncol 20:2025-30. 2002
    ..The purpose of this study was to determine whether the extent of palpable cancer within the prostate predicts outcome after radical prostatectomy...
  73. pmc Does a delay between diagnosis and radical prostatectomy increase the risk of disease recurrence?
    Andrew J Vickers
    Department of Urology, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Cancer 106:576-80. 2006
    ..In the current study, the authors evaluated whether time from biopsy to radical prostatectomy (RP) was predictive of postoperative biochemical disease recurrence (BCR)...
  74. ncbi request reprint The surgical learning curve for prostate cancer control after radical prostatectomy
    Andrew J Vickers
    Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, 1275 York Ave, New York, NY 10021, USA
    J Natl Cancer Inst 99:1171-7. 2007
    ..We analyzed the surgical learning curve for prostate cancer recurrence after radical prostatectomy...
  75. pmc Effects of pathologic stage on the learning curve for radical prostatectomy: evidence that recurrence in organ-confined cancer is largely related to inadequate surgical technique
    Andrew J Vickers
    Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Eur Urol 53:960-6. 2008
    ..We previously demonstrated that there is a learning curve for open radical prostatectomy. We sought to determine whether the effects of the learning curve are modified by pathologic stage...
  76. pmc Modified technique for neurovascular bundle preservation during radical prostatectomy: association between technique and recovery of erectile function
    Timothy A Masterson
    Department of Surgery, Urology Service, Memorial Sloan Kettering Cancer Center, New York, NY10021, USA
    BJU Int 101:1217-22. 2008
    ..To prospectively evaluate whether a modified surgical technique for neurovascular bundle (NVB) preservation during radical prostatectomy (RP) is associated with an improvement in erectile function (EF) recovery after RP...
  77. pmc Comprehensive prospective comparative analysis of outcomes between open and laparoscopic radical prostatectomy conducted in 2003 to 2005
    Karim Touijer
    Department of Surgery, Service of Urology, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    J Urol 179:1811-7; discussion 1817. 2008
    ..In a nonrandomized prospective fashion we compared the oncological, functional and morbidity outcomes after laparoscopic and retropubic radical prostatectomy...
  78. pmc Prediction of significant prostate cancer diagnosed 20 to 30 years later with a single measure of prostate-specific antigen at or before age 50
    Hans Lilja
    Department of Clinical Laboratories, Memorial Sloan Kettering Cancer Center, New York, New York, USA
    Cancer 117:1210-9. 2011
    ..This provides replication using an independent data set and allows estimates of the association between early PSA and subsequent advanced cancer (clinical stage ≥T3 or metastases at diagnosis)...
  79. pmc An exploratory study of endorectal magnetic resonance imaging and spectroscopy of the prostate as preoperative predictive biomarkers of biochemical relapse after radical prostatectomy
    Kristen L Zakian
    Department of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    J Urol 184:2320-7. 2010
    ..We determined whether pretreatment endorectal magnetic resonance imaging/magnetic resonance spectroscopic imaging predicts biochemical recurrence after radical prostatectomy...
  80. ncbi request reprint Outcomes following negative prostate biopsy for patients with persistent disease after radiotherapy for prostate cancer
    Jacob H Cohen
    Department of Urology, State University of New York Downstate Medical School, Brooklyn, NY 11203, USA
    Int Braz J Urol 36:44-8. 2010
    ..Our study examines outcomes for patients with a negative prostate biopsy performed for rising prostate-specific antigen (PSA) levels after prostate radiation...
  81. doi request reprint The impact of repeat biopsies on infectious complications in men with prostate cancer on active surveillance
    Behfar Ehdaie
    Urology Service, Sidney Kimmel Center for Prostate and Urologic Cancers, Memorial Sloan Kettering Cancer Center, New York, New York Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, New York
    J Urol 191:660-4. 2014
    ..Prostate biopsy related infectious complications are associated with significant morbidity. The risk of infectious complications in patients with prostate cancer on active surveillance remains under studied...
  82. ncbi request reprint Favorable clinical outcomes of three-dimensional computer-optimized high-dose-rate prostate brachytherapy in the management of localized prostate cancer
    Yoshiya Yamada
    Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Brachytherapy 5:157-64. 2006
    ..To report PSA relapse-free survival and toxicity outcomes of prostate cancer patients who have undergone three-dimensional computer-optimized high-dose-rate (HDR) brachytherapy with external beam radiotherapy as definitive treatment...
  83. doi request reprint Postoperative systems models more accurately predict risk of significant disease progression than standard risk groups and a 10-year postoperative nomogram: potential impact on the receipt of adjuvant therapy after surgery
    Michael J Donovan
    Aureon Biosciences, Yonkers, NY 10701, USA
    BJU Int 109:40-5. 2012
    ..To compare the performance of a systems-based risk assessment tool with standard defined risk groups and the 10-year postoperative nomogram for predicting disease progression, including biochemical relapse and clinical (systemic) failure...
  84. ncbi request reprint Defining biochemical recurrence of prostate cancer after radical prostatectomy: a proposal for a standardized definition
    Andrew J Stephenson
    Department of Urology, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    J Clin Oncol 24:3973-8. 2006
    ..Ten definitions of BCR were evaluated to identify the one that best explains metastatic progression...
  85. pmc The clinical features of anterior prostate cancers
    Theresa M Koppie
    Department of Urology, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    BJU Int 98:1167-71. 2006
    ..To identify the clinical characteristics of anterior prostate cancers (APCs) and to compare these with posterior prostate cancers (PPCs)...
  86. pmc The natural history of noncastrate metastatic prostate cancer after radical prostatectomy
    Ofer Yossepowitch
    Department of Urology, Memorial Sloan Kettering Cancer Center, New York, NY, USA
    Eur Urol 51:940-7; discussion 947-8. 2007
    ..To characterise the natural history of metastatic prostate cancer after radical prostatectomy (RP) in patients followed expectantly for rising prostate-specific antigen (PSA) (noncastrate metastases)...
  87. pmc Prostate cancer diagnosed after repeat biopsies have a favorable pathological outcome but similar recurrence rate
    Ernesto Lopez-Corona
    Department of Urology, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    J Urol 175:923-7; discussion 927-8. 2006
    ..We investigated whether repeat prostate biopsies are associated with more favorable prognoses, less extensive disease or higher rates of IC in patients who are ultimately diagnosed with prostate cancer and treated with RRP...
  88. ncbi request reprint Radical prostatectomy shortly after prostate biopsy does not affect operative difficulty or efficacy
    Scott E Eggener
    Department of Urology, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Urology 69:1128-33. 2007
    ..Many urologists recommend an interval of at least 4 to 6 weeks between prostate biopsy and RP...
  89. ncbi request reprint Prognostic impact of positive surgical margins in surgically treated prostate cancer: multi-institutional assessment of 5831 patients
    Pierre I Karakiewicz
    Department of Urology, Memorial Sloan Kettering Cancer Center, New York, New York, USA
    Urology 66:1245-50. 2005
    ....
  90. ncbi request reprint High-risk localised prostate cancer: multimodal treatment strategies combining neoadjuvant hormonal therapy and/or chemotherapy with radical prostatectomy
    James A Eastham
    Expert Opin Emerg Drugs 8:291-5. 2003
    ..These studies will help define the role of multimodal treatment strategies in this high-risk patient population...
  91. ncbi request reprint Long-term outcome following radical prostatectomy in men with clinical stage T3 prostate cancer
    Brett S Carver
    Department of Urology, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    J Urol 176:564-8. 2006
    ..We evaluated patients at our institution who underwent radical prostatectomy for clinical stage T3 prostate cancer to determine their long-term clinical outcomes...
  92. ncbi request reprint Free PSA isoforms and intact and cleaved forms of urokinase plasminogen activator receptor in serum improve selection of patients for prostate cancer biopsy
    Thomas Steuber
    Department of Urology, Memorial Sloan Kettering Cancer Center, New York, NY, USA
    Int J Cancer 120:1499-504. 2007
    ..0.715, p=0.039). In this setting, hK2 did not add diagnostic information. Measurements of individual forms of suPAR and PSA isoforms contributed significantly to discrimination of men with PCa from those with no evidence of malignancy...
  93. doi request reprint Comparison of stage migration patterns between Europe and the USA: an analysis of 11 350 men treated with radical prostatectomy for prostate cancer
    Andrea Gallina
    Cancer Prognostics and Health Outcomes Unit, University of Montreal, Montreal, Quebec, Canada
    BJU Int 101:1513-8. 2008
    ..To examine the stage migration patterns in patients treated with radical prostatectomy (RP) for prostate cancer in Europe and in the USA in the last 20 years...
  94. pmc Surgeon experience is strongly associated with biochemical recurrence after radical prostatectomy for all preoperative risk categories
    Eric A Klein
    Glickman Urological and Kidney Institute, Cleveland Clinic, Cleveland, Ohio, USA
    J Urol 179:2212-6; discussion 2216-7. 2008
    ..In the current study we determined whether the effects of the learning curve are modified by patient risk, as defined by preoperative tumor characteristics...
  95. pmc Association of cysteine-rich secretory protein 3 and beta-microseminoprotein with outcome after radical prostatectomy
    Anders S Bjartell
    Departments of Surgery Urology, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Clin Cancer Res 13:4130-8. 2007
    ..We investigated whether these markers are related to biochemical recurrence and whether addition of the markers improves prediction of recurring disease...
  96. pmc The role of SPINK1 in ETS rearrangement-negative prostate cancers
    Scott A Tomlins
    Michigan Center for Translational Pathology, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    Cancer Cell 13:519-28. 2008
    ..We identified the aggressive 22RV1 cell line as a SPINK1 outlier expression model and demonstrate that SPINK1 knockdown in 22RV1 attenuates invasion, suggesting a functional role in ETS rearrangement-negative prostate cancers...
  97. pmc Pattern of prostate-specific antigen (PSA) failure dictates the probability of a positive bone scan in patients with an increasing PSA after radical prostatectomy
    Zohar A Dotan
    Department of Quantitative Health Sciences, The Cleveland Clinic Foundation, 9500 Euclid Avenue Wb 4, Cleveland, OH 44195, USA
    J Clin Oncol 23:1962-8. 2005
    ..We studied patient characteristics to build a predictive model for a positive scan...
  98. pmc Gleason grade remains an important prognostic predictor in men diagnosed with prostate cancer while on finasteride therapy
    Brett S Carver
    Department of Urology, Memorial Sloan Kettering Cancer Center, New York, NY, USA
    BJU Int 95:509-12. 2005
    ....
  99. ncbi request reprint Salvage therapy for locally recurrent prostate cancer after external beam radiotherapy
    Andrew J Stephenson
    Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
    Curr Treat Options Oncol 5:357-65. 2004
    ..A long-term cure is possible for patients with locally recurrent prostate cancer after radiation therapy. Local salvage therapy must be instituted early to be successful in the course of progressive disease...