GENE DIRESTA

Summary

Affiliation: Memorial Sloan-Kettering Cancer Center
Country: USA

Publications

  1. ncbi "Artificial lymphatic system": a new approach to reduce interstitial hypertension and increase blood flow, pH and pO2 in solid tumors
    G R DiResta
    Memorial Sloan Kettering Cancer Center s Department of Surgery Orthopaedic Service, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Ann Biomed Eng 28:543-55. 2000
  2. ncbi Enhancing the uptake of chemotherapeutic drugs into tumors using an "artificial lymphatic system"
    G R DiResta
    Memorial Sloan Kettering Cancer Center s Department of Surgery Orthopaedic Service, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Ann Biomed Eng 28:556-64. 2000
  3. ncbi Cell proliferation of cultured human cancer cells are affected by the elevated tumor pressures that exist in vivo
    Gene R DiResta
    Department of Surgery Orthopaedic Surgery, Memorial Sloan Kettering Cancer Center, Weill Medical College of Cornell University, New York, NY 10021, USA
    Ann Biomed Eng 33:1270-80. 2005
  4. ncbi Use of an absorbable membrane to position biologically inductive materials in the periprosthetic space of cemented joints
    Gene R DiResta
    Orthopaedics Research Laboratory, Memorial Sloan Kettering Cancer Center, RRL 409, 430 E67th St, New York, NY 10021, USA
    J Biomech 39:833-43. 2006
  5. ncbi Use of an artificial lymphatic system during carboplatin infusion to improve canine osteosarcoma blood flow and clinical response
    Gene R DiResta
    Orthopaedic Surgical Service, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, New York, 10021 6007, USA
    Ann Surg Oncol 14:2411-21. 2007
  6. ncbi Influence of carboplatin infusion on osteosarcoma blood flow
    Gene R DiResta
    Memorial Sloan Kettering Cancer Center, Department of Surgery, Associated with Weill Medical College of Cornell University, Orthopaedic Surgery Service, 1275 York Avenue, New York, NY 10021 6007, USA
    Cancer Chemother Pharmacol 62:545-9. 2008
  7. ncbi Bisphosphonate delivery to tubular bone allografts
    Gene R DiResta
    Department of Surgery Orthopaedic Surgical Service, Memorial Sloan Kettering Cancer Center, Weill Medical College of Cornell University, 1275 York Ave, Suite A342, New York, NY 10065 6004, USA
    Clin Orthop Relat Res 466:1871-9. 2008
  8. ncbi Elevated physiologic tumor pressure promotes proliferation and chemosensitivity in human osteosarcoma
    Saminathan S Nathan
    Orthopaedic Surgery Service, Department of Surgery, Memorial Sloan-Kettering Cancer Center, 1275A York Avenue, New York, NY 10021, USA
    Clin Cancer Res 11:2389-97. 2005
  9. ncbi Tumor interstitial fluid pressure may regulate angiogenic factors in osteosarcoma
    Saminathan S Nathan
    Musculoskeletal Oncology Service, Department of Orthopaedic Surgery, Yong Loo Lin School of Medicine, National University of Singapore, 5, Lower Kent Ridge Road, Singapore 119074, Singapore
    J Orthop Res 26:1520-5. 2008

Research Grants

  1. ENHANCED THERAPY RESPONSE IN OSTEOSARCOMA
    GENE DIRESTA; Fiscal Year: 2001

Detail Information

Publications9

  1. ncbi "Artificial lymphatic system": a new approach to reduce interstitial hypertension and increase blood flow, pH and pO2 in solid tumors
    G R DiResta
    Memorial Sloan Kettering Cancer Center s Department of Surgery Orthopaedic Service, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Ann Biomed Eng 28:543-55. 2000
    ..The experimental and mathematical findings suggest that ALS aspiration may be a viable way of reducing IFP and increasing BFR, pO2, and pH and should enhance solid tumor chemo and radiation therapy...
  2. ncbi Enhancing the uptake of chemotherapeutic drugs into tumors using an "artificial lymphatic system"
    G R DiResta
    Memorial Sloan Kettering Cancer Center s Department of Surgery Orthopaedic Service, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Ann Biomed Eng 28:556-64. 2000
    ..2% in Sarcoma tumor (p<0.05). The shrinkage study demonstrated that one-drain aspirated tumors shrank 90% faster (p<0.01) than control tumors, while three-drain aspirated tumors shrank 123% faster than control tumors (p<0.01)...
  3. ncbi Cell proliferation of cultured human cancer cells are affected by the elevated tumor pressures that exist in vivo
    Gene R DiResta
    Department of Surgery Orthopaedic Surgery, Memorial Sloan Kettering Cancer Center, Weill Medical College of Cornell University, New York, NY 10021, USA
    Ann Biomed Eng 33:1270-80. 2005
    ..The findings suggest that hydrostatic pressure either increases or decreases tumor proliferation rates depending on cell type. Furthermore, cell death was not associated with apoptosis...
  4. ncbi Use of an absorbable membrane to position biologically inductive materials in the periprosthetic space of cemented joints
    Gene R DiResta
    Orthopaedics Research Laboratory, Memorial Sloan Kettering Cancer Center, RRL 409, 430 E67th St, New York, NY 10021, USA
    J Biomech 39:833-43. 2006
    ..Aseptic loosening and lameness occurred within 12 months, quicker than the 30 months reported in a retrospective clinical review of canine hip arthroplasty...
  5. ncbi Use of an artificial lymphatic system during carboplatin infusion to improve canine osteosarcoma blood flow and clinical response
    Gene R DiResta
    Orthopaedic Surgical Service, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, New York, 10021 6007, USA
    Ann Surg Oncol 14:2411-21. 2007
    ....
  6. ncbi Influence of carboplatin infusion on osteosarcoma blood flow
    Gene R DiResta
    Memorial Sloan Kettering Cancer Center, Department of Surgery, Associated with Weill Medical College of Cornell University, Orthopaedic Surgery Service, 1275 York Avenue, New York, NY 10021 6007, USA
    Cancer Chemother Pharmacol 62:545-9. 2008
    ....
  7. ncbi Bisphosphonate delivery to tubular bone allografts
    Gene R DiResta
    Department of Surgery Orthopaedic Surgical Service, Memorial Sloan Kettering Cancer Center, Weill Medical College of Cornell University, 1275 York Ave, Suite A342, New York, NY 10065 6004, USA
    Clin Orthop Relat Res 466:1871-9. 2008
    ..Flow resistance was reduced with octylphenoxy polyethoxy ethanol but unaffected with beractant. Pumped allografts displayed a more homogeneous indicator distribution in less time than soaking while surfactants enhanced fluid movement...
  8. ncbi Elevated physiologic tumor pressure promotes proliferation and chemosensitivity in human osteosarcoma
    Saminathan S Nathan
    Orthopaedic Surgery Service, Department of Surgery, Memorial Sloan-Kettering Cancer Center, 1275A York Avenue, New York, NY 10021, USA
    Clin Cancer Res 11:2389-97. 2005
    ..Variations in tumor interstitial fluid pressure have the potential to alter chemotherapeutic effects...
  9. ncbi Tumor interstitial fluid pressure may regulate angiogenic factors in osteosarcoma
    Saminathan S Nathan
    Musculoskeletal Oncology Service, Department of Orthopaedic Surgery, Yong Loo Lin School of Medicine, National University of Singapore, 5, Lower Kent Ridge Road, Singapore 119074, Singapore
    J Orthop Res 26:1520-5. 2008
    ..Immunohistochemical assessment for VEGF-A (p = 0.01), VEGF-C (p = 0.008), and TPA (p = 0.0001) translation were consistent with the findings on PCR. Our data suggests that some molecules in angiogenesis are regulated by changes in IFP...

Research Grants3

  1. ENHANCED THERAPY RESPONSE IN OSTEOSARCOMA
    GENE DIRESTA; Fiscal Year: 2001
    ..The MSKCC Therapeutics faculty believes that the ALS, if successful in this model, has promise as an adjunct for limb salvage procedures and in the treatment of many unresectable or disfiguring tumors. ..