Liang Deng

Summary

Affiliation: Memorial Sloan-Kettering Cancer Center
Country: USA

Publications

  1. pmc Innate immune response of human plasmacytoid dendritic cells to poxvirus infection is subverted by vaccinia E3 via its Z-DNA/RNA binding domain
    Hua Cao
    Dermatology Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York, United States of America
    PLoS ONE 7:e36823. 2012
  2. pmc Vaccinia virus subverts a mitochondrial antiviral signaling protein-dependent innate immune response in keratinocytes through its double-stranded RNA binding protein, E3
    Liang Deng
    Department of Medicine, Dermatology Service, Molecular Biology Program, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    J Virol 82:10735-46. 2008
  3. pmc Myxoma virus induces type I interferon production in murine plasmacytoid dendritic cells via a TLR9/MyD88-, IRF5/IRF7-, and IFNAR-dependent pathway
    Peihong Dai
    Molecular Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    J Virol 85:10814-25. 2011
  4. pmc Vaccinia virus infection attenuates innate immune responses and antigen presentation by epidermal dendritic cells
    Liang Deng
    Molecular Biology Program, Sloan Kettering Institute, 1275 York Avenue, New York, NY 10021, USA
    J Virol 80:9977-87. 2006
  5. pmc Identification of novel antipoxviral agents: mitoxantrone inhibits vaccinia virus replication by blocking virion assembly
    Liang Deng
    Dermatology Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    J Virol 81:13392-402. 2007
  6. doi request reprint Modified Vaccinia Virus Ankara Triggers Type I IFN Production in Murine Conventional Dendritic Cells via a cGAS/STING-Mediated Cytosolic DNA-Sensing Pathway
    Peihong Dai
    Dermatology Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York, United States of America Molecular Biology Program, Memorial Sloan Kettering Cancer Center, New York, New York, United States of America
    PLoS Pathog 10:e1003989. 2014
  7. doi request reprint Structure-function analysis of STING activation by c[G(2',5')pA(3',5')p] and targeting by antiviral DMXAA
    Pu Gao
    Structural Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    Cell 154:748-62. 2013
  8. pmc Altered cutaneous immune parameters in transgenic mice overexpressing viral IL-10 in the epidermis
    Wanhong Ding
    Department of Dermatology, Joan and Sanford I Weill Medical College of Cornell University, New York, New York 10021, USA
    J Clin Invest 111:1923-31. 2003
  9. ncbi request reprint Thalidomide inhibits tumor necrosis factor-alpha production and antigen presentation by Langerhans cells
    Liang Deng
    Department of Dermatology, Joan and Sanford I Weill Medical College of Cornell University, New York, New York 10021, USA
    J Invest Dermatol 121:1060-5. 2003

Collaborators

Detail Information

Publications9

  1. pmc Innate immune response of human plasmacytoid dendritic cells to poxvirus infection is subverted by vaccinia E3 via its Z-DNA/RNA binding domain
    Hua Cao
    Dermatology Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York, United States of America
    PLoS ONE 7:e36823. 2012
    ..The myxoma virus ortholog of vaccinia E3 (M029) lacks the N-terminal Z-DNA/RNA binding domain, which might contribute to the immunostimulating properties of myxoma virus...
  2. pmc Vaccinia virus subverts a mitochondrial antiviral signaling protein-dependent innate immune response in keratinocytes through its double-stranded RNA binding protein, E3
    Liang Deng
    Department of Medicine, Dermatology Service, Molecular Biology Program, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    J Virol 82:10735-46. 2008
    ..IRF3 phosphorylation is induced in keratinocytes infected with DeltaE3L, an event that depends on MAVS. The response of keratinocytes to DeltaE3L is unaffected by genetic ablation of Toll-like receptor 3 (TLR3), TRIF, TLR9, and MyD88...
  3. pmc Myxoma virus induces type I interferon production in murine plasmacytoid dendritic cells via a TLR9/MyD88-, IRF5/IRF7-, and IFNAR-dependent pathway
    Peihong Dai
    Molecular Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    J Virol 85:10814-25. 2011
    ....
  4. pmc Vaccinia virus infection attenuates innate immune responses and antigen presentation by epidermal dendritic cells
    Liang Deng
    Molecular Biology Program, Sloan Kettering Institute, 1275 York Avenue, New York, NY 10021, USA
    J Virol 80:9977-87. 2006
    ..Vaccinia virus infection of primary LCs strongly inhibited their capacity for antigen-specific activation of T cells. Our results highlight suppression of the skin immune response as a feature of orthopoxvirus infection...
  5. pmc Identification of novel antipoxviral agents: mitoxantrone inhibits vaccinia virus replication by blocking virion assembly
    Liang Deng
    Dermatology Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    J Virol 81:13392-402. 2007
    ..Despite its favorable activity in cell culture, mitoxantrone administered intraperitoneally at the maximum tolerated dose failed to protect mice against a lethal intranasal infection with vaccinia virus...
  6. doi request reprint Modified Vaccinia Virus Ankara Triggers Type I IFN Production in Murine Conventional Dendritic Cells via a cGAS/STING-Mediated Cytosolic DNA-Sensing Pathway
    Peihong Dai
    Dermatology Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York, United States of America Molecular Biology Program, Memorial Sloan Kettering Cancer Center, New York, New York, United States of America
    PLoS Pathog 10:e1003989. 2014
    ..We present evidence that vaccinia virulence factors E3 and N1 inhibit the activation of IRF3 and the induction of IFNB gene in MVA-infected cDCs. ..
  7. doi request reprint Structure-function analysis of STING activation by c[G(2',5')pA(3',5')p] and targeting by antiviral DMXAA
    Pu Gao
    Structural Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    Cell 154:748-62. 2013
    ..Our structural and functional analysis highlights the unexpected versatility of STING in the recognition of natural and synthetic ligands within a small-molecule pocket created by the dimerization of STING...
  8. pmc Altered cutaneous immune parameters in transgenic mice overexpressing viral IL-10 in the epidermis
    Wanhong Ding
    Department of Dermatology, Joan and Sanford I Weill Medical College of Cornell University, New York, New York 10021, USA
    J Clin Invest 111:1923-31. 2003
    ..These findings support the concept that IL-10 is an important regulator of cutaneous immune function...
  9. ncbi request reprint Thalidomide inhibits tumor necrosis factor-alpha production and antigen presentation by Langerhans cells
    Liang Deng
    Department of Dermatology, Joan and Sanford I Weill Medical College of Cornell University, New York, New York 10021, USA
    J Invest Dermatol 121:1060-5. 2003
    ..Thalidomide inhibits TNF-alpha production and the antigen-presenting ability of epidermal LCs. These mechanisms may contribute to the therapeutic effects observed with this agent...

Research Grants2

  1. Poxvirus interface with skin immune system, development of anti-poxvirus drugs
    Liang Deng; Fiscal Year: 2007
    ..It will also allow us to develop novel antipoxvirus drugs and test them in an in vivo mouse skin model. ..