Research Topics
Genomes and Genes
| C Cordon-CardoSummaryAffiliation: Memorial Sloan-Kettering Cancer Center Country: USA Publications
| Collaborators
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Detail Information
Publications
High-resolution characterization of the pancreatic adenocarcinoma genomeAndrew J Aguirre
Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA
Proc Natl Acad Sci U S A 101:9067-72. 2004..Thus, the integration of DNA and RNA profiles provides a highly productive entry point for the discovery of genes involved in the pathogenesis of pancreatic adenocarcinoma...
Rb inactivation promotes genomic instability by uncoupling cell cycle progression from mitotic controlEva Hernando
Department of Pathology, Memorial Sloan Kettering Cancer Center New York, New York 10021, USA
Nature 430:797-802. 2004....- Genetic studies and molecular markers of bladder cancerC Cordon-Cardo
Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
Semin Surg Oncol 13:319-27. 1997..The implementation of objective predictive assays to identify these alterations in clinical material will enhance our ability to assess tumor biological activities and to design effective treatment regimes... - Distinct altered patterns of p27KIP1 gene expression in benign prostatic hyperplasia and prostatic carcinomaC Cordon-Cardo
Memorial Sloan Kettering Cancer, New York, NY 10021, USA
J Natl Cancer Inst 90:1284-91. 1998..This study was undertaken to identify and to assess potential alterations of p27KIP1 gene expression in patients with benign prostatic hyperplasia (BPH) and patients with prostate cancer... - Applications of molecular diagnostics: solid tumor genetics can determine clinical treatment protocolsC Cordon-Cardo
Division of Molecular Pathology, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
Mod Pathol 14:254-7. 2001..The molecular characterization therefore has an important prognostic and practical role in diagnosis... - A polymorphism in HDM2 (SNP309) associates with early onset in superficial tumors, TP53 mutations, and poor outcome in invasive bladder cancerMarta Sanchez-Carbayo
Division of Molecular Pathology, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
Clin Cancer Res 13:3215-20. 2007..In this study, we aim to evaluate the SNP309 in bladder cancer and to link it to TP53 status... - Ku70: a candidate tumor suppressor gene for murine T cell lymphomaG C Li
Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
Mol Cell 2:1-8. 1998..These findings directly demonstrate that Ku70 deficiency facilitates neoplastic growth and suggest a novel role of the Ku70 locus in tumor suppression... - Role of PML in cell growth and the retinoic acid pathwayZ G Wang
Department of Human Genetics and Molecular Biology Program, Memorial Sloan Kettering Cancer Center, Sloan Kettering Division, Graduate School of Medical Sciences, Cornell University, New York, NY 10021, USA
Science 279:1547-51. 1998..These results indicate that PML is a critical component of the RA pathway and that disruption of its activity by the PML-RARalpha fusion protein may be important in APL pathogenesis... - Molecular abnormalities of mdm2 and p53 genes in adult soft tissue sarcomasC Cordon-Cardo
Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York 10021
Cancer Res 54:794-9. 1994..The overexpression of p53 and mdm2 proteins in the nuclei of tumor cells did not always correlate well with gene amplification at the mdm2 locus or mutation at the p53 gene. The possible reasons for these discrepancies are discussed... - Prostate cancer cell cycle regulators: response to androgen withdrawal and development of androgen independenceD B Agus
Department of Medicine, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA
J Natl Cancer Inst 91:1869-76. 1999..To understand the factors associated with regression of prostate cancers after androgen withdrawal, we studied cell cycle regulator changes in the CWR22 human prostate cancer xenograft model... - Expression of p27(kip) and other cell cycle regulators in malignant peripheral nerve sheath tumors and neurofibromas: the emerging role of p27(kip) in malignant transformation of neurofibromasH P Kourea
Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York, USA
Am J Pathol 155:1885-91. 1999..001). Furthermore, detection of cytoplasmic p27 expression was found to be a prognostic factor for poor survival in MPNSTs (P = 0.03, relative risk = 2.4)... - Ku70 is required for DNA repair but not for T cell antigen receptor gene recombination In vivoH Ouyang
Department of Medical Physics and Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York 10021, USA
J Exp Med 186:921-9. 1997..These results suggest that distinct but overlapping repair pathways may mediate DNA DSB repair and V(D)J recombination... - Characterization of molecular abnormalities in human fibroblastic neoplasms: a model for genotype-phenotype association in soft tissue tumorsA Hoos
Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, New York 10021, USA
Cancer Res 61:3171-5. 2001..pRB and Ki-67 status may be useful to predict recurrence in certain subsets of patients... - Altered patterns of RB expression define groups of soft tissue sarcoma patients with distinct biological and clinical behaviorD Polsky
Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, USA
Histol Histopathol 21:743-52. 2006..In this study, we examined adult soft tissue sarcomas (ASTS) to determine if alterations of pRB were associated with distinct patterns of pRB expression and clinical outcome... - Pten is essential for embryonic development and tumour suppressionA Di Cristofano
Department of Human Genetics, Memorial Sloan Kettering Cancer Center, Sloan Kettering Institute, New York, NY 10021, USA
Nat Genet 19:348-55. 1998..These results support the notion that PTEN haploinsufficiency plays a causal role in CD, LDD and BZS pathogenesis, and demonstrate that Pten is a tumour suppressor essential for embryonic development... - Two cytodifferentiation agent-induced pathways, differentiation and apoptosis, are distinguished by the expression of human papillomavirus 16 E7 in human bladder carcinoma cellsV M Richon
Cell Biology Program, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
Cancer Res 57:2789-98. 1997.... - p27 and Rb are on overlapping pathways suppressing tumorigenesis in miceM S Park
Program in Molecular Biology, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
Proc Natl Acad Sci U S A 96:6382-7. 1999..Importantly, we detected both pituitary and thyroid tumors earlier in the Rb+/-p27-/- mice. We therefore propose that Rb and p27 cooperate to suppress tumor development by integrating different regulatory signals... - Involvement of the Ink4a gene (p16 and p19arf) in murine tumorigenesisI Orlow
Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
Int J Oncol 15:17-24. 1999.... - Association of p27Kip1 levels with recurrence and survival in patients with stage C prostate carcinomaR J Cote
Department of Pathology, University of Southern California School of Medicine Norris Comprehensive Cancer Center, Los Angeles 90033, USA
J Natl Cancer Inst 90:916-20. 1998..We examined whether cellular levels of the cyclin-kinase inhibitor p27Kip1 (also known as p27) in prostate tumors could be used to predict progression of this disease... - Impaired Fas response and autoimmunity in Pten+/- miceA Di Cristofano
Department of Human Genetics Molecular Biology Program, Memorial Sloan Kettering Cancer Center, Sloan Kettering Institute, 1275 York Avenue, New York, NY 10021, USA
Science 285:2122-5. 1999..These results indicate that Pten is an essential mediator of the Fas response and a repressor of autoimmunity and thus implicate the PI 3-kinase/Akt pathway in Fas-mediated apoptosis... - Lipopolysaccharide induces disseminated endothelial apoptosis requiring ceramide generationA Haimovitz-Friedman
Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York 10021, USA
J Exp Med 186:1831-41. 1997..These investigations demonstrate that LPS induces a disseminated form of endothelial apoptosis, mediated sequentially by TNF and ceramide generation, and suggest that this cascade is mandatory for evolution of the endotoxic syndrome... - Validation of tissue microarrays for immunohistochemical profiling of cancer specimens using the example of human fibroblastic tumorsA Hoos
Department of Pathology, Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA
Am J Pathol 158:1245-51. 2001..Concordance of triplicate cores is high (96 to 98%) for two category distinction and decreases with the complexity of the phenotypes being analyzed (91%)... - Acid sphingomyelinase-deficient human lymphoblasts and mice are defective in radiation-induced apoptosisP Santana
Laboratory of Signal Transduction, Memorial Sloan Kettering Cancer Center New York, New York 10021, USA
Cell 86:189-99. 1996..These genetic models provide definitive evidence for the involvement of acid sphingomyelinase in one form of stress-induced apoptosis... - Mutation of Pten/Mmac1 in mice causes neoplasia in multiple organ systemsK Podsypanina
Departments of Pathology and Medicine, College of Physicians and Surgeons, Columbia University, 630 W 168th Street, P and S 14 453, New York, NY 10032, USA
Proc Natl Acad Sci U S A 96:1563-8. 1999..Taken together, these data suggest that PTEN is a regulator of apoptosis and proliferation that behaves as a "landscaper" tumor suppressor in the gut and a "gatekeeper" tumor suppressor in other organs... - The catalytic subunit of DNA-dependent protein kinase selectively regulates p53-dependent apoptosis but not cell-cycle arrestS Wang
Department of Medical Physics, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021 and Los Alamos National Laboratory, Los Alamos, NM 87545, USA
Proc Natl Acad Sci U S A 97:1584-8. 2000..Whereas Atm selects for cell-cycle arrest but not apoptosis, DNA-PKcs selects for apoptosis but not cell-cycle arrest... - Intranuclear compartmentalization of cyclin E during the cell cycle: disruption of the nucleoplasm-nucleolar shuttling of cyclin E in bladder cancerG Juan
Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
Cancer Res 61:1220-6. 2001..These observations suggest that the nucleolus mediates a cyclin E "shuttling" between the nucleus and the cytoplasm that is probably involved in its regulation and that this mechanism could be disrupted in bladder cancer... - Role of promyelocytic leukemia (PML) protein in tumor suppressionE M Rego
Department of Human Genetics and Molecular Biology Program, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
J Exp Med 193:521-29. 2001.... - Molecular analyses of the mitotic checkpoint components hsMAD2, hBUB1 and hBUB3 in human cancerE Hernando
Department of Pathology, Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA
Int J Cancer 95:223-7. 2001..These results suggest that mutations of the hsMAD2, hBUB1 and hBUB3 genes are very rare in bladder tumors and that hsMAD2 alterations are also infrequent in soft-tissue sarcomas and hepatocellular carcinomas... - Response of prostate cancer to anti-Her-2/neu antibody in androgen-dependent and -independent human xenograft modelsD B Agus
Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
Cancer Res 59:4761-4. 1999..These results suggest the utility of Herceptin in the treatment of human prostate cancer... - Evaluation of the telomeric repeat amplification protocol (TRAP) assay for telomerase as a diagnostic modality in recurrent bladder cancerG Dalbagni
Urology Service, Department of Surgery, Laboratories of Developmental Hematopoiesis, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
Clin Cancer Res 3:1593-8. 1997..The TRAP assay is reproducible, highly specific, and not dependent on the expertise of the cytopathologist. These results suggest that this assay should be further investigated as a diagnostic tool for bladder cancer... - Cigarette smoking and chromosome 9 alterations in bladder cancerZ F Zhang
Department of Epidemiology, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
Cancer Epidemiol Biomarkers Prev 6:321-6. 1997.... - Cell surface antigens of human melanocytes and melanoma. Expression of adenosine deaminase binding protein is extinguished with melanocyte transformationA N Houghton
Memorial Sloan Kettering Cancer Center, New York 10021
J Exp Med 167:197-212. 1988..These studies demonstrate that ADAbp expression is lost with malignant transformation of melanocytes, presumably at an early stage in the transformation process... - Pten and p27KIP1 cooperate in prostate cancer tumor suppression in the mouseA Di Cristofano
Department of Human Genetics, Memorial Sloan Kettering Cancer Center, Sloan Kettering Institute, New York, New York, USA
Nat Genet 27:222-4. 2001..Our findings reveal the crucial relevance of the combined tumor-suppressive activity of Pten and p27(Kip1) through the control of cell-cycle progression... - Expression of granulocyte-macrophage colony-stimulating factor receptors in human prostate cancerC I Rivas
Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
Blood 91:1037-43. 1998..These findings imply that both hyperplastic and neoplastic prostatic tissues may be responsive to GM-CSF... - Positron emission tomography of a human prostate cancer xenograft: association of changes in deoxyglucose accumulation with other measures of outcome following androgen withdrawalD B Agus
Department of Medicine and Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
Cancer Res 58:3009-14. 1998..The results suggest that serial monitoring of DOG accumulation using PET scanning may be useful as an early indicator of treatment efficacy and other outcome measures in prostate cancer... - Tissue microarray profiling of cancer specimens and cell lines: opportunities and limitationsA Hoos
Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York, USA
Lab Invest 81:1331-8. 2001..These approaches offer the opportunity to conduct pilot and validation studies of potential targets using clinical samples linked to clinicopathological databases... - Mzf1 controls cell proliferation and tumorigenesisM Gaboli
Molecular Biology Program, Memorial Sloan Kettering Cancer Center, Sloan Kettering Division, Graduate School of Medical Sciences, Cornell University, New York, New York 10021, USA
Genes Dev 15:1625-30. 2001..These findings demonstrate that Mzf1 can act as a tumor/growth suppressor in the hemopoietic compartment... - Alterations of cell cycle regulators affecting the RB pathway in nonfamilial retinoblastomaM Orjuela
Department of Pediatrics and School of Public Health, Columbia University, New York, NY 10021, USA
Hum Pathol 32:537-44. 2001..Thus, the inclusion of molecular markers may become useful adjuncts to clinicopathological staging and subsequent determination of therapy... - Expression of ras proto-oncogene proteins in normal human tissuesM E Furth
DeWitt Wallace Research Laboratory, Memorial Sloan Kettering Cancer Center, New York, New York 10021
Oncogene 1:47-58. 1987..The observed distribution of p21ras suggests a role for these proteins both in cellular proliferation and in certain specialized cellular functions... - Genetic alterations in tp53 in recurrent urothelial cancer: a longitudinal studyG Dalbagni
Department of Urology, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
Clin Cancer Res 7:2797-801. 2001..We postulated that if tumor cells at different points in the natural history of the disease contain an identical mutation in the TP53 gene, this pattern could provide evidence for the monoclonality of the recurrent bladder tumors... - Inhibition of transformed cell growth and induction of cellular differentiation by pyroxamide, an inhibitor of histone deacetylaseL M Butler
Cell Biology Program, Memorial Sloan-Kettering Cancer Center, New York, New York 10021, USA
Clin Cancer Res 7:962-70. 2001..CONCLUSIONS: The findings suggest that pyroxamide may be a useful agent for the treatment of malignancy and that induction of p21/WAF1 in transformed cells by pyroxamide may contribute to the antitumor effects of this agent... - Expression of c-kit and kit ligand proteins in normal human tissuesA Lammie
Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY 10021
J Histochem Cytochem 42:1417-25. 1994..In the central nervous system, KL expression was confined to Golgi and Purkinje cells in the cerebellum. These results suggest a role for this receptor and its ligand in the maintenance of a variety of fully differentiated tissues... - HER-2/neu (p185neu) protein expression in the natural or treated history of prostate cancerI Osman
Genitourinary Oncology Service, Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, New York 10021, USA
Clin Cancer Res 7:2643-7. 2001..It also emphasizes the importance of characterizing tumors at determined points in the natural or treated history of prostate cancer when targeting treatment to specific biological processes... - Assessing interactions between mdm-2, p53, and bcl-2 as prognostic variables in muscle-invasive bladder cancer treated with neo-adjuvant chemotherapy followed by locoregional surgical treatmentF C Maluf
The Genitourinary Oncology Service, Division of Solid Tumor Oncology, Department of Medicine, Memorial Sloan Kettering Cancer Center and the Department of Medicine, Joan and Sanford Weill Medical College of Cornell University, New York, USA
Ann Oncol 17:1677-86. 2006..Both individual and cooperative effects of these gene products may affect the biological behavior of primary bladder cancers and long-term outcome to standard therapy... - HDM2 protein overexpression, but not gene amplification, is related to tumorigenesis of cutaneous melanomaD Polsky
Ronald O. Perelman Department of Dermatology, New York University School of Medicine/Veterans Affairs Medical Center, New York, New York 10016, USA
Cancer Res 61:7642-6. 2001..HDM2 amplification occurs infrequently, and other mechanisms that up-regulate HDM2 expression are under investigation... - Applications of array technology: identification of molecular targets in bladder cancerM Sanchez-Carbayo
Division of Molecular Pathology, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
Br J Cancer 89:2172-7. 2003..This review summarizes bladder cancer studies dealing with both in vitro models and clinical specimens, using distinct microarray platforms for target discovery... - Type I transforming growth factor beta receptor maps to 9q22 and exhibits a polymorphism and a rare variant within a polyalanine tractB Pasche
Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
Cancer Res 58:2727-32. 1998..The clinical and biological significance of TbetaR-I(6A) homozygosity needs to be further investigated... - Endothelial apoptosis as the primary lesion initiating intestinal radiation damage in miceF Paris
Laboratory of Signal Transduction and, Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
Science 293:293-7. 2001..This study provides a basis for new approaches to prevent radiation damage to the bowel... - Sulindac inhibits neointimal formation after arterial injury in wild-type and apolipoprotein E-deficient miceE D Reis
Departments of Surgery, Medicine, and Pathology, and Zena and Michael A Wiener Cardiovascular Institute, Mount Sinai School of Medicine, 1 Gustave L Levy Place, New York, NY 10029, USA
Proc Natl Acad Sci U S A 97:12764-9. 2000..These results demonstrate sulindac reduces neointimal formation in both normolipidemic and hyperlipidemic settings and raise the possibility that similar benefits may be obtained in patients undergoing angioplasty and related procedures... - Delivery of replication-competent retrovirus expressing Escherichia coli purine nucleoside phosphorylase increases the metabolism of the prodrug, fludarabine phosphate and suppresses the growth of bladder tumor xenograftsE Kikuchi
Department of Urology, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
Cancer Gene Ther 14:279-86. 2007.... - Neuroblastic and Schwannian stromal cells of neuroblastoma are derived from a tumoral progenitor cellJ Mora
Department of Pediatrics, Memorial Sloan-Kettering Cancer Center, New York, New York 10021, USA
Cancer Res 61:6892-8. 2001.... - Evaluation of alterations in the tumor suppressor genes INK4A and INK4B in human bladder tumorsI Orlow
Department of Epidemiology and Biostatistics, Memorial Sloan-Kettering Cancer Center, New York, NY, USA
Methods Mol Biol 179:43-59. 2002 - A critical role for choline kinase-alpha in the aggressiveness of bladder carcinomasE Hernando
Molecular Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, USA
Oncogene 28:2425-35. 2009..05). Finally, treatment with a ChoKalpha-specific inhibitor resulted in a significant inhibition of tumor growth (P=0.02) and in a relevant increase in survival (P=0.03)... - Blood group-related antigens in human germ cell tumorsR J Motzer
Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York
Cancer Res 48:5342-7. 1988..If so, it is possible that the heterogeneous expression of blood group substances in seminomas with atypical histologies is an indication of differentiation towards nonseminomatous germ cell tumor... - Macrophage-derived chemokine expression in classical Hodgkin's lymphoma: application of tissue microarraysC V Hedvat
Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
Mod Pathol 14:1270-6. 2001..High levels of MDC expression were specific to CHD cases because only low levels of MDC were observed in a minor subset of LPHD, NHL or normal lymphoid tissues... - The expression of the Hu (paraneoplastic encephalomyelitis/sensory neuronopathy) antigen in human normal and tumor tissuesJ Dalmau
Department of Neurology, Memorial Sloan Kettering Cancer Center, New York, NY 10021
Am J Pathol 141:881-6. 1992..In lung tumors, the Hu antigen is restricted in its expression to all small cell carcinomas. A few other neuroendocrine-related tumors, especially neuroblastomas (50%), also express the antigen... - High Ki-67 proliferative index predicts disease specific survival in patients with high-risk soft tissue sarcomasA Hoos
Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA
Cancer 92:869-74. 2001.... - Altered patterns of retinoblastoma gene product expression in adult soft-tissue sarcomasM S Karpeh
Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA
Br J Cancer 72:986-91. 1995..It is postulated that RB alterations are primary events in human sarcomas and may be involved in tumorigenesis or early phases of tumour progression in these neoplasias... - Family history of cancer, body weight, and p53 nuclear overexpression in Duke's C colorectal cancerZ F Zhang
Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
Br J Cancer 71:888-93. 1995..The results suggest that p53 overexpression may be related to genetic predisposition to colorectal cancer, and p53-positive and p53-negative colorectal cancers may be controlled by different aetiological pathways... - Improved prediction of prostate cancer recurrence through systems pathologyCarlos Cordon Cardo
Memorial Sloan Kettering Cancer Center, New York, NY, USA
J Clin Invest 117:1876-83. 2007..This robust platform has broad applications in patient diagnosis, treatment management, and prognostication... - p73beta-Mediated apoptosis requires p57kip2 induction and IEX-1 inhibitionSusana Gonzalez
Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, USA
Cancer Res 65:2186-92. 2005..In the clinical context, these results might have potential therapeutic implications, because p73beta could induce alternative apoptotic responses in tumors harboring p53 mutations... - Safety and biologic activity of intravenous BCL-2 antisense oligonucleotide (G3139) and taxane chemotherapy in patients with advanced cancerMichael J Morris
Genitourinary Oncology Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
Appl Immunohistochem Mol Morphol 13:6-13. 2005..These data support the dose selection of ongoing phase 2 studies of G3139 at 7 mg/kg/d and docetaxel 75 mg/m2... - Molecular profiling of tumor progression in head and neck cancerThomas J Belbin
Department of Pathology, Albert Einstein College of Medicine Montefiore Medical Center, Bronx, NY 10461, USA
Arch Otolaryngol Head Neck Surg 131:10-8. 2005..To assess gene expression changes associated with tumor progression in patients with squamous cell carcinoma of the oral cavity... - Application of in situ hybridization probes for MLH-1 and MSH-2 in tissue microarrays of paraffin-embedded malignant melanomas: correlation with immunohistochemistry and tumor stageMonika Korabiowska
Department of Pathology, Reinhard Nieter Hospital, Wilhelmshaven, Germany
Hum Pathol 35:1543-8. 2004..Tissue microarrays can be used successfully in both in situ hybridization and immunohistochemistry to analyze the expression of DNA mismatch-repair genes... - Racial disparity of epidermal growth factor receptor expression in prostate cancerBrian Shuch
Department of Urology, New York University Cancer Institute, New York, NY, USA
J Clin Oncol 22:4725-9. 2004..CONCLUSION: Our data demonstrate that race contributes significantly to variability of EGFR expression in prostate cancer. Racial background may have an impact on the design of clinical trials to test the efficacy of anti-EGFR agents... - Genetic and immunophenotype analyses of TP53 in bladder cancer: TP53 alterations are associated with tumor progressionNadina Erill
BIOPAT, , Barcelona, Spain
Diagn Mol Pathol 13:217-23. 2004.... 
Systems pathology approach for the prediction of prostate cancer progression after radical prostatectomyMichael J Donovan
Aureon Laboratories Inc, 28 Wells Ave, Yonkers, NY 10701, USA
J Clin Oncol 26:3923-9. 2008..We developed such a tool through integration of clinicopathologic data with image analysis and quantitative immunofluorescence of prostate cancer tissue...- Preclinical validation of anti-TMEFF2-auristatin E-conjugated antibodies in the treatment of prostate cancerDaniel E H Afar
Protein Design Labs, Inc, 34801 Campus Drive, Fremont, CA 94555, USA
Mol Cancer Ther 3:921-32. 2004..These data support the further evaluation and clinical testing of huPr1-vcMMAE as a novel therapeutic for the treatment of metastatic and hormone-resistant prostate cancer... - Decreased retinoid X receptor-alpha protein expression in basal cells occurs in the early stage of human prostate cancer developmentGloria E Mao
Department of Epidemiology, School of Public Health, University of California Los Angeles, Los Angeles, CA, USA
Cancer Epidemiol Biomarkers Prev 13:383-90. 2004..These findings suggest that chemoprevention strategies with retinoids may be most effective if applied during the early stages of transformation... - Drg1 expression in 131 colorectal liver metastases: correlation with clinical variables and patient outcomesManish A Shah
Department of Medicine, Division of Solid Tumor Oncology, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
Clin Cancer Res 11:3296-302. 2005..The clinical evaluation of Drg1 in colorectal cancer has been limited. We performed this study to evaluate the role of Drg1 in a large cohort of patients with metastatic colorectal cancer who were irinotecan naive... - A phase I clinical trial of the sequential combination of irinotecan followed by flavopiridolManish A Shah
Department of Medicine, Division of Solid Tumor Oncology, Gastrointestinal Oncology Service, Memorial Sloan Kettering Cancer Center, New York, New York, USA
Clin Cancer Res 11:3836-45. 2005..Toxicity can be predicted by baseline bilirubin. Clinical activity is encouraging and may correlate to changes in p21 and Drg1 levels in patients with wild type p53 tumors following therapy... - Expression of p63 in diffuse large B-cell lymphomaCyrus V Hedvat
Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
Appl Immunohistochem Mol Morphol 13:237-42. 2005..Even though in univariate analysis p63 expression did not correlate with overall survival, the association of p63 with increased proliferative index suggests its involvement in DLBCL tumor progression... - Genomic and proteomic profiles reveal the association of gelsolin to TP53 status and bladder cancer progressionMarta Sanchez-Carbayo
Tumor Markers Group, Spanish National Cancer Center, Madrid, Spain
Am J Pathol 171:1650-8. 2007..This study further reveals that TP53 mutations are frequent events in bladder cancer progression and identified gelsolin related to TP53 status, tumor staging, and clinical outcome by independent high-throughput strategies... - PML inhibits HIF-1alpha translation and neoangiogenesis through repression of mTORRosa Bernardi
Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, Sloan Kettering Institute, 1275 York Avenue, New York, New York 10021, USA
Nature 442:779-85. 2006..Thus, our findings identify PML as a novel suppressor of mTOR and neoangiogenesis... - Analysis of DNA mismatch repair gene expression and mutations in thyroid tumoursIlka Ruschenburg
Cytological Laboratory, Einbeck, Germany
Anticancer Res 26:2107-12. 2006..No point mutations in the DNA mismatch repair genes MSH2 (exon 12, 13) and MLH1 (exon 15, 16) were found... - Altered expression of DNA double-strand repair genes Ku70 and Ku80 in carcinomas of the oral cavityMonika Korabiowska
Institute of Pathology, Reinhard Nieter Hospital, Academic Hospital of the University Göttingen, Wilhelmshaven, Germany
Anticancer Res 26:2101-5. 2006..Additionally, the expression of Ku70 was highly significantly related to smoking habits. Our results demonstrated that defects of DNA double-strand repair genes play an important role in the tumour progression of oral carcinomas... - Comparative oncogenomics identifies NEDD9 as a melanoma metastasis geneMinjung Kim
Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA
Cell 125:1269-81. 2006..Thus, comparative oncogenomics has enabled the identification and facilitated the validation of a highly relevant cancer gene governing metastatic potential in human melanoma... - Identification and validation of oncogenes in liver cancer using an integrative oncogenomic approachLars Zender
Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA
Cell 125:1253-67. 2006..Our results establish a tractable model of liver cancer, identify two oncogenes that cooperate by virtue of their coamplification in the same genomic locus, and suggest an efficient strategy for the annotation of human cancer genes... - Chk2 suppresses the oncogenic potential of DNA replication-associated DNA damageTravis H Stracker
Molecular Biology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, Cornell University Graduate School of Medical Sciences, New York, NY 10021, USA
Mol Cell 31:21-32. 2008..These data suggest that Chk2 suppresses the oncogenic potential of DNA damage arising during S and G2 phases of the cell cycle... - Defining molecular profiles of poor outcome in patients with invasive bladder cancer using oligonucleotide microarraysMarta Sanchez-Carbayo
Division of Molecular Pathology and Computational Biology Center Memorial Sloan Kettering Cancer Center, New York, NY, USA
J Clin Oncol 24:778-89. 2006..Bladder cancer is a common malignancy characterized by a poor clinical outcome when tumors progress into invasive disease. We sought to define genetic signatures characteristic of aggressive clinical behavior in advanced bladder tumors... - Profiling bladder cancer using targeted antibody arraysMarta Sanchez-Carbayo
Division of Molecular Pathology, Memorial Sloan Kettering Cancer Center, New York, New York, USA
Am J Pathol 168:93-103. 2006.... - A novel logistic model based on clinicopathological features predicts microsatellite instability in colorectal carcinomasAnna Colomer
BIOPAT, , Barcelona, Spain
Diagn Mol Pathol 14:213-23. 2005..It will also assist in identifying a subset of patients likely to benefit from adjuvant chemotherapy... - Gene expression profiling in single cells within tissuePaola Capodieci
Aureon Laboratories, 28 Wells Avenue, Yonkers, New York 10701, USA
Nat Methods 2:663-5. 2005..This identifies single-cell gene expression patterns by probing multiple, unique nascent RNA transcripts and yields predictive quantitative gene expression signatures... - Application of new in situ hybridization probes for Ku70 and Ku80 in tissue microarrays of paraffin-embedded malignant melanomas: correlation with immunohistochemical analysisMonika Korabiowska
Department of Cytopathology, Georg August University, Goettingen, Germany
Hum Pathol 35:210-6. 2004..The laboratory procedure is much more complicated than the immunohistochemical method, however... - p53 and RB: simple interesting correlates or tumor markers of critical predictive nature?Carlos Cordon-Cardo
J Clin Oncol 22:975-7. 2004 - Loss of the tumor suppressor PML in human cancers of multiple histologic originsCarmela Gurrieri
Molecular Biology Program and Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
J Natl Cancer Inst 96:269-79. 2004..However, its role in the pathogenesis of human cancers other than APL is still unclear. We therefore assessed the status and expression of the PML gene in solid tumors of multiple histologic origins... - Tissue microarray molecular profiling of early, node-negative adenocarcinoma of the rectum: a comprehensive analysisAxel Hoos
Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, New York 10021, USA
Clin Cancer Res 8:3841-9. 2002..However, down-regulation of p27 appears to be associated with a trend toward reduced DFS and DSS, which suggests further investigation of other p27-related pathways potentially relevant for metastatic disease... - Molecular profiling of bladder cancer using cDNA microarrays: defining histogenesis and biological phenotypesMarta Sanchez-Carbayo
Division of Molecular Pathology, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
Cancer Res 62:6973-80. 2002..However, it appears that deregulation of cell adhesion is a common event associated with tumor progression in uroepithelial neoplasms... - Loss of p63 expression is associated with tumor progression in bladder cancerMarshall J Urist
Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
Am J Pathol 161:1199-206. 2002..These data indicate that in contrast to the skin and prostate, p63 is not required for formation of a bladder epithelium but is indispensable for the specific differentiation of a transitional urothelium... - Allotype imbalance or microsatellite mutation in low-grade soft tissue sarcomas of the extremities in adultsNam Hoon Cho
Department of Pathology, Yonsei University College of Medicine, Seodaemoon ku, Shinchon dong, Seoul, Korea
J Pathol 198:21-9. 2002..In conclusion, whereas microsatellite mutation seems an uncommon event during the evolution of low-grade fibrosarcoma of the extremities in adults, the loss of DNA-PKcs defines a biologically more aggressive subset... - Amplification of the 3q26.3 locus is associated with progression to invasive cancer and is a negative prognostic factor in head and neck squamous cell carcinomasBhuvanesh Singh
Laboratory of Epithelial Cancer Biology, The Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
Am J Pathol 161:365-71. 2002..6; 95% confidence interval = 1.9 to 29.6). The findings suggest that the 3q copy number status is an important marker for tumor progression and prognostication in patients with head and neck squamous cell carcinoma... - Alteration of p53 pathway in squamous cell carcinoma of the head and neck: impact on treatment outcome in patients treated with larynx preservation intentIman Osman
Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA
J Clin Oncol 20:2980-7. 2002..Prospective and larger studies are necessary before integration of these molecular markers as part of molecular staging and predictors for organ preservation or other outcomes... - Decreased expression of Ku70/Ku80 proteins in malignant melanomas of the oral cavityMonika Korabiowska
Department of Cytopathology, University of Gottingen, Germany
Anticancer Res 22:193-6. 2002..05). We conclude that decreased Ku70/80 expression in malignant melanomas of the oral cavity and loss of correlation between these markers may influence progression of oral melanomas... - Differential expression of DNA nonhomologous end-joining proteins Ku70 and Ku80 in melanoma progressionMonika Korabiowska
Department of Cytopathology, , Germany
Mod Pathol 15:426-33. 2002..To summarize, earlier phases of melanoma progression seem to be connected with the loss of expression of Ku proteins. Metastatic spread is related to dysregulation of the Ku70 and Ku80 axis... - The precrystalline cytoplasmic granules of alveolar soft part sarcoma contain monocarboxylate transporter 1 and CD147Marc Ladanyi
Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
Am J Pathol 160:1215-21. 2002..The possible basis for the overproduction or impaired surface localization of these proteins in ASPS remains unclear... - Methylthioadenosine phosphorylase gene deletions are common in osteosarcomaJosé M García-Castellano
Orthopaedic Surgery Service, affiliated with Weil Medical College of Cornell University, New York, NY 10021, USA
Clin Cancer Res 8:782-7. 2002..The aim of this study was to investigate the frequency of molecular alterations in MTAP in osteosarcoma... - Phase I trial of BCL-2 antisense oligonucleotide (G3139) administered by continuous intravenous infusion in patients with advanced cancerMichael J Morris
Genitourinary Oncology Service, Division of Solid Tumor Oncology, Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, New York 10021, USA
Clin Cancer Res 8:679-83. 2002..Current randomized trials are using the highest daily dose established in this study given by shorter infusion periods (i.e., 7 mg/kg/day for 5-7 days) to enhance the antitumor activity of standard cytotoxic drugs... - Adrenocortical carcinoma: clinical, morphologic, and molecular characterizationAlexander Stojadinovic
Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA
J Clin Oncol 20:941-50. 2002..Multimolecular phenotyping demonstrates that the molecular complexity and heterogeneity of these neoplasms are such that targeted therapy needs to be patient specific... - p63 expression profiles in human normal and tumor tissuesCharles J Di Como
Division of Molecular Pathology, Department of Pathology, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
Clin Cancer Res 8:494-501. 2002..The p63 gene, located on chromosome 3q27-28, is a member of the p53 gene family. The product encoded by the p63 gene has been reported to be essential for normal development... - Impact of alterations affecting the p53 pathway in bladder cancer on clinical outcome, assessed by conventional and array-based methodsMing-Lan Lu
Department of Pathology, Memorial Sloan-Kettering Cancer Center, New York, New York 10021, USA
Clin Cancer Res 8:171-9. 2002..015), and it appears to be a significant prognostic factor associated with patient survival... - p27 deficiency desensitizes Rb-/- cells to signals that trigger apoptosis during pituitary tumor developmentCarmen Carneiro
Department of Molecular Biology, Menmorial Sloan Kettering Cancer Center, New York, NY 10021, USA
Oncogene 22:361-9. 2003..From these studies, we concluded that the absence of p27 disabled the trigger for an Arf-dependent apoptotic response in Rb-/- tumor cells. This suggests a novel mechanism by which the loss of p27 may impact on tumor development...