David J Chung

Summary

Affiliation: Memorial Sloan-Kettering Cancer Center
Country: USA

Publications

  1. doi request reprint T-cell Exhaustion in Multiple Myeloma Relapse after Autotransplant: Optimal Timing of Immunotherapy
    David J Chung
    Laboratory of Cellular Immunobiology, Sloan Kettering Institute for Cancer Research, Memorial Sloan Kettering Cancer Center, New York, New York Adult Bone Marrow Transplant Service, Division of Hematologic Oncology, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York Myeloma Service, Division of Hematologic Oncology, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York The Rockefeller University, New York, New York Weill Cornell Medical College, New York, New York
    Cancer Immunol Res 4:61-71. 2016
  2. pmc Langerhans-type and monocyte-derived human dendritic cells have different susceptibilities to mRNA electroporation with distinct effects on maturation and activation: implications for immunogenicity in dendritic cell-based immunotherapy
    David J Chung
    Laboratory of Cellular Immunobiology, New York, NY, USA
    J Transl Med 11:166. 2013
  3. pmc Indoleamine 2,3-dioxygenase-expressing mature human monocyte-derived dendritic cells expand potent autologous regulatory T cells
    David J Chung
    Laboratory of Cellular Immunobiology, Division of Hematologic Oncology, Memorial Sloan Kettering Cancer Center, 1275 York Ave, New York, NY 10065, USA
    Blood 114:555-63. 2009
  4. pmc Human Langerhans cells use an IL-15R-α/IL-15/pSTAT5-dependent mechanism to break T-cell tolerance against the self-differentiation tumor antigen WT1
    Emanuela Romano
    Laboratory of Cellular Immunobiology, Immunology Program, Sloan Kettering Institute for Cancer Research, New York, NY 10065, USA
    Blood 119:5182-90. 2012
  5. doi request reprint CD34-Selected Allogeneic Hematopoietic Stem Cell Transplantation for Patients with Relapsed, High-Risk Multiple Myeloma
    Eric Smith
    Hematology Oncology BMT Fellowship Program, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York Memorial Sloan Kettering Cancer Center, New York, New York
    Biol Blood Marrow Transplant 22:258-67. 2016
  6. pmc Peptide-loaded Langerhans cells, despite increased IL15 secretion and T-cell activation in vitro, elicit antitumor T-cell responses comparable to peptide-loaded monocyte-derived dendritic cells in vivo
    Emanuela Romano
    Laboratory of Cellular Immunobiology, Immunology Program, Sloan Kettering Institute for Cancer Research, New York, New York, USA
    Clin Cancer Res 17:1984-97. 2011
  7. pmc A phase 2 single-center study of carfilzomib 56 mg/m2 with or without low-dose dexamethasone in relapsed multiple myeloma
    Nikoletta Lendvai
    Myeloma Service, Memorial Sloan Kettering Cancer Center, New York, NY Department of Medicine, Weill Medical College of Cornell University, New York, NY and
    Blood 124:899-906. 2014

Collaborators

Detail Information

Publications7

  1. doi request reprint T-cell Exhaustion in Multiple Myeloma Relapse after Autotransplant: Optimal Timing of Immunotherapy
    David J Chung
    Laboratory of Cellular Immunobiology, Sloan Kettering Institute for Cancer Research, Memorial Sloan Kettering Cancer Center, New York, New York Adult Bone Marrow Transplant Service, Division of Hematologic Oncology, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York Myeloma Service, Division of Hematologic Oncology, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York The Rockefeller University, New York, New York Weill Cornell Medical College, New York, New York
    Cancer Immunol Res 4:61-71. 2016
    ..Cancer Immunol Res; 4(1); 61-71. ©2015 AACR. ..
  2. pmc Langerhans-type and monocyte-derived human dendritic cells have different susceptibilities to mRNA electroporation with distinct effects on maturation and activation: implications for immunogenicity in dendritic cell-based immunotherapy
    David J Chung
    Laboratory of Cellular Immunobiology, New York, NY, USA
    J Transl Med 11:166. 2013
    ..A detailed comparative evaluation of the effects of mRNA electroporation on LCs versus moDCs, however, is needed...
  3. pmc Indoleamine 2,3-dioxygenase-expressing mature human monocyte-derived dendritic cells expand potent autologous regulatory T cells
    David J Chung
    Laboratory of Cellular Immunobiology, Division of Hematologic Oncology, Memorial Sloan Kettering Cancer Center, 1275 York Ave, New York, NY 10065, USA
    Blood 114:555-63. 2009
    ....
  4. pmc Human Langerhans cells use an IL-15R-α/IL-15/pSTAT5-dependent mechanism to break T-cell tolerance against the self-differentiation tumor antigen WT1
    Emanuela Romano
    Laboratory of Cellular Immunobiology, Immunology Program, Sloan Kettering Institute for Cancer Research, New York, NY 10065, USA
    Blood 119:5182-90. 2012
    ..These data support the use of mRNA-electroporated LCs, or moDCs supplemented with exogenous rhuIL-15, as vaccines for cancer immunotherapy to break tolerance against self-differentiation antigens shared by tumors...
  5. doi request reprint CD34-Selected Allogeneic Hematopoietic Stem Cell Transplantation for Patients with Relapsed, High-Risk Multiple Myeloma
    Eric Smith
    Hematology Oncology BMT Fellowship Program, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York Memorial Sloan Kettering Cancer Center, New York, New York
    Biol Blood Marrow Transplant 22:258-67. 2016
    ..This study demonstrates notable safety and efficacy of CD34-selected HSCT in patients with multiply relapsed MM, including those with high-risk cytogenetics. ..
  6. pmc Peptide-loaded Langerhans cells, despite increased IL15 secretion and T-cell activation in vitro, elicit antitumor T-cell responses comparable to peptide-loaded monocyte-derived dendritic cells in vivo
    Emanuela Romano
    Laboratory of Cellular Immunobiology, Immunology Program, Sloan Kettering Institute for Cancer Research, New York, New York, USA
    Clin Cancer Res 17:1984-97. 2011
    ..We compared the efficacy of human Langerhans cells (LC) as tumor immunogens in vivo with monocyte-derived dendritic cells (moDC) and investigated how interleukin 15 (IL15) supports optimal DC-stimulated antitumor immunity...
  7. pmc A phase 2 single-center study of carfilzomib 56 mg/m2 with or without low-dose dexamethasone in relapsed multiple myeloma
    Nikoletta Lendvai
    Myeloma Service, Memorial Sloan Kettering Cancer Center, New York, NY Department of Medicine, Weill Medical College of Cornell University, New York, NY and
    Blood 124:899-906. 2014
    ..Seven patients (16%) discontinued treatment due to AEs. Carfilzomib 56 mg/m(2) ± dexamethasone was tolerable and provided durable responses. This trial was registered at www.clinicaltrials.gov as #NCT01351623. ..