Jayanta Chaudhuri

Summary

Affiliation: Memorial Sloan-Kettering Cancer Center
Country: USA

Publications

  1. pmc The splicing regulator PTBP2 interacts with the cytidine deaminase AID and promotes binding of AID to switch-region DNA
    Urszula Nowak
    Graduate Program in Immunology and Microbial Pathogenesis, Weill Cornell Medical School, New York, New York, USA
    Nat Immunol 12:160-6. 2011
  2. pmc CtIP promotes microhomology-mediated alternative end joining during class-switch recombination
    Mieun Lee-Theilen
    Immunology Program, Memorial Sloan Kettering Cancer Center, New York, New York, USA
    Nat Struct Mol Biol 18:75-9. 2011
  3. ncbi request reprint Immunology. Antibodies get a break
    Jayanta Chaudhuri
    Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Science 315:335-6. 2007
  4. pmc A DNA break- and phosphorylation-dependent positive feedback loop promotes immunoglobulin class-switch recombination
    Bao Q Vuong
    Immunology Program, Memorial Sloan Kettering Cancer Center, Gerstner Sloan Kettering Graduate School, New York, New York, USA
    Nat Immunol 14:1183-9. 2013
  5. doi request reprint Specific recruitment of protein kinase A to the immunoglobulin locus regulates class-switch recombination
    Bao Q Vuong
    Memorial Sloan Kettering Cancer Center, New York, New York, USA
    Nat Immunol 10:420-6. 2009
  6. ncbi request reprint Regulation of immunoglobulin class-switch recombination: choreography of noncoding transcription, targeted DNA deamination, and long-range DNA repair
    Allysia J Matthews
    Immunology Program, Memorial Sloan Kettering Cancer Center, New York, New York, USA Immunology and Microbial Pathogenesis Program, Weill Cornell Graduate School of Medical Sciences, New York, New York, USA
    Adv Immunol 122:1-57. 2014
  7. pmc Combinatorial mechanisms regulating AID-dependent DNA deamination: interacting proteins and post-translational modifications
    Bao Q Vuong
    Immunology Program, Memorial Sloan Kettering Cancer Center, Gerstner Sloan Kettering Graduate School, 1275 York Avenue, New York, NY 10065, United States
    Semin Immunol 24:264-72. 2012
  8. ncbi request reprint Evolution of the immunoglobulin heavy chain class switch recombination mechanism
    Jayanta Chaudhuri
    Immunology Program, Memorial Sloan Kettering Cancer Center, New York, New York, USA
    Adv Immunol 94:157-214. 2007
  9. pmc AID stabilizes stem-cell phenotype by removing epigenetic memory of pluripotency genes
    Ritu Kumar
    Department of Surgery, Weill Cornell Medical College, New York, New York 10065, USA
    Nature 500:89-92. 2013
  10. pmc Binding of AID to DNA Does Not Correlate with Mutator Activity
    Allysia J Matthews
    Immunology Program, Memorial Sloan Kettering Cancer Center, Gerstner Sloan Kettering Graduate School, New York, NY 10065 andImmunology and Microbial Pathogenesis Program, Weill Cornell Medical School, New York, NY 10065
    J Immunol 193:252-7. 2014

Collaborators

  • Bao Q Vuong
  • Jing Wang
  • Kevin D Mills
  • Anna Katerina Hadjantonakis
  • Olivier Elemento
  • Uttiya Basu
  • Raif S Geha
  • John P Manis
  • M Jasin
  • Allysia J Matthews
  • Frederick W Alt
  • Simin Zheng
  • Sean Rooney
  • Ali A Zarrin
  • Fatma Dedeoglu
  • Ritu Kumar
  • Mieun Lee-Theilen
  • Urszula Nowak
  • Haifa H Jabara
  • Shira Fraenkel
  • Darryll D Dudley
  • Solomon Husain
  • Lauren J DiMenna
  • Silvia Muñoz-Descalzo
  • Todd Evans
  • Nadine Schrode
  • Lauren Dimenna
  • Philipp Franck
  • Ting Chun Liu
  • Dierdre Kelly
  • Shilpee Dutt
  • Sonia Franco
  • Fredrick W Alt
  • Michael M Murphy
  • Yu Weng
  • Yehudit Bergman
  • Gloria Esposito
  • Raul Mostoslavsky
  • Klaus Rajewsky
  • Roberta Pelanda
  • Howard Cedar
  • Tatiana I Novobrantseva
  • Steffen Jung
  • Craig H Bassing
  • Ming Tian
  • Louis Du Pasquier
  • Nicole Stokes
  • Bruce Horwitz
  • Dhruv Kaushal
  • Dan Foy
  • Chengming Zhu
  • David Lombard
  • Hwei Ling Cheng
  • JoAnn Sekiguchi
  • Jeff DeVido
  • Scott Whitlow

Detail Information

Publications23

  1. pmc The splicing regulator PTBP2 interacts with the cytidine deaminase AID and promotes binding of AID to switch-region DNA
    Urszula Nowak
    Graduate Program in Immunology and Microbial Pathogenesis, Weill Cornell Medical School, New York, New York, USA
    Nat Immunol 12:160-6. 2011
    ..PTBP2 is thus an effector of CSR that promotes the binding of AID to switch-region DNA...
  2. pmc CtIP promotes microhomology-mediated alternative end joining during class-switch recombination
    Mieun Lee-Theilen
    Immunology Program, Memorial Sloan Kettering Cancer Center, New York, New York, USA
    Nat Struct Mol Biol 18:75-9. 2011
    ..Our results establish CtIP as a bona fide component of microhomology-dependent A-NHEJ and unmask a hitherto unrecognized physiological role of microhomology-mediated end joining in a C-NHEJ-proficient environment...
  3. ncbi request reprint Immunology. Antibodies get a break
    Jayanta Chaudhuri
    Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Science 315:335-6. 2007
  4. pmc A DNA break- and phosphorylation-dependent positive feedback loop promotes immunoglobulin class-switch recombination
    Bao Q Vuong
    Immunology Program, Memorial Sloan Kettering Cancer Center, Gerstner Sloan Kettering Graduate School, New York, New York, USA
    Nat Immunol 14:1183-9. 2013
    ..Our results identify a positive feedback loop for the amplification of DNA breaks at S regions through the phosphorylation- and ATM-dependent interaction of AID with APE1. ..
  5. doi request reprint Specific recruitment of protein kinase A to the immunoglobulin locus regulates class-switch recombination
    Bao Q Vuong
    Memorial Sloan Kettering Cancer Center, New York, New York, USA
    Nat Immunol 10:420-6. 2009
    ..We propose that PKA nucleates the formation of active AID complexes specifically on S regions to generate the high density of DNA lesions required for CSR...
  6. ncbi request reprint Regulation of immunoglobulin class-switch recombination: choreography of noncoding transcription, targeted DNA deamination, and long-range DNA repair
    Allysia J Matthews
    Immunology Program, Memorial Sloan Kettering Cancer Center, New York, New York, USA Immunology and Microbial Pathogenesis Program, Weill Cornell Graduate School of Medical Sciences, New York, New York, USA
    Adv Immunol 122:1-57. 2014
    ..Finally, we summarize recent data on the potential role of AID in the maintenance of the pluripotent stem cell state during epigenetic reprogramming. ..
  7. pmc Combinatorial mechanisms regulating AID-dependent DNA deamination: interacting proteins and post-translational modifications
    Bao Q Vuong
    Immunology Program, Memorial Sloan Kettering Cancer Center, Gerstner Sloan Kettering Graduate School, 1275 York Avenue, New York, NY 10065, United States
    Semin Immunol 24:264-72. 2012
    ....
  8. ncbi request reprint Evolution of the immunoglobulin heavy chain class switch recombination mechanism
    Jayanta Chaudhuri
    Immunology Program, Memorial Sloan Kettering Cancer Center, New York, New York, USA
    Adv Immunol 94:157-214. 2007
    ....
  9. pmc AID stabilizes stem-cell phenotype by removing epigenetic memory of pluripotency genes
    Ritu Kumar
    Department of Surgery, Weill Cornell Medical College, New York, New York 10065, USA
    Nature 500:89-92. 2013
    ..AID regulates this late step, removing epigenetic memory to stabilize the pluripotent state. ..
  10. pmc Binding of AID to DNA Does Not Correlate with Mutator Activity
    Allysia J Matthews
    Immunology Program, Memorial Sloan Kettering Cancer Center, Gerstner Sloan Kettering Graduate School, New York, NY 10065 andImmunology and Microbial Pathogenesis Program, Weill Cornell Medical School, New York, NY 10065
    J Immunol 193:252-7. 2014
    ..Furthermore, our findings suggest that S regions are preferred targets for AID and, aided by polypyrimidine tract binding protein-2, act as "sinks" to sequester AID activity from other genomic regions. ..
  11. ncbi request reprint Class-switch recombination: interplay of transcription, DNA deamination and DNA repair
    Jayanta Chaudhuri
    Howard Hughes Medical Institute, Center for Blood Research and Department of Genetics, Harvard University Medical School, Boston, Massachusetts 02115, USA
    Nat Rev Immunol 4:541-52. 2004
  12. ncbi request reprint Mechanism and control of V(D)J recombination versus class switch recombination: similarities and differences
    Darryll D Dudley
    Howard Hughes Medical Institute, The Children s Hospital Boston, CBR Institute for Biomedical Research, and Harvard Medical School, Boston, MA 02115, USA
    Adv Immunol 86:43-112. 2005
    ..In this review, we compare and contrast V(D)J recombination and CSR, with particular emphasis on the role of the initiating enzymes and DNA repair proteins in these processes...
  13. ncbi request reprint B-cell receptor cross-linking delays activation-induced cytidine deaminase induction and inhibits class-switch recombination to IgE
    Haifa H Jabara
    Division of Immunology, Children s Hospital, Boston, MA 02115, USA
    J Allergy Clin Immunol 121:191-196.e2. 2008
    ..During differentiation, B cells receive signals by antigen through the B-cell receptor (BCR) and signals that induce isotype switching...
  14. ncbi request reprint An evolutionarily conserved target motif for immunoglobulin class-switch recombination
    Ali A Zarrin
    Howard Hughes Medical Institute, The Children s Hospital, CBR Institute for Biomedical Research, and Department of Genetics, Harvard University Medical School, Boston, Massachusetts 02115, USA
    Nat Immunol 5:1275-81. 2004
    ..We propose that AGCT is a primordial CSR motif that targets AID through a non-R-loop mechanism involving an AID-replication protein A complex...
  15. ncbi request reprint Transcription-targeted DNA deamination by the AID antibody diversification enzyme
    Jayanta Chaudhuri
    Howard Hughes Medical Institute, The Children s Hospital, The Center for Blood Research, and Department of Genetics, Harvard University Medical School, Boston, Massachusetts 02115, USA
    Nature 422:726-30. 2003
    ..We conclude that transcription targets the DNA deamination activity of AID to dsDNA by generating secondary structures that provide ssDNA substrates...
  16. ncbi request reprint Replication protein A interacts with AID to promote deamination of somatic hypermutation targets
    Jayanta Chaudhuri
    Howard Hughes Medical Institute, Children s Hospital, Center for Blood Research and Department of Genetics, Harvard University Medical School, Boston, Massachusetts 02115, USA
    Nature 430:992-8. 2004
    ..We propose that B-cell-specific AID-RPA complexes preferentially bind to ssDNA of small transcription bubbles at SHM 'hotspots', leading to AID-mediated deamination and RPA-mediated recruitment of DNA repair proteins...
  17. ncbi request reprint Allelic 'choice' governs somatic hypermutation in vivo at the immunoglobulin kappa-chain locus
    Shira Fraenkel
    The Hebrew University Hadassah Medical School, Jerusalem 91120, Israel
    Nat Immunol 8:715-22. 2007
    ..Thus, it seems that the epigenetic mechanisms that initially bring about monoallelic variable-(diversity)-joining rearrangement continue to be involved in the control of antibody diversity at later stages of B cell development...
  18. ncbi request reprint Regulation of activation induced deaminase via phosphorylation
    Uttiya Basu
    The Howard Hughes Medical Institute, The Children s Hospital, The CBR Institute for Biomedical Research, and Department of Genetics, Harvard Medical School, Boston, MA 02115, USA
    Adv Exp Med Biol 596:129-37. 2007
    ..Here, we will discuss the implications of recent studies that demonstrate the role of AID phosphorylation in augmenting AID activity with respect to these two processes...
  19. ncbi request reprint The AID antibody diversification enzyme is regulated by protein kinase A phosphorylation
    Uttiya Basu
    The Howard Hughes Medical Institute, The Children s Hospital, The CBR Institute for Biomedical Research, and Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nature 438:508-11. 2005
    ..We conclude that PKA has a critical role in post-translational regulation of AID activity in B cells...
  20. ncbi request reprint The role of the non-homologous end-joining pathway in lymphocyte development
    Sean Rooney
    Howard Hughes Medical Institute, The Children s Hospital, The Department of Genetics, Harvard Medical School and The Center for Blood Research, Boston, MA 02115, USA
    Immunol Rev 200:115-31. 2004
    ..In this review, we discuss the factors that constitute this pathway as well as the evidence of their involvement in two lymphoid-specific DNA recombination events...
  21. ncbi request reprint Induction of activation-induced cytidine deaminase gene expression by IL-4 and CD40 ligation is dependent on STAT6 and NFkappaB
    Fatma Dedeoglu
    Division of Immunology, Children s Hospital and Department of Pediatrics, Harvard Medical School, Harvard Medical School, Boston, MA 02115, USA
    Int Immunol 16:395-404. 2004
    ..These results suggest that signals delivered via CD40 that activate NFkappaB synergize with signals delivered via the IL-4 receptor that activate STAT6 to induce optimal AID gene expression...
  22. ncbi request reprint Leaky Scid phenotype associated with defective V(D)J coding end processing in Artemis-deficient mice
    Sean Rooney
    Howard Hughes Medical Institute, The Children s Hospital, The Center for Blood Research, Harvard Medical School, Brigham and Women s Hospital, Boston, MA 02115, USA
    Mol Cell 10:1379-90. 2002
    ..Finally, Artemis deficiency leads to chromosomal instability in fibroblasts, demonstrating that Artemis functions as a genomic caretaker...

Research Grants2

  1. ELUCIDATION OF IMMUNOGLOBULIN CLASS SWITCH RECOMBINATION AND SOMATIC HYPERMUTATIO
    Jayanta Chaudhuri; Fiscal Year: 2009
    ..It is now clear that a large majority of B cell tumors arise due to mistargeted AID activity. Experiments proposed here will elucidate the role of AID in both immunity and cancer. ..
  2. ELUCIDATION OF IMMUNOGLOBULIN CLASS SWITCH RECOMBINATION AND SOMATIC HYPERMUTATIO
    Jayanta Chaudhuri; Fiscal Year: 2010
    ..It is now clear that a large majority of B cell tumors arise due to mistargeted AID activity. Experiments proposed here will elucidate the role of AID in both immunity and cancer. ..