Jayanta Chaudhuri

Summary

Affiliation: Memorial Sloan-Kettering Cancer Center
Country: USA

Publications

  1. ncbi Immunology. Antibodies get a break
    Jayanta Chaudhuri
    Immunology Program, Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA
    Science 315:335-6. 2007
  2. ncbi Evolution of the immunoglobulin heavy chain class switch recombination mechanism
    Jayanta Chaudhuri
    Immunology Program, Memorial Sloan Kettering Cancer Center, New York, New York, USA
    Adv Immunol 94:157-214. 2007
  3. ncbi Specific recruitment of protein kinase A to the immunoglobulin locus regulates class-switch recombination
    Bao Q Vuong
    Memorial Sloan Kettering Cancer Center, New York, New York, USA
    Nat Immunol 10:420-6. 2009
  4. ncbi B-cell receptor cross-linking delays activation-induced cytidine deaminase induction and inhibits class-switch recombination to IgE
    Haifa H Jabara
    Division of Immunology, Children s Hospital, Boston, MA 02115, USA
    J Allergy Clin Immunol 121:191-196.e2. 2008
  5. ncbi Mechanism and control of V(D)J recombination versus class switch recombination: similarities and differences
    Darryll D Dudley
    Howard Hughes Medical Institute, The Children's Hospital Boston, CBR Institute for Biomedical Research, and Harvard Medical School, Boston, MA 02115, USA
    Adv Immunol 86:43-112. 2005
  6. ncbi An evolutionarily conserved target motif for immunoglobulin class-switch recombination
    Ali A Zarrin
    Howard Hughes Medical Institute, The Children's Hospital, CBR Institute for Biomedical Research, and Department of Genetics, Harvard University Medical School, Boston, Massachusetts 02115, USA
    Nat Immunol 5:1275-81. 2004
  7. ncbi Replication protein A interacts with AID to promote deamination of somatic hypermutation targets
    Jayanta Chaudhuri
    Howard Hughes Medical Institute, Children s Hospital, Center for Blood Research and Department of Genetics, Harvard University Medical School, Boston, Massachusetts 02115, USA
    Nature 430:992-8. 2004
  8. ncbi Class-switch recombination: interplay of transcription, DNA deamination and DNA repair
    Jayanta Chaudhuri
    Howard Hughes Medical Institute, Center for Blood Research and Department of Genetics, Harvard University Medical School, Boston, Massachusetts 02115, USA
    Nat Rev Immunol 4:541-52. 2004
  9. ncbi Transcription-targeted DNA deamination by the AID antibody diversification enzyme
    Jayanta Chaudhuri
    Howard Hughes Medical Institute, The Children s Hospital, The Center for Blood Research, and Department of Genetics, Harvard University Medical School, Boston, Massachusetts 02115, USA
    Nature 422:726-30. 2003
  10. ncbi The role of the non-homologous end-joining pathway in lymphocyte development
    Sean Rooney
    Howard Hughes Medical Institute, The Children's Hospital, The Department of Genetics, Harvard Medical School and The Center for Blood Research, Boston, MA 02115, USA
    Immunol Rev 200:115-31. 2004

Research Grants

  1. ELUCIDATION OF IMMUNOGLOBULIN CLASS SWITCH RECOMBINATION AND SOMATIC HYPERMUTATIO
    Jayanta Chaudhuri; Fiscal Year: 2010

Collaborators

  • M Jasin
  • John P Manis
  • Raif S Geha
  • Frederick W Alt
  • Uttiya Basu
  • Sean Rooney
  • Fatma Dedeoglu
  • Bao Q Vuong
  • Haifa H Jabara
  • Shira Fraenkel
  • Shilpee Dutt
  • Darryll D Dudley
  • Ali A Zarrin
  • Stephania Macchiarulo
  • G Stanley McKnight
  • Cristina Irimia
  • Mieun Lee
  • Shaheen Kabir
  • Fredrick W Alt
  • Yu Weng
  • Sonia Franco
  • Michael M Murphy
  • Klaus Rajewsky
  • Steffen Jung
  • Yehudit Bergman
  • Gloria Esposito
  • Howard Cedar
  • Raul Mostoslavsky
  • Tatiana I Novobrantseva
  • Roberta Pelanda
  • Ryan T Phan
  • Abhishek Datta
  • Jason Patrick Schrum
  • Gang Li
  • Sheila Ranganath
  • Craig H Bassing
  • Craig Alpert
  • Dhruv Kaushal
  • Ming Tian
  • Nicole Stokes
  • Bruce Horwitz
  • Louis Du Pasquier
  • Chengming Zhu
  • Jeff DeVido
  • David Lombard
  • Scott Whitlow
  • Dan Foy
  • JoAnn Sekiguchi
  • Hwei Ling Cheng

Detail Information

Publications15

  1. ncbi Immunology. Antibodies get a break
    Jayanta Chaudhuri
    Immunology Program, Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA
    Science 315:335-6. 2007
  2. ncbi Evolution of the immunoglobulin heavy chain class switch recombination mechanism
    Jayanta Chaudhuri
    Immunology Program, Memorial Sloan Kettering Cancer Center, New York, New York, USA
    Adv Immunol 94:157-214. 2007
    ....
  3. ncbi Specific recruitment of protein kinase A to the immunoglobulin locus regulates class-switch recombination
    Bao Q Vuong
    Memorial Sloan Kettering Cancer Center, New York, New York, USA
    Nat Immunol 10:420-6. 2009
    ..We propose that PKA nucleates the formation of active AID complexes specifically on S regions to generate the high density of DNA lesions required for CSR...
  4. ncbi B-cell receptor cross-linking delays activation-induced cytidine deaminase induction and inhibits class-switch recombination to IgE
    Haifa H Jabara
    Division of Immunology, Children s Hospital, Boston, MA 02115, USA
    J Allergy Clin Immunol 121:191-196.e2. 2008
    ..During differentiation, B cells receive signals by antigen through the B-cell receptor (BCR) and signals that induce isotype switching...
  5. ncbi Mechanism and control of V(D)J recombination versus class switch recombination: similarities and differences
    Darryll D Dudley
    Howard Hughes Medical Institute, The Children's Hospital Boston, CBR Institute for Biomedical Research, and Harvard Medical School, Boston, MA 02115, USA
    Adv Immunol 86:43-112. 2005
    ..In this review, we compare and contrast V(D)J recombination and CSR, with particular emphasis on the role of the initiating enzymes and DNA repair proteins in these processes...
  6. ncbi An evolutionarily conserved target motif for immunoglobulin class-switch recombination
    Ali A Zarrin
    Howard Hughes Medical Institute, The Children's Hospital, CBR Institute for Biomedical Research, and Department of Genetics, Harvard University Medical School, Boston, Massachusetts 02115, USA
    Nat Immunol 5:1275-81. 2004
    ..We propose that AGCT is a primordial CSR motif that targets AID through a non-R-loop mechanism involving an AID-replication protein A complex...
  7. ncbi Replication protein A interacts with AID to promote deamination of somatic hypermutation targets
    Jayanta Chaudhuri
    Howard Hughes Medical Institute, Children s Hospital, Center for Blood Research and Department of Genetics, Harvard University Medical School, Boston, Massachusetts 02115, USA
    Nature 430:992-8. 2004
    ..We propose that B-cell-specific AID-RPA complexes preferentially bind to ssDNA of small transcription bubbles at SHM 'hotspots', leading to AID-mediated deamination and RPA-mediated recruitment of DNA repair proteins...
  8. ncbi Class-switch recombination: interplay of transcription, DNA deamination and DNA repair
    Jayanta Chaudhuri
    Howard Hughes Medical Institute, Center for Blood Research and Department of Genetics, Harvard University Medical School, Boston, Massachusetts 02115, USA
    Nat Rev Immunol 4:541-52. 2004
  9. ncbi Transcription-targeted DNA deamination by the AID antibody diversification enzyme
    Jayanta Chaudhuri
    Howard Hughes Medical Institute, The Children s Hospital, The Center for Blood Research, and Department of Genetics, Harvard University Medical School, Boston, Massachusetts 02115, USA
    Nature 422:726-30. 2003
    ..We conclude that transcription targets the DNA deamination activity of AID to dsDNA by generating secondary structures that provide ssDNA substrates...
  10. ncbi The role of the non-homologous end-joining pathway in lymphocyte development
    Sean Rooney
    Howard Hughes Medical Institute, The Children's Hospital, The Department of Genetics, Harvard Medical School and The Center for Blood Research, Boston, MA 02115, USA
    Immunol Rev 200:115-31. 2004
    ..In this review, we discuss the factors that constitute this pathway as well as the evidence of their involvement in two lymphoid-specific DNA recombination events...
  11. ncbi The AID antibody diversification enzyme is regulated by protein kinase A phosphorylation
    Uttiya Basu
    The Howard Hughes Medical Institute, The Children s Hospital, The CBR Institute for Biomedical Research, and Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nature 438:508-11. 2005
    ..We conclude that PKA has a critical role in post-translational regulation of AID activity in B cells...
  12. ncbi Regulation of activation induced deaminase via phosphorylation
    Uttiya Basu
    The Howard Hughes Medical Institute, The Children s Hospital, The CBR Institute for Biomedical Research, and Department of Genetics, Harvard Medical School, Boston, MA 02115, USA
    Adv Exp Med Biol 596:129-37. 2007
    ..Here, we will discuss the implications of recent studies that demonstrate the role of AID phosphorylation in augmenting AID activity with respect to these two processes...
  13. ncbi Allelic 'choice' governs somatic hypermutation in vivo at the immunoglobulin kappa-chain locus
    Shira Fraenkel
    The Hebrew University Hadassah Medical School, Jerusalem 91120, Israel
    Nat Immunol 8:715-22. 2007
    ..Thus, it seems that the epigenetic mechanisms that initially bring about monoallelic variable-(diversity)-joining rearrangement continue to be involved in the control of antibody diversity at later stages of B cell development...
  14. ncbi Induction of activation-induced cytidine deaminase gene expression by IL-4 and CD40 ligation is dependent on STAT6 and NFkappaB
    Fatma Dedeoglu
    Division of Immunology, Children s Hospital and Department of Pediatrics, Harvard Medical School, Harvard Medical School, Boston, MA 02115, USA
    Int Immunol 16:395-404. 2004
    ..These results suggest that signals delivered via CD40 that activate NFkappaB synergize with signals delivered via the IL-4 receptor that activate STAT6 to induce optimal AID gene expression...
  15. ncbi Leaky Scid phenotype associated with defective V(D)J coding end processing in Artemis-deficient mice
    Sean Rooney
    Howard Hughes Medical Institute, The Children s Hospital, The Center for Blood Research, Harvard Medical School, Brigham and Women s Hospital, Boston, MA 02115, USA
    Mol Cell 10:1379-90. 2002
    ..Finally, Artemis deficiency leads to chromosomal instability in fibroblasts, demonstrating that Artemis functions as a genomic caretaker...

Research Grants2

  1. ELUCIDATION OF IMMUNOGLOBULIN CLASS SWITCH RECOMBINATION AND SOMATIC HYPERMUTATIO
    Jayanta Chaudhuri; Fiscal Year: 2010
    ..It is now clear that a large majority of B cell tumors arise due to mistargeted AID activity. Experiments proposed here will elucidate the role of AID in both immunity and cancer. ..